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| 1 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 2 | Behavior of Siderophile and Chalcophile Elements in the Subcontinental Lithospheric Mantle beneath the Changbaishan Volcano,NE China显示文摘The mantle xenoliths in the Quaternary ChangbaishanVolcano in southern Jilin Province contain spinel-facies lherzolites.The equilibration temperatures for these samples range from 902oC to 1064oC based on the two-pyroxene thermometer of Brey and K?hler(1990),and using the oxybarometry of Nell and Wood(1991),the oxidation state was estimated from FMQ-1.32 to-0.38 with an average value of FMQ-0.81(n=8),which is comparable to that of abyssal peridotites and the asthenospheric mantle.The fO2 values of peridotites,together with their bulk rock compositions(e.g.,Mg#,Al2O3,CaO,Ni,Co,Cr) and mineral compositions(e.g.,Mg# of olivine and pyroxene,Cr# [=Cr/[Cr+Al]] and Mg# [=Mg/[Mg+Fe2+] of spinel),suggest that the present-day subcontinental lithospheric mantle(SCLM) beneath the Changbaishan Volcano most likely formed from an upwelling asthenosphere at some time after the late Mesozoic and has undergone a low degree of partial melting.The studied lherzolite xenoliths show low concentrations of S,Cu,and platinum group elements(PGE),which plot a flat pattern on primitive-mantle normalized diagram.Very low concentrations in our samples suggest that PGEs occur as alloys or hosted by silicate and oxide minerals.The compositions of the studied samples are similar to those of peridotite xenoliths in the Longgang volcanic field(LVF) in their mineralogy and bulk rock compositions including the abundance of chalcophile and siderophile elements.However,they are distinctly different from those of peridotite xenoliths in other areas of the North China Craton(NCC) in terms of Cu,S and PGE.Our data suggest that the SCLM underlying the northeastern part of the NCC may represent a distinct unit of the newly formed lithospheric mantle. | WANG Jian LIU Jinlin HATTORI Keiko XU Wenliang XIE Zhipeng SONG Yue | 2012 | Acta Geologica Sinica(English Edition)2012，86，2： | 8 |
| 3 | Facile preparation of pH-responsive PEGylated prodrugs for activated intracellular drug delivery显示文摘PEGylated prodrug,covalent attaching polyethylene glycol(PEG) polymer chains to therapeutic drugs,is one of the most promising techniques to improve the water-solubility,stability,and therapeutic effect of drugs.In this study,three PEGylated acid-sensitive prodrugs DOX-PEG-DOX with different molecular weights,were prepared via Schiff-base reaction between aldehyde-modified PEG and the amino groups of doxorubicin(DOX).This kind of amphiphilic polymeric prodrug could be self-assemble into nanoparticles in aqueous solution.The average particle size and morphologies of the prodrug nanoparticles under different pH conditions were observed by dynamic light scattering(DLS) and transmission electron microscopy(TEM),re s pectively.It turned out that the nanoparticles could be kept stable in the physiological environment,but degraded in acidic medium.Subsequently,we also investigated in vitro drug release behavior and found that the prodrug had acid-sensitive property.The cytotoxicity and intracellular uptake assays revealed that the prodrugs could rapidly internalized by HeLa or HepG2 cells to release DOX and effectively inhibited the proliferation of the tumor cells,which have the potential for use in cancer therapy. | Yue Song Dian Li Jinlin He Mingzu Zhang Peihong Ni | 2019 | Chinese Chemical Letters2019，30，12： | 3 |
| 4 | Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system显示文摘Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss. Four-octyl itaconate(4-OI) is a cell-permeable itaconate derivative and has been recognized as a promising therapeutic target for the treatment of inflammatory diseases. Here, we explored, for the first time,the protective effect of 4-OI on inhibiting periodontal destruction, ameliorating local inflammation, and the underlying mechanism in periodontitis. Here we showed that 4-OI treatment ameliorates inflammation induced by lipopolysaccharide in the periodontal microenvironment. 4-OI can also significantly alleviate inflammation and alveolar bone loss via Nrf2 activation as observed on samples from experimental periodontitis in the C57BL/6 mice. This was further confirmed as silencing Nrf2 blocked the antioxidant effect of 4-OI by downregulating the expression of downstream antioxidant enzymes. Additionally, molecular docking simulation indicated the possible mechanism under Nrf2 activation. Also, in Nrf2-/-mice, 4-OI treatment did not protect against alveolar bone dysfunction due to induced periodontitis, which underlined the importance of the Nrf2 in 4-OI mediated periodontitis treatment.Our results indicated that 4-OI attenuates inflammation and oxidative stress via disassociation of KEAP1-Nrf2 and activation of Nrf2 signaling cascade. Taken together, local administration of 4-OI offers clinical potential to inhibit periodontal destruction,ameliorate local inflammation for more predictable periodontitis. | Liangjing Xin Fuyuan Zhou Chuangwei Zhang Wenjie Zhong Shihan Xu Xuan Jing Dong Wang Si Wang Tao Chen Jinlin Song | 2022 | International Journal of Oral Science2022，14，3： | 3 |
| 5 | Effects of short-term anoxic treatment on antioxidant ability and membrane integrity of postharvest kiwifruit during storage显示文摘 | Lili Song Haiyan Gao Hangjun Chen Jinlin Mao Yongjun Zhou Wenxuan Chen Yueming Jiang | 2008 | Food Chemistry2008，，： | 2 |
| 6 | Genkwadane F-I,New Daphnane-type Diterpenes from the Flower Buds of Daphne genkwa Sieb.et Zucc.Exhibit Anti-tumor Activities via lnducing Apoptosis显示文摘of main observation and conclusion Genkwadane F-I(1-4),four new diterpenes,along with four known ones(5-8),were isolated from the flower buds of D.genkwa.The structures including absolute configurations of 1-4 were determined based on the analysis of NMR and ECD calculations.All compounds were evaluated for their cytotoxicities against MCF-7 and Hep3B cell lines,among which compounds 3 and 4 showed significant activities.Compound 4 exhibited the most potent activity with IC50 values of 1.33μM against MCF-7,and the IC50 values of compound 3 against MCF-7 and Hep3B were 5.54μM and 8.73μM;respectively.Further studies by Hoechst 33258 staining and Annexin V/PI analysis demonstrated that compounds 3 and 4 could induce apoptosis to exhibit anti-tumor activities. | Xuewen Hou Jingjie Chen Xuefen Hou Pinyi Gao Jinlin Wang Shaojiang Song Lingzhi Li | 2020 | Chinese Journal of Chemistry2020，38，12： | 1 |
| 7 | The Geological Significance of the Deformation and Geochronology of the Xiaotian–Mozitan Shear Zone in the Dabie Orogenic Belt(East-Central China)显示文摘The Xiaotian–Mozitan Shear Zone(XMSZ)is the boundary of the Dabie High-grade Metamorphic Complex(DHMC)and the North Huaiyang Tectonic Belt.It was deformed in ductile conditions with a top-to-NW/WNW movement.Geothermometers applied to mineral parageneses in mylonites of the shear zone give a temperature range of 623–691°C for the predeformation and 515–568°C for the syndeformation,respectively,which indicates a retrograde process of evolution.A few groups of zircon U-Pb ages were obtained from undeformed granitic veins and different types of deformed rocks in the zone.Zircons from the felsic ultramylonites are all magmatic,producing a weighted mean 206Pb/238U age of 754±8.1 Ma,which indicates the time of magmatic activities caused by rifting in the Neoproterozoic.Zircons from the granitic veins,cutting into the mylonites,are also of magmatic origin,producing a weighted mean 206 Pb/238 U age of 130±2.5 Ma,which represents the time of regional magmatic activity in the Cretaceous.Zircons from the mylonitic gneisses are of anatectic-metamorphic origins and are characterized by a core-mantle interior texture,which yielded several populations of ages including the Neoproterozoic ages with a weighted mean 206 Pb/238 U age of 762±18 Ma,similar to that of the felsic ultramylonites and the Early Cretaceous ages with a weighted mean 206Pb/238U age of 143±1.8 Ma,indicating the anatectic metamorphism in the Dabie Orogenic Belt(DOB).Based on integrated analysis of the structure,thermal conditions of ductile deformation and the contact relations of the dated rocks,the activation time of the Xiaotian–Mozitan Shear Zone is constrained between~143 Ma and 130 Ma,during which the DOB was undergoing a transition in tectonic regime from compression to extension.Therefore,the deformation and evolution of this shear zone plays an instrumental role in fully understanding this process.This research also inclines us to the interpretation of it as an extensional detachment,with regard to the tectonic properties of the shear zone.It may also be part of a continental scale extension in the background of the North China Block’s cratonic destruction,dominated by the subduction and roll-back of the Paleo-Pacific plate,but more detailed work is needed in order to unravel its complicated development. | HUANG Peng SONG Chuanzhong XIAO Wenjiao LI Jiahao ZHOU Kefa WANG Jinlin NIJIATI Abuduxun LI Zhenwei | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 1 |
| 8 | pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats显示文摘Precise and controlled drug delivery to treat periodontitis in patients with diabetes remains a significant clinical challenge.Nanoparticle-based drug delivery systems offer a potential therapeutic strategy;however,the low loading efficiency,non-responsiveness,and single effect of conventional nanoparticles hinder their clinical application.In this study,we designed a novel self-assembled,dual responsive,and dual drug-loading nanocarrier system,which comprised two parts:the hydrophobic lipid core formed by 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-Poly(ethylene glycol)(DSPE-PEG)loaded with alpha-lipoic acid(ALA);and a hydrophilic shell comprising a poly(amidoamine)dendrimer(PAMAM)that electrostatically adsorbed minocycline hydrochloride(Mino).This unique design allows the controlled release of antioxidant/ALA under lipase stimulation from periodontal pathogens and antimicrobial/Mino under the low pH of the inflammatory microenvironment.In vivo and in vitro studies confirmed that this dual nanocarrier could inhibit the formation of subgingival microbial colonies while promoting osteogenic differentiation of cells under diabetic pathological conditions,and ameliorated periodontal bone resorption.This effective and versatile drug-delivery strategy has good potential applications to inhibit diabetes-associated periodontal bone loss. | Lu Wang Yuzhou Li Mingxing Ren Xu Wang Lingjie Li Fengyi Liu Yiqing Lan Sheng Yang Jinlin Song | 2022 | Bioactive Materials2022，7，12： | 1 |
| 9 | 短期氮处理(缺氧处理)对采后猕猴桃贮藏过程中抗氧化能力和质膜完整性的影响显示文摘将猕猴桃用氮气处理6 h后,在(1±1)℃、相对湿度为95%~100%条件下贮藏35 d,最后在20℃下放置3 d,测定果实硬度、质膜透性、硫代巴比妥酸反应产物(TBARS)、过氧化氢含量、超氧阴离子生成速率、脂氧合酶(LOX)、超氧化物歧化酶(SOD)和过氧化物酶(POD)的活性。 | Lili Song Haiyan Gao Hangjun Chen Jinlin Mao Yongjun Zhou Wenxuan Chen Yueming Jiang | 2010 | 保鲜与加工2010，10，6： | 1 |
| 10 | Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration显示文摘Diabetes mellitus(DM)aggravates periodontitis,resulting in accelerated periodontal bone resorption.Disordered glucose metabolism in DM causes reactive oxygen species(ROS)overproduction resulting in compromised bone healing,which makes diabetic periodontal bone regeneration a major challenge.Inspired by the natural bone healing cascade,a mesoporous silica nanoparticle(MSN)-incorporated PDLLA(poly(DL-lactide))-PEG-PDLLA(PPP)thermosensitive hydrogel with stepwise cargo release is designed to emulate the mesenchymal stem cell“recruitment-osteogenesis”cascade for diabetic periodontal bone regeneration.During therapy,SDF-1 quickly escapes from the hydrogel due to diffusion for early rat bone marrow stem cell(rBMSC)recruitment.Simulta-neously,slow degradation of the hydrogel starts to gradually expose the MSNs for sustained release of metformin,which can scavenge the overproduced ROS under high glucose conditions to reverse the inhibited osteogenesis of rBMSCs by reactivating the AMPK/β-catenin pathway,resulting in regulation of the diabetic microenvironment and facilitation of osteogenesis.In vitro experiments indicate that the hydrogel markedly restores the inhibited migration and osteogenic capacities of rBMSCs under high glucose conditions.In vivo results suggest that it can effectively recruit rBMSCs to the periodontal defect and significantly promote periodontal bone regeneration under type 2 DM.In conclusion,our work provides a novel therapeutic strategy of a bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration. | He Wang Xiaowei Chang Qian Ma Boyang Sun Han Li Jinmin Zhou Yiyao Hu Xiaoyu Yang Jie Li Xin Chen Jinlin Song | 2023 | Bioactive Materials2023，，3： | 1 |
| 11 | Bioinspired Andrias davidianus-Derived wound dressings for localized drug-elution显示文摘Local drug delivery has received increasing attention in recent years.However,the therapeutic efficacy of local delivery of drugs is still limited under certain scenarios,such as in the oral cavity or in wound beds after resection of tumors.In this study,we introduce a bioinspired adhesive hydrogel derived from the skin secretions of Andrias davidianus(SSAD)as a wound dressing for localized drug elution.The hydrogel was loaded with aminoguanidine or doxorubicin,and its controlled drug release and healing-promoting properties were verified in a diabetic rat palatal mucosal defect model and a C57BL/6 mouse melanoma-bearing model,respectively.The results showed that SSAD hydrogels with different pore sizes could release drugs in a controllable manner and accelerate wound healing.Transcriptome analyses of the palatal mucosa suggested that SSAD could significantly upregulate pathways linked to cell adhesion and extracellular matrix deposition and had the ability to recruit keratinocyte stem cells to defect sites.Taken together,these findings indicate that property-controllable SSAD hydrogels could be a promising biofunctional wound dressing for local drug delivery and promotion of wound healing. | Xiang Liu Xiang Mao Guo Ye Menghong Wang Ke Xue Yan Zhang Hongmei Zhang Xiaoqiao Ning Man Zhao Jinlin Song Yu Shrike Zhang Ximu Zhang | 2022 | Bioactive Materials2022，7，9： | 0 |
| 12 | Highly Efficient Self-Trapped Bluish White-Light Emission from[Pb4Cl5]3+Nodes in a Moisture-Tolerant Metal–Organic Framework显示文摘Highly luminescent zero-dimensional(0D)metal halide clusters attract widespread attention owing to strong exciton confinement and populated self-trapped states but often exhibit narrow emission and are susceptible to hydrolysis.Herein,we demonstrate a moisture-resistant metal–organic framework(MOF)consisting of cationic 0D[Pb_(4)Cl_(5)]^(3+)nodes bridged by adamantanetetracarboxylate.Upon near-UV excitation,the material emits intrinsic broadband bluish white-light emission with high external quantum efficiency of 35%and a color rendering index of 76.Unlike organoammonium cations in lead perovskites,the Pb-carboxylate coordination affords the MOF to be chemically stable and photostable in high humidity.The photoemitter exhibits undiminished photoemissions under ambient conditions[∼60%relative humidity(RH)]upon continuous UV irradiation(143 mW/cm^(2),365 nm)for 7 days.The insertion of[Na_(4)Cl]^(3+)moieties will connect 0D units into two-dimensional(2D)metal halide layers to limit structural strain and decrease the quantum efficiency from 35%to 15%,confirming the key importance of 0D units for efficient emission. | Jinlin Yin Yuan Yu Xueling Song Yilin Jiang Honghan Fei | 2022 | CCS Chemistry2022，4，2： | 0 |
| 13 | Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis显示文摘Extracellular vesicles(EVs)derived from mesenchymal stem cells(MSCs)have emerged as a new mode of intercellular crosstalk and are responsible for many of the thera-peutic effects of MSCs.To promote the application of MSC-EVs,recent studies have focused on the manipulation of MSCs to improve the production of EVs and EV-mediated activities.The current paper details an optimization method using non-invasive low-intensity pulsed ul-trasound(LIPUS)as the stimulation for improving oral MSC-EV production and effectiveness.Stem cells from apical papilla(SCAP),a type of oral mesenchymal stem cell,displayed inten-sity-dependent pro-osteogenic and anti-inflammatory responses to LIPUS without significant cytotoxicity or apoptosis.The stimuli increased the secretion of EVs by promoting the expres-sion of neutral sphingomyelinases in SCAP.In addition,EVs from LIPUS-induced SCAP exhibited stronger efficacy in promoting the osteogenic differentiation and anti-inflammation of peri-odontal ligament cells in vitro and alleviating oral inflammatory bone loss in vivo.In addition,LIPUS stimulation affected the physical characteristics and miRNA cargo of SCAP-EVs.Further investigations indicated that miR-935 is an important mediator of the pro-osteogenic and anti-inflammatory capabilities of LIPUS-induced SCAP-EVs.Taken together,these findings demonstrate that LIPUS is a simple and effective physical method to optimize SCAP-EV produc-tion and efficacy. | Tingwei Zhang Ziqi Chen Mengyuan Zhu Xuan Jing Xiaohui Xu Xulei Yuan Mengjiao Zhou Yanan Zhang Miao Lu Duanjing Chen Shihan Xu Jinlin Song | 2023 | Genes & Diseases2023，10，4： | 0 |
| 14 | Flexible,breathable,and reinforced ultra-thin Cu/PLLA porous-fibrous membranes for thermal management and electromagnetic interference shielding显示文摘Electromagnetic interference shielding and thermal management by wearable devices show great po-tential in emerging digital healthcare.Conventional metal films implementing the functions must sacri-fice either flexibility or permeability,which is far from optimal in practical applications.In this work,an ultra-thin(15μm),flexible,and porous Cu/PLLA fibrous membrane is developed by depositing cop-per particles on the polymer substrate.With novel acetone&heat treatment procedure,the mem-brane is considerably stronger while maintaining the porous fibre structure.Its fantastic breathabil-ity and super high electrical conductivity(9471.8130 S/cm)enable the composites to have fast electri-cal heating characteristics and excellent thermal conductivity for effective thermal management.Mean-while,the porous polymer substrate structure greatly enhances the diffusion of conductive substances and increases the electromagnetic interference shielding effectiveness of the membranes(7797.98 dB cm^(2)/g at the H band and 8072.73 dB cm^(2)/g at the Ku band respectively).The composites present high flexibility,breathability,and strength with the functions of thermal management and electromag-netic shielding,showing great potential for future portable electronic devices and wearable integrated garments. | Jinlin Chang Chen Meng Bowen Shi Wenyuan Wei Renzhi Li Jinmin Meng Haobin Wen Xiangyu Wang Jun Song Zhirun Hu Zekun Liu Jiashen Li | 2023 | Journal of Materials Science & Technology2023，，30： | 0 |
| 15 | Systemic antibiotics increase microbiota pathogenicity and oral bone loss显示文摘Periodontitis is the most widespread oral disease and is closely related to the oral microbiota.The oral microbiota is adversely affected by some pharmacologic treatments.Systemic antibiotics are widely used for infectious diseases but can lead to gut dysbiosis,causing negative effects on the human body.Whether systemic antibiotic-induced gut dysbiosis can affect the oral microbiota or even periodontitis has not yet been addressed.In this research,mice were exposed to drinking water containing a cocktail of four antibiotics to explore how systemic antibiotics affect microbiota pathogenicity and oral bone loss.The results demonstrated,for the first time,that gut dysbiosis caused by long-term use of antibiotics can disturb the oral microbiota and aggravate periodontitis.Moreover,the expression of cytokines related to Th17 was increased while transcription factors and cytokines related to Treg were decreased in the periodontal tissue.Fecal microbiota transplantation with normal mice feces restored the gut microbiota and barrier,decreased the pathogenicity of the oral microbiota,reversed the Th17/Treg imbalance in periodontal tissue,and alleviated alveolar bone loss.This study highlights the potential adverse effects of long-term systemic antibiotics-induced gut dysbiosis on the oral microbiota and periodontitis.A Th17/Treg imbalance might be related to this relationship.Importantly,these results reveal that the periodontal condition of patients should be assessed regularly when using systemic antibiotics in clinical practice. | Xulei Yuan Fuyuan Zhou He Wang Xinxin Xu Shihan Xu Chuangwei Zhang Yanan Zhang Miao Lu Yang Zhang Mengjiao Zhou Han Li Ximu Zhang Tingwei Zhang Jinlin Song | 2023 | International Journal of Oral Science2023，15，1： | 0 |
| 16 | Metformin ameliorates HMGB1-mediated oxidative stress through mTOR pathway in experimental periodontitis显示文摘Periodontitis is an oral chronic inflammatory disease.Inhibiting tissue destruction and promoting tissue regeneration are important means for the treatment of periodontitis.Metformin not only has hypoglycemic effect but also has anti-inflammatory effect.Metformin has been shown to inhibit oxidative stress and activate autophagy through AMPK/mTOR pathway.High mobility group box 1(HMGB1)has been implicated in the pathogenesis of many inflammatory diseases including periodontitis,it can participate in the induction of oxidative stress.HMGB1 is an autophagy regulator under oxidative stress,which can activate mTOR pathway.However,it is not clear whether metformin is related to HMGB1 and its mechanism in the process of periodontitis.Cell viability and expression of inflammatory cytokines were clarified by Cell Counting Kit-8,real-time PCR and enzyme-linked immunosorbent assay.Western blot and immunofluorescence were conducted to determine HMGB1 intracellular localization and expression of autophagy-associated proteins in vitro.Experimental periodontitis mice model was induced by administering a ligature.Immunohistochemistry was performed to detect the expression and localization of HMGB1 in vivo.The results of CCK-8,real-time PCR,enzyme-linked immunosorbent assay,Western blot and immunofluorescence showed lipopolysaccharide(LPS)treatment inhibited cell viability,and increased HMGB1 expression at a dose-independent manner.Metformin can reduce the effect of LPS.It also improves autophagy pathway inhibited by LPS and down-regulates mTOR expression.In addition,metformin attenuated alveolar bone resorption induced by ligation.This study provides new evidence for that metformin is a potential drug for the treatment of periodontitis and HMGB1 may be a potential target for periodontal intervention. | Boyang Sun Siqi Ying Qian Ma Han Li Jie Li Jinlin Song | 2023 | Genes & Diseases2023，10，2： | 0 |
| 17 | Effect of 3D anchorage attachment on the alleviating tipping/extrusion of premolars for en-mass distalization of maxillary molars with clear aligners:A finite element study显示文摘This study aimed to explore the optimal invisible orthodontic force system during the en-mass distalization of two maxillary molars to minimize the side effect of anchorage loss by changing the direction of the application of the orthodontic force system.A high bio-fidelity 3D finite element model including maxilla,periodontal ligament,dentition,clear aligner,3D anchorage attachment and mini-implant was established.Different lengths of lateral hooks of 3D-printed anchorage attachments and mini-implant positions into the palatal alveolus were considered.A 200 g distal force was applied to the lateral hooks of different horizontal lengths(3.26 mm,6.52 mm and 9.78 mm)with the mini-implant as the application point.Using ABAQUS software,orthodontic tooth movements under 12 different clinical treatment designs were analyzed and calculated.The 3D anchorage attachment enhanced the anchorage of anterior teeth and alleviated the tipping/extrusion of premolars.In contrast to without clear aligners,length of the lateral hook had a negligible effect on both mesial tipping and buccal tipping with clear aligners,which could then be ignored.The change in mesial tipping was less and nearly remained constant despite of the different heights of the mini-implant.The 3D anchorage attachment assisted clear aligner can avoid the side effects of anterior tooth proclination caused by insufficient anchorage.The length of the lateral hook,and height of the mini-implant in this invisible orthodontic force system hardly affects the tooth movement of anchorage units.Clear aligners can effectively control the rotation and tipping of anchorage units caused by 3D anchorage attachment. | Lurong Jia Chunjuan Wang Yao He Chao Wang Antonio Apicella Jinlin Song Yubo Fan | 2023 | Medicine in Novel Technology and Devices2023，，2： | 0 |
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