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| 1 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 2 | The secretion profile of mesenchymal stem cells and potential applications in treating human diseases显示文摘Mesenchymal stromal/stem cells(MSCs)possess multi-lineage differentiation and self-renewal potentials.MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases,due to the potent immunoregulatory functions of MSCs.An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions.Growth factors,cytokines,chemokines,extracellular matrix components,and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms.These secretory factors contribute to immune modulation,tissue remodeling,and cellular homeostasis during regeneration.In this review,we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases. | Yuyi Han Jianxin Yang Jiankai Fang Yipeng Zhou Eleonora Candi Jihong Wang Dong Hua Changshun Shao Yufang Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 6 |
| 3 | Temperature-sensitive splicing is an important molecular regulation mechanism of thermosensitive genic male sterility in rice显示文摘Photoperiod and temperature-sensitive genetic male sterility (PGMS and TGMS) plants have a number of desirable characteristics for hybrid production. Two-line hybrids developed using the PGMS/TGMS system now account for a large proportion of rice production in China. In this paper, we summarize recent advances on molecular regulation mechanisms and genetics of PGMS/TGMS in rice. We suggest that temperature-sensitive splicing, an important posttranscriptional regulatory mechanism in modulating gene expression and eventually development and differentiation, is also an important molecular regulation mechanism of TGMS in rice. We review those factors involved in temperature-sensitive splicing like cis splice site, snRNA, trans premRNA splicing protein and SR proteins, and delineate that splicing could be regulated by a complex cell signaling pathway. These might shed light on other unknown molecular PGMS/TGMS mechanisms. | CHEN RongZhi PAN YuFang WANG Yang ZHU LiLi HE GuangCun | 2009 | Chinese Science Bulletin2009，54，14： | 4 |
| 4 | The acoustic characteristics of clause, sentence and paragraph boundaries in Chinese Putonghua显示文摘包括子句,简单句子,复合句子和段,讲话单位的声学、知觉的特征被学习。声学的特征基于一个讲话语料库的分析由十独白组成了。独白的察觉的边界力量(PBS ) 被 25 个参加者在五点的规模上标记。主要结果如下:(1 ) 在子句的 PBS 有重要差别(相应于 intonational 短语) ,句子(包括的简单句子和复合句子) 和段。但是简单句子和复合句子的 PBS 是一样,并且重设并且暂停的沥青也不在这些二种边界之间是显著地不同的。(2 ) 过去常区分子句,句子和段的基于沥青的暗示看起来是边界前和边界以后的音节之间的差别,然而并非简单地也的沥青价值音节独自一个。(3 ) 偏斜主要发生在 intonational 短语以内,而在句子或在段没有一致全球偏斜。(4 ) 暂停更长并且更在更大的讲话单位的边界被改变。而且,在之间有重要积极关联暂停沥青的持续时间和度在子句边界,然而并非在句子或段边界重设。 | WANG Bei YANG Yufang Lü Shinan | 2006 | Chinese Journal of Acoustics2006，25，4： | 2 |
| 5 | The prevalence of thyroid nodules and its relationship with metabolic parameters in a Chinese community-based population aged over 40 years显示文摘 | Hongwei Guo Min Sun Wei He Huanhuan Chen Wen Li Jinmei Tang Wei Tang Jieli Lu Yufang Bi Guang Ning Tao Yang Yu Duan | 2014 | Endocrine2014，，： | 2 |
| 6 | A Comparative Study of Ionospheric Correction on SAR Interferometry—A Case Study of L’Aquila Earthquake显示文摘Synthetic Aperture Radar Interferometry(InSAR)has shown its potential on seismic deformation monitoring since it can achieve the accuracy of centimeter level or even the millimeter level.However,the irregular varieties of ionosphere can induce the additional phase delay on SAR interferometry,restricting its further application in high-precision deformation monitoring.Although several methods have been proposed to correct the ionospheric phase delay on SAR interferometry,the performances of them haven't been evaluated and compared.In this study,three commonly used methods,including polynomial fitting,azimuth offset and split-spectrum are applied to L'Aquila Earthquake to correct the ionospheric phase delay on two Phased Array type L-band Synthetic Aperture Radar(PALSAR)onboard the Advanced Land Observing Satellite-1(ALOS-1)images.The result indicates that these three methods can effectively correct the ionospheric phase delay error for SAR interferometry,where the standard deviations of the ionosphere-corrected results have decreased by almost a factor of 1.8 times for polynomial fitting method,4.2 times for azimuth offset method and 2.5 times for split-spectrum method,compared to those of the original phase.Furthermore,the result of the sliding distribution inversion of the seismic fault shows the best performance for split-spectrum method. | Yufang HE Wu ZHU Yang LEI Qin ZHANG Zhenhong LI | 2022 | Journal of Geodesy and Geoinformation Science2022，5，1： | 2 |
| 7 | Methodological exploration on the construction of a traditional Chinese medicine nursing expert consensus based on evidence--taking stroke as an example显示文摘Objective: To explore the methodology of the evidence-based expert consensus formulation process of traditional Chinese medicine(TCM) nursing taking stroke as an example.Methods: First, preliminary and comprehensive presentation of all stroke-related symptoms and corresponding TCM nursing techniques involved were revealed through bibliometric analysis. Then, selection of stroke symptoms and TCM nursing techniques for inclusion in the consensus was performed using an expert consultation method. Next, we determined the search strategy for a precise evidence search;conducted an evaluation of evidence quality and the grade of the evidence;and completed evidence extraction, evidence analysis, and evidence synthesis based on the included symptoms and TCM nursing techniques. The Delphi method was then applied to determine the strength of each recommendation and the choice of nursing care points by referring to the Grading of Recommendations, Assessment, Development, and Evaluations grid. Finally, we conducted an external expert validation of the Delphi results to form an expert consensus guideline.Results: Through the bibliometric analysis, 22 stroke symptoms and 18 TCM nursing techniques were identified in the literature. Then, after expert consultation, 22 symptoms and 111 pairs of symptoms combined with TCM nursing techniques were selected for the evidence search. Evidence integration yielded 10 stroke symptoms corresponding to 29 bodies of evidence;these 10 symptoms were retained through the Delphi consultation, and recommendation strength results for 26 recommendations were obtained. A total of 9 symptoms were further retained for expert external validation to form 24 recommendations, with a recommendation process score range of 7.64-9.99 points and a more scientific and standardized recommendation-formation process.Conclusion: Owing to the current limited conditions of evidence-based resources for TCM nursing, the present consensus-building process represents only a preliminary exploration of an evidence-based expert consensus for TCM nursing to provide a reference for a more scientific and standardized methodology. | Xuejing Li Ke Peng Meiqi Meng Liu Han Dan Yang Junqiang Zhao Yufang Hao | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，2： | 2 |
| 8 | Regional Structure and Spatial Morphology Characteristics of Oasis Urban Agglomeration in Arid Area——A Case of Urban Agglomeration in Northern Slope of Tianshan Mountains,Northwest China显示文摘It is great important to the health development of urban agglomeration to correctly understand the formation and development law of regional structure of urban agglomeration.Employing the analysis methods like fractal theory and quantitative statistics,coupling with the use of remote sensing images and other spatial data,this article discusses the urban agglomeration of oasis on the northern slope of the Tianshan Mountains in an arid area,and conducts the researches on its city scale,spatial distribution and individual form from 1990 to 2005.The result shows that it has loose hierarchical scale structure and polarization trend of population distribution while its hierarchical scale structure tends to mature.Under the influence of natural conditions,the spatial layout of urban agglomeration of oasis has macro characteristics that suggest cities distributed along oasis edges(dense or sparse),spatially expand along rivers,and cluster around traffic branches.The connectivity among the cities is high and shows an internal organization form of a banding distribution.The whole spatial shape of the internal structure of cities presents a 'dumbbell' form,with mononuclear phenomenon receding and multi-nuclear appearing gradually.Individual cities spatially expand along rivers,portraying a long strip appearance.It indicates that the urban agglomeration of oasis shows regular and close structure but with a tendency to be complicated form and the loose structure.In the development of urban agglomeration,the authors recommend that the development of the city with good economic development conditions should be strengthened,and more attention be put into regional planning. | ZHANG Yufang YANG Degang ZHANG Xinhuan DONG Wen ZHANG Xiaolei | 2009 | Chinese Geographical Science2009，19，4： | 2 |
| 9 | Electrochemical Sensor for Sensitive Determination of Ga(III) Ion Based on β-Cyclodextrin Incorporated Multi-walled Carbon Nanotubes and Imprinted Sol-gel Composite Film显示文摘为踪迹镓离子的察觉的一个新奇传感器[Ga (III )] 被一个金电极的逐步的修正与 -cyclodextrin 创造(-CD)/multi-walled 碳 nanotubes (MWCNT ) 和一个离子印了聚合物(IIP ) 。传感器表面形态学被扫描电子显微镜学描绘。印的传感器的电气化学的表演被周期的 voltammetry,微分脉搏 voltammetry 和 chronoamperometry 调查。传感器向目标 Ga (III ) 离子显示了优秀选择。同时,介绍 MWCNT 显示了显著催化活动,并且 CD 表明了重要丰富能力。一条线性刻度曲线被获得从 5.0 | Hu,Yufang Zhang,Zhaohui Zhang,Huabin Luo,Lijuan Zhang,Minglei Yang,Xiao Yao,Shouzhuo | 2012 | Chinese Journal of Chemistry2012，30，2： | 2 |
| 10 | Analysis of energy conversion characteristics in liquefaction of algae显示文摘 | YANG Yufang FENG Chuanping INAMORI Y | 2004 | Resources Conservation & Recycling2004，43，1： | 1 |
| 11 | Strategy for metabonomics research based on high-performance liquid chromatography and liquid chromatography coupled with tandem mass spectrometry 显示文摘 | Yang Jun Xu Guowang Zheng Yufang | 2005 | J Chromatogr A2005，1084，： | 1 |
| 12 | Apoptosis of circulating lymphocytes induced by whole body γ-irradiation and its mechanism显示文摘 | Cui Yufang Gao Yabing Yang Hong | 1999 | J Environ Pathol Toxicol Oncol1999，18，： | 1 |
| 13 | Prepara- tion and characteristics of interferon alpha poly ( lactic-co- glycolic acid) microspheres 显示文摘 | YANG Fan SONG Fenglan PAN Yufang | 2010 | J Microencapsul2010，27，2： | 1 |
| 14 | A novel approach to Finafloxacin hydrochloride (BAY35-3377)显示文摘 | Jian Hong Zonghua Zhang Huoxing Lei Haiying Cheng Yufang Hu Wanliang Yang Yinglin Liang Debasis Das Shu-Hui Chen Ge Li | 2009 | Tetrahedron Letters2009，，21： | 1 |
| 15 | Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases显示文摘 | Jun Yang Guowang Xua Yufang Zheng | 2004 | J Chromatogr B Analyt Technol Biomed Life Sci2004，813，12： | 1 |
| 16 | Genome-wide identification of quantitative trait loci for important plant and flower traits in petunia using a high-density linkage map and an interspecific recombinant inbred population derived from Petunia integrifolia and P.axillaris显示文摘Petunia is a very important flower in the global floriculture industry and has played a critical role as a model in plant genetic studies.Owing to limited genetic variability in commercial germplasm,development of novel petunia phenotypes and new varieties has become increasingly difficult.To enrich petunia germplasm and facilitate genetic improvement,it is important to explore genetic variation in progenitor species that may contain highly valuable genes/alleles.In this study,an interspecific recombinant inbred population(168 recombinant inbreds)derived from Petunia integrifolia×P.axillaris were phenotyped for days to anthesis(DTA),flower count(Flower_C),flower diameter(Flower_D),flower length(Flower_L),plant height(Plant_H),plant spread(Plant_S),and plant size(Plant_Z)in 2014 and 2015.Transgressive segregation was observed for all traits in both years.The broad-sense heritability on a 2-year basis varied from 0.38(Flower_C)to 0.82(Flower_L).Ten QTL were consistently identified in both years and by two mapping strategies[multiple QTL mapping(MQM)in MapQTL and inclusive composite interval mapping(ICIM)in IciMapping].Major QTL explained up to 30.2,35.5,and 47.1%of the total phenotypic variation for Plant_S,Flower_L,and Flower_D,respectively.These findings should be of significant values for introgression of desirable genes from wild petunias into commercial varieties and future genetic improvement of this important flower. | Zhe Cao Yufang Guo Qian Yang Yanhong He Mohammed I.Fetouh Ryan M.Warner Zhanao Deng | 2019 | Horticulture Research2019，6，1： | 1 |
| 17 | The influence of discourse hierarchy on the acoustic manifestation of focus in standard Chinese显示文摘一个语音的实验被进行调查讲话焦点的声学的特征是否受到讲话层次的影响。六个说话者被指示朗读 32 组试验性的材料。在不同讲话层次的 foci 的持续时间,沥青范围, f0 最大值,和 f0 最小为统计分析被提取。结果表明在讲话层次更高嵌入的 foci 把相对更长的持续时间和更多搭范围扩展;而且与音调联合的变化,在不同讲话层次的 foci 在他们 f0 最大值和 f0 最小特征的表明显著地不同。明确地说,为非低的音调联合,,在更高的讲话层次的 foci 为低音调的联合与更高的 f0 最大值被读,在更高的讲话层次的 foci 与更低的 f0 最小被明白表示。 | ZHAO Jianjun YANG Xiaohong YANG Yufang LU Shinan | 2011 | Chinese Journal of Acoustics2011，30，4： | 1 |
| 18 | Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases显示文摘 | Jun Yang Guowang Xu Yufang Zheng | 2004 | J Chrematogr B Analyt Technol Biomed Life Sci2004，813，12： | 1 |
| 19 | A General and Programmable Synthesis of Graphene-Based Composite Aerogels by a Melamine-Sponge-Templated Hydrothermal Process显示文摘Three-dimensional(3D)graphene networks are performance boosters for functional nanostructures in energy-related fields.Although tremendous intriguing nanostructures-decorated 3D graphene networks have been realized,on-demand decoration of nanostructures in the specified position of interest within the whole 3D graphene skeleton is still out of reach,shedding limitations on constructing more sophisticated components with programmable structures which offer enormous potential for the enhancement of performance and exploration of new functions.Here,we report the melamine-sponge(MS)-templated hydrothermal method capable of realizing reduced graphene oxide(RGO)-nanostructure composite aerogels with programmable structures and compositions.The key of this method is using the MS template to preset the structures of choice through programmable solution-processed immobilization of graphene oxide(GO)and nanostructures.Remarkably,the hydrothermal treatment simultaneously removed the MS template and reduced the GO networks without changing the preset structures.We showcased nine typical RGO-nanostructures composite aerogels to demonstrate the versatility of the MS-templated hydrothermal method. | Jin Ge Hong-Wu Zhu Yuan Yang Yufang Xie Gang Wang Jin Huang Lu-An Shi Oliver G Schmidt Shu-Hong Yu | 2020 | CCS Chemistry2020，2，2： | 1 |
| 20 | Determination of impurities in highly pure platinum by inductively coupled plasma - atomic emission spectrometry 显示文摘 | Zhang Xinhua Li Huifen Yang Yufang | 1995 | Talanta1995，42，： | 1 |
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