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| 1 | Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model显示文摘Early weaning induces intestinal injury,leading to a series of long-term symptoms such as inflammation,malabsorption and diarrhea.In this study,we hypothesized that microbes and theirmetabolitesmodulate the host's inflammatory response to early weaning stress in a goatmodel.A total of 18 female Tibetan goat kids(n?9)wereweaned fromtheirmothers at 28 d(D28)and 60 d(D60)postpartum.D60 and D28 groupswere fed the same solid diet ad libitum fromweaning to 75 d of age.The colonic epithelium was subject to RNAsequencing,the caecal digesta metabolomics were assessed by liquid chromatographyetandem mass spectrometry(LC-MS/MS),and the caecal microbiota composition was analysed by 16S ribosomal RNA gene sequencing.We foundthatearlyweaningsubstantially increased the colonic pro-apoptotic gene expressionof B-cell lymphoma associated X(Bax),caspase-9,and caspase-3,and decreased the expression of zonula occludens-1(ZO-1)and claudin-1(P<0.01).In addition,a significant Bacteroides acidifaciens enrichmentwas observed in the hindgut of early-weaned goats(P<0.01),which negatively correlated with lysophosphatidylcholine products.Similarly,the chemokine signaling,IL-17 signaling,and peroxisome proliferatorsactivated receptor(PPAR)signaling pathways were upregulated in the colonic mucosa of the early-weaned goats.By applying caecal microbiota transplantation from goats to defaunated C57/6J mice,we confirmed that caecalmicrobiota of D28 goat kids increased the relative abundance of B.acidifaciens and significantly upregulated the genes of Bax,G proteinecoupled receptor(GPR)109A,GPR 43,fatty acid binding protein 6,nuclear receptor subfamily 1 group H member 3,angiotensin converting enzyme 2,and IL-6 expression(P<0.05),and decreased ZO-1,and claudin-1 protein expression in the mice jejunum and colon(P<0.001).These results proposed that the hindgut microbiota andmetabolites mediate the barrier functionweakening duringearlyweaning,and the relative abundance of B.acidifacienswas negatively correlatedwiththe hindgut barrier gene expression.This studydemonstrateshowweaningstress canaffectkeyhostemicrobe interaction regulators in the hindgut,in a lysophosphatidylcholine dependent and independent manner.Furthermore,based on our mice data,these results are transferable to other mammal species. | Ke Zhang Yangbin Xu Yuxin Yang Mengmeng Guo Ting Zhang Bo Zong Shuhong Huang Langda Suo Baohua Ma Xiaolong Wang Yujiang Wu Daniel Brugger Yulin Chen | 2022 | Animal Nutrition2022，，3： | 2 |
| 2 | Dual-function perovskite light-emitting/sensing devices for optical interactive display显示文摘Interactive display devices integrating multiple functions have become a development trend of display technology.The excellent luminescence properties of perovskite quantum dots(PQDs)make it an ideal luminescent material for the next generation of wide-color gamut displays.Here we design and fabricate dual-function light-sensing/displaying light-emitting devices based on PQDs.The devices can display information as an output port,and simultaneously sense outside light signals as an input port and modulate the display information in a non-contact mode.The dual functions were attributed to the device designs:(1)the hole transport layer in the devices also acts as the light-sensing layer to absorb outside light signals;(2)the introduced hole trapping layer interface can trap holes originating from the light-sensing layer,and thus tune the charge transport properties and the light-emitting intensities.The sensing and display behavior of the device can be further modulated by light signals with different time and space information.This fusion of sensing and display functions has broad prospects in non-contact interactive screens and communication ports. | Songman Ju Yangbin Zhu Hailong Hu Yang Liu Zhongwei Xu Jinping Zheng Chaomin Mao Yongshen Yu Kaiyu Yang Lihua Lin Tailiang Guo Fushan Li | 2022 | Light(Science & Applications)2022，11，12： | 0 |
| 3 | Nitride-reinforced HfNbTaTiV high-entropy alloy with excellent room and elevated-temperature mechanical properties显示文摘Nitride-reinforced(HfNbTaTiV)_(90)N_(10) high-entropy alloy aiming at high-temperature applications is de-signed in this paper.Abundant FCC nitride phases are formed in situ in theBCC matrix by arc melt-ing technique,without complex deformation or heat treatment.The(HfNbTaTiV)_(90)N_(10) alloy exhibits a remarkable yield strength of 2716 MPa and ultimate compressive strength of 2833 MPa with a plas-tic strain of 10%at room temperature.Besides,the alloy remains a high yield strength of 279 MPa at 1400℃.The nitride phases play an essential role in maintaining the excellent strength-ductility com-bination at room temperature and enhancing the high-temperature softening resistance.Alternating BCC and FCC phases possess the semi-coherent interface,which not only strengthens the BCC matrix but also promotes the compatible deformation of the duplex microstructure.The lattice coherency structure of the semi-coherent interface is conducive to the slip transfer of partial dislocations through the interface,which facilitates the accommodation of plastic deformation.The cross-slip of the screw dislocations ef-fectively eliminates stress concentration and leads to good ductility of the dual-phase alloy.The results demonstrate that the nitride phases achieve coordinate deformation with the matrix without deteriorat-ing the ductility of the(HfNbTaTiV)_(90)N_(10) alloy. | Bingjie Wang Qianqian Wang Bo Sun Jinyong Mo Yangbin Guo Xiubing Liang Baolong Shen | 2023 | Journal of Materials Science & Technology2023，，18： | 0 |
| 4 | Two homologous INDOLE-3-ACETAIVHDE (IAM) HYDROLASE genes are required for the auxin effects of IAM in Arabidopsis显示文摘Indole-3-acetamide(IAM)is the first confirmed auxin biosynthetic intermediate in some plant pathogenic bacteria.Exogenously applied IAM or production of IAM by overexpressing the bacterial iaaM gene in Arabidopsis causes auxin overproduction phenotypes.However,it is still inconclusive whether plants use IAM as a key precursor for auxin biosynthesis.Herein,we reported the isolation IAM HYDROLASE 1(IAMH1)gene in Arabidopsis from a forward genetic screen for IAM-insensitive mutants that display normal auxin sensitivities.IAMH1 has a close homolog named IAMH2 that is located right next to IAMH1on chromosomeⅣin Arabidopsis.We generated iamh1 iamh2 double mutants using our CRISPR/Cas9gene editing technology.We showed that disruption of the IAMH genes rendered Arabidopsis plants resistant to IAM treatments and also suppressed the iaaM overexpression phenotypes,suggesting that IAMH1 and IAMH2 are the main enzymes responsible for converting IAM into indole-3-acetic acid(IAA)in Arabidopsis.The iamh double mutants did not display obvious developmental defects,indicating that IAM does not play a major role in auxin biosynthesis under normal growth conditions.Our findings provide a solid foundation for clarifying the roles of IAM in auxin biosynthesis and plant development. | Yangbin Gao Xinhua Dai Yuki Aoi Yumiko Takebayashi Liping Yang Xiaorui Guo Qiwei Zeng Hanchuanzhi Yu Hiroyuki Kasahara Yunde Zhao | 2020 | Journal of Genetics and Genomics2020，47，3： | 0 |
| 5 | Ignite the Sparks of BYOD Teaching Mode of Universities显示文摘With the constant development of the technology and the society, BYOD (Bring Your Own Device) is an inevitable issue of the education field. Universities, as the frontier position of the educational field, properly bring the 'BYOD' to the class, which enriches the teaching means and further extends the teaching space. It promotes the development of the teaching mode in the reformation of teaching process of boosting the distribution and acquisition of teaching resources, teaching interaction and effect evaluation. | Hesong Liu Guo Cheng Qisheng Wang Yangbin Xie | 2018 | Review of Educational Theory2018，1，1： | 0 |
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