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| 1 | Bacteroides ovatus-mediated CD27^(−)MAIT cell activation is associated with obesity-related T2D progression显示文摘Type 2 diabetes(T2D)is highly associated with obesity.However,the factors that drive the transition from excessive weight gain to glucose metabolism disruption are still uncertain and seem to revolve around systemic immune disorder.Mucosal-associated invariant T(MAIT)cells,which are innate-like T cells that recognize bacterial metabolites,have been reported to be altered in obese people and to lead to metabolic dysfunction during obesity.By studying the immunophenotypes of blood MAIT cells from a cross-sectional cohort of obese participants with/without T2D,we found an elevation in CD27^(-)negative(CD27−)MAIT cells producing a high level of IL-17 under T2D obese conditions,which could be positively correlated with impaired glucose metabolism in obese people.We further explored microbial translocation caused by gut barrier dysfunction in obese people as a triggering factor of MAIT cell abnormalities.Specifically,accumulation of the bacterial strain Bacteroides ovatus in the peripheral blood drove IL-17^(-)producing CD27−MAIT cell expansion and could be associated with T2D risk in obese individuals.Overall,these results suggest that an aberrant gut microbiota–immune axis in obese people may drive or exacerbate T2D.Importantly,CD27−MAIT cell subsets and Bacteroides ovatus could represent targets for novel interventional strategies.Our findings extend current knowledge regarding the clinical relevance of body mass index(BMI)-associated variation in circulating MAIT cells to reveal the role of these cells in obesity-related T2D progression and the underlying cellular mechanisms. | Yue Li Yi Yang Jin Wang Peihong Cai Mei Li Xixiang Tang Ying Tan Yuchan Wang Fan Zhang Xiaofeng Wen Qiaoxing Liang Yuanpeng Nie Tufeng Chen Xiang Peng Xuemin He Yanhua Zhu Guojun Shi Wai WCheung Lai Wei Yanming Chen Yan Lu | 2022 | Cellular & Molecular Immunology2022，19，7： | 2 |
| 2 | A Rate of Convergence of Physics Informed Neural Networks for the Linear Second Order Elliptic PDEs显示文摘In recent years,physical informed neural networks(PINNs)have been shown to be a powerful tool for solving PDEs empirically.However,numerical analysis of PINNs is still missing.In this paper,we prove the convergence rate to PINNs for the second order elliptic equations with Dirichlet boundary condition,by establishing the upper bounds on the number of training samples,depth and width of the deep neural networks to achieve desired accuracy.The error of PINNs is decomposed into approximation error and statistical error,where the approximation error is given in C2 norm with ReLU^(3)networks(deep network with activation function max{0,x^(3)})and the statistical error is estimated by Rademacher complexity.We derive the bound on the Rademacher complexity of the non-Lipschitz composition of gradient norm with ReLU^(3)network,which is of immense independent interest. | Yuling Jiao Yanming Lai Dingwei Li Xiliang Lu Fengru Wang Yang Wang Jerry Zhijian Yang | 2022 | Communications in Computational Physics2022，31，4： | 2 |
| 3 | A piece wise circuit for DC-DC converters显示文摘 | Ye Qiang Lai Xinquan linear slope compensation Li Yanming | 2008 | Journal of Semiconductor2008，29，2： | 1 |
| 4 | A CMOS Piecewise Curvature compensated Voltage Reference显示文摘 | Lai Xinquan Xu Ziyou Li Yanming | | 0，，01： | 1 |
| 5 | A CMOS Piecewise Curvature-compensated Voltage Reference显示文摘 | Lai Xinquan Xu Ziyou Li Yanming | 2009 | Microelectronics Journal2009，40，1： | 1 |
| 6 | A CMOS piecewise curvature-compensated voltage reference 显示文摘 | Lai Xinquan Xu Ziyou Li Yanming | 2009 | Microelectronics Journal2009，40，1： | 1 |
| 7 | A CMOS piecewise curvature-compensated voltage reference 显示文摘 | Lai Xinquan Xu Ziyou Li Yanming | 2009 | Microelectronics Journal2009，40，1： | 1 |
| 8 | Effects of Seawater Acidification on Early Development of Clam Cyclina sinensis显示文摘Anthropogenic emission of atmospheric carbon dioxide (CO2) has led to a rapid increase in atmospheric CO2 concentra- tion. Increasing atmospheric CO2 can reduce seawater pH and carbonate ions, which may adversely affect the survival of the larvae of calcareous animals. Cyclina sinensis is a commercially and ecologically important species in several Asian countries. Living in coast shallow waters, this species has experienced the coastal environmental changes frequently throughout its life cycle. In this study, we simulated possible future seawater pH values including 8.2, 7.8 and 7.4 and examined the effects of ocean acidification on the early development of C. sinensis. Clam embryos were incubated for 48 h (2 d) in control and high-CO2 seawater to compare embryo- genesis, larval growth and swimming behavior. Fertilization rate was quite sensitive to pH, and moderate acidification could induce a significant decrease in fertilization rate. However, only extreme acidification could bring significant negative effect to hatching rate, body size, and average path velocity of trochophora. Moreover, with seawater acidification, C. sinensis needs much more time to reach the same developmental stage, which increases the risk of larva survival. Together with recent studies demonstrating negative impacts of high CO2 on fertilization and larva swimming behavior, the results imply a future decrease of C. sinensis populations in oceans if its acclimation to the predicted environmental alteration does not occur. | SUI Yanming ZHOU Kai LAI Qifang YAO Zongli GAO Pengchen | 2019 | Journal of Ocean University of China2019，18，4： | 1 |
| 9 | Apiecewise linear slope compensation circuit for DC -DC converters 显示文摘 | YE Qiang LAI Xinquan LI Yanming | 2008 | J Semicond2008，29，2： | 1 |
| 10 | Synthesis of reversible PAD4 inhibitors via copper-catalyzed C-H arylation of benzimidazole显示文摘PAD4 is a promising epigenetic drug target for various cancers and immune diseases. In this work, we applied a Cu-catalyzed C–H arylation reaction of N-heteroarene to the synthesis of complex non-covalent PAD4 inhibitors bearing a bi-heteroaryl pharmacophore. This strategy allowed us to access various analogs of C_2-aryl substituted benzimidazoles from a common benzimidazole core and easily accessible aryl iodides. Preliminary SAR studies revealed the indole motif of GSK-484 is critical to its activity. Replacing the N-cyclopropylmethyl group to N-benzyl group on the indole ring of GSK-484 resulted in more than5-fold increase in cell killing efficacy against 4T1 cell line. | Zhengwei Guo Lai Shi Bo Wang Gang He Yanming Wang Gong Chen | 2019 | Science China Chemistry2019，62，5： | 1 |
| 11 | Nonlinear Analysis for the Three-dimensional Temperature fields in Cold Region Tennels显示文摘 | Zhang Xuefu Lai Yanming Yu Wenbing | 2002 | Cold Regions Science and Technology2002，35，1： | 1 |
| 12 | A piece- wise linear slope compensation circuit for DC-DC converters显示文摘 | YE Qiang LAI Xinquan LI Yanming | 2008 | J Semicond2008，29，2： | 1 |
| 13 | Convergence Rate Analysis for Deep Ritz Method显示文摘Using deep neural networks to solve PDEs has attracted a lot of attentions recently.However,why the deep learning method works is falling far behind its empirical success.In this paper,we provide a rigorous numerical analysis on deep Ritz method(DRM)[47]for second order elliptic equations with Neumann boundary conditions.We establish the first nonasymptotic convergence rate in H^(1)norm for DRM using deep networks with ReLU^(2)activation functions.In addition to providing a theoretical justification of DRM,our study also shed light on how to set the hyperparameter of depth and width to achieve the desired convergence rate in terms of number of training samples.Technically,we derive bound on the approximation error of deep ReLU^(2)network in C^(1)norm and bound on the Rademacher complexity of the non-Lipschitz composition of gradient norm and ReLU^(2)network,both of which are of independent interest. | Chenguang Duan Yuling Jiao Yanming Lai Dingwei Li Xiliang Lu Jerry Zhijian Yang | 2022 | Communications in Computational Physics2022，31，4： | 0 |
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