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| 1 | Recent progress on nanoparticle-based drug delivery systems for cancer therapy显示文摘The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size and surface characteristics are the key components of nanotherapeutics, and are designed to passively or actively deliver anti-cancer drugs to tumor cells. We provide an overview of nanoparticle-based drug delivery methods and cancer therapies based on tumor-targeting delivery strategies that have been developed in recent years. | Yanru Xin Mingming Yin Liyuan Zhao Fanling Meng Liang Luo | 2017 | Cancer Biology & Medicine2017，14，3： | 10 |
| 2 | A review of β-Ga_2O_3 single crystal defects, their effects on device performance and their formation mechanism显示文摘As a wide-bandgap semiconductor(WBG), β-Ga_2O_3 is expected to be applied to power electronics and solar blind UV photodetectors. In this review, defects in β-Ga_2O_3 single crystals were summarized, including dislocations, voids, twin, and small defects. Their effects on device performance were discussed. Dislocations and their surrounding regions can act as paths for the leakage current of SBD in single crystals. However, not all voids lead to leakage current. There's no strong evidence yet to show small defects affect the electrical properties. Doping impurity was definitely irrelated to the leakage current. Finally, the formation mechanism of the defects was analyzed. Most small defects were induced by mechanical damages. The screw dislocation originated from a subgrain boundary. The edge dislocation lying on a plane slightly tilted towards the(102) plane, the(101) being the possible slip plane. The voids defects like hollow nanopipes, PNPs, NSGs and line-shaped grooves may be caused by the condensation of excess oxygen vacancies, penetration of tiny bubbles or local meltback. The nucleation of twin lamellae occurred at the initial stage of 'shoulder part' during the crystal growth. These results are helpful in controlling the occurrence of crystal defects and improving the device performance. | Bo Fu Zhitai Jia Wenxiang Mu Yanru Yin Jian Zhang Xutang Tao | 2019 | Journal of Semiconductors2019，40，1： | 5 |
| 3 | Attempted preparation of La_(0.5)Ba_(0.5)MnO_(3-δ) leading to an in-situ formation of manganate nanocomposites as a cathode for proton-conducting solid oxide fuel cells显示文摘A La_(0.5)Ba_(0.5)MnO_(3-δ) oxide was prepared using the sol-gel technique.Instead of a pure phase,La_(0.5)Ba_(0.5)MnO_(3-δ) was discovered to be a combination of La_(0.7)Ba_(0.3)MnO_(3-δ) and BaMnO_(3).The in-situ production of La_(0.7)Ba_(0.3)MnO_(3-δ)+BaMnO_(3) nanocomposites enhanced the oxygen vacancy(Vo)formation compared to single-phase La_(0.7)Ba_(0.3)MnO_(3-δ) or BaMnO_(3),providing potential benefits as a cathode for fuel cells.Subsequently,La_(0.7)Ba_(0.3)MnO_(3-δ)+BaMnO_(3) nanocomposites were utilized as the cathode for proton-conducting solid oxide fuel cells(H-SOFCs),which significantly improved cell performance.At 700 C,H-SOFC with a La_(0.7)Ba_(0.3)MnO_(3-δ)+BaMnO_(3) nanocomposite cathode achieved the highest power density(1504 mW·cm^(-2))yet recorded for H-SOFCs with manganate cathodes.This performance was much greater than that of single-phase La_(0.7)Ba_(0.3)MnO_(3-δ)or BaMnO_(3) cathode cells.In addition,the cell demonstrated excellent working stability.First-principles calculations indicated that the La_(0.7)Ba_(0.3)MnO_(3-δ)/BaMnO_(3) interface was crucial for the enhanced cathode performance.The oxygen reduction reaction(ORR)free energy barrier was significantly lower at the La_(0.7)Ba_(0.3)MnO_(3-δ)/BaMnO_(3) interface than that at the La_(0.7)Ba_(0.3)MnO_(3-δ) or BaMnO_(3) surfaces,which explained the origin of high performance and gave a guide for the construction of novel cathodes for H-SOFCs. | Rui Zhou Yanru Yin Hailu Dai Xuan Yang Yueyuan Gu Lei Bi | 2023 | Journal of Advanced Ceramics2023，12，6： | 1 |
| 4 | Study and control of three-phase PWM rectifier based on dual single-input single-out- put model 显示文摘 | YIN Zhonggang LIU Jing ZHONG Yanru | 2013 | IEEE Transactions on Industrial Informatics2013，9，2： | 1 |
| 5 | Tailoring cobalt-free La_(0.5)Sr_(0.5)FeO_(3-δ)cathode with a nonmetal cation-doping strategy for high-performance proton-conducting solid oxide fuel cells显示文摘A nonmetal doping strategy was exploited for the conventional La_(0.5)Sr_(0.5)FeO_(3-δ)(LSF)cathode,allowing high performance for proton-conducting solid oxide fuel cells(H-SOFCs).Unlike previous studies focusing on the utilization of metal oxides as dopants,phosphorus,which is a nonmetal element,was used as the cation dopant for LSF by partially replacing Fe ions to form the new La_(0.5)Sr_(0.5)Fe_(0.9)P_(0.1)O_(3-δ)(LSFP)compound.The H-SOFC using the LSFP cathode showed a two-fold peak power density as compared to that using the LSF cathode.Both experimental studies and first-principle calculations were used to unveil the mechanisms for the high performance of the LSFP cells. | Yanru Yin Hailu Dai Shoufu Yu Lei Bi Enrico Traversa | 2022 | SusMat2022，2，5： | 1 |
| 6 | Optimization of betulin extraction process显示文摘 | Yongguang Yin Yanru Cui Hongwei Ding | 2007 | Inonotus obliquus with pulsed electric fields2007，，23： | 1 |
| 7 | Taking advantage of Li-evaporation in LiCoO_(2) as cathode for proton-conducting solid oxide fuel cells显示文摘LiCoO_(2),a widely used electrode material for Li-ion batteries,was found to be suitable as a cathode material for proton-conducting solid oxide fuel cells(H-SOFCs).Although the evaporation of Li in LiCoO_(2) was detrimental to the Li-ion battery performance,the Li-evaporation was found to be beneficial for the H-SOFCs.The partial evaporation of Li in the LiCoO_(2) material preparation procedure led to the in-situ formation of the LiCoO_(2)+Co_(3)O_(4) composite.Compared to the cell using the pure phase LiCoO_(2) cathode that only generated moderate fuel cell performance,the H-SOFCs using the LiCoO_(2)+Co_(3)O_(4) cathode showed a high fuel cell performance of 1160 mW·cm^(-2) at 700℃,suggesting that the formation of Co_(3)O_(4) was critical for enhancing the performance of the LiCoO_(2) cathode.The first-principles calculation gave insights into the performance improvements,indicating that the in-situ formation of Co_(3)O_(4) due to the Li-evaporation in LiCoO_(2) could dramatically decrease the formation energy of oxygen vacancies that is essential for the high cathode performance.The evaporation of Li in LiCoO_(2),which is regarded as a drawback for the Li-ion batteries,is demonstrated to be advantageous for the H-SOFCs,offering new selections of cathode candidates for the H-SOFCs. | Yangsen XU Shoufu YU Yanru YIN Lei BI | 2022 | Journal of Advanced Ceramics2022，11，12： | 1 |
| 8 | Successful preparation of BaCo_(0.5)Fe_(0.5)O_(3–δ)cathode oxide by rapidly cooling allowing for high-performance proton-conducting solid oxide fuel cells显示文摘A pure phase BaCo_(0.5)Fe_(0.5)O_(3–δ)(BCF),which cannot be obtained before,is successfully prepared in this study by using the calcination method with a rapid cooling procedure.The successful preparation of BCF allows the evaluation of this material as a cathode for proton-conducting solid oxide fuel cells(H-SOFCs)for the first time.An H-SOFC using the BCF cathode achieves an encouraging fuel cell performance of 2012 mW·cm–2 at 700,two℃-fold higher than that of a similar cell using the classical high-performance Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3–δ)(BSCF)cathode.First-principles calculations reveal the mechanism for the performance enhancement,indicating that the new BCF cathode significantly lowers the energy barriers in the oxygen reduction reaction(ORR)compared with the BSCF cathode.Therefore,improved cathode performance and fuel cell output are obtained for the BCF cell.The fuel cell using the BCF cathode also shows excellent long-term stability that can work stably for nearly 900 h without noticeable degradations.The fuel cell performance and long-term stability of the current BCF cell are superior to most of the H-SOFCs reported in previous reports,suggesting that BCF is a promising cathode for H-SOFCs. | Yanru Yin Yanbin Zhou Yueyuan Gu Lei Bi | 2023 | Journal of Advanced Ceramics2023，12，3： | 1 |
| 9 | Study and control of three-phase PWM rectifier based on dual single-input single-output model显示文摘 | Yin Zhonggang Liu Jing Zhong Yanru | 2013 | IEEE Trans on Industrial Informat- ics2013，9，2： | 1 |
| 10 | A review on the dewaterability of bio-sludge and ultrasound pretreatment 显示文摘 | Xuan Yin Pingfang Han Xiaoping Lu Yanru Wang | 2004 | Ultrasonics Sonochemistry2004，，11： | 1 |
| 11 | A Kaposi’s sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy显示文摘Dilated cardiomyopathy(DCM)is the leading cause of heart transplantation.By microRNA(miRNA)array,a Kaposi’s sarcoma-associated herpes virus(KSHV)-encoded miRNA,kshv-miR-K12-1-5p,was detected in patients with DCM.The KSHV DNA load and kshv-miR-K12-1-5p level in plasma from 696 patients with DCM were measured and these patients were followed-up. | Yanru Zhao Huaping Li Hengzhi Du Zhongwei Yin Mengying He Jiahui Fan Xiang Nie Yang Sun Huiying Hou Beibei Dai Xudong Zhang Yuanyuan Cai Kunying Jin Nan Ding Zheng Wen Jiang Chang Chen Chen Dao Wen Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 1 |
| 12 | Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy显示文摘Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized treatment.This study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative CRT.The associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression model.Functional experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 variant.Results:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(P<0.05).There was a substantial cumulative effect of three genetic polymorphisms(CASP4 rs571407,ALOX5 rs2242332,and HO-1 rs17883419)on OS.Genetic variations in the CASP4 and ALOX5 gene haplotypes were associated with a higher OS.We demonstrated,for the first time,that rs702365[G]>[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory response.Conclusions:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment. | Hongxia Chen Luxi Yin Jie Yang Ningxin Ren Jinna Chen Qixuan Lu Ying Huang Yanru Feng Weihu Wang Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin Wen Tan Dongxin Lin | 2023 | Cancer Biology & Medicine2023，20，4： | 0 |
| 13 | Entropy engineering design of high-performing lithiated oxide cathodes for proton-conducting solid oxide fuel cells显示文摘A new medium entropy material LiCo_(0.25)Fe_(0.25)Mn_(0.2)5Ni_(0.2)5O_(2)(LCFMN)is proposed as a cathode for proton-conducting solid oxide fuel cells(H-SOFCs).Unlike traditional LiXO_(2)(X=Co,Fe,Mn,Ni)lithiated oxides,which have issues like phase impurity,poor chemical compatibility,or poor fuel cell performance,the new LCFMN material mitigates these problems,allowing for the successful preparation of pure phase LCFMN with good chemical and thermal compatibility to the electrolyte.Furthermore,the entropy engineering strategy is found to weaken the covalence bond between the metal and oxygen in the LCFMN lattice,favoring the creation of oxygen vacancies and increasing cathode activity.As a result,the H-SOFC with the LCFMN cathode achieves an unprecedented fuel cell output of 1803 mW·cm^(−2)at 700℃,the highest ever reported for H-SOFCs with lithiated oxide cathodes.In addition to high fuel cell performance,the LCFMN cathode permits stable fuel cell operation for more than 450 h without visible degradation,demonstrating that LCFMN is a suitable cathode choice for H-SOFCs that combining high performance and good stability. | Yufeng Li Yangsen Xu Yanru Yin Hailu Dai Yueyuan Gu Lei Bi | 2023 | Journal of Advanced Ceramics2023，12，11： | 0 |
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