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| 1 | Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin:Analysis of 1,085 WHO classified cases in a single institution in China显示文摘Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma(DLBCL)patients in China according to the primary site.Methods: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary site.Results: In the 1,085 patients, 679(62.6%) cases were nodal DLBCL(N-DLBCL) and 406 cases(37.4%) were extranodal DLBCL(EN-DLBCL). The most common sites of N-DLBCL were lymphonodus(64.8%), Waldeyer's ring(19.7%), mediastinum(12.8%) and spleen(2.7%), while in EN-DLBCL, stomach(22.4%), intestine(16.0%),nose and sinuses(8.9%), testis(8.4%), skin(7.9%), thyroid(6.9%), central nervous system(CNS)(6.4%), breast(5.7%), bone(3.4%), and salivary gland(2.7%) were most common. N-DLBCL patients tend to present B symptoms, bulky disease, and elevated LDH more often, while age >60 years, extranodal sites >1, Ann Arbor stage I or II, bone marrow involvement, and Ki-67 index >90% were usually seen in EN-DLBCL. The 5-year overall survival(OS) rate and progression-free survival(PFS) rate for all patients were 62.5% and 54.2%. The 5-year OS rate for patients with N-DLBCL and EN-DLBCL were 65.5% and 56.9%(P=0.008), and the 5-year PFS were57.0% and 49.0%(P=0.020). Waldeyer's ring originated DLBCL possessed the highest 5-year OS rate(83.6%) and PFS rate(76.9%) in N-DLBCL. The top five EN-DLBCL subtypes with favorable prognosis were stomach,breast, nose and sinuses, lung, salivary gland, with 5-year OS rate: 70.3%, 69.6%, 69.4%, 66.7% and 63.6%,respectively. While CNS, testis, oral cavity and kidney originated EN-DLBCL faced miserable prognosis, with 5-year OS rate of 26.9%, 38.2%, and 42.9%.Conclusions: In our study, primary sites were associated with clinical characteristics and outcomes. Compared with EN-DLBCL, N-DLBCL had better prognosis. | Yuankai Shi Ying Han Jianliang Yang Peng Liu Xiaohui He Changgong Zhang Shengyu Zhou Liqiang Zhou Yan Qin Yongwen Song Yueping Liu Shulian Wang Jing Jin Lin Gui Yan Sun | 2019 | Chinese Journal of Cancer Research2019，31，1： | 19 |
| 2 | Degradation of organic pollutants by a Co_3O_4 -graphite composite electrode in an electro-Fenton-like system显示文摘A novel composite electrode was constructed by pressing together Co3O4 and graphite and it was used as the cathode in an electro-Fenton-like (EFL) system. The poor electron transport characteristic of Co3O4 was overcome by incorporating graphite. In situ electro-catalytic generation of hydroxyl radicals (·OH) occurred at high current efficiencies from pH 2-10, extending the traditional Fenton reaction pH range. Cyclic voltammetry and AC impedance spectrometry were used to characterize the composite electrode. The ability of the EFL system to degrade organic compounds was investigated using sulforhodamine B (SRB) and 2,4-dichlorophenol (2,4-DCP) as probes. Decoloration of SRB (1.0×10-5 mol/L) was complete (100%) in 150 min and SRB was effectively degraded from pH 2-10. The decomposition of SRB was studied using Fourier transform infrared spectroscopy (FT-IR) and total organic carbon (TOC) analysis and results indicated that the final degradation products were carbon dioxide, carboxylic acids and amines. The EFL system also decomposed 2,4-DCP and the degradation was 98.6% in 240 min. Electro-catalytic degradation of SRB occurs by a ·OH mechanism. After 5 times reused, the degradation rate of SRB did not significantly slow down. The electrode shows excellent potential for use in advanced oxidation processes (AOPs) used to treat persistent organic pollutants (POPs) in wastewater. | LIU Shuan GU Yan WANG ShuLian ZHANG Yu FANG YanFen JOHNSON David M HUANG YingPing | 2013 | Chinese Science Bulletin2013，58，19： | 18 |
| 3 | Photocatalytic properties of hierarchical BiOXs obtained via an ethanol-assisted solvothermal process显示文摘In this study, bismuth oxyhalide(Bi OXs(X_Cl, Br, I)) semiconductors were prepared by a simple solvothermal method, with ethanol serving as solvent and a series of tetrabutylammonium halide surfactants as halogen sources. Under identical synthetic conditions, Bi OBr was more readily constructed into regular flower-like hierarchical architectures. The photocatalytic properties of the materials were studied by monitoring the degradation of rhodamine B(Rh B),with visible light absorption, and colorless salicylic acid(SA). It was found that both Rh B and SA were rapidly degraded on the surface of Bi OBr. Bi OCl was rather active for the degradation of Rh B,but ineffective toward the degradation of SA. However, neither Rh B nor SA could be degraded effectively in the case of Bi OI. Further experiments such as UV–visible spectroscopy and detection of U OH and O2 Uradicals suggest that the electronic structure of the Bi OX photocatalysts is responsible for the difference in their activities. | Manke Jia Xiaolong Hu Shulian Wang Yingping Huang Lirong Song | 2015 | Journal of Environmental Sciences2015，27，9： | 5 |
| 4 | Catalysis of organic pollutant photodegradation by metal phthalocyanines immobilized on TiO_2@SiO_2显示文摘A TiO2@SiO2 hybrid support was prepared by the sol-precipitation method using n-octylamine as a template.The photocatalyst manganese phthalocyanine tetrasulfonic acid (MnPcS) was immobilized on the support to form MnPcS-TiO2@SiO2.X-ray diffraction (XRD) and UV-Visible diffuse reflectance spectra (UV-Vis DRS) were employed to characterize the catalyst.The photocatalytic degradation of rhodamine B (RhB) and the catalytic oxidation of o-phenylenediamine (OPDA) under visible light irradiation were used as probe reactions.The mineralization efficiency and the degradation mechanism were evaluated using chemical oxygen demand (COD Cr) assays and electron spin resonance (ESR),respectively.RhB was efficiently degraded by immobilized MnPcS-TiO2@SiO2 under visible light irradiation.Complete decolorization of RhB occurred after 240 min of irradiation and 64.02% COD Cr removal occurred after 24 h of irradiation.ESR results indicated that the oxidation process was dominated by the hydroxyl radical (·OH) and superoxide radical (O-·2) generated in the system. | WANG ShuLian FANG YanFen YANG Yong LIU JunZi DENG AnPing ZHAO XiaoRong HUANG YingPing | 2011 | Chinese Science Bulletin2011，56，10： | 5 |
| 5 | Down-staging depth score to predict outcomes in locally advanced rectal cancer achieving ypl stage after neoadjuvant chemo-radiotherapy versus de novo stage pl cohort:A propensity score-matched analysis显示文摘Objective:Prognosis of patients with locally advanced rectal cancer(LARC)but achieving yp T1–2N0 stage after neoadjuvant concurrent chemo-radiotherapy(CRT)has been shown to be favorable.This study aims to determine whether the long-term outcome of yp T1–2N0 cases can be comparable to that of p T1–2N0 cohort that received definitive surgery for early disease.Method:From January 2008 to December 2013,449 consecutive patients with rectal cancer were treated and their outcome maintained in a database.Patients with LARC underwent total mesorectal excision(TME)surgery at4–8 weeks after completion of CRT,and those achieving stage yp I were identified as a group.As a comparison,stage p I group pertains to patients whose initially limited disease was not upstaged after TME surgery alone.After propensity score matching(PSM),comparisons of local regional control(LC),distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were performed using Kaplan-Meier analysis and log-rank test between yp I and p I groups.Down-staging depth score(DDS),a novel method of evaluating CRT response,was used for subset analysis.Results:Of the 449 patients,168 matched cases were generated for analysis.Five-year LC,DMFS,DFS and OS for stage p I vs.yp I groups were 96.7%vs.96.4%(P=0.796),92.7%vs.73.6%(P=0.025),91.2%vs.73.6%(P=0.080)and 93.1%vs.72.3%(P=0.040),respectively.In the DDS-favorable subset of the yp I group,LC,DMFS,DFS and OS resulted in no significant differences in comparison with the p I group(P=0.384,0.368,0.277 and0.458,respectively).Conclusions:LC was comparable in both groups;however,distant metastasis developed more frequently in down-staged LARC than de novo early stage cases,reflecting the need to improve the efficacy of systemic treatment despite excellent pathologic response.DDS can be an indicator to identify a subset of the yp I group whose longterm oncologic outcomes are as good as those of stage p I cohort. | Ning Li Jing Jin Jing Yu Shuai Li Yuan Tang Hua Ren Wenyang Liu Shulian Wang Yueping Liu Yongwen Song Hui Fang Zihao Yu Yexiong Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 6 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 7 | Management of acquired rectourethral fistulas in adults显示文摘Rectourethral fistula is an uncommon but devastating condition resulting from surgery,radiation,trauma,inflammation,or occasionally anorectal anomaly.Because of involving the urinary and the digestive system,surgical repair can be challenging.More than 40 different surgical approaches were described in the literature.However,no standardized management exists due to the rarity and complexity of the problem.Spontaneous closure of fistula is rare and most cases need reconstructive procedures.Appropriate preoperative assessment is crucial for the decision of operation time and method.Gradually accumulating evidence indicates surgeons should take fistula size,tissue health and vascularity associated with radiation or infection,urethral stricture,and bladder neck sclerosis into consideration and make a proper treatment plan according to the features of various approaches.Accurate preoperative evaluation and proper approach selection would increase success rates.Multiple surgical team corporation,including colorectal,urological and plastic surgeons,would optimize the outcomes. | Shulian Chen Rang Gao Hong Li Kunjie Wang | 2018 | Asian Journal of Urology2018，5，3： | 2 |
| 8 | Phylogenetic and Morphological Investigation of a Dunaliella Strain Isolated from Yuncheng Salt Lake,China显示文摘A Dunaliella strain was isolated from Yuncheng Salt Lake,Shanxi,China(111.05°E,35.03°N).Morphological characteristics and molecular data were used to evaluate the relationship of this algal strain to other | WANG Feipeng FENG Jia WANG Jie LI Bo XIE Shulian | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 2 |
| 9 | Screening of Benzoic Acid Biodegradation Strains显示文摘Three strains BQ,BJ,and BS utilizing benzoic acid as the sole carbon source were achieved from Yichang City,Hubei Province,China,through selective enrichment and domestication.Both BQ and BJ were primarily identified as Acinetobacter.spp while BS was Geotrichum.spp.After three domestications,the removal rates of BQ,BJ,and BS to chemical oxygen demand(COD) value of benzoic acid were 62.41%,94.44%,and 43.34%,respectively.The strains were mixed cultured,and the degradation rates of strains to benzoic acid at different temperature,pH and benzoic acid concentration were determined.The results show that the optimum degradation conditions about strains were pH 7.0,temperature 30 ℃,and aerobic with 1 500 mg/L of concentration of benzoic acid.In this condition,the COD removal rate of strains to benzoic acid reached 84.93%. | WANG Shulian,ZHANG Liping,WANG Xiaoxing,CHEN Dengxia,LI Xiaocong,HUANG Yingping Alan G.MacDiarmid Research Institute of Renewable Energy,China Three Gorges University,Yichang 443002,Hubei,China | 2010 | Wuhan University Journal of Natural Sciences2010，15，6： | 2 |
| 10 | Degradation of organic pollutants by visible light synergistic electro-Fenton oxidation process显示文摘Visible light irradiation combined with homogeneous iron and/or hydrogen peroxide to degrade organic dye rhodamine B (RhB) and small molecular compound 2,4-dichlorophenol (2,4-DCP) in a home-made bottle reactor was assessed. The concen-tration of oxidize species, Fe3+ and Fe2+ were determined during the degradation process. The results demonstrated that visible light irradiation combined with electro-Fenton improved the degradation efficiency. Moreover, both RhB and 2,4-DCP were mineralized during visible light synergistic electro-Fenton oxidation process. 95.0% TOC (total organic carbon) removal rate of RhB occurred after 90 min and 96.7% of COD (chemical oxygen demand) removal rate after 65 min of irradiation. 91.3% TOC removal rate of 2,4-DCP occurred after 16 h of irradiation and 99.9% COD removal rate occurred after 12 h of illumination. The degradation and oxidation process was dominated by the hydroxyl radical ( · OH) generated in the system. Both the impressed electricity and dye sensitization by visible light facilitated the conversion between Fe3+ and Fe 2+ , thus, improving Fenton reaction efficiency. | WANG ShuLian WANG Qi FANG YanFen HUANG YingPing | 2013 | Science China Chemistry2013，56，6： | 1 |
| 11 | Esophageal Cancer Located at the Neck and Upper Thorax Treated with Concurrent Chemoradiation: A Single-Institution Experience显示文摘 | Shulian Wang Zhongxing Liao Yuan Chen Joe Y. Chang Melanda Jeter Thomas Guerrero Jaffer Ajani Alexandria Phan Stephen Swisher Pamela Allen James D. Cox Ritsuko Komaki | 2006 | Journal of Thoracic Oncology2006，，3： | 1 |
| 12 | Structural modeling of SMA fiber hybrid active thin-walled composite beams显示文摘 | Ren Yongsheng Yang Shulian Wang Xiaohui | 2009 | Composite Structures2009，91，： | 1 |
| 13 | The Intelligent Fault Diagnosis of Wind Turbine Gearbox based on Artificial Neural Network显示文摘 | YANG Shulian LI Wenhai WANG Canlin | 2008 | Proceedings of International Conference on Condition Monitoring and Diagnosis2008，，： | 1 |
| 14 | Bismuth oxybromide promoted detoxification of cylindrospermopsin under UV and visible light illumination显示文摘 | Shulian Wang Wanhong Ma Yanfen Fang Manke Jia Yingping Huang | 2013 | Applied Catalysis B: Environmental2013，，： | 1 |
| 15 | Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy显示文摘Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized treatment.We examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative CRT.Methods:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were included.All patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were evaluated.Clinicopathological factors related to long-term prognosis were analyzed using univariate and multivariate analyses.The down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term outcomes.Results:The median follow-up period for survivors was 30 months.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and ypN0.Decision curve analysis further affirmed that DDS had the largest net benefit.The DDS cut-off value was 4.pCR and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS. | Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin | 2021 | Chinese Journal of Cancer Research2021，33，4： | 1 |
| 16 | Risk Factors for Pericardial Effusion in Inoperable Esophageal Cancer Patients Treated With Definitive Chemoradiation Therapy显示文摘 | Xiong Wei H. Helen Liu Susan L. Tucker Shulian Wang Radhe Mohan James D. Cox Ritsuko Komaki Zhongxing Liao | 2008 | International Journal of Radiation Oncology Biology Physics2008，，3： | 1 |
| 17 | Confined optical field based on surface plasmon polaritons 显示文摘 | Qingyan Wang Jia Wang Shulian Zhang | 2007 | Proceedings of SPIE2007，6831，： | 1 |
| 18 | Structural modeling of SMA fiber hybrid active thin-walled composite beams 显示文摘 | Ren Yongsheng Yang Shulian Wang Xiaohui | 2009 | Composite Structures2009，91，： | 1 |
| 19 | FISCAL TRANSPARENCY AT THE CHINESE PROVINCIAL LEVEL显示文摘 | SHULIAN DENG JUN PENG CONG WANG | 2013 | Public Admin2013，，4： | 1 |
| 20 | Esophageal Cancer Located at the Neck and Upper Thorax Treated with Concurrent Chemoradiation:A Single-Institution Experience显示文摘 | Shulian Wang Zhongxing Liao Yuan Chen | 2006 | J Thorac Oncol2006，1，： | 1 |
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