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| 1 | WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation显示文摘心肌的局部缺血是血流动的减小引起到心的一个心条件,阻止心收到足够的氧。心肌的局部缺血全球性是死亡的最普通的原因。心 ischemic preconditioning (欧洲电脑生产厂商) 对局部缺血和 ischemia-reperfusion 损害导致的心肌的房间死亡有保护的效果。WDR26 最近作为蛋白质被识别了被增加后面的老鼠心脏的欧洲电脑生产厂商。WDR26 能支持 H9c2 房间的增长并且通过禁止 apoptosis.?However 保护 cardiomyocytes 免于氧化应力,它在心肌的局部缺血的角色是不清楚的。这研究的目的是在心肌的局部缺血和 H9c2 房间组织缺氧探索 WDR26 的角色。我们的结果证明 WDR26 被心肌的局部缺血和 H9c2 房间组织缺氧导致。WDR26 通过禁止保护 H9c2 房间免于组织缺氧损害 ? LDH 版本和增加的房间生存能力。WDR26 在 H9c2 房间的组织缺氧支持导致组织缺氧的 autophagy。我们进一步证明在 H9c2 房间组织缺氧, WDR26 增加 mitochondrial 膜潜力,从而线粒体的增加 Parkin translocation。在 Parkin 是在线粒体的 translocated 以后, WDR26 能在 H9c2 房间的组织缺氧增加 mitochondrial 蛋白质 ubiquitination。WDR26 是对组织缺氧的反应的一个调停人,并且 WDR26 在调停组织缺氧的 autophagy 和 mitophagy 起一个重要作用。这研究在组织缺氧期间在 cardiomyocyte 损害提供新奇卓见进 WDR26 的保护的角色。WDR26 可以为心肌的局部缺血的处理用作一个潜在的目标。 | Yansheng Feng Jia Zhao Huifang Hou Hui Zhang Yunjuan Jiao Jiangang Wang Yongling Wang Yinping Sun | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 13 |
| 2 | High-speed image reconstruction for optically sectioned,super-resolution structured illumination microscopy显示文摘Super-resolution structured illumination microscopy(SR-SIM)is an outstanding method for visualizing the subcellular dynamics in living cells.To date,by using elaborately designed systems and algorithms,SR-SIM can achieve rapid,optically sectioned,SR observation with hundreds to thousands of time points.However,real-time observation is still out of reach for most SIM setups as conventional algorithms for image reconstruction involve a heavy computing burden.To address this limitation,an accelerated reconstruction algorithm was developed by implementing a simplified workflow for SR-SIM,termed joint space and frequency reconstruction.This algorithm results in an 80-fold improvement in reconstruction speed relative to the widely used Wiener-SIM.Critically,the increased processing speed does not come at the expense of spatial resolution or sectioning capability,as demonstrated by live imaging of microtubule dynamics and mitochondrial tubulation. | Zhaojun Wang Tianyu Zhao Huiwen Hao Yanan Cai Kun Feng Xue Yun Yansheng Liang Shaowei Wang Yujie Sun Piero RBianco Kwangsung Oh Ming Lei | 2022 | Advanced Photonics2022，4，2： | 9 |
| 3 | Large-scale highly ordered periodic Au nano-discs/graphene and graphene/Au nanoholes plasmonic substrates for surface-enhanced Raman scattering显示文摘In this paper,the study of using masks to directly generate large area,highly ordered and periodical nanostructure has been exhibited.Periodic Au nano-discs(NDs)arrays have been fabricated on top of graphene by using holey SigN4 mask which is directly fixed on top of graphene and Au metal is deposited through the holes in mask by thermal evaporation method under vacuum condition.This fabrication method provides an easy,fast and cost efficiency way to generate periodical nanostructure.Also,Au nanoholes(NHs)structure has been studied by using holey SigN4 as a template.The surface-enhanced Raman scattering(SERS)sensitvities of periodical Au NDs/graphene and graphene/Au NHs hybrid structures have been systematically studied.The internal mechanisms could be explained by chemical mechanism effect of graphene and electromagnetic mechanism effect of metallic nano-structures.The enhancement factors have been systematically investigated by varying the diameter and the thickness of Au discs and Au NHs.Raman mappings of Au NDs with 2.5 um diameter ilustrate that the larger SERS enhancements exist in the rim of NDs which has good agreement with the electric field simulation result.The SERE enhancement factors of fluorescein obtained from Au NDs/graphene substrates shows an improvement factor of 500%in comparison of graphene substrate.The calculated SERS enhancement factors of graphene/Au NHs achieve 1,200%in comparison of graphene/planar Au film substrate. | Yansheng Liu Feng Luo | 2019 | Nano Research2019，12，11： | 2 |
| 4 | Spatial Raman mapping investigation of SERS performance related to localized surface plasmons显示文摘In this research,it reported a novel three-dimensional(3D)metallic hybrid system by introducing single-layer graphene(SLG)between silver nanoparticles(NPs)and silver nano-discs(NDs)arrays(Ag NPs/SLG/Ag NDs).By combining the plasmonic metallic nanostructures and the unique physical/chemical properties of graphene,Ag NPs/SLG/Ag NDs hybrid substrate was fabricated,and it exhibited extremely high surface-enhanced Raman scattering(SERS)performance.By tuning the diameter of Ag NDs,the SERS performance of Ag NPs/SLG/Ag NDs hybrid substrate has been systematically studied.The detection limit for rhodamine 6g(R6G)could reach the concentrations as low as 1×10^−12 mol/L,and the average enhancement factor(EF)of the Ag NPs/SLG/Ag NDs substrate could reach 5.65×10^8.These advantages indicated that the Ag NPs/SLG/Ag NDs hybrid substrate could be regarded as a candidate for organic molecules detection under extremely low concentration.Besides,spatial Raman mapping of Ag NPs/SLG/Ag NDs with 2.5μm diameter NDs showed the larger SERE signal existed around the rim of Ag NDs which was related to the localized surface plasmons.This phenomenon was contributed by a larger electromagnetic field which was tuned by Ag NPs and the edge of Ag NDs.This mechanism also has been confirmed by the electromagnetic simulation result. | Yansheng Liu Feng Luo | 2020 | Nano Research2020，13，1： | 2 |
| 5 | A combined backstepping and small-gain approach to robust adaptive fuzzy control for strict-feedback nonlinear systems 显示文摘 | YANG Yansheng FENG Gang REN Junsheng | 2004 | IEEE Transactions on Systems Man and Cybernetics-Part A: Systems and Humans2004，34，3： | 1 |
| 6 | Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography-electrospray tandem mass spectrometry显示文摘 | Feng F Yansheng Z Wei Y | | 0，，20： | 1 |
| 7 | Long noncoding RNA HOTAIR involvement in cancer显示文摘 | Yansheng Wu Li Zhang Yang Wang Hui Li Xiubao Ren Feng Wei Wenwen Yu Xudong Wang Lun Zhang Jinpu Yu Xishan Hao | 2014 | Tumor Biology2014，，10： | 1 |
| 8 | Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography–electrospray tandem mass spectrometry显示文摘 | Feng Feng Yansheng Zhao Wei Yong Li Sun Guibin Jiang Xiaogang Chu | 2011 | Journal of Chromatography B2011，，20： | 1 |
| 9 | Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography-electrospray tandem mass spectrometry 显示文摘 | Feng Feng Yansheng zhao Wei Yong | 2011 | Journal of Chromatography B2011，879，： | 1 |
| 10 | A Combined Backstepping and Small-Gain Approach to Robust Adaptive Fuzzy Control for Strict-Feedback Nonlinear Systems显示文摘 | Yang Yansheng Feng Gang Ren Junsheng | 2004 | IEEE Transactions on Systems Man and Cybernetics-Part A:Systems and Humans2004，34，3： | 1 |
| 11 | Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography-electrospray tandem mass spectrometry显示文摘 | Feng Feng Yansheng Zhao Wei Yong | 2011 | Journal of Chromatography B2011，879，： | 1 |
| 12 | Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography-electrospray tandem mass spectrometry显示文摘 | Feng F Yansheng Zh Wei Y | 2011 | J Chromatogr B2011，879，20： | 1 |
| 13 | Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography-electrospray tandem mass spectrometry显示文摘 | Feng Feng Zhao Yansheng Yong Wei | 2011 | Journal of Chromatography B2011，20，879： | 1 |
| 14 | Synthetic process and spark plasma sintering of SrIrO_(3) composite oxide显示文摘Single phase of SrIrO_(3) powders and ceramics were obtained by solid-state chemical reaction method and spark plasma sintering(SPS)technique,respectively.Phase evolutions,characteristics,morphology and resistivity of the samples were studied by using thermogravimetric analysis-differential scanning calorimetry(TG-DSC),X-ray diffractometry(XRD),field emission scanning electron microscopy(FESEM)and four-point probe method,respectively.The results showed that the reaction process to form SrIrO_(3) phase occurred between SrCO_(3) and IrO_(2) directly during the heating process.By using optimum fabrication conditions established from the TG-DSC results,single phase of SrIrO_(3) powders was synthesized at 800-1000℃.SrIrO_(3) ceramics were sintered by SPS technique at 1000-1100℃with a pressure of 30 MPa,showing a high relative density of 92%-96%and dense microstructure.The room-temperature resistivity of SrIrO_(3) ceramics was about 2×10^(-4)Ω×m.The present study can provide high-quality ceramic target for the preparation of SrIrO_(3) films in traditional physical vapor deposition(PVD)method. | Yongshang TIAN Yansheng GONG Zhaoying LI Feng JIANG Hongyun JIN | 2013 | Journal of Advanced Ceramics2013，2，4： | 0 |
| 15 | A study of plasmon-driven catalytic 4-NBT to DMAB in the dry film by using spatial Raman mapping spectroscopy显示文摘Plasmon-driven catalytic reaction(PDCR)as a part of photocatalysis has attracted immense attention.Due to the collective oscillation of free electrons at the surface of metallic nanostructures,the charge distributions store energy from the incident light that could transfer energy to molecules that promote photocatalysis.As an environment-friendly and green photocatalysis process,PDCR illustrates a brilliant future.In this study,the PDCR efficiency of photo-reducing 4-nitro-benzenthiol(4-NBT)dry film to p,p'-dimercaptoazobenzene(DMAB)in ambient conditions has been studied by using Ag nanodiscs(NDs)and Ag nanoparticles(NPs)as catalysts.The distribution of catalytic efficiency of 4-NBT to DMAB using an individual Ag ND catalyst has been illustrated using spatial Raman mapping.The result is direct evidence that the PDCR efficiency has a positive correlation with plasmon-induced electromagnetic field intensity.Additionally,time-dependent surface-enhanced Raman scattering(SERS)experiments reveal that the PDCR of 4-NBT to DMAB is reciprocal.The discovery in this research will aid to improve the PDCR performance and modulate the catalysis reaction for a high reduction of 4-NBT in industrial. | Yansheng Liu Junpeng Deng Zhicheng Jin Tianxing Liu Jin Zhou Feng Luo Guofu Wang | 2022 | Nano Research2022，15，7： | 0 |
| 16 | 11.2 W/mm power density AlGaN/GaN high electron-mobility transistors on a GaN substrate显示文摘In this letter,high power density AlGaN/GaN high electron-mobility transistors(HEMTs)on a freestanding GaN substrate are reported.An asymmetricΓ-shaped 500-nm gate with a field plate of 650 nm is introduced to improve microwave power performance.The breakdown voltage(BV)is increased to more than 200 V for the fabricated device with gate-to-source and gate-to-drain distances of 1.08 and 2.92μm.A record continuous-wave power density of 11.2 W/mm@10 GHz is realized with a drain bias of 70 V.The maximum oscillation frequency(f_(max))and unity current gain cut-off frequency(f_(t))of the AlGaN/GaN HEMTs exceed 30 and 20 GHz,respectively.The results demonstrate the potential of AlGaN/GaN HEMTs on freestanding GaN substrates for microwave power applications. | Yansheng Hu Yuangang Wang Wei Wang Yuanjie Lv Hongyu Guo Zhirong Zhang Hao Yu Xubo Song Xingye zhou Tingting Han Shaobo Dun Hongyu Liu Aimin Bu Zhihong Feng | 2024 | Journal of Semiconductors2024，45，1： | 0 |
| 17 | Targeted treatment strategy for patients with severe pulmonary hypertension secondary to connective tissue diseases显示文摘Background:Pulmonary arterial hypertension(PAH)associated with connective tissue diseases(CTD)(CTD-PAH)remains a difficult challenge in clinical practice.We aimed to evaluate the effects of targeted vasodilators in patients with severe CTD-PAH.Methods:The data of 53 patients with severe CTD-PAH hospitalized at the Department of Rheumatology and Immunology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,were retrospectively reviewed.Patients were followed up for an average of 2 years to track their outcomes.The efficacy of treatment and the survival rate of patients with severe CTD-PAH were determined.Results:Among the causes of severe CTD-PAH,systemic lupus erythematosus(SLE)was the most common(39.6%),and the age at onset in patients with SLE-PAH was younger than that of patients with other CTD.Bosentan was more effective than sildenafil in reducing pulmonary artery pressure,improving cardiac function,and increasing survival time.Combination therapy with targeted vasodilators significantly improved the prognosis of patients with severe CTD-PAH compared with monotherapy.Conclusions:Patients with severe CTD-PAH should be treated early with targeted vasodilators.In this study,bosentan was superior to sildenafil.Combined treatment might be an option for severe CTD-PAH. | Bo Jiang Chun Wang Yansheng Jin Guanjun Guo Kangxing Zhou Xuebing Feng Genhong Yao | 2023 | Rheumatology & Autoimmunity2023，3，3： | 0 |
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