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| 1 | Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells显示文摘Cucurbitacin B (崽) ,从 Cucurbitaceae 植物孤立的 triterpenoid 混合物,作为一个有希望的反癌症代理人被报导了,还它的行动机制仍然是争论的。在这研究,我们在鼠科的 B16F10 黑瘤房间探索了崽的潜在的机制。反增长和反侵略效果在有教养的房间被估计,并且在 vivo 反肿瘤,活动在一个鼠科的下的黑瘤模型被评估。流动 cytometry 被采用分析细胞周期分发和反应的氧种(ROS ) 层次。肌动朊层次被西方的污点分析决定,并且微分表示蛋白质的侧面被一条量的 proteomic 途径识别。结果证明那崽在房间增长,殖民地形成,以及移植和黑瘤房间的侵略潜力上施加了禁止的效果。下的黑瘤的生长显著地在当时,与崽对待的老鼠被禁止与控制相比组。而且,崽治疗引起了快速的房间膜 blebbing 和变丑,并且导致了 G2/M-phase 拘捕和 multiploid 房间的形成。尤其是, G 肌动朊水池很快被弄空,肌动朊总数在崽处理以后快速被形成。很多细胞骨架规章的蛋白质是调整的差别。ROS 生产的阻塞显著地减少了 G 肌动朊弄空能力和崽的反肿瘤活动。这些调查结果显示那崽在黑瘤房间通过 ROS 依赖的肌动朊聚集导致 G 肌动朊水池的快速的弄空,它可以部分至少说明它的反肿瘤活动。 | Yanting Zhang Dongyun Ouyang Lihui Xu Yuhua Ji Qingbing Zha Jiye Cai Xianhui He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 19 |
| 2 | Regional Concentration and Region-based Urban Transition:China's Mega-urban Region Formation in the 1990s显示文摘 | Zheng Yanting Chen Tian Cai Jianming | 2009 | Urban Geography2009，30，3： | 1 |
| 3 | New horizons for therapeutic applications of nanozymes in oral infection显示文摘As a category of nanomaterials with excellent catalytic efficiency,great substrate specificity,and highrecovery efficiency,nanozymes have attracted increasing attention in various biomedical applications.Currently,numbers of nanozyme-assisted strategies have been well developed for the theranostics ofvarious diseases by taking advantages of their multienzyme-like characteristics,low cost,and highstability.As the most prevalent oral diseases,oral infection poses a global hazard to human health,andcurrent therapeutic options are insufficient to resolve all the clinical issues.Based on their admirableactivity,nanozymes can be frequently employed in the identification and treatment of various oral infectious disorders.Herein,we provide a brief review focused on the classification of nanozymes,analysesof nanozyme-based antibacterial mechanism,research progress in oral bacterial control,and representative studies of nanozyme-assisted oral inflammatory management.Moreover,major challenges andpotential opportunities regarding the use of nanozymes in oral infectious diseases are also highlightedand discussed.This review not only summarizes the recent studies of nanozymes in oral infection butalso promotes the further development of enzyme-mimetic strategies towards various oral diseases. | Yanting Cai Yue Li Jin Zhang Nan Tang Xingfu Bao Zhen Liu | 2023 | Particuology2023，，9： | 0 |
| 4 | Boosting the energy density of aqueous MXene-based supercapacitor by integrating 3D conducting polymer hydrogel cathode显示文摘The wide-spread proliferation of aqueous MXene-based supercapacitor has been largely shadowed by the limited cell potential window(typically in the range of 0-0.6 V).To address this baffling issue,designing asymmetric supercapacitor(ASC)is proposed as a rational strategy to enlarge the potential window(thus energy density)of individual cell in aqueous electrolytes.To this date,however,it still remains a great challenge to develop easy fabricating,3D nanostructured,and pseudocapacitive cathode materials that can perfectly match with MXene anodematerials.In this work,we propose a supramolecular strategy to construct conducting polymer hydrogel(CPH)with highly interconnected 3D nanostructures and large pseudocapacitance,which can finely match with 2D Ti_(3)C_(2)T_(x).The as-assembled CPH//Ti_(3)C_(2)T_(x) ASCwith CPH cathode and MXene anode can operate in a broadened potential window of 1.15 V in aqueous PVA/H_(2)SO_(4) gel electrolyte with remarkably improved energy density of 16.6μWh/cm^(2)(nine times higher than that of symmetric MXene supercapacitor).Additionally,this ASC exhibits outstanding cyclic stability with no trackable performance decay over 30,000 galvanostatic charge and discharge cycles.It is demonstrated in this work that employing positive CPH electrode is a feasible yet promising strategy to enhance the potential window and energy density of aqueous MXene supercapacitors. | Xiang Chu Yihan Wang Lucheng Cai Haichao Huang Zhong Xu Yanting Xie Cheng Yan Qing Wang Haitao Zhang Hong Li Weiqing Yang | 2022 | SusMat2022，2，3： | 0 |
| 5 | Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3显示文摘The TEA domain(TEAD)family proteins(TEAD1-4)are essential transcription factors that control cell differentiation and organ size in the Hippo pathway.Although the sequences and structures of TEAD family proteins are highly conserved,each TEAD isoform has unique physiological and pathological functions.Therefore,the development and discovery of subtype selective inhibitors for TEAD protein will provide important chemical probes for the TEAD-related function studies in development and diseases.Here,we identified a novel TEAD 1/3 covalent inhibitor(DC-TEADin1072)with biochemical IC50 values of 0.61±0.02 and 0.58±0.12μmol/L against TEAD1 and TEAD3,respectively.Further chemical optimization based on DC-TEAD in 1072 yielded a selective TEAD3 inhibitor DCTEAD3 in03 with the IC_(50) value of 0.16±0.03μmol/L,which shows 100-fold selectivity over other TEAD isoforms in activity-based protein profiling(ABPP)assays.In cells,DC-TEAD3 in03 showed selective inhibitory effect on TEAD3 in GAL4-TEAD(1-4)reporter assays with the IC50 value of1.15μmol/L.When administered to zebrafish juveniles,experiments showed that DC-TEAD3 in03 reduced the growth rate of zebrafish caudal fins,indicating the importance of TEAD3 activity in controlling proportional growth of vertebrate appendages. | Tian Lu Yong Li Wenchao Lu TWGM Spitters Xueyu Fang Jun Wang Simian Cai Jing Gao Yanting Zhou Zhe Duan Huan Xiong Liping Liu Qi Li Hualiang Jiang Kaixian Chen Hu Zhou Hua Lin Huijin Feng Bing Zhou Christopher L.Antos Cheng Luo | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 0 |
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