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| 1 | Oral administration of a non-absorbable plant cellexpressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis显示文摘AIM To evaluate the immunomodulatory effect of oral administration of PRX-106 in the high-fat diet model.METHODS For 22 wk, C57BL/6 HFD-fed mice received daily oral treatments with BY-2 cells expressing recombinant antitumor necrosis factor alpha fusion protein(PRX-106). Mice were followed for serum liver enzyme and triglyceride levels, liver histology and intrahepatic and systemic FACS.RESULTS The orally administered non-absorbable PRX-106 w a s b i o l o g i c a l l y a c t i v e. A l t e r e d d i s t r i b u t i o n o f CD4+CD25+Fox P3+ between the liver and spleen and an increase in the intrasplenic-to-intrahepatic CD4+CD25+Fox P3+ ratio and a decrease in the intrasplenic-to-intrahepatic CD8+CD25+Fox P3+ ratio were observed. An increase in intrahepatic NKT cells and a decrease in the intrasplenic-to-intrahepatic NKT ratio were noted. Assessment of the CD4-to-CD8 ratios showed sequestration of CD8+ lymphocytes in the liver. These effects were associated with a decrease in serum triglyceride levels, decrease in the aspartate aminotransferase levels, serum glucose levels, and HOMA-IR score. A decrease in hepatic triglycerides content was observed in the high dose-treated mice.CONCLUSION Orally administered PRX-106 shows biological activity and exerts an immunomodulatory effect, alleviating liver damage. The data suggest that PRX-106 may provide an oral immunotherapy for nonalcoholic steatohepatitis. | Yaron Ilan Ami Ben Ya'acov Yehudit Shabbat Svetlana Gingis-Velitski Einat Almon Yoseph Shaaltiel | 2016 | World Journal of Gastroenterology2016，22，39： | 3 |
| 2 | Deoxygenation and elevation of intracellular magnesium induce tyrosine phosphorylation of band 3 in human erythrocytes显示文摘 | Alexander B Yehudit Z Alexander N | 1999 | FEBS Lett1999，455，： | 1 |
| 3 | Question-Posing Capability as an Alternative Evaluation Method: Analysis of an En vironmental Case Study 显示文摘 | Yehudit J Dori Orit Herseovitz | 1999 | Journal of Research in Science Teaching1999，36，4： | 1 |
| 4 | Homologous adaptation to oxidative stress induced by the photosensitized Pd-bacteriochlorophyll derivative (WST11) in culture endothelial cells显示文摘 | Vicki P Yehudit P Ohad M | 2004 | J Biol Chem2004，279，45： | 1 |
| 5 | A lectin array-based methodology for the analysis of protein glycosylation显示文摘 | Rakefet Rosenfeld Haim Bangio Gerrit J. Gerwig Revital Rosenberg Ronny Aloni Yossi Cohen Yehudit Amor Inbar Plaschkes Johannis P. Kamerling Ruth Ben-Yakar Maya | 2006 | Journal of Biochemical and Biophysical Methods2006，，3： | 1 |
| 6 | How Does Technology-Enabled Active Learning Affect Undergraduate Students' Understanding of Electromagnetism Concepts?显示文摘 | Yehudit Judy Dori & John Belcher | 2005 | The Journal of the Learning Sciences2005，14，2： | 1 |
| 7 | Vascular Endothelial Growth Factor and Angiopoietin in Liver Regeneration显示文摘 | | 2001 | Biochemical and Biophysical Research Communications2001，287，： | 1 |
| 8 | Development and implementation of inquiry-based and computerized-based laboratories: reforming high schoolchemistry in Israel显示文摘 | Nitza Barneaa Yehudit Judy Dori and Avi Hofsteind | 2010 | Chemistry Education Research and Practice2010，，11： | 1 |
| 9 | Vascular Endothelial Growth Factor and Angiopoietin in Liver Regeneration显示文摘 | Nidal Mawasi | 2001 | Biochemical and Biophysical Research Communications2001，287，： | 1 |
| 10 | K-Ar age,whole- rock and isotope geochemistry of A-type granitoids in the Div- rii-Sivas Region,eastern-central Anatolia,Turkey显示文摘 | Durmus B Z Yehudit H Arehart G B | 2007 | Lithos2007，97，12： | 1 |
| 11 | Reusable and sustainable science and engineering education显示文摘 | Doff J Yehudit | 2008 | Jottmal of Science Education and Technology2008，，2： | 1 |
| 12 | A commercially-viable, one-step process for production of green diesel from soybean oil on Pt/SAPO-11显示文摘 | Moti Herskowitz Miron V. Landau Yehudit Reizner Dov Berger | 2013 | Fuel2013，，： | 1 |
| 13 | 保持低速,保持复杂显示文摘黑色的森林,一处来自无名之域的荒芜沼泽,从黑色森林中树木上剥落的黑色径直地贯穿了由沼泽水塘构建出的视平线,无论是空间装置作品还是绘画或者视频影像,都充满了一种压制和紧张感,这些都是依浩特·莎丝波特丝(Yehudit Sasportas)作品中经常出现的元素,也构成了她独特的艺术风格。莎丝波特丝是一位描述和呈现临界状态的高手,呈现“尚未出现”和“刚刚逝去”的不确定瞬间,呈现社会现实与个体的无意识混合空间是其艺术创作的核心内容。一方面,莎丝波特丝试图将景观的存在和人类感知相结合。 | 示人 Yehudit Sasportas | 2018 | 青年视觉2018，，6： | 0 |
| 14 | Vestiges of the Cold War in Libya’s“Arab Spring”:Revisiting Libya’s Relations with the Soviet Union显示文摘Although Muammar al-Qaddafi was known to fanatically adhere to a broad set of zealous principles,when threats and challenges to his political survival mounted,sporadic breaches in the country’s rigid wall of ideology in regard to Libya’s international relations appeared,evincing Qaddafi’s ability to demonstrate pragmatism when required in order to maintain his grip on power.This article will explore Libya’s strategic-military alignment with the USSR and offer a retrospective analysis of one of the lesser-discussed chapters in Tripoli’s tempestuous and belligerent foreign policy during the height of the Cold war era,spanning the period of 1974-1989. | Yehudit RONEN | 2014 | Asian Journal of Middle Eastern and Islamic Studies2014，8，2： | 0 |
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