| 1 | Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis显示文摘Depression is a serious public-health issue.Recent reports have suggested higher susceptibility to viral infections in depressive patients.However,how depression affects antiviral innate immune signaling remains unknown.Here,we revealed a reduction in expression of Abelson helper integration site 1(AHI1)in the peripheral blood mononuclear cells(PBMCs)and macrophages from the patients with major depressive disorder(MDD),which leads to attenuated antiviral immune response.We found that depression-related arginine vasopressin(AVP)induces reduction of AHI1 in macrophages.Further studies demonstrated that AHI1 is a critical stabilizer of basal type-I-interferon(IFN-I)signaling.Mechanistically,AHI1 recruits OTUD1 to deubiquitinate and stabilize Tyk2,while AHI1 reduction downregulates Tyk2 and IFN-I signaling activity in macrophages from both MDD patients and depression model mice.Interestingly,we identified a clinical analgesic meptazinol that effectively stimulates AHI1 expression,thus enhancing IFN-I antiviral defense in depression model mice.Our study promotes the understanding of the signaling mechanisms of depression-mediated antiviral immune dysfunction,and reveals meptazinol as an enhancer of antiviral innate immunity in depressive patients. | Hong-Guang Zhang Bin Wang Yong Yang Xuan Liu Junjie Wang Ning Xin Shifeng Li Ying Miao Qiuyu Wu Tingting Guo Yukang Yuan Yibo Zuo Xiangjie Chen Tengfei Ren Chunsheng Dong Jun Wang Hang Ruan Miao Sun Xingshun Xu Hui Zheng | 2022 | Cell Research2022，32，10： | 3 |
| 2 | Separating the effects of two dimensions on ecosystem services:Environmental variables and net trade-offs显示文摘Spatial and temporal changes in ecosystem services(ESs)are driven by two types of factors:environmental factors and trade-offs/synergies between services.In the ecological conservation red line(ECRL)area,in which national ecological security and social sustainable development are guaranteed,it is particularly important to clarify the driving mechanism of ESs for the management of ecosystems.In this study,soil conservation,water yield,and carbon sequestration in Beijing’s ECRL area are quantified,and GeoDetector is used to identify the factors influencing the trade-offs/synergies between ESs.Moreover,partial correlation analysis is used to calculate the net trade-offs/synergies and compare them with the extent to which environmental variables contribute to ESs.The results are as follows:environmental variables and trade-offs/synergies have different effects on the changes in ESs,and their interactions can enhance the determinative power of the corresponding individual variable.The land use intensity is an extremely important factor affecting the trade-offs/synergies between the three services,indicating that rational land use planning in Beijing’s ECRL area is crucial for avoiding the negative impacts of trade-offs and enabling coordinated optimization of ESs.After the elimination of the cross-influence of environmental variables,the trade-offs/synergies change significantly,and the impact of environmental variables on ESs is compared with the net trade-offs/synergies.Environmental variables are the driving forces of the spatiotemporal changes in soil conservation.Precipitation and carbon sequestration have similar effects on water yield.Spatiotemporal changes in carbon sequestration are closely related to the other two services,with smaller influences from environmental variables. | ZUO Liyuan JIANG Yuan GAO Jiangbo DU Fujun ZHANG Yibo | 2023 | Journal of Geographical Sciences2023，33，4： | 0 |
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