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您的检索式：作者名="Yichen Kuang"
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| 1 | In situ forming oxygen/ROS-responsive niche-like hydrogel enabling gelation-triggered chemotherapy and inhibition of metastasis显示文摘Though the development of the diverse hypoxia-activated prodrugs(HAPs)has made great progresses in the last several decades,current cancer therapy based on HAPs still suffers many obstacles,e.g.,poor therapeutic outcome owing to hard deep reaching to hypoxic region,and the occurrence of metastasis due to hypoxia.Inspired by engineered niches,a novel functional chitosan polymer(CS-FTP)is synthesized for construction of a hydrogel-based bio-niche(CS-FTP-gel)in aiming at remodeling tumor hypoxic microenvironment.The CS-FTP polymers are crosslinked to form a niche-like hydrogel via enzyme-mediated oxygen-consumable dimerization after injected into tumor,in which a HAP(i.e.,AQ4N)could be physically encapsulated,resulting in enhanced tumor hypoxia to facilitate AQ4N-AQ4 toxic transformation for maximizing efficacy of chemotherapy.Furthermore,Pazopanib(PAZ)conjugated onto the CS backbone via ROS-sensitive linker undergoes a stimuli-responsive release behavior to promote antiangiogenesis for tumor starvation,eventually contributing to the inhibition of lung metastasis and synergistic action with AQ4N-based chemotherapy for an orthotopic 4T1 breast tumor model.This study provides a promising strategy for hypoxia-based chemotherapy and demonstrates an encouraging clinical potential for multifunctional hydrogel applicable for antitumor treatment. | Shi-Xiong Chen Ji Zhang Fengfeng Xue Wei Liu Yichen Kuang Bingxin Gu Shaoli Song Hangrong Chen | 2023 | Bioactive Materials2023，，3： | 0 |
| 2 | Thianthrene Radical Cation as a Transient SET Mediator:Photoinduced Thiocyanation and Selenocyanation of Arylthianthrenium Salts显示文摘Comprehensive Summary A novel transient SET mediator approach has been developed for the photoinduced radical-radical cross coupling reaction.Using the in-situ generated thianthrene radical cation as the transient SET mediator,the thiocyanation and selenocyanation of aryl thianthrenium salts have been realized under the mild conditions without the need for photocatalyst or single electron donor.In comparison with the photocatalyst enabled process,the protocol features mild conditions,simple manipulation,a broad substrate scope,excellent functional group and heterocycle tolerance.Due to the feasible accessibility of aryl thianthrenium salts,this method has also been applied in the efficient synthesis of a bioactive molecule,and the late-stage functionalization of complex arenes. | Xiao-Yue Chen Xin Kuang Yichen Wu Jian Zhou Peng Wang | 2023 | Chinese Journal of Chemistry2023，41，16： | 0 |
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