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您的检索式：作者名="Yidian ZHANG"
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| 1 | Inverse design of low boom configurations using proper orthogonal decomposition and augmented Burgers equation显示文摘Mitigation of sonic boom to an acceptable stage is a key point for the next generation of supersonic transports. Meanwhile, designing a supersonic aircraft with an ideal ground signature is always the focus of research on sonic boom reduction. This paper presents an inverse design approach to optimize the near-field signature of an aircraft, making it close to the shaped ideal ground signature after the propagation in the atmosphere. Using the Proper Orthogonal Decomposition(POD) method, a guessed input of augmented Burgers equation is inversely achieved. By multiple POD iterations, the guessed ground signatures successively approach the target ground signature until the convergence criteria is reached. Finally, the corresponding equivalent area distribution is calculated from the optimal near-field signature through the classical Whitham F-function theory. To validate this method, an optimization example of Lockheed Martin 1021 is demonstrated. The modified configuration has a fully shaped ground signature and achieves a drop of perceived loudness by 7.94 PLdB. This improvement is achieved via shaping the original near-field signature into wiggles and damping it by atmospheric attenuation. At last, a nonphysical ground signature is set as the target to test the robustness of this inverse design method and shows that this method is robust enough for various inputs. | Yidian ZHANG Jiangtao HUANG Zhenghong GAO Chao WANG Bowen SHU | 2019 | Chinese Journal of Aeronautics2019，32，6： | 7 |
| 2 | A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies显示文摘Intraneuronal accumulation of hyperphosphorylated tau is a hallmark pathology shown in over twenty neurodegenerative disorders,collectively termed as tauopathies,including the most common Alzheimer's disease(AD).Therefore,selectively removing or reducing hyperphosphorylated tau is promising for therapies of AD and other tauopathies.Here,we designed and synthesized a novel DEPhosphorylation TArgeting Chimera(DEPTAC)to specifically facilitate the binding of tau to Ba-subunit-contalning protein phosphatase 2A(PP2A-Ba),the most active tau phosphatase in the brain.The DEPTAC exhibited high efficiency in dephosphorylating tau at multiple AD-associated sites and preventing tau accumulation both in vitro and in vivo.Further studies revealed that DEPTAC significantly improved microtubule assembly,neurite plasticity,and hippocampus-dependent learning and memory in transgenic mice with inducible overexpression of truncated and neurotoxic human tau N368.Our data provide a strategy for selective removal of the hyperphosphorylated tau,which sheds new light for the targeted therapy of AD and related-tauopathies. | Jie Zheng Na Tian Fei Liu Yidian Zhang Jingfen Su Yang Gao Mingmin Deng Linyu Wei Jingwang Ye Honglian Li Jian-Zhi Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
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