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| 1 | Exosome-mimicking nanovesicles derived from efficacy-potentiated stem cell membrane and secretome for regeneration of injured tissue显示文摘Translation of exosome-based therapies to pharmaceutical use is hindered by difficulties in large-scale and cost-effective production of clinical-grade exosomes.The rational design of nanovesicles that mimic the functionalities and physicochemical properties of exosomes may circumvent these issues.In this study,membranes and secretome from efficacy-potentiated mesenchymal stem cells(MSCs)were developed into size-controllable nanovesicles(Meseomes).MSCs were primed with interferon-y(IFNy)and tumor necrosis factor-a(TNFa),harvested,and exosome-mimicking Meseomes were subsequently synthesized via one-step extrusion.Meseomes demonstrated significant enhancement of pro-angiogenic,pro-proliferative,antiinflammatory,and anti-fibrotic effects on endothelial cells,macrophages,and hepatic stellate cells in vitro.Meseomes from primed MSCs benefited from an enrichment of bioactive and therapeutic molecules compared to nanovesicles from unprimed MSCs,as validated by liquid chromatography-mass spectrometry(LC-MS)proteomic analysis.Systemic administration of Meseomes to acute liver injury models resulted in the recovery of liver function,attenuated tissue necrosis.Further assessment of locally administered Meseomes in acute hindlimb ischemia models resulted in the salvage of the majority of the ischemic hindlimb(>80%),which was due to enhanced angiogenesis and M2 macrophage polarization.The versatility and therapeutic efficacy of our developed acellular Meseomes offer an appealing alternative to traditional cell or exosome therapies for regenerative and translational medicine. | Chunxiao Qi Xiangsheng Liu Dengke Zhi Yifan Tai Yufei Liu Qiqi Sun Kai Wang Shufang Wang Adam C.Midgley Deling Kong | 2022 | Nano Research2022，15，2： | 0 |
| 2 | Erratum to:Exosome-mimicking nanovesicles derived from efficacypotentiated stem cell membrane and secretome for regeneration of injured tissue显示文摘Erratum to Nano Research 2022,15(2):1680–1690 http://gffzzd3cc09b8251d45dfsbwx0wcnnfok966n0.ffgz.tsg.suse.edu.cn/10.1007/s12274-021-3868-z The article Exosome-mimicking nanovesicles derived from efficacy-potentiated stem cell membrane and secretome for regeneration of injured tissue,written by Chunxiao Qi et al.,was erroneously published with duplicated microscopy panels in Fig.3(d). | Chunxiao Qi Xiangsheng Liu Dengke Zhi Yifan Tai Yufei Liu Qiqi Sun Kai Wang Shufang Wang Adam C.Midgley Deling Kong | 2022 | Nano Research2022，15，8： | 0 |
| 3 | Improving solar control of magnetism in ternary organic photovoltaic system with enhanced photo-induced electrons doping显示文摘§The growing demand for storage space has promoted in-depth research on magnetic performance regulation in an energy-saving way.Recently,we developed a solar control of magnetism,allowing the magnetic moment to be manipulated by sunlight instead of the magnetic field,current,or laser.Here,binary and ternary photoactive systems with different photon-to-electron conversions are proposed.The photovoltaic/magnetic heterostructures with a ternary system induce larger magnetic changes due to higher short current density(J SC)(20.92 mA·cm^(−2))compared with the binary system(11.94 mA·cm^(−2)).During the sunlight illumination,ferromagnetic resonance(FMR)shift increases by 80%(from 169.52 to 305.48 Oe)attributed to enhanced photo-induced electrons doping,and the variation of saturation magnetization(M S)is also amplified by 14%(from 9.9%to 11.3%).Furthermore,photovoltaic performance analysis and the transient absorption(TA)spectra indicate that the current density plays a major role in visible light manipulating magnetism.These findings clarify the laws of sunlight control of magnetism and lay the foundation for the next generation solar-driven magneto-optical memory applications. | Yujing Du Shiping Wang Lei Wang Shengye Jin Yifan Zhao Tai Min Zhuangde Jiang Ziyao Zhou Ming Liu | 2022 | Nano Research2022，15，3： | 0 |
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