6篇
您的检索式：作者名="Yijian Yao"
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| 1 | Investigation on natural resources and species conservation of Ophiocordyceps sinensis, the famous medicinal fungus endemic to the Tibetan Plateau显示文摘 | Wenjing Wang Ke Wang Xiaoliang Wang Ruiheng Yang Yi Li Yijian Yao | 2018 | Protein & Cell2018，9，8： | 5 |
| 2 | Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models显示文摘 | Meng Yu Yuhua Fu Yijian Liang Haikun Song Yao Yao Peng Wu Yuwei Yao Yuyin Pan Xue Wen Lixiang Ma Saiyin Hexige Yu Ding Shouqing Luo Boxun Lu | 2017 | Cell Research2017，27，12： | 5 |
| 3 | Isolation,characterization of melanin derived from Ophiocordyceps sinensis,an en-tomagenous fungus endemic to the Tibetan Plateau显示文摘 | Dong Caihong Yao Yijian | 2012 | Journal of Bioscience and Bioengineering2012，113，4： | 1 |
| 4 | Nutritional requirements of mycelial growth of Cordyceps sinensis in sued cultmberged culture显示文摘 | DONG CAIHONG YAO YIJIAN | 2005 | Journal of Appned Microbioloy2005，99，3： | 1 |
| 5 | The CAS Bio-specimen Centers in Sound Progress显示文摘Bio-specimen centers, including herbaria and zoological museums, are the most integrated places for the storage of specimens, which are real samples and the most important vouchers for taxonomic and biodiversity studies. The information carried by | LI Liangqian QIAO Gexia YAO Yijian | 2010 | Bulletin of the Chinese Academy of Sciences2010，24，4： | 0 |
| 6 | miR-139-5p mediates the palmitate-induced inhibition of insulin secretion by targeting neuronal pentraxin 1 in INS-1 cells显示文摘High fatty acid reduces insulin secretion in pancreatic β-cells and miR-139-5p is increased in diabetic pancreatic tissues and induces islet β-cell apoptosis.However,to date,there is no study exploring whether or not miR-139-5p is involved in high fatty acid-induced insulin secretion.In the present study,INS-1 cells were exposed to different concentrations(0.1,0.2,and 0.4 mM)of palmi-tate for different time periods(12,24,and 48 h).The expression levels of miR-139-5p and neuronal pentraxin 1(NPTX1)were evaluated by real-time PCR and western blot analysis.The regulation of NPTX1 by miR-139-5p was examined by luciferase assay.Cell transfection was conducted using Lipo8000 or Lipofectamine RNAiMAX.Potassium or glucose-stimulated insulin secretion levels were used to verify the function of miR-139-5p or NPTX1 in insulin secretion.Insulin secretion levels were detected by radioimmunoassay.We found that miR-139-5p was increased in INS-1 cells stimulated with palmitate.In addition,miR-139-5p was also elevated in islets of high-fat diet-fed mice and db/db mice compared to those in islets of normal diet-fed mice and wild-type mice.Knockdown of miR-139-5p could reverse high fatty acid-induced insulin secretion defects in INS-1 cells.Furthermore,we demonstrated that NPTX1 is a target of miR-139-5p.miR-139-5p mediated palmitate-induced insulin secretion defects by targeting NPTX1.Moreover,palmitate treatment declined the expression of NPTX1 and the NPTX1 expression was also decreased in islets of high-fat diet-fed mice and db/db mice.Impaired NPTX1 expression is involved in fatty acid-induced insulin secretion defects.Collectively,our results illustrate that the induction of β-cell insulin secretion defects by fatty acids is mediated,at least in part,by miR-139-5p via downregulation of NPTX1 expression. | Kai Zhang Yijian Zhang Cheng Chen Yuexing Yuan Xiaotian Jiang Xiangjiang Yuan Yao Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 0 |
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