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| 1 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 2 | Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice显示文摘 | Hui Su Yuexing Yuan Xiao-Ming Wang Wayne Bond Lau Yajing Wang Xiaoliang Wang Erhe Gao Walter J. Koch Xin-Liang Ma | 2013 | Basic Research in Cardiology2013，，1： | 1 |
| 3 | Endothelial dysfunction in adiponectin deficiency and its mechanisms involved 显示文摘 | Yu Cao Ling Tao Yuexing Yuan | 2009 | Journal of Molecular and Cellular Cardiology2009，46，3： | 1 |
| 4 | Adiponectin Cardioprotection After Myocardial Ischemia/Reperfusion Involves the Reduction of Oxidative/Nitrative Stress显示文摘 | Ling Tao Erhe Gao Xiangying Jiao Yuexing Yuan Shuzhuang Li Theodore A. Christopher Bernard L. Lopez Walter Koch Lawrence Chan Barry J. Goldstein Xin L. Ma | 2007 | Circulation2007，，11： | 1 |
| 5 | C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway显示文摘 | Qijun Zheng Yuexing Yuan Wei Yi Wayne Bond Lau Yajing Wang Xiaoliang Wang Yang Sun Bernard L. Lopez Theodore A. Christopher Jonathan M. Peterson G. William Wong Shiqiang Yu Dinghua Yi Xin-Liang Ma | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，11： | 1 |
| 6 | Adiponectin: An Indispensable Molecule in Rosiglitazone Cardioprotection Following Myocardial Infarction显示文摘 | Ling Tao Yajing Wang Erhe Gao Hangxiang Zhang Yuexing Yuan Wayne B. Lau Lawrence Chan Walter J. Koch Xin L. Ma | 2010 | Circulation Research2010，，2： | 1 |
| 7 | Endothelial dysfunction in adiponectin deficiency and its mechanisms involved显示文摘 | Yu Cao Ling Tao Yuexing Yuan Xiangying Jiao Wayne Bond Lau Yajing Wang Theodore Christopher Bernard Lopez Lawrence Chan Barry Goldstein Xin L. Ma | 2008 | Journal of Molecular and Cellular Cardiology2008，，3： | 1 |
| 8 | Down-regulation of CASK in glucotoxicity- nduced insulin dysfunction in pancreatic β cells显示文摘高葡萄糖的水平在胰腺的房间,而是机制遗体上施加有害效果不清楚。Calcium/calmodulin-dependent 丝氨酸蛋白质 kinase (木桶) 在 neurotransmitters 的神经开发和版本起一个重要作用,并且可能在在胰腺的房间膜上胰岛素抛锚起一个作用。组织缺氧可诱导的因素(HIF1 ) 1 涉及房间机能障碍。这研究的目的是提供木桶能涉及导致 glucotoxicity 的胰岛素分泌物机能障碍的一些基本证据在 INS-1E 房间由 HIF1 调停了。木桶 overexpression plasmid, HIF1 收缩筋(CoCl 2), 和 HIF1 选择禁止者(KC7F2 ) 被使用。结果证明有高葡萄糖的长期的刺激能在 INS-1E 房间导致胰岛素分泌物机能障碍。木桶的 Overexpression 部分在胰岛素分泌物上颠倒了高葡萄糖的效果。CoCl 2 减少了木桶的表示,但是 KC7F2 颠倒了导致 glucotoxicity 的木桶水平减小。这些结果建议在 INS-1E 房间的导致 glucotoxicity 的胰岛素分泌物缺点能被 HIF1 经由木桶的下面规定调停。 | Yao Wang Nana Hao Haiyan Lin Tianyuan Wang Jinyang Xie Yuexing Yuan | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 1 |
| 9 | Adiponectin: An Indispensable Molecule in Rosiglitazone Cardioprotection Following Myocardial Infarction显示文摘 | Ling Tao Yajing Wang Erhe Gao Hangxiang Zhang Yuexing Yuan Wayne B. Lau Lawrence Chan Walter J. Koch Xin L. Ma | 2010 | Circulation Research2010，，2： | 1 |
| 10 | Identification of natural allelic variation in TTL1 controlling thermotolerance and grain size by a rice super pan-genome∞显示文摘Continuously increasing global temperatures present great challenges to food security.Grain size,one of the critical components determining grain yield in rice(Oryza sativa L.),is a prime target for genetic breeding.Thus,there is an immediate need for genetic improvement in rice to maintain grain yield under heat stress.However,quantitative trait loci(QTLs)endowing heat stress tolerance and grain size in rice are extremely rare.Here,we identified a novel negative regulator with pleiotropic effects,Thermo‐Tolerance and grain Length 1(TTL1),from the super pan‐genomic and transcriptomic data.Loss‐of‐function mutations in TTL1 enhanced heat tolerance,and caused an increase in grain size by coordinating cell expansion and proliferation.TTL1 was shown to function as a transcriptional regulator and localized to the nucleus and cell membrane.Furthermore,haplotype analysis showed that hapL and hapS of TTL1 were obviously correlated with variations of thermotolerance and grain size in a core collection of cultivars.Genome evolution analysis of available rice germplasms suggested that TTL1 was selected during domestication of the indica and japonica rice subspecies,but still had much breeding potential for increasing grain length and thermotolerance.These findings provide insights into TTL1 as a novel potential target for the development of high‐yield and thermotolerant rice varieties. | Yarong Lin Yiwang Zhu Yuchao Cui Hongge Qian Qiaoling Yuan Rui Chen Yan Lin Jianmin Chen Xishi Zhou Chuanlin Shi Huiying He Taijiao Hu Chenbo Gu Xiaoman Yu Xiying Zhu Yuexing Wang Qian Qian Cuijun Zhang Feng Wang Lianguang Shang | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 11 | A Method for Effectively Overcoming Tight Functional Linkage Between Genes in Rice by CRISPR/Cas9 System显示文摘Anthocyanins are widely distributed in one or more parts of rice(Oryza sativa L.)plants,including seed coat,stigma,apiculus,leaf sheath and leaf blade,and are the main pigments used in rice to achieve different colors(Hou et al,2009;Aizza and Dornelas,2011).In rice,tissue-specific color traits(especially the color of apiculus,namely the lemma and palea of the spikelet)are not only important for rice variety identification but also important for linkage analysis and rice domestication research(Saitoh et al,2004;Fan et al,2007;Lin et al,2019).The apiculus color is controlled by the complementary functions of three pairs of dominant genes,C,A and P.Gene C(chromogen)is a pigment gene,which is the basic gene for producing pigments.Gene A(activator)activates gene C,converting the chromogen into anthocyanins,and gene P(purple)controls the distribution of anthocyanins in various organs(Reddy,1996;Sakamoto et al,2001). | LI Sanfeng SHEN Lan HU Ping WU Xianmei YUAN Qiaoling RAO Yuchun QIAN Qian WANG Kejian ZHU Xudong SHANG Lianguang WANG Yuexing | 2020 | Rice science2020，27，3： | 0 |
| 12 | miR-139-5p mediates the palmitate-induced inhibition of insulin secretion by targeting neuronal pentraxin 1 in INS-1 cells显示文摘High fatty acid reduces insulin secretion in pancreatic β-cells and miR-139-5p is increased in diabetic pancreatic tissues and induces islet β-cell apoptosis.However,to date,there is no study exploring whether or not miR-139-5p is involved in high fatty acid-induced insulin secretion.In the present study,INS-1 cells were exposed to different concentrations(0.1,0.2,and 0.4 mM)of palmi-tate for different time periods(12,24,and 48 h).The expression levels of miR-139-5p and neuronal pentraxin 1(NPTX1)were evaluated by real-time PCR and western blot analysis.The regulation of NPTX1 by miR-139-5p was examined by luciferase assay.Cell transfection was conducted using Lipo8000 or Lipofectamine RNAiMAX.Potassium or glucose-stimulated insulin secretion levels were used to verify the function of miR-139-5p or NPTX1 in insulin secretion.Insulin secretion levels were detected by radioimmunoassay.We found that miR-139-5p was increased in INS-1 cells stimulated with palmitate.In addition,miR-139-5p was also elevated in islets of high-fat diet-fed mice and db/db mice compared to those in islets of normal diet-fed mice and wild-type mice.Knockdown of miR-139-5p could reverse high fatty acid-induced insulin secretion defects in INS-1 cells.Furthermore,we demonstrated that NPTX1 is a target of miR-139-5p.miR-139-5p mediated palmitate-induced insulin secretion defects by targeting NPTX1.Moreover,palmitate treatment declined the expression of NPTX1 and the NPTX1 expression was also decreased in islets of high-fat diet-fed mice and db/db mice.Impaired NPTX1 expression is involved in fatty acid-induced insulin secretion defects.Collectively,our results illustrate that the induction of β-cell insulin secretion defects by fatty acids is mediated,at least in part,by miR-139-5p via downregulation of NPTX1 expression. | Kai Zhang Yijian Zhang Cheng Chen Yuexing Yuan Xiaotian Jiang Xiangjiang Yuan Yao Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 0 |
| 13 | Insulin-resistance and depression cohort data mining to identify nutraceutical related DNA methylation biomarker for type 2 diabetes显示文摘Insulin-resistance(IR)is one of the most important precursors of type 2 diabetes(T2D).Recent evidence suggests an association of depression with the onset of T2D.Accumu-lating evidence shows that depression and T2D share common biological origins,and DNA methylation examination might reveal the link between lifestyle,disease risk,and potential therapeutic targets for T2D.Here we hypothesize that integrative mining of IR and depression cohort data will facilitate predictive biomarkers identification for T2D.We utilized a newly proposed method to extract gene-level information from probe level data on genome-wide DNA methylation array.We identified a set of genes associated with IR and depression in clin-ical cohorts.By overlapping the IR-related nutraceutical-gene network with depression net-works,we identified a common subnetwork centered with Vitamin D Receptor(VDR)gene.Preliminary clinical validation of gene methylation set in a small cohort of T2D patients and controls was established using the Sequenome matrix-assisted laser desorption ionization-time flight mass spectrometry.A set of sites in the promoter regions of VDR showed a signifi-cant difference between T2D patients and controls.Using a logistic regression model,the optimal prediction performance of these sites was AUC Z 0.902,and an odds ratio Z 19.76.Thus,monitoring the methylation status of specific VDR promoter region might help stratify the high-risk individuals who could potentially benefit from vitamin D dietary sup-plementation.Our results highlight the link between IR and depression,and the DNA methyl-ation analysis might facilitate the search for their shared mechanisms in the etiology of T2D. | Fengji Liang Yuan Quan Andong Wu Ying Chen Ruifeng Xu Yuexing Zhu Jianghui Xiong | 2021 | Genes & Diseases2021，8，5： | 0 |
| 14 | A new construction method of LDPC codes for optical transmission systems显示文摘基于系统地构造的 Gallager (SCG ) 的构造方法(4, k ) 代码,低密度同等值支票(LDPC ) 的一个新改进构造方法代码被建议。与 SCG 的构造方法相比(4, k ) 代码以前改善了,建议构造方法有一些优点,例如保存存储空格并且在硬件实现减少计算复杂性。然后 LDPC (5929, 5624 ) 有 5.42% 冗余性的代码被建议方法构造。模拟结果和分析表演构造 LDPC (5929, 5624 ) 代码一个经典芦苇贤明之人(RS ) 比那些有更好的错误修正性能,更低的冗余性和更低的译码复杂性(255, 239 ) 代码。因此, LDPC (5929, 5624 ) 代码,在 LDPC 代码上由建议构造方法构造了,对光传播系统更好合适的罐头。 | Jianguo YUAN Yuexing JIA Wenjuan BI Liang XU | 2012 | Frontiers of Optoelectronics2012，5，3： | 0 |
| 15 | Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia显示文摘2013年10月12—13日中国生理学会张锡钧基金会第十二届全国青年优秀生理学学术论文交流会在湖南长沙顺利召开。由各省生理学会推荐的37名参赛选手的论文参与评选,会议展示了选手们近3年来在生理学研究方面所取得的最新研究成果。经过专家对参评者论文和现场报告的综合评判,评出一等奖、二等奖、三等奖、特别奖、最佳表达奖、最佳答辩奖和最佳图标奖共11名。从2013年第6期开始,《生理通讯》将陆续转载获奖者的参评论文各一篇,以飨读者。 | Yajing Wang Jianli Zhao Yanqing Zhang Wayne Bond Lau Li-Yuan Jiao Baojiang Liu Yuexing Yuan Xiaoliang Wang Ling Tao Erhe Gao Walter J. Koch Xin-Liang Ma | 2013 | 生理通讯2013，32，6： | 0 |
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