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| 1 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 2 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 3 | Cotton flavonoid structural genes related to the pigmentation in brown fibers显示文摘 | Xiao YH Zhang ZS Yin MH | 2007 | Biochemical and Biophysical Research Communications2007，358，1： | 1 |
| 4 | Bel-2 Functions in an antioxidant pathway to prevent apoptosis显示文摘 | David MH Zoltan NO Yin XM | 1993 | Cell1993，75，1： | 1 |
| 5 | Tumor-suppressive mieroRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells 显示文摘 | Ren XS Yin MH Zhang X | 2014 | Caneer Lett2014，344，2： | 1 |
| 6 | A simple technique to harvest two kidneys from one donor rat for transplantation显示文摘 | Yin M Booster MH vd Bogaard AE | 1994 | Lab Anim1994，28，： | 1 |
| 7 | The role of contrast-enhanced sonography of focal liver lesions before percutaneous biopsy显示文摘 | Wu W Chen MH Yin SS | 2006 | A JR Am J Roentgenol2006，187，3： | 1 |
| 8 | Inhibitory effect of BR on DEN-induced precancerous hepatic foci and antioxidative activities in rats显示文摘 | Yin ZZ Jin HL Shen MH | 1999 | Chin J Cancer Res1999，11，3： | 1 |
| 9 | C-reactive protein in children with obstructive sleep apnea and the effects of treatment显示文摘 | Li AM Chan MH Yin J So HK Ng SK Chan IM | 2008 | Pediatr Pulmonol2008，43，1： | 1 |
| 10 | Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines显示文摘 | Yin MH Kang DG Choi DH | 2005 | J Ethnopharmacol2005，99，1： | 1 |
| 11 | C-reactive protein in children with obstructive sleep apnea and the effects of treatment显示文摘 | Li AM Chan MH Yin J | 2008 | Pediatr Pulmonol2008，43，1： | 1 |
| 12 | Sertoli cells induce xenolymphocyte apoptosis in vitro显示文摘 | Yin ZZ Xie L Zeng MH | 2006 | Transplant Proc2006，38，10： | 1 |
| 13 | Focal liver lesions can sonowae-enhaneed ultrasound be used to differentiate malignant from benign lesions显示文摘 | DAI Y CHEN MH YIN SS | 2007 | Invest Radiol2007，42，8： | 1 |
| 14 | C-reactive protein in children with obstructive sleep apnea and the effects of treatment显示文摘 | Li AM Chan MH Yin J | 2008 | Pediatr Pul- monol2008，43，1： | 1 |
| 15 | A simple technique to harvest two kidneys from one donor rat fortransplantation显示文摘 | Yin M Booster MH van der Bogaard AE | 1994 | Lab Anim1994，28，： | 1 |
| 16 | Bid deficiency ameliorates ischemic renal failure and delays animal death in C57BL/6 mice显示文摘 | Wei Q Yin XM Wang MH | 2006 | Am J Physiol Renal Physiol2006，290，1： | 1 |
| 17 | Focal liver lesions : can SonoVue enchanced ultrasound be used to differentiate malignant from be- nign lesions? 显示文摘 | Dai Y Chen MH Yin SS | 2007 | Invest Radiol2007，42，8： | 1 |
| 18 | Tumore suppressive microRNA-449a induces growth arrest and seneseenceby targeting E2F3 in human lung cancer cells 显示文摘 | Ren XS Yin MH Zhang X ct al | 2014 | Cancer Lett2014，344，2： | 1 |
| 19 | Micro - and macro - levelcorrelates of adiposity in children 显示文摘 | Yin Z Moore JB Johnson MH | 2012 | J Public Health Manag Pract2012，18，5： | 1 |
| 20 | Bid deficiency ameliorates ischemic renal failure and delays animal death in C57BL/6 mice 显示文摘 | Wei Q Yin XM Wang MH | 2006 | Am J Physiol Renal Physiol2006，290，： | 1 |
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