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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Functional and surface-active membranes from poly(vinylidene fluoride)-graft-poly(acrylic acid) prepared via RAFT-mediated graft copolymerization显示文摘 | Ying L Yu W H Kang E T | 2004 | Langmuir2004，20，： | 1 |
| 3 | Colloidal dispersion of nano- scale ZnO powders using amphibious and anionic polyelectrolytes显示文摘 | YING K L HSIEH T E HSIEH Y F | 2009 | Ceramics International2009，35，3： | 1 |
| 4 | Highly selective echnique-molecular imprinting显示文摘 | Ying T L Gao M J Zhang X L | 2001 | Chin J Anal Chern2001，29，1： | 1 |
| 5 | Recent advances in radio resource management for heterogeneous LTE/LTE-A networks 显示文摘 | Ying L L Chuah T C Loo J | 2014 | IEEE Communications Surveys & Tutorials2014，16，4： | 1 |
| 6 | Relationship between circadian oscillations of Hev-erbo expression and intracellular levels of its ligand, heme显示文摘 | ROGERS P M YING L BURRIS T P | 2008 | Biochemical and Biophysical Research Communications2008，368，4： | 1 |
| 7 | Asymptotic normality of a class of adaptive statistics with applications to synthetic data methods for censored regression显示文摘 | Lai T L Ying Z Zhang Z K | 1995 | Journal of Multivariate Analysis1995，52，2： | 1 |
| 8 | Reagentless ampero- metric biosensors highly sensitive to hydrogen peroxide, glucose and lactose based on N-methyl phenazine methosulfate incorporated in a Nation film as an electron transfer mediator between horseradish peroxidase and an electrode显示文摘 | Liu H Y Ying T L Sun K | 1997 | Analytica Chimica Acta1997，344，3： | 1 |
| 9 | The nature of cobalt species in Co-ZSM-5 NO emission control catalysts显示文摘 | Trudeau M L Ying J Y | 1996 | J Phys Chem1996，41，13： | 1 |
| 10 | Electrosorption of ions from aqueous solutions by carbon aerogel: An electrical double-layer model显示文摘 | Yang K L Ying T Y Yiacoumi S | 2001 | Langmuir2001，17，6： | 1 |
| 11 | Characterization of membranes prepared from blends of poly(acrylic acid)-graft-poly(vinylidene fluoride) with poly (N-isopropylacrylamide) and their temperature and pH-sensitive microfiltration 显示文摘 | Ying L Kang E T Neoh K G | 2003 | J Memb Sci2003，224，： | 1 |
| 12 | Three-dimensional ultrasound appearanceof pelvic floor in nulliparous women and pelvic organ prolapsewomen 显示文摘 | Ying T Li Q Xu L | 2012 | International Journal of Medical Sciences2012，9，10： | 1 |
| 13 | 查看详情显示文摘 | Ying X T Luo J L Wang P N Cui M Q Zhao Y D Li G Zhu P P | | 0，，： | 1 |
| 14 | Ultra-thin freestanding diamond window for soft X-ray optics显示文摘 | Ying X T Luo J L Wang P N | 2003 | Diamond Related Mater2003，12，37： | 1 |
| 15 | Molecular cloning and characterization of cytosolic manganese superoxide dismutase (cytMn-SOD) from the giant freshwater prawn Macrobrachium rosenbergii 显示文摘 | Winton C Ying H T Chun H L | 2006 | Fish Shellfish Immunol2006，20，： | 1 |
| 16 | An approach to studying lung cancer-related proteins in human blood显示文摘 | XIAO T YING W LI L | 2005 | Mol Cell Proteomics2005，4，10： | 1 |
| 17 | Diagnosis of unknownnonhematological tumors by bone marrow biopsy:a retrospectiveanalysis of 10,112 samples 显示文摘 | Xiao L Luxi S Ying T | 2009 | J Cancer Res Clin Oncol2009，135，5： | 1 |
| 18 | A two-dimensional proteome map of shigella flexneri显示文摘 | Liao X Ying T Y Wang H L | 2003 | Electrophoresis2003，24，16： | 1 |
| 19 | A novel magnetic separation technique:Selectiveseparation of ultrafine particles by magnetophoresis 显示文摘 | Ying T Prenger F C Worl L A | 2004 | Separation Science and Technology2004，39，12： | 1 |
| 20 | Vacuolar Ca2+/H+ transport activity is required for systemic phosphate homeostasis involving shoot-out-root signaling in araidnpsis 显示文摘 | Tzu Y L Kyaw A Ching Y T Tzu Y C Ying S C Tzyy J C | 2011 | Plant Physiology2011，156，3： | 1 |
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