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| 1 | Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma显示文摘很少长期的发炎怎么贡献 hepatocellular 癌(HCC ) 的前进被知道,特别癌症的开始。揭开从长期的发炎的批评转变到在网络水平的 HCC 和分子的机制,我们用我们的动态网络 biomarker (DNB ) 分析了土拨鼠肝炎 virus/c-myc 鼠标和匹配年龄的 wt-C57BL/6 鼠标的时间系列 proteomic 数据模型。DNB 分析显示在转基因的老鼠的出生以后的第 5 月是癌症开始的批评时期,就在批评转变前,它与临床的症状一致。同时,联系 DNB 的网络在批评转变前后显示出蛋白质表示和 coexpression 层次的激烈的倒置。DNB, PLA2G6 和 CYP2C44 的二个成员,与他们的联系差别一起表示了蛋白质,被发现导致 arachidonic 酸新陈代谢的机能障碍,进一步通过短暂受体潜力隧道的煽动性的调停人规定激活煽动性的回答,并且最后导致肝 detoxification 和恶意的转变的缺陷到癌症。作为一个 c-Myc 目标, PLA2G6 断然在表示与 c-Myc 相关,显示出从减少到在 carcinogenesis 期间增加的一个趋势,与在批评转变的最小的点或付小费给的点。相应 PLA2G6 和 c-Myc 的如此的趋势也在人的 hepatocarcinogenesis 期间被观察,与在高级 dysplastic 小瘤(就在 carcinogenesis 前的一个阶段) 的最小的点。我们的学习暗示 PLA2G6 可能在 hepatocarcinogenesis 期间作为象著名 c-Myc 一样的 oncogene 工作,当 PLA2G6 和 c-Myc 的 downregulation 能是显示逼近的 carcinogenesis 的一个警告信号时。 | Meiyi Li Chen Li Wei-Xin Liu Conghui Liu Jingru Cui Qingrun Li Hong Ni Yingcheng Yang Chaochao Wu Chunlei Chen Xing Zhen Tao Zeng Mujun zhao Lei Chen Jiarui Wu Rong Zeng Luonan Chen | 2017 | Journal of Molecular Cell Biology2017，9，6： | 12 |
| 2 | Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population显示文摘Serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar I disorder (BP-I), a mood disorder, is not clear. We selected 21 singlenucleotide polymorphisms (SNPs) within the HTR2A gene, 8 within the SLC6A4 gene and 23 within the TPH2 gene for genotyping using the GoldenGate genotyping assay. A total of 375 patients with BP-I and 475 normal controls were recruited. Two out of 21 SNPs (rs1475196 and rs9567747) in the HTR2A gene and 1/23 SNPs (rs17110566) in the TPH2 gene were significantly associated with BP-I, both genotype-wise and allele-wise. Furthermore, a specific haplotype in the HTR2A gene showed a significant association with BP-I. Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I. | Bo Xiang Zhenxing Yang Yin Lin Lijie Guan Xuan Li Wei Deng Zeyu Jiang Guohui Lao Qiang Wang Xiaoyu Hao Xiang Liu Yingcheng Wang Liansheng Zhao Xiaohong Ma Tao Li Liping Cao Xun Hu | 2014 | Neuroscience Bulletin2014，30，1： | 2 |
| 3 | Time-series-based prediction of complex oscillator networks via compressive sensing显示文摘 | Wang Wenxu Yang Rui Lai Yingcheng | 2011 | EPL2011，94，4： | 1 |
| 4 | Predicting catastrophes in nonlinear dynamical systems by compressive sensing显示文摘 | Wang Wenxu Yang Rui Lai Yingcheng | 2011 | Physical Review Letters2011，106，15： | 1 |
| 5 | Traffic-driven ep- idemic spreading on networks of mobile agents 显示文摘 | Yang Hanxin Wang Wenxu Lai Yingcheng | 2012 | Europhysics Letters2012，98，68： | 1 |
| 6 | Predicting catastrophes in nonlinear dynamical systems by compressive sensing显示文摘 | Wang Wenxu Yang Rui Lai Yingcheng | 2011 | Physical Review Letters2011，106，15： | 1 |
| 7 | Progress in Marine Oil Spill Optical Remote Sensing: Detected Targets, Spectral Response Characteristics, and Theories显示文摘 | Yingcheng Lu Xiang Li Qingjiu Tian Guang Zheng Shaojie Sun Yongxue Liu Qiang Yang | 2013 | Marine Geodesy2013，，3： | 1 |
| 8 | Analysis of Meteorological Epidemic Factors and Soil Improvement Controlling Technology of Tobacco Bacterial Wilt (Ralstonia solanacarum)显示文摘[Objective] The paper was to analyze the meteorological epidemic factors for occurrence and prevalence of tobacco bacterial wilt( Ralstonia solanacarum),and to study control effects of different soil conditioners on the bacterial disease in Gaoligongshan demonstration area of green,ecological,high quality tobacco leaf production. [Method] The plots attacked by tobacco bacterial wilt over the years were selected and the incidence of the disease was periodically surveyed in tobacco growth period in 2012,2103 and 2014,respectively. 10 d Effective accumulated temperature and rainfall were counted according to the meteorological data,and the relationship between meteorological factors and disease index was analyzed. The control effects of three kinds of soil conditioners ' Zhuanggenfeng',refined fulvic acid and lime on tobacco bacterial wilt were tested. [Result] The analysis results of meteorological factors showed that 10 d effective accumulated temperature and rainfall were positively correlated to disease index. The variation curve of 10 d effective accumulated temperature and rainfall reflected the change trend of disease index. The p H values were increased by 0. 57,0. 50 and 0. 72 respectively after applying ' Zhuanggenfeng',refined fulvic acid and lime. The average control effects on tobacco bacterial wilt were 60. 74%-62. 18%,53. 05%-59. 53%,and 48. 59%-58. 53%,respectively. [Conclusion] 10 d Effective accumulated temperature and rainfall could be used as important reference for disease forecasting and controlling. The usage of soil conditioner has a certain prevention and control effect on tobacco bacterial wilt disease by forming soil conditions conducive to flue-cured tobacco growth but adverse to disease survival,which is an effective auxiliary method against the disease. | Yang Peiwen Yang Qunhui Ni Ming Guo Yingcheng Xiao Zhixin Hu Zhiming Li Jiarui Yang Mingying | 2017 | Plant Diseases and Pests2017，8，4： | 0 |
| 9 | 临近空间探测和科学试验平台需求展望显示文摘It is an important scientific research activity in China to carry out near-space exploration and scientific experiments via aerospace carriers.Early near-space exploration projects mainly used aircraft,balloons,sounding rockets and Earth satellites to carry out space environment exploration.With the development of China’s space science and technology,microgravity science has become a frontier science that has developed rapidly in the past 20 years.With the continuous progress of national space science and technology,the demand for near-space exploration and scientific experiments is increasing year by year.In the next 2 to 3 years,many advanced science activities and the associated technologies need to conduct corresponding experimental research work.This paper mainly analyzes the significance of scientific research and the ways to realize near-space exploration at home and abroad,and analyzes the directions and innovations that can be carried out in the future. | YANG Haoliang WANG Yingcheng WU Weiping YANG Yiqiang | 2020 | Aerospace China2020，21，3： | 0 |
| 10 | Identification of inflammatory factor-related genes associated with the prognosis and immune cell infiltration in colorectal cancer patients显示文摘This study aims to identify the inflammatory factor-related genes which help to predict the prognosis of patients with colorectal cancer.GSEA(Gene Set Enrichment Analysis)was used to acquire inflammation-related genes and the corresponding expression information was collected from TCGA database to determine the DEGs(differentially-expressed genes)in CRC patients.We conducted enrichment analysis and PPI(protein–protein interaction)of these DEGs.Besides,key genes that are both differentially-expressed and prognosis-related were screened out,which were used to establish the prognostic model.We obtained 79 DEGs and 19 prognostic genes,10 prognostic-related differential genes were eventually screened.These genes were used to construct the prognostic model.We also identified that the immune infiltration score of macrophages between different risk groups was significantly different and similar distinction was witnessed in immune function score of APC(antigen-presenting cell)co-stimulation and type I IFN(interferon)response. | Jialing Hu Yingcheng He Kaili Liao Qijun Yang Yuhan Xu Gaoquan Cao Xiaozhong Wang | 2023 | Genes & Diseases2023，10，5： | 0 |
| 11 | Pilot test of polymer microsphere alternate surfactant flood(PMAS)with mixtures of anionic-cationic surfactants under harsh conditions in a sandstone reservoir显示文摘The first pilot test of polyacrylamide microsphere alternate surfactant flood(PMAS)with mixtures of anionic-cationic surfactants(Sa/c)was carried out for a high-temperature,high-salinity,and highhardness sandstone reservoir to demonstrate the potential of this novel technique to improve oil recovery.A critical micelle concentration(CMC)of 4.82 mg/L,an ultralow interfacial tension(IFT)of 8104 mN/m,and a high oil solubilization of 22 were obtained.Static and dynamic adsorptions of Sa/c on natural core containing 15 wt%clay were reduced to about 2.20 and 0.30 mg/g-core,respectively,with the addition of adsorption inhibitor(AI).Since June 2014,the pilot test of PMAS was carried out in a Sinopec reservoir with a temperature of 87C,a salinity of 260,393 mg/L,and a hardness of 6,401 mg/L.Twelve cycles of alternative injection of 0.0125 PV Sa/c with a concentration of 0.1%and 0.0125 PV polyacrylamide microsphere with a concentration of 0.2%were conducted at an injection rate of 0.1 PV/yr,for a total of 0.3 PV chemical injection.As a result,the net daily oil production increased from 0 t to 6.5 t,and the water cut decreased from 96.3%to 93.8%,leading to an ultimate improved oil recovery of 6.3%original oil-in-place. | Yingcheng Li Jun Jin Zhiqing Su Weidong Zhang Xinning Bao Baolun Niu Changhua Yang Xinyue Wu Xiaodong Zhai Li Zhang Rong Guo Yong Meng Xiujuan He Zhiqin Shen Hui Zhang Ou Sha | 2023 | Petroleum Research2023，8，3： | 0 |
| 12 | Identification of TP53 mutation-associated prognostic genes and investigation of the immune cell infiltration in patients with hepatocellular carcinoma显示文摘Primary liver cancer,which is mainly composed of hepatocellular carcinoma(HcC),is the sixth most common type of cancer worldwide and the thirdmost common cause of cancer mortality.1 The total number of mutations present in tumor specimens is called tumor mutation burden(TMB)and it is an emerging biomarker of immunotherapy response.2 TMB can predict clinical responses to immunotherapy such as ICl(immune checkpoint inhibitor)treatments and higher TMB is related to better survival.3 TP53,a gene encoding a tumor suppressor protein that triggers apoptosis and cell cycle arrest,is one of the most prevalent mutations in 25%-30%of HCC patients.4 Research shows that TP53 mutations in HCC patients are associated with advanced tumor grade and poor prognosis.5 To identify the TP53 mutation-related genes which can predict HCC patients'prognosis and explore the immune cell infiltration,we constructed a risk model based on six TP53 mutation-related genes which can accurately predict patients'prognosis.Besides,six immune cells with a similar expression pattern were identified in The Cancer Genome Atlas(TCGA)and International Cancer Genome Consortium(ICGC)databases. | Qijun Yang Lianke Gao Yuhan Xu Gaoquan Cao Yingcheng He Wenyige Zhang Xue Zhang Chengfeng Wu Kaili Liao Xiaozhong Wang | 2024 | Genes & Diseases2024，11，2： | 0 |
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