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| 1 | The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice显示文摘动脉粥样硬化(作为) 疾病被多重因素导致,包括基因、环境的元素。现在的学习的目的是在致病上调查高胆固醇,高蛋氨酸食谱,和 apolipoprotein E 缺乏(ApoE/) 的全面效果作为。ApoE/ 老鼠用高胆固醇和蛋氨酸饮食被喂 15 个星期导致 hyperlipidemia 和 hyperhomocysteinemia。genomic DNA (gDNA ) 和 B1 的 methylation 层次在大动脉的纸巾的重复元素被两 methylation 依赖的限制分析测量并且嵌套 methylation 特定的聚合酶链反应(PCR ) 。Methylation 顺序偏爱模式是由有限制 endonuclease 消化的 DNA 接受甲基的能力的 assayed。DNA methyltransferase-1 的 mRNA 表示, 3 (DNMT1, 3 ) 被即时 PCR 检测。S-adenosylmethionine (SAM ) 和 S-adenosylhomocysteine (SAH ) 的集中被高效的液体层析决定。结果显示出 gDNA 和 B1 的 hypomethylation 重复元素。DNMT1 的 mRNA 表示被减少。SAM, SAH,和 SAM/SAH 比率的层次被增加。动脉粥样硬化患者损害区域强烈与风险因素相关。DNA demethylation 的分发被喜欢而不是 non-CpG 岛,它可以在 DNA 正直和 genomic 不稳定性上建议 hypomethylation 的主要影响。总的来说,我们的数据不含糊地证明高胆固醇,高蛋氨酸食谱,和 ApoE/ 的全面角色不与一个单个风险因素的角色一致地一致。DNA methylation 模式在这是相当复杂的并且取决于基因背景和许多深奥风险因素。 | Yideng Jiang Huiping Zhang Tao Sun Ju Wang Weiwei Sun Huihui Gong Binbin Yang Yingkang Shi Jun Wei | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 16 |
| 2 | A deep seismic sounding profile across the Tianshan Mountains显示文摘The deep seismic sounding profile across the Tianshan Mountains revealed a two-layer crustal structure in the Tianshan region, namely the lower and upper crusts. Lateral variations of layer velocity and thickness are evidently shown. Low-velocity layers spread discontinuously at the bottom of the upper crust. The Mono depth is 47 km in the Kuytun area and 50 km in the Xayar area. In the Tianshan Mountains, the Moho becomes deeper with the maximum depth of 62 km around the boundary between the southern and northern Tianshan Mountains. The average velocity ranges from 6.1 to 6.3 km/s in the crust and 8.15 km/s at the top of the upper mantle. Two groups of reliable reflective seismic phases of the Moho (Pm1 and Pm2) are recognized on the shot record section of the Kuytun area. A staked and offset region, 20-30 km long, is displayed within a shot-geophone distance of 190-210 km in Pm1 and Pm2. Calculation shows that the Moho is offset by 10 km in the northern Tianshan region, 62 km deep in the south while | LU Deyuan LI Qiusheng GAO Rui LI Yingkang LI Dexing LIU Wen ZHANG Zhiying | 2000 | Chinese Science Bulletin2000，45，22： | 9 |
| 3 | Upper crustal structure under Jingtai–Hezuo profile in Northeastern Tibet from topography-dependent eikonal traveltime tomography显示文摘The Northeastern Tibetan plateau records Caledonian Qilian orogeny and Cenozoic reactivation by continental collision between the Indian and Asian plates. In order to provide the constraint on the Qilian orogenic mechanism and the expansion of the plateau,wide-angle seismic data was acquired along a 430 km-long profile between Jingtai and Hezuo. There is strong height variation along the profile,which is dealt by topography flattening scheme in our crustal velocity structure reconstruction. We herein present the upper crustal P-wave velocity structure model resulting from the interpretation of first arrival dataset from topography-dependent eikonal traveltime tomography. With topography flattening scheme to process real topography along the profile,the evenness of ray coverage times of the image area(upper crust)is improved,which provides upper crustal velocity model comparable to the classic traveltime tomography(with model expansion scheme to process irregular surface). The upper crustal velocity model shows zoning character which matcheswith the tectonic division of the Qaidam-Kunlun-West Qinling belt,the Central and Northern Qilian,and the Alax blocks along the profile. The resultant upper crustal P-wave velocity model is expected to provide important base for linkage between the mapped surface geology and deep structure or geodynamics in Northeastern Tibet. | Ting Ma Zhongjie Zhang Peng Wang Yingkang Li | 2014 | Earthquake Science2014，27，2： | 2 |
| 4 | Crustal structure of seismic velocity in southern tibet and east-westward escape of the crustal material显示文摘 | Zhongjie Zhang Jiwen Teng Yingkang Li S. Klemperer Liqiang Yang | 2004 | Science in China Series D: Earth Sciences2004，，6： | 1 |
| 5 | Status and progress of China SKA Regional Centre prototype显示文摘The Square Kilometre Array(SKA)project consists of delivering two largest radio telescope arrays being built by the SKA Observatory(SKAO),which is an intergovernmental organization bringing together nations from around the world with China being one of the major member countries.The computing resources needed to process,distribute,curate and use the vast amount of data that will be generated by the SKA telescopes are too large for the SKAO to manage on its own.To address this challenge,the SKAO is working with the international community to create a shared,distributed data,computing and networking capability called the SKA Regional Centre Alliance.In this model,the SKAO will be supported by a global network of SKA Regional Centres(SRCs)distributed around the world in its member countries to build an end-to-end science data system that will provide astronomers with high-quality science products.SRCs undertake deep processing,scientific analysis,and long-term storage of the SKA data,as well as user support.China has been actively participating in and promoting the construction of SRCs.This paper introduces the international cooperation and ongoing prototyping of the global SRC network,the basis for the construction of the China SRC and describes in detail the progress of the China SRC prototype.The paper also presents examples of scientific applications of SKA precursor and pathfinder telescopes performed using resources from the China SRC prototype.Finally,the future prospects of the China SRC are presented. | Tao An Xiaocong Wu Baoqiang Lao Shaoguang Guo Zhijun Xu Weijia Lv Yingkang Zhang Zhongli Zhang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，12： | 1 |
| 6 | 3D motion and geometric information system of single-antenna radar based on incomplete 1D range data显示文摘A 3D motion and geometric information system of single-antenna radar is proposed,which can be supported by spotlight synthetic aperture radar(SAR) system and inverse SAR(ISAR) system involving relative 3D motion of the rigid target.In this system,applying the geometry invariance of the rigid target,the unknown 3D shape and motion of the radar target can be reconstructed from the 1D range data of some scatterers extracted from the high-resolution range image.Compared with the current 1D-to-3D algorithm,in the proposed algorithm,the requirement of the 1D range data is expanded to incomplete formation involving large angular motion of the target and hence,the quantity of the scatterers and the abundance of 3D motion are enriched.Furthermore,with the three selected affine coordinates fixed,the multi-solution problem of the reconstruction is solved and the technique of nonlinear optimization can be successfully utilized in the system.Two simulations are implemented which verify the higher robustness of the system and the better performance of the 3D reconstruction for the radar target with unknown relative motion. | Yingkang Zhang Yang Xiao Shaohai Hu | 2011 | Journal of Systems Engineering and Electronics2011，22，3： | 1 |
| 7 | Crustal structure of seismic velocity in southern tibet and east-westward escape of the crustal material显示文摘 | Zhongjie Zhang Jiwen Teng Yingkang Li S. Klemperer Liqiang Yang | 2004 | Science in China Series D: Earth Sciences2004，，6： | 1 |
| 8 | In-situ fabrication of carbon compound NiFeMo-P anchored on nickel foam as bi-functional catalyst for boosting overall water splitting显示文摘The efficient non-noble metal-based bifunctional electrocatalyst for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)has attracted great interest,which is highly significant to enhance the efficiency of hydrogen production from water electrolysis.Herein,inspired by the appropriate hydrogen adsorption free energy of transition metal alloy and the strong corrosion resistance of phosphide in alkaline electrolyte,carbon compound NiFeMo-P anchored on nickel foam(NiFeMo-P-C)is obtained by simple one-pot hydrothermal and subsequent hydrogen reduction treatment.Remarkably,the NiFeMo-P-C exhibits excellent bifunctional electrocatalytic performances toward HER and OER with low overpotentials of 87 and 196 mV at 10 mA·cm^(-2),respectively.Moreover,the electrolyzer using NiFeMo-P-C as both cathode and anode only requires a cell voltage of 1.50 V to reach a current density of 10 mA·cm^(-2),along with an outstanding long-term stability for 50 h.The synergistic effect among alloys and phosphide,partially broken hollow morphology and porous nickel foam substrate jointly impart NiFeMo-P-C high electrocatalytic activity and superior durability. | Xiangyang Zhou Tingting Yang Ting Li Youju Zi Sijing Zhang Lei Yang Yingkang Liu Juan Yang Jingjing Tang | 2023 | Nano Research Energy2023，2，4： | 0 |
| 9 | Tight gas charging and accumulation mechanisms and mathematical model显示文摘The gas-water distribution and production heterogeneity of tight gas reservoirs have been summarized from experimental and geological observations, but the charging and accumulation mechanisms have not been examined quantitatively by mathematical model. The tight gas charging and accumulation mechanisms were revealed from a combination of physical simulation of nuclear magnetic resonance coupling displacement, numerical simulation considering material and mechanical equilibria, as well as actual geological observation. The results show that gas migrates into tight rocks to preferentially form a gas saturation stabilization zone near the source-reservoir interface. When the gas source is insufficient, gas saturation reduction zone and uncharged zone are formed in sequence from the source-reservoir interface. The better the source rock conditions with more gas expulsion volume and higher overpressure, the thicker the gas saturation stabilization and reduction zones, and the higher the overall gas saturation. When the source rock conditions are limited, the better the tight reservoir conditions with higher porosity and permeability as well as larger pore throat, the thinner the gas saturation stabilization and reduction zones, but the gas saturation is high. The sweet spot of tight gas is developed in the high-quality reservoir near the source rock, which often corresponds to the gas saturation stabilization zone. The numerical simulation results by mathematical model agree well with the physical simulation results by nuclear magnetic resonance coupling displacement, and reasonably explain the gas-water distribution and production pattern of deep reservoirs in the Xujiaweizi fault depression of the Songliao Basin and tight gas reservoirs in the Linxing-Huangfu area of the Ordos Basin. | ZHOU Nengwu LU Shuangfang ZHANG Pengfei LIN Zizhi XIAO Dianshi LU Jiamin ZHU Yingkang LIU Yancheng LIN Liming WANG Min JIANG Xinyu LIU Yang WANG Ziyi LI Wenbiao | 2023 | Petroleum Exploration and Development2023，50，6： | 0 |
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