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| 1 | The landscape of gene-CDS-haplotype diversity in rice:Properties,population organization,footprints of domestication and breeding,and implications for genetic improvement显示文摘Polymorphisms within gene coding regions represent the most important part of the overall genetic diversity of rice.We characterized the gene-coding sequence-haplotype(gcHap)diversity of 45963 rice genes in 3010 rice accessions.With an average of 226±390 gcHaps per gene in rice populations,rice genes could be classified into three main categories:12865 conserved genes,10254 subspecific differentiating genes,and 22844 remaining genes.We found that 39218 rice genes carry>255179 major gcHaps of potential functional importance.Most(87.5%)of the detected gcHaps were specific to subspecies or populations.The inferred proto-ancestors of local landrace populations reconstructed from conserved predominant(ancient)gcHaps correlated strongly with wild rice accessions from the same geographic regions,supporting a multiorigin(domestication)model of Oryza sativa.Past breeding efforts generally increased the gcHap diversity of modern varieties and'caused significant frequency shifts in predominant gcHaps of 14266 genes due to independent selection in the two subspecies.Low frequencies of“favorable”gcHaps at most known genes related to rice yield in modern varieties suggest huge potential for rice improvement by mining and pyramiding of favorable gcHaps.The gcHap data were demonstrated to have greater power than SNPs for the detection of causal genes that affect complex traits.The rice gcHap diversity dataset generated in this study would facilitate rice basic research and improvement in the future. | Fan Zhang Chunchao Wang Min Li Yanru Cui Yingyao Shi Zhichao Wu Zhiqiang Hu Wensheng Wang Jianlong Xu Zhikang Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 2 | Breeding by selective introgression: Theory, practices, and lessons learned from rice显示文摘Future demands for increased productivity and resilience to abiotic/biotic stresses of major crops require new technologies of breeding by design(BBD)built on massive information from functional and population genomics research.A novel strategy of breeding by selective introgression(BBSI)has been proposed and practiced for simultaneous improvement,genetic dissection and allele mining of complex traits to realize BBD.BBSI has three phases:a)developing large numbers of trait-specific introgression lines(ILs)using backcross breeding in elite genetic backgrounds as the material platform of BBD;b)efficiently identifying genes or quantitative trait loci(QTL)and mining desirable alleles affecting different target traits from diverse donors as the information platform of BBD;and c)developing superior cultivars by BBD using designed QTL pyramiding or marker-assisted recurrent selection.Phase(a)has been implemented massively in rice by many Chinese research institutions and IRRI,resulting in the development of many new green super rice cultivars plus large numbers of ILs in 30+elite genetic backgrounds.Phase(b)has been demonstrated in a series of proof-of-concept studies of high-efficiency genetic dissection of rice yield and tolerance to abiotic stresses using ILs and DNA markers.Phase(c)has also been implemented by designed QTL pyramiding,resulting in a prototype of BBD in several successful cases.The BBSI strategy can be easily extended for simultaneous trait improvement,efficient gene and QTL discovery and allele mining of complex traits using advanced breeding lines from crosses between a common'backbone'parent and a set of elite parents in conventional pedigree breeding programs.BBSI can be relatively easily adopted by breeding programs with small budgets,but the BBSI-based BBD strategy can be fully and more efficiently implemented by large seed companies with sufficient capacity. | Fan Zhang Yingyao Shi Jauhar Ali Jianlong Xu Zhikang Li | 2021 | The Crop Journal2021，9，3： | 3 |
| 3 | Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication显示文摘 | Renate K?nig Yingyao Zhou Daniel Elleder Tracy L. Diamond Ghislain M.C. Bonamy Jeffrey T. Irelan Chih-yuan Chiang Buu P. Tu Paul D. De Jesus Caroline E. Lilley Shannon Seidel Amanda M. Opaluch Jeremy S. Caldwell Matthew D. Weitzman Kelli L. Kuhen Sourav B | 2008 | Cell2008，，1： | 1 |
| 4 | Simultaneous improvement and genetic dissection of grain yield and its related traits in a backbone parent of hybrid rice ( Oryza sativa L.) using selective introgression显示文摘 | Hongjun Zhang Hui Wang Yiliang Qian Jiafa Xia Zefu Li Yingyao Shi Linghua Zhu Jauhar Ali Yongming Gao Zhikang Li | 2013 | Molecular Breeding2013，，1： | 1 |
| 5 | A preliminary study into the economic burden of cerebral palsy in China显示文摘 | Bin Wang Yingyao Chen Jie Zhang Jun Li Yan Guo David Hailey | 2008 | Health policy2008，，2： | 1 |
| 6 | Critical thickness of rust layer at inner and out surface cracking of concrete cover in reinforced concrete structures显示文摘 | Zhao Yuxi Yu Jiang Wu Yingyao | 2012 | Corrosion Science2012，59，： | 1 |
| 7 | Characterization of intermolecular interaction between cyanidin-3-glucoside and bovine serum albumin: Spectroscopic and molecular docking methods显示文摘 | SHI Jiehua WANG Jing ZHU Yingyao | 2013 | Luminescence2013，，： | 1 |
| 8 | Characterization of interaction between isoliquiritigenin and bovine serum albumin: Spectroscopic and molecular docking methods显示文摘 | SHI Jiehua WANG Jing ZHU Yingyao | 2014 | Journal of Luminescence2014，145，： | 1 |
| 9 | Can health technology assessments assist the global campaign against poverty?显示文摘Although a key tenant of the Sustainable Development Goals is to achieve universal health coverage,the global drug gap persists-cver a third of the global population lack access to essential medicines.Without access to affordable drugs,people have worse health outcomes,higher medical expenses,and productivity loss,pushing them into poverty.Health technology assessments(HTAs)offer an opportunity to decrease the global drug gap and increase access to essential medicines by overcoming barriers to medicine access.These barriers include drug procurement,drug affordability for payers and patients,a patienfs ability to obtain essential medicines,and health system capacity.Using HTAs can therefore close the global drug gap by increasing access to affordable essential medicines.In turn,people have better health outcomes,spend less money on medical care,and can have better productivity.Ultimately,use of HTAs can lift the population out of poverty and force fewer people into poverty by creating better health outcomes at affordable prices. | Debra Renee Winberg Ye Lu Yingyao Chen Lizheng Shi | 2021 | Global Health Journal2021，5，3： | 1 |
| 10 | Lipase - catalyzed acidolysis of canola oil with caprylic acid to pro- duce medium -, long - and medium - chain - type struc- tured lipids 显示文摘 | WANG Yingyao LUAN Xia XU Xuebing | 2012 | Food Bioprod Process2012，90，4： | 1 |
| 11 | Health technology assessment development in China显示文摘 | Yingyao Chen David Banta Zhiliu Tang | 2009 | Int J Technol Assess Health Care2009，25，1： | 1 |
| 12 | Aqueous enzymatic extrac-tion of oil and protein hydrolysates from peanut显示文摘 | WANG Yingyao WANG Zhang | 2008 | FoodSci Technol Res2008，14，6： | 1 |
| 13 | Effects of Maternal Folic Acid Supplementation on Hepatic Apoptosis-Related Gene Expressions between Intrauterine Growth Restriction and Normal Body Weight Piglets显示文摘Intrauterine growth retardation(IUGR)causes significantly negative effects on the methylation status of genes related to cell apoptosis compared with normal body weight(NBW)piglets.Thus,the objective of the present study was to examine the effects of maternal dietary folic acid supplementation on genes expression profile for hepatic apoptosis in IUGR and NBW piglets.Twenty four Yorkshire gilts were allocated randomly to one of the two diets:control(C,folic acid 1.3 mg/kg)or folic acid supplementation(FS,folic acid 30 mg/kg)after mating.Gene expressions in liver samples were determined and revealed that the mRNA expressions of p53,BCL-2 associated X protein(Bax),and Cyclin-dependent kinase inhibitor 1A(CDKN1A)were upregulated in IUGR piglets compared with NBW piglets fed C diets,but could be reversed by maternal folic acid supplementation.The expressions of vascular endothelial growth factor(VEGF),Serine-protein Kinase-Ataxia Telangiectasia Mutated(ATM),and Cadherin-associated protein-beta-catenin 1(CTNNB1)were influenced by maternal folic acid supplementation significantly,but were not influenced by birth weight.Expression of p53 binding protein-MDM-2(MDM-2)remained unchanged.In conclusion,these results demonstrated that maternal folic acid supplementation could exert positive effects on genes related to apoptosis in IUGR and NBW piglets,which might facilitate their postnatal health and growth performance. | BingYu JingboLiu YingYao DaiwenChen | 2010 | Journal of Animal Science and Biotechnology2010，1，2： | 1 |
| 14 | Estimating first-price auctions with an unknown number of bidders:A misclassification approach显示文摘 | Yonghong An Yingyao Hu Matthew Shum | | 0，，157： | 1 |
| 15 | Aqueous enzymatic extraction of oil and protein hydrolysates from peanut显示文摘 | Wang Yingyao Wang Zhang Cheng Shangwei | 2008 | Food Science and Technology Research2008，14，6： | 1 |
| 16 | The Plasmodium falciparum sexual development transcriptome: A microarray analysis using ontology-based pattern identification显示文摘 | Jason A. Young Quinton L. Fivelman Peter L. Blair Patricia de la Vega Karine G. Le Roch Yingyao Zhou Daniel J. Carucci David A. Baker Elizabeth A. Winzeler | 2005 | Molecular & Biochemical Parasitology2005，，： | 1 |
| 17 | Critical thickness of rust layer at inner and out surface cracking of concrete cover in reinforced concrete structures显示文摘 | Yuxi Zhao Jiang Yu Yingyao Wu Weiliang Jin | 2012 | Corrosion Science2012，，59： | 1 |
| 18 | A preliminary study into the economic burden of cerebral palsy in China显示文摘 | Wang Bin Chen Yingyao Zhang Jie | 2008 | Health Policy2008，87，2： | 1 |
| 19 | Technique for Order Preference by Similarity to an Ideal Solution-based comprehensive health assessment of composite insulators for overhead transmission lines显示文摘There are a lot of quantitative performance characterisation methods for composite insulators.However,how to apply the characterisation methods with different dimensions to comprehensively assess the health state of composite insulators remains a big problem for operators and researchers.A comprehensive health assessment model for composite insulators based on the Technique for Order Preference by Similarity to an Ideal Solution(TOPSIS)method is proposed in this study.Fourteen composite insulators from four regions in Yunnan Province,China,and five quantitative characterisation indicators of the insulators,namely hardness,hydrophobicity,loss of hydrophobicity,recovery of hydrophobicity,and trap charge,are selected to verify the model.The results show that the Pearson correlation coefficient of the TOPSIS-based comprehensive health score with operating time is 0.72,which is better than the other single indicator.By introducing the operating time into the TOPSIS-based model,we can also obtain the ageing resistance performance of the composite insulator.This work provides a new idea to assess the health state and ageing performance of composite insulators. | Zhikang Yuan Zhouhang Yang Lijun Jin Gangjie Zhou Yingyao Zhang Hanqing Wang Cong Wang Youping Tu | 2023 | High Voltage2023，8，1： | 0 |
| 20 | G-quadruplexes folding mediates downregulation of PBX1 expression in melanoma显示文摘Dear Editor,Pre-B-cell leukemia homeobox transcription factor 1(PBX1)is identified at t(1;19)chromosomal translocations in acute pre-B-cell leukemia and is involved in regulating multiple biological processes.1 Importantly,accumulating evidence have suggested that dysregulation of PBX1 have been shown to be involved in tumorigenesis,poor prognosis and drug resistance.1 It has been shown that the expression of PBX1 is increased in melanoma cells and overexpression of PBX1 significantly promotes the melanoma cell growth. | Yutong Sui Feilin Liu Song Zheng Xiaomei Liu Pingli Sun Chunli Yao Yingyao Zhang Hongwen Gao Xinghua Gao Jinyu Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
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