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| 1 | Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography显示文摘By binding molecular probes that target tumor cells, gold nanoparticles (AuNPs) with superior characteristics have shown great potential in tumor molecular imaging studies. The non-invasive, high-resolution, and three-dimensional imaging of the targeted AuNPs within the tumor is desirable for both diagnosis and therapy. In this study, gold nanoflowers (AuNFs) are presented as a novel contrast agent for photoacoustic tomography (PAT). By binding to folic acid, the molecular probe, the tail-vein injected AuNFs concentrated within the tumor site in mice; this was clearly visualized by three-dimensional (3D) PAT imaging. In addition, toxicity assay proved that AuNFs were harmless to living cells and animals. Our results demonstrate that AuNFs have great potential in tumor molecular imaging. | Yuanyuan Jiang Zijian Deng Dan Yang Xin Deng Qi Li Yinlin Sha Changhui Li Dongsheng Xu | 2015 | Nano Research2015，8，7： | 8 |
| 2 | Separation and analysis of the soluble trimer of Aβ_(1-40) and its effects on the rise in intracellular calcium显示文摘The oligomers of Aβ1-40 peptide in PBS buffer solution were analyzed by SEC and native PAGE, and the trimer of Aβ1-40 was also isolated by SEC. In addition, the effects of the soluble Aβ1-40 trimer on intracellular free calcium (Ca2+) balance of hippocampal neurons of postnatal rats were investi- gated by fluorescence microscopy. The experimental results indicated that Aβ1-40 peptide existed in the form of low molecular weight oligomers in 0.231 mmol/L fresh Aβ1-40 solution (20 mmol/L sodium phosphate buffer, pH 7.4, 0.02% sodium azide) within 24 h and the soluble trimer was the most abundant species. Both the trimeric and the fibrillar Aβ1-40 were able to increase the intracellular Ca2+ concentration, but the Aβ1-40 trimer caused a gradual rise and the potential was also stronger than that of the fibrils at the same concentration. In addition there were dif- ferent response modes for trimeric and fibrillar Aβ1-40, meaning that there are different mechanisms of in- crease in intracellular Ca2+ caused by Aβ1-40. | ZHENG Xiaohui WANG Lijun ZHANG Lan HONG Yuankai HUANG Lixin SHA Yinlin | 2006 | Chinese Science Bulletin2006，51，7： | 1 |
| 3 | Interaction of HIV-1 fusion peptide and its mutant with lipid membrane显示文摘HIVWT and HIVV2E represent the 23 amino acids fusion peptide of HIV-1 gp41 N terminus and its position 2 mutant (Val→Glu). We have studied the structure-function relationship of HIVWT and HIVV2E when they interact with acidic and neutral lipid membranes. The results show that HIVWT and HIVV2E have the same conformational characteristics and tendencies of conformational transition but definitely different functions: HIVWT destabilizes membrane and induces fusion by adopting predominant α-helix conformation when interacting with acidic POPG membrane, its phenylalanine residues can penetrate into the hydrophobic core of POPG bilayer; HIVV2E also adopts predominant α-helix when interacting with POPG membrane, but it cannot destabilize POPG membrane and induce fusion, the phenylalanine residues of it are located near the surface of POPG bilayer. HIVWT and HIVV2E both adopt predominant β-sheet conformation to interact with neutral POPC membrane, and cannot destabilize POPC membrane and induce fusion, | QIU Yang SHA Yinlin HUANG Lixin LIN Kechun NIE Songqing | 2000 | Chinese Science Bulletin2000，45，9： | 1 |
| 4 | Erratum to: Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography显示文摘 | Yuanyuan Jiang Zijian Deng Dan Yang Xin Deng Oi Li Yinlin Sha Changhui Li Dongsheng Xu | 2017 | Nano Research2017，10，3： | 0 |
| 5 | Bio-rational design of photosystem Ⅱ inhibitors (Ⅰ)──Molecular modeling of cyanoacrylates and ureas in photosystem Ⅱ D1 protein of Pisum sativum显示文摘Molecular modeling of cyanoacrylates and ureas with D1 protein of Pisum sativum have been presented. Studies show that these two kinds of inhibitors occupy the similar region in the D1 protein. Cyanoacrylates have more binding sites than ureas, thus they have higher activities. | LIU Huayin\+1, SHA Yinlin\+1, LU Rongjian\+1, YANG Huazheng\+ 1*and LAI Luhua\+2 1. Institute of Elemento_Organic Chemistry and State Key Laboratory of Elemento_Organic Chemistry, Nankai University, Tianjin 300071, China 2. Institute of Physical Chemis | 1998 | Chinese Science Bulletin1998，43，8： | 0 |
| 6 | Effect of Ab_(1-40) on membrane permeability and intracellular free Ca^(2+) of nerve cells显示文摘The effects of soluble and fibrillar Ab1-40 on membrane permeability and intracellular free Ca2+ of nerve cells were investigated by the laser confocal microscopy. Results indicate that: i) Effects of soluble and fibrillar Ab1-40 on cell membrane permeability are both concentration-de- pendent. Soluble Ab1-40 increases membrane permeability only at concentration of 3 mmol/L, while the toxic effect of fibrillar Ab1-40 is much stronger, its evident effect begins from 1 mmol/L. When its concentration rose to 3 mmol/L, not only the membrane permeability increased, but also the nuclear membrane broke seriously. ii) Both soluble and fibrillar Ab1-40 at high concentrations increased the intracellular free Ca2+, and the increased amplitudes are concentration-dependent. However, the fibrillar one induces the increase of intracellular Ca2+ much quicker and synchronously. These results indicate that some correlation exists between the neurotoxicity of high concentration soluble and fibrillar Ab1-40 and the change of physico-chemical properties and intracellular Ca ion imbalance. | MA Xiaocui, SHA Yinlin, LIN Kechun & NIE Songqing Department of Biophysics, Peking University Health Science Center, Beijing 100083, China | 2003 | Chinese Science Bulletin2003，48，10： | 0 |
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