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| 1 | Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis显示文摘Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide,but the molecular basis underlying its development remains unclear.An accumulating body of evidence supports gasdermin D(GSDMD)-mediated pyroptosis as a key component in the development of various pulmonary diseases.However,there is little experimental evidence connecting silicosis and GSDMD-driven pyroptosis.In this work,we investigated the role of GSDMD-mediated pyroptosis in silicosis.Single-cell RNA sequencing of healthy and silicosis human and murine lung tissues indicated that GSDMD-induced pyroptosis in macrophages was relevant to silicosis progression.Through microscopy we then observed morphological alterations of pyroptosis in macrophages treated with silica.Measurement of interleukin-1βrelease,lactic dehydrogenase activity,and real-time propidium iodide staining further revealed that silica induced pyroptosis of macrophages.Additionally,we verified that both canonical(caspase-1-mediated)and non-canonical(caspase-4/5/11-mediated)signaling pathways mediated silica-induced pyroptosis activation,in vivo and in vitro.Notably,Gsdmd knockout mice exhibited dramatically alleviated silicosis phenotypes,which highlighted the pivotal role of pyroptosis in this disease.Taken together,our results demonstrated that macrophages underwent GSDMD-dependent pyroptosis in silicosis and inhibition of this process could serve as a viable clinical strategy for mitigating silicosis. | Meiyue Song Jiaxin Wang Youliang Sun Junling Pang Xiaona Li Yuan Liu Yitian Zhou Peiran Yang Tianhui Fan Ying Liu Zhaoguo Li Xianmei Qi Baicun Li Xinri Zhang Jing Wang Chen Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 5 |
| 2 | Molybdenite Re–Os and albite 40 Ar/ 39 Ar dating of Cu–Au–Mo and magnetite porphyry systems in the Yangtze River valley and metallogenic implications显示文摘 | Jingwen Mao Yitian Wang Bernd Lehmann Jinjie Yu Andao Du Yanxiong Mei Yongfeng Li Wenshuan Zang Holly J. Stein Taofa Zhou | 2005 | Ore Geology Reviews2005，，3： | 2 |
| 3 | Fabrication and biological evaluation of 3D-printed calcium phosphate ceramic scaffolds with distinct macroporous geometries through digital light processing technology显示文摘Digital light processing(DLP)-based 3D printing technique holds promise in fabricating scaffolds with high precision.Here raw calcium phosphate(CaP)powders were modified by 5.5%monoalcohol ethoxylate phosphate(MAEP)to ensure high solid loading and low viscosity.The rheological tests found that photocurable slurries composed of 50wt%modified CaP powders and 2wt%toners were suitable for DLP printing.Based on geometric models designed by computer-aided design(CAD)system,three printed CaP ceramics with distinct macroporous structures were prepared,including simple cube,octet-truss and inverse face-centered cube(fcc),which presented the similar phase composition and microstructure,but the different macropore geometries.Inverse fcc group showed the highest porosity and compressive strength.The in vitro and in vivo biological evaluations were performed to compare the bioactivity of three printed CaP ceramics,and the traditional foamed ceramic was used as control.It suggested that all CaP ceramics exhibited good biocompatibility,as evidence by an even bone-like apatite layer formation on the surface,and the good cell proliferation and spreading.A mouse intramuscular implantation model found that all of CaP ceramics could induce ectopic bone formation,and foam group had the strongest osteoinduction,followed by inverse fcc,while cube and octet-truss had the weakest one.It indicated that macropore geometry was of great importance to affect the osteoinductivity of scaffolds,and spherical,concave macropores facilitated osteogenesis.These findings provide a strategy to design and fabricate high-performance orthopedic grafts with proper pore geometry and desired biological performance via DLP-based 3D printing technique. | Jing Wang Yitao Tang Quanle Cao Yonghao Wu Yitian Wang Bo Yuan Xiangfeng Li Yong Zhou Xuening Chen Xiangdong Zhu Chongqi Tu Xingdong Zhang | 2022 | Regenerative Biomaterials2022，9，1： | 2 |
| 4 | Graphene oxide coated three-dimensional printed biphasic calcium phosphate scaffold for angiogenic and osteogenic synergy in repairing critical-size bone defect显示文摘The custom-tailored medicine requires a developmental strategy that integrates excellent osteogene-sis with mechanical stability to enhance the reconstruction of the critical-size bone defect(CSBD)and the healing process in weight-bearing bone.We prepared three-dimensional(3D)printed biphasic cal-cium phosphate(BCP)scaffolds composited with nano-graphene oxide(GO).The biological effects of the GO/BCP composite scaffolds could induce the differentiation of rat bone marrow stem cells(BM-SCs)and the migration of human umbilical vein endothelial cells(HUVECs)for bone repair.The proper ratio of GO in the composite scaffold regulated the composites’surface roughness and hydrophilicity to a suitable range for the adhesion and proliferation of BMSCs and HUVECs.Besides,the GO/BCP composite scaffold increased osteogenesis and angiogenesis by activating BMP-2,RUNX-2,Smad1/4,and VEGF.The customized intramedullary nail combined with GO/BCP scaffold was applied to repair CSBD(2.0 cm in length)in a beagle femur model.This fixation strategy was confirmed by finite element analysis.In vivo,the results indicated that the custom-made internal fixation provided sufficient stability in the early stage,ensuring bone healing in a considerable mechanical environment.At 9 months postoperatively,longitudi-nal bony union and blood vessels in osteon were observed in the CSBD area with partial degradation in the 0.3%GO/BCP group.In the three-point bending test,the ultimate load of 0.3%GO/BCP group reached over 50%of the normal femur at 9 months after repair.These results showed a promising application of osteogenic GO/BCP scaffold and custom-made intramedullary nails in repairing CSBD of the beagle femur.This effective strategy could provide an option to treat the clinical CSBD in weight-bearing bones. | Yitian Wang Yonghao Wu Yuqi Zhang Xiangfeng Li Li Min Quanle Cao Yi Luo Xiao Yang Minxun Lu Yong Zhou Xiangdong Zhu Chongqi Tu Xingdong Zhang | 2023 | Journal of Materials Science & Technology2023，，14： | 1 |
| 5 | Construction and application of an ontology-based domain-specific knowledge graph for petroleum exploration and development显示文摘The massive amount and multi-sourced,multi-structured data in the upstream petroleum industry impose great challenge on data integration and smart application.Knowledge graph,as an emerging technology,can potentially provide a way to tackle the challenges associated with oil and gas big data.This paper proposes an engineering-based method that can improve upon traditional natural language processing to construct the domain knowledge graph based on a petroleum exploration and development ontology.The exploration and development knowledge graph is constructed by assembling Sinopec’s multi-sourced heterogeneous database,and millions of nodes.The two applications based on the constructed knowledge graph are developed and validated for effectiveness and advantages in providing better knowledge services for the oil and gas industry. | Xianming Tang Zhiqiang Feng Yitian Xiao Ming Wang Tianrui Ye Yujie Zhou Jin Meng Baosen Zhang Dongwei Zhang | 2023 | Geoscience Frontiers2023，14，5： | 1 |
| 6 | Molybdenite Re–Os and albite 40 Ar/ 39 Ar dating of Cu–Au–Mo and magnetite porphyry systems in the Yangtze River valley and metallogenic implications显示文摘 | Jingwen Mao Yitian Wang Bernd Lehmann Jinjie Yu Andao Du Yanxiong Mei Yongfeng Li Wenshuan Zang Holly J. Stein Taofa Zhou | 2005 | Ore Geology Reviews2005，，3： | 1 |
| 7 | Molybdenite Re-Os and albite ^40Ar/^39Ar dating of Cu-Au-Mo and magnetite porphyry systems in the Yangtze River valley and metallogenic implications显示文摘 | Mao Jingwen Wang Yitian Bernd Lehmann Yu Jinjie Du Andao Mei Yanxiong Li Yongfeng Zang Wenshuan Holly J Stein Zhou Tafa | 2006 | Ore Geology Reviews2006，29，： | 1 |
| 8 | Improved catalytic performance of CO_(2) electrochemical reduction reaction towards ethanol on chlorine-modified Cu-based electrocatalyst显示文摘Effective electrochemical conversion of CO_(2) to value-added liquid multi-carbon products driven by renewable energy is a promising approach to alleviate excessive CO_(2) emission and achieve large-scale renewable energy storage.However,the selectivity and catalytic activity towards liquid multi-carbon products of CO_(2) electroreduction reaction are still unsatisfactory due to the sluggish C-C coupling process and the formation of complex oxygen-containing intermediates.Hence,designing and fabricating highly effective electrocatalysts is crucial for practical applications in this field.Here,we developed Cl-modified Cu catalyst(Cu-Cl)for efficient electrochemical reduction of CO_(2) to ethanol.The optimal Faradaic efficiency and partial current density of ethanol on the Cu-Cl sample reached 26.2%and 343.2 mA·cm^(-2) at-0.74 V(vs.reversible hydrogen electrode(RHE)),which were 1.66 and 1.76 times higher than those of the catalyst without Cl decoration,outperforming those in most previously reported works.Density functional theory(DFT)calculations revealed that the Cl-modified Cu surface suppressed the parasitic hydrogen evolution reaction(HER)and reduced the energy barrier for the C-C coupling process,making the formation of key intermediates favorable for ethanol production.Thus,the decoration of Cl on the Cu surface facilitated ethanol formation. | Yifan Liu Hehua Tang Yitian Zhou Bo-Lin Lin | 2024 | Nano Research2024，17，5： | 0 |
| 9 | Single-cell transcriptional profile of ACE2 in healthy and failing human hearts显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)pandemic,which is caused by SARS-Co V-2,has gained serious attention from medical practitioners around the world in the past few months.Approximately 20%of critically ill COVID-19 patients were reported to have suffered myocardial injury.The specific mechanism of this pathology requires further investigation(Yang et al.,2020). | Yitian Zhou Yongfa Huang Xiaomin Song Xiaoxiao Guo Junling Pang Jing Wang Shuyang Zhang Chen Wang | 2021 | Science China(Life Sciences)2021，64，4： | 0 |
| 10 | Application of osteoinductive calcium phosphate ceramics in giant cell tumor of the sacrum:report of six cases显示文摘This study aimed at evaluating the possibility and effectiveness of osteoinductive bioceramics to fill the tumor cavity following the curettage of sacral giant cell tumor(GCT).Six patients(four females and two males,25–45 years old)underwent nervesparing surgery,in which the tumor was treated by denosumab,preoperative arterial embolization and extensive curettage.The remaining cavity was filled with commercial osteoinductive calcium phosphate(CaP)bioceramics,whose excellent osteoinductivity was confirmed by intramuscular implantation in beagle canine.All patients were followed by computed tomography(CT)scans postoperatively.According to the modified Neer criterion,five cases obtained Type I healing status,and one case had Type II.At the latest follow-up,no graft-related complications and local recurrence were found.The CT scan indicated a median time of healing initiation of 3months postoperatively,and the median time for relatively complete healing was 12months.The excellent bone regenerative ability of the ceramics was also confirmed by increased CT attenuation value,blurred boundary and cortical rim rebuilding.In conclusion,osteoinductive CaP bioceramics could be an ideal biomaterial to treat the large remaining cavity following extensive curettage of sacral GCT.However,further investigation with more cases and longer follow-up was required to confirm the final clinical effect. | Yitian Wang Xiangfeng Li Yi Luo Li Zhang Hezhong Chen Li Min Qing Chang Yong Zhou Chongqi Tu Xiangdong Zhu Xingdong Zhang | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 11 | On or Off:Life-Changing Decisions Made by Vibrio cholerae Under Stress显示文摘Vibrio cholerae,the causative agent of the infectious disease,cholera,is commonly found in brackish waters and infects human hosts via the fecal-oral route.V.cholerae is a master of stress resistance as V.cholerae’s dynamic lifestyle across different physical environments constantly exposes it to diverse stressful circumstances.Specifically,V.cholerae has dedicated genetic regulatory networks to sense different environmental cues and respond to these signals.With frequent outbreaks costing a tremendous amount of lives and increased global water temperatures providing more suitable aquatic habitats for V.cholerae,cholera pandemics remain a probable catastrophic threat to humanity.Understanding how V.cholerae copes with different environmental stresses broadens our repertoire of measures against infectious diseases and expands our general knowledge of prokaryotic stress responses.In this review,we summarize the regulatory mechanisms of how V.cholerae fights against stresses in vivo and in vitro. | Yitian Zhou Zachariah LLee Jun Zhu | 2020 | Infectious Microbes & Diseases2020，2，4： | 0 |
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