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| 1 | Vascular remodeling and mobilization of bone marrow-derived cells in cuff-induced vascular injury in LDL receptor knockout mice显示文摘背景:脉管的改变是在为象动脉粥样硬化, postangioplasty 休息合并和 transplant 动脉病那样的各种各样的脉管的混乱的脉管的损害的一个重要病理学的过程。最近,病理学的变化和骨髓的角色导出房间疯狂在动脉粥样硬化和休息合并被学习。但是在 neointima 的损害形成和在血胆脂醇过多的在礼品的脉管的改变的损害的房间招募的方式充分还没被理解。方法:LDL 受体基因的双 transgenic 老鼠大美人(LDL -/-) 并且表示无所不在地绿的荧光灯的蛋白质(GFP ) 被跨 breeding LDL -/- 老鼠带着表示 GFP 转基因的老鼠获得。LDL -/- 老鼠(22 - 24 星期年龄) 包含 1.25% 的喂的多脂饮食(w/w ) 胆固醇受到 9Gy 照耀并且收到了骨髓(BM ) 从双 transgenic 老鼠的房间。四个星期以后,一只非紧缩的手铐被放在恰好大腿骨的动脉附近。在另外一个以后 2 个星期,权利和左大腿骨的动脉被收获并且使遭到了到组织化学的分析。Apoptosis 是分析原位使用 TUNEL 试金。结果:在手铐放置以后的二个星期,动脉粥样硬化患者损害在由泡沫细胞的巨大的累积组成的内膜发展了。与 anti-alpha 染色的织物平滑肌肌动朊(SMA ) 抗体,在内层的损害区域显示出很多个 SMA 积极的房间。他们为 GFP 也是积极的,显示到在在导致手铐的脉管的改变损害的内膜的 SMC 的那导出 BM 的房间罐头 differentiate。在外膜以及内膜的内皮衬里的众多的小容器为 CD31 和 GFP 两个都是积极的。在 2 个星期掴损害以后,内膜和媒介显示出很多 TUNEL 积极的信号,显示在脉管的改变的 apoptosis 的存在。结论:在老鼠的动脉粥样硬化患者损害能在 hypercholesterolemic 条件下面在 2 星期导致手铐的脉管的损害以后在内膜被开发。我们的数据清楚地也显示导出髓的房间面对血胆脂醇过多在这些损害的形成区分了到平滑肌和 endothelial 的那根骨头。 | XU Yang ARAI Hidenori MURAYAMA Toshinori KITA Toru YOKODE Masayuki | 2008 | Chinese Medical Journal2008，，3： | 7 |
| 2 | Prevention of atherosclerotic progression in Watanabe rabbits by probucol 显示文摘 | Nagano Y Yokode M | 1988 | Am J Cardiol1988，62，： | 1 |
| 3 | N-acetylcysteine reduces the severity of atherosclerosis in apolipoprotein E-deficient mice by reducing superoxide production 显示文摘 | Shimada K Murayama T Yokode M | 2009 | Circ J2009，73，7： | 1 |
| 4 | Dlet-induced hypercholestrolemia in mice:prevention by overexpression of LDL receptors显示文摘 | Yokode RE Hammer SI | 1990 | Science1990，250，： | 1 |
| 5 | T-lymphocyte subsets in patients with squamous cell carcinoma of the head and neck显示文摘 | Furusaka T Yokode Y Nakajima M | 1986 | Auris Nasus Larynx1986，13，： | 1 |
| 6 | Toward the realiza- tion of a better aged society: messages from gerontology and geriatrics 显示文摘 | Arai H Ouchi Y Yokode M | 2012 | Geriatr Gerontol Int2012，12，1： | 1 |
| 7 | Diet-induced hyper cholesterolemiu in mice显示文摘 | Yokode M Hammer RE Ishibashi S | 1990 | Science1990，250，4985： | 1 |
| 8 | Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors显示文摘 | Yokode M Hammer RE Ishibashi S | 1990 | Science1990，250，4985： | 1 |
| 9 | Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit,an animal model for familial hypercholesterolemia显示文摘 | Nagano Y Yokode M | 1987 | Proc Nac Acad Sci USA1987，84，： | 1 |
| 10 | Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia 显示文摘 | Kita T Nagano Y Yokode M | 1987 | Proc Natl Acad Sci USA1987，84，16： | 1 |
| 11 | Toward the realization of a better aged society:messages from gerontology and geriatrics显示文摘 | Arai H Ouchi Y Yokode M | 2012 | Geriatrics & gerontology international2012，12，： | 1 |
| 12 | Toward therealization of a better aged society : messages fromgerontology and geriatrics显示文摘 | Arai H Ouchi Y Yokode M | 2012 | Geriatr Gerontol Int2012，12，： | 1 |
| 13 | Hypercholesterolemia contributes to the development of atherosclerosis and vascular remodeling by recruiting bone marrow-derived cells in cuff-induced vascular injury显示文摘 | Yang Xu Hidenori Arai Toshinori Murayama Toru Kita Masayuki Yokode | 2007 | Biochemical and Biophysical Research Communications2007，，3： | 1 |
| 14 | Probucol prevents the progression of atheroatherosclerosis in Watanabe heritable hyperlipidemic rabbit,an animal model for familial hypercholesterolemia显示文摘 | Kita T Nagano Y Yokode M | 1987 | Proci Natl1987，84，1： | 1 |
| 15 | Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors显示文摘 | Yokode M Hammer RE Ishibashi S | 1990 | Science1990，250，4985： | 1 |
| 16 | Cholesterol Efflux Effect of High Density Lipoprotein is Impaired by Whole Cigarette Smoke Extracts Through Lipid Peroxidation显示文摘 | Kazuhisa Ueyama Masayuki Yokode Hidenori Arai Yutaka Nagano Li Zhi-Xiang Mikimaro Cho Toru Kita | 1997 | Free Radical Biology and Medicine1997，，1： | 1 |
| 17 | Nano-sized carbon black exposure exacerbates atherosclerosis inLDL-receptor knockout mice显示文摘 | Niwa Y Hiura Y Murayama T Yokode M Iwai N | 2007 | Circ J2007，71，7： | 1 |
| 18 | Cholesterol efflux effect of high density lipoprotein is impaired by whole cigarette smoke extracts through lipid peroxidation 显示文摘 | Ueyama K Yokode M Arai H | 1998 | Free Radic Biol Med1998，24，1： | 1 |
| 19 | Toward the realization of a betteraged society:messages from gerontology and geriatrics显示文摘 | Arai H Ouchi Y Yokode M | 2012 | GeriatrGerontol Int2012，12，1： | 1 |
| 20 | Toward the realization of a better aged society: messages from gerontology and geriatrics显示文摘 | Arai H Ouchi Y Yokode M | 2012 | Geriatr Gerontol Int2012，12，1： | 1 |
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