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| 1 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 2 | Vascular remodeling and mobilization of bone marrow-derived cells in cuff-induced vascular injury in LDL receptor knockout mice显示文摘背景:脉管的改变是在为象动脉粥样硬化, postangioplasty 休息合并和 transplant 动脉病那样的各种各样的脉管的混乱的脉管的损害的一个重要病理学的过程。最近,病理学的变化和骨髓的角色导出房间疯狂在动脉粥样硬化和休息合并被学习。但是在 neointima 的损害形成和在血胆脂醇过多的在礼品的脉管的改变的损害的房间招募的方式充分还没被理解。方法:LDL 受体基因的双 transgenic 老鼠大美人(LDL -/-) 并且表示无所不在地绿的荧光灯的蛋白质(GFP ) 被跨 breeding LDL -/- 老鼠带着表示 GFP 转基因的老鼠获得。LDL -/- 老鼠(22 - 24 星期年龄) 包含 1.25% 的喂的多脂饮食(w/w ) 胆固醇受到 9Gy 照耀并且收到了骨髓(BM ) 从双 transgenic 老鼠的房间。四个星期以后,一只非紧缩的手铐被放在恰好大腿骨的动脉附近。在另外一个以后 2 个星期,权利和左大腿骨的动脉被收获并且使遭到了到组织化学的分析。Apoptosis 是分析原位使用 TUNEL 试金。结果:在手铐放置以后的二个星期,动脉粥样硬化患者损害在由泡沫细胞的巨大的累积组成的内膜发展了。与 anti-alpha 染色的织物平滑肌肌动朊(SMA ) 抗体,在内层的损害区域显示出很多个 SMA 积极的房间。他们为 GFP 也是积极的,显示到在在导致手铐的脉管的改变损害的内膜的 SMC 的那导出 BM 的房间罐头 differentiate。在外膜以及内膜的内皮衬里的众多的小容器为 CD31 和 GFP 两个都是积极的。在 2 个星期掴损害以后,内膜和媒介显示出很多 TUNEL 积极的信号,显示在脉管的改变的 apoptosis 的存在。结论:在老鼠的动脉粥样硬化患者损害能在 hypercholesterolemic 条件下面在 2 星期导致手铐的脉管的损害以后在内膜被开发。我们的数据清楚地也显示导出髓的房间面对血胆脂醇过多在这些损害的形成区分了到平滑肌和 endothelial 的那根骨头。 | XU Yang ARAI Hidenori MURAYAMA Toshinori KITA Toru YOKODE Masayuki | 2008 | Chinese Medical Journal2008，，3： | 7 |
| 3 | Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy: a single center study显示文摘 | Yukio Osaki Yoshihide Ueda Hiroyuki Marusawa Jun Nakajima Toru Kimura Ryuichi Kita Hiroki Nishikawa Sumio Saito Shinichiro Henmi Azusa Sakamoto Yuji Eso Tsutomu Chiba | 2012 | Journal of Gastroenterology2012，，4： | 3 |
| 4 | Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis显示文摘 | Mitsuhiro Yokoyama Hideki Origasa Masunori Matsuzaki Yuji Matsuzawa Yasushi Saito Yuichi Ishikawa Shinichi Oikawa Jun Sasaki Hitoshi Hishida Hiroshige Itakura Toru Kita Akira Kitabatake Noriaki Nakaya Toshiie Sakata Kazuyuki Shimada Kunio Shirato | 2007 | The Lancet2007，，9567： | 2 |
| 5 | Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage显示文摘 | Yasuhide Kuwabara Koh Ono Takahiro Horie Hitoo Nishi Kazuya Nagao Minako Kinoshita Shin Watanabe Osamu Baba Yoji Kojima Satoshi Shizuta Masao Imai Toshihiro Tamura Toru Kita Takeshi Kimura | 2011 | Circulation: Cardiovascular Genetics2011，，： | 2 |
| 6 | Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 correlates with oxidative stress markers in stable coronary artery disease显示文摘 | Fumihiko Kamezaki Kazuhito Yamashita Hiromi Tasaki Noriaki Kume Hirokazu Mitsuoka Toru Kita Tetsuo Adachi Yutaka Otsuji | 2008 | International Journal of Cardiology2008，，2： | 2 |
| 7 | Radiofrequency ablation for hepatocellular carcinoma显示文摘 | Hiroki Nishikawa Toru Kimura Ryuichi Kita Yukio Osaki | 2013 | International Journal of Hyperthermia2013，，6： | 2 |
| 8 | Japanese Atherosclerosis Society Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases显示文摘Death due to cardiovascular diseases including those related to atherosclerosis,particularly myocardial infarction,and cerebrovascular accidents,particularly cerebral infarction and stroke,have accounted for a high percentage of death cause,reaching 30%,along with cancer in the mortality statistics of Japanese. | Toru Kita | 2009 | 中国动脉硬化杂志2009，17，7： | 2 |
| 9 | Link betweenHelicobacter pylori-associated gastritis and duodenal ulcer显示文摘 | Hiroshi Saita Dr. Motonobu Murakami Jung Kenn Yoo Sanae Teramura Hiroshi Dekigai Youji Takahashi Toru Kita | 1993 | Digestive Diseases and Sciences1993，，1： | 1 |
| 10 | High Risk for Bradyarrhythmic Complications in Patients With Brugada Syndrome Caused by SCN5A Gene Mutations显示文摘 | Takeru Makiyama Masaharu Akao Keiko Tsuji Takahiro Doi Seiko Ohno Kotoe Takenaka Atsushi Kobori Tomonori Ninomiya Hidetada Yoshida Makoto Takano Naomasa Makita Fumiko Yanagisawa Yukei Higashi Youichi Takeyama Toru Kita Minoru Horie | 2005 | Journal of the American College of Cardiology2005，，11： | 1 |
| 11 | Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice显示文摘 | Tsuneaki Kawashima Yasutaka Inuzuka Junji Okuda Takao Kato Shinichiro Niizuma Yodo Tamaki Yoshitaka Iwanaga Akira Kawamoto Michiko Narazaki Tetsuya Matsuda Souichi Adachi Genzou Takemura Toru Kita Takeshi Kimura Tetsuo Shioi | 2011 | Journal of Molecular and Cellular Cardiology2011，，6： | 1 |
| 12 | MicroRNA-1 and MicroRNA-133 in Spontaneous Myocardial Differentiation of Mouse Embryonic Stem Cells 显示文摘 | Tomohide Takaya MA Koh Ono MD Teruhisa Kawamura MD Rieko Takanabe MA Shinji Kaichi MD Tatsuya Morimoto MD Hiromichi Wada MD Toru Kita MD Akira Shimatsu MD Koji Hasegawa MD | 2009 | Circ J2009，73，： | 1 |
| 13 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 14 | Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1)显示文摘 | Hirokazu Mitsuoka Noriaki Kume Kazutaka Hayashida Atsuko Inui-Hayashiada Yo Aramaki Masako Toyohara Toshikazu Jinnai Eiichiro Nishi Toru Kita | 2008 | Atherosclerosis2008，，1： | 1 |
| 15 | Measurements of baseline and follow-up concentrations of cardiac troponin-T and brain natriuretic peptide in patients with heart failure from various etiologies显示文摘 | Ryoji Taniguchi Yukihito Sato Yukiko Nishio Takeshi Kimura Toru Kita | 2006 | Heart and Vessels2006，，6： | 1 |
| 16 | Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1) in Atherogenesis显示文摘 | Noriaki Kume Toru Kita | 2001 | Trends in Cardiovascular Medicine2001，，1： | 1 |
| 17 | A Vitamin D Analog Ameliorates Glomerular Injury on Rat Glomerulonephritis显示文摘 | Kojiro Makibayashi Mitsuyoshi Tatematsu Michinori Hirata Naoshi Fukushima Kenichiro Kusano Seiji Ohashi Hideharu Abe Kogo Kuze Atsushi Fukatsu Toru Kita Toshio Doi | 2001 | The American Journal of Pathology2001，，5： | 1 |
| 18 | Hypercholesterolemia contributes to the development of atherosclerosis and vascular remodeling by recruiting bone marrow-derived cells in cuff-induced vascular injury显示文摘 | Yang Xu Hidenori Arai Toshinori Murayama Toru Kita Masayuki Yokode | 2007 | Biochemical and Biophysical Research Communications2007，，3： | 1 |
| 19 | Effect of treatment with branched‐chain amino acids during sorafenib therapy for unresectable hepatocellular carcinoma显示文摘 | Haruhiko Takeda Hiroki Nishikawa Eriko Iguchi Yoshiaki Ohara Azusa Sakamoto Sumio Saito Norihiro Nishijima Akihiro Nasu Hideyuki Komekado Ryuichi Kita Toru Kimura Yukio Osaki | 2014 | Hepatol Res2014，，3： | 1 |
| 20 | Cholesterol Efflux Effect of High Density Lipoprotein is Impaired by Whole Cigarette Smoke Extracts Through Lipid Peroxidation显示文摘 | Kazuhisa Ueyama Masayuki Yokode Hidenori Arai Yutaka Nagano Li Zhi-Xiang Mikimaro Cho Toru Kita | 1997 | Free Radical Biology and Medicine1997，，1： | 1 |
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