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| 1 | Impact of dendritic cell vaccines pulsed with Wilms’ tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers显示文摘 | Hidenori Takahashi Masato Okamoto Shigetaka Shimodaira Shun-ichi Tsujitani Masaki Nagaya Takefumi Ishidao Junji Kishimoto Yoshikazu Yonemitsu | 2012 | European Journal of Cancer2012，，： | 3 |
| 2 | Dendritic cell-based vaccine for pancreatic cancer in Japan显示文摘'Vaccell' is a dendritic cell(DC)-based cancer vaccine which has been established in Japan. The DCs play central roles in deciding the direction of host immune reactions as well as antigen presentation. We have demonstrated that DCs treated with a streptococcal immune adjuvant OK-432, produce interleukin-12, induce Th1-dominant state, and elicit anti-tumor effects, more powerful than those treated with the known DCmaturating factors. We therefore decided to mature DCs by the OK-432 for making an effective DC vaccine, Vaccell. The 255 patients with inoperable pancreatic cancer who received standard chemotherapy combined with DC vaccines, were analyzed retrospectively. Survival time of the patients with positive delayed type hypersensitivity(DTH) skin reaction was significantly prolonged as compared with that of the patients with negative DTH. The findings strongly suggest that there may be 'Responders' for the DC vaccine in advanced pancreatic cancer patients. We next conducted a smallscale prospective clinical study. In this trial, we pulsed HLA class Ⅱ-restricted WT1 peptide(WT1-Ⅱ) in addition to HLA class Ⅰ-restricted peptide(WT1-Ⅰ) into the DCs. Survival of the patients received WT1-Ⅰ and-Ⅱ pulsed DC vaccine was significantly extended as compared to that of the patients received DCs pulsed with WT1-Ⅰ or WT1-Ⅱ alone. Furthermore, WT1-specific DTH positive patients showed significantly improved the overall survival as well as progressionfree survival as compared to the DTH negative patients. The activation of antigen-specific immune responses by DC vaccine in combination with standard chemotherapy may be associated with a good clinical outcome in advanced pancreatic cancer. We are now planning a pivotal study of the Vaccell in appropriate protocols in Japan. | Masato Okamoto Masanori Kobayashi Yoshikazu Yonemitsu Shigeo Koido Sadamu Homma | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 2 |
| 3 | Prognostic factors related to add-on dendritic cell vaccines on patients with inoperable pancreatic cancer receiving chemotherapy: a multicenter analysis显示文摘 | Masanori Kobayashi Shigetaka Shimodaira Kazuhiro Nagai Masahiro Ogasawara Hidenori Takahashi Hirofumi Abe Mitsugu Tanii Masato Okamoto Sun-ichi Tsujitani Seiichi Yusa Takefumi Ishidao Junji Kishimoto Yuta Shibamoto Masaki Nagaya Yoshikazu Yonemitsu | 2014 | Cancer Immunology, Immunotherapy2014，，： | 2 |
| 4 | Study on Hydroformed Bellows (2nd report),Stress Calculation on Hydroformed Bellows Deflection Reflecting Thickness Difference at OD and ID显示文摘 | Shiyama Asahiko Suefji Yoshihiro Yonemitsu Masato | 1991 | Journal of the Japan Society of Precision Engineering/Seimitsu Kogaku Kaishi1991，57，10： | 1 |
| 5 | Type IV collagen 7s domain is an independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage显示文摘 | Masato Yoneda Hironori Mawatari Koji Fujita Kyoko Yonemitsu Shingo Kato Hirokazu Takahashi Hiroyuki Kirikoshi Masahiko Inamori Yuichi Nozaki Yasunobu Abe Kensuke Kubota Satoru Saito Tomoyuki Iwasaki Yasuo Terauchi Shinji Togo Shiro Maeyama Atsushi Nakajim | 2007 | Journal of Gastroenterology2007，，5： | 1 |
| 6 | High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH显示文摘 | Masato Yoneda Hironori Mawatari Koji Fujita Hiroshi Iida Kyoko Yonemitsu Shingo Kato Hirokazu Takahashi Hiroyuki Kirikoshi Masahiko Inamori Yuichi Nozaki Yasunobu Abe Kensuke Kubota Satoru Saito Tomoyuki Iwasaki Yasuo Terauchi Shinji Togo Shiro Maeyama At | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 7 | High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH显示文摘 | Masato Yoneda Hironori Mawatari Koji Fujita Hiroshi Iida Kyoko Yonemitsu Shingo Kato Hirokazu Takahashi Hiroyuki Kirikoshi Masahiko Inamori Yuichi Nozaki Yasunobu Abe Kensuke Kubota Satoru Saito Tomoyuki Iwasaki Yasuo Terauchi Shinji Togo Shiro Maeyama At | 2007 | Journal of Gastroenterology2007，，7： | 1 |
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