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| 1 | Efficacy of Shouzhangshen(Rhizoma Gymnadeniae Crassinervidis)extract against acute high altitude hypoxia-induced brain injury in mice显示文摘OBJECTIVE:To evaluate the protective effect of Shouzhangshen(Rhizoma Gymnadeniae Crassinervidis)extract against acute high altitude hypoxia-induced brain injury in mice.METHODS:Sixty C57BL/6J mice were selected and assigned to six groups(n=10):normal control group,low-pressure hypoxia group,positive control group(dexamethasone 500 mg/kg),and three groups treated with Shouzhangshen extract(250,500,and 750 mg/kg,respectively).The Morris water maze test was performed to evaluate alterations in spatial learning and memory deficits.Nissl staining was performed to detect Nissl bodies and neuron damage.Hypoxia-inducible factor(HIF)-1α,interleukin(IL)-1β,tumor necrosis factor(TNF)-α,vascular endothelial growth factor(VEGF),and malondialdehyde(MDA)expression in brain tissue and serum,as well as superoxide dismutase(SOD)and glutathione(GSH)activity in brain tissues were measured by enzyme-linked immunosorbent assays,quantitative real-time-polymerase chain reaction and western blots.RESULTS:The Morris water maze test results showed that Shouzhangshen extract can significantly reduce the latency and swimming distance to escape onto a visible platform,increase neuron density and hierarchy and the number of pyramidal neurons,and decrease the expression of HIF-1α,IL-1β,TNF-α,and VEGF mRNAs and proteins in both brain tissue and serum(P<0.05).Furthermore,significantly lower MDA expression and higher GSH activity were detected in the three groups treated with Shouzhangshen compared with the low-pressure hypoxia group(P<0.05).However,no significant alteration was observed for SOD activity(P>0.05).CONCLUSION:Our findings suggest that Shouzhangshen extract may have a significant effect on acute high altitude hypoxia-induced brain injury in mice. | ZHANG Yongcang LIU Tonghua LIU Lan ZONG Yonghua LI Yu XIONG Hai WU Lili | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 1 |
| 2 | Disturbance of theOPG/RANK/RANKL pathway and systemic inflammation inCOPD patients with emphysema and osteoporosis 显示文摘 | Peng B Yongcang S Jianmin J | 2011 | RespirRes’2011，12，1： | 1 |
| 3 | Fabrication of silicon wafer with ultra low reflectance by chemical etching method显示文摘 | Yingli Cao Aimin Liu Honghao Li Yiting Liu Fen Qiao Zengquan Hu Yongcang Sang | 2011 | Applied Surface Science2011，，17： | 1 |
| 4 | Dynamic modeling of degradation data 显示文摘 | JIANG Mingxiao ZHANG Yongcang | 2002 | IEEE Proceedings Annual Reliability and Maintainability Symposium2002，，： | 1 |
| 5 | Lattice Effect on the Transport Properties in Double Doped La_(2/3)(Ca_(1-x)Sr_x)_(1/3)MnO_3 Films显示文摘The transport properties in the La2/3(Ca1-xSrx)1/3MnO3 (x=0, 1/3, 2/3) films prepared using the RF magnetronsputtering method were investigated. The effect of the Ca, Sr double-doping at the A position in the La2/3A1/3MnO3on the structure of the targets and transport of the films has been studied. With the increase of x, the structures of thetargets transform from the rhombohedral phase to the cubic phase; the metal-insulator phase transition temperature(TP) of the films increases; and the corresponding peak resistivity decreases. All the phenomena can be qualitativelyexplained by the lattice effect. | Kexin JIN Changle CHEN Shenggui ZHAO Yongcang WANG Zhoumo SONG Xiao YUAN | 2005 | Journal of Materials Science & Technology2005，21，6： | 0 |
| 6 | Laser-induced Voltage in La_(0.85)Sr_(0.015)MnO_3/Fe Heterostructure显示文摘在 Si (100 ) 底层上扔的 La_(0.85 )Sr_(0.015 ) MnO_3/Fe 异种结构被劈啪作响的磁控管准备。在在在在 77 K 的 current-in-plane 几何学 andcurrent-perpendicular-to-plane 几何学之间的电压信号的样品和差别的导致激光的电压被调查。这差别能被归因于不同运输机制。 | Kexin JIN Changle CHEN Shenggui ZHAO Yongcang WANG Zhoumo SONG Xiao YUAN | 2006 | Journal of Materials Science & Technology2006，22，4： | 0 |
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