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| 1 | Effect of Dongchongxiacao(Cordyceps) therapy on contrast-induced nephropathy in patients with type 2 diabetes and renal insufficiency undergoing coronary angiography显示文摘OBJECTIVE: To study the protective effects of Dongchongxiacao(Cordyceps)(DCXC) on contrast-induced nephropathy(CIN) in patients with type 2 diabetes and renal insufficiency undergoing coronary angiography.METHODS: A total of 120 patients with type 2 diabetes whose estimated glomerular filtration rate(e GFR) was ≤ 60 m L/minee grou·1.73 m2,were divided randomly into thrps,basic treatment group(n = 41),standard DCXC therapy group(n = 39,2-g corbrin capsules,3 times/d,3 days before and after angiography),and intensive DCXC therapy group(n = 40,3-g corbrin capsules,3 times/d,3 days before and after angiography). Serum creatinine(Scr)and e GFR were assessed at the time of admission to hospital,and on days 1,2 and 3 after angiography. Urine neutrophil-gelatinase-associated-lipocalin(NGAL),kidney injury molecule-1(KIM-1) and interleukin-18(IL-18) were measured before angiography and at day 1 after angiography for all patients. The primary end point was the prevalence of CIN. The secondary end point was a 25% or greater reduction in e GFR.RESULTS: CIN occurred in 11 of 120 patients(9.17 %). The prevalence of CIN was lower in the DCXC treatment groups than in the basic treatment group(P < 0.05),with a more significant decrease in the prevalence of CIN in the intensive DCXC therapy group(P < 0.01). Compared with the basic treatment group,a lower proportion of patients in the DCXC treatment groups had an e GFR decrease of 25% or greater(P < 0.05); patients with an e GFR decrease of 25% or greater accounted for an even lower proportion in the intensive DCXC therapy group(P < 0.01). Within 1 day of the procedure,urine levels of KIM-1,NGAL and IL-18 in patients in the intensive DCXC therapy group were lower than those in the basic treatment group and standard therapy group(P < 0.05).CONCLUSION: DCXC treatment may protect against CIN in patients with type 2 diabetes and renal insufficiency undergoing coronary angiography,with intensive DCXC therapy being more effective. | Zhao Kai Li Yongjian Gao Sheng Lin Yu | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 15 |
| 2 | Failure mechanism of Mesozoic soft rock roadway in Shajihai coal mine and its surrounding rock control显示文摘In view of the buckling failure caused by large deformation of Mesozoic soft rock roadway in Shajihai mining area, such as serious roof fall, rib spalling, floor heave, etc., based on the detail site investigation,theoretical analysis, mineral composition test, microstructure test, water-physical property test and field experiments were carried out. And we revealed the compound failure mechanism of Mesozoic soft rock roadway in Shajihai mining area, namely the molecule expansion-shear slip of weak structural plane-construction disturbance. On this basis, the coupling support technology whose core is constant resistance with large deformation bolt was proposed. The feature of this supporting technology is that a new type of structural composite material was used, which makes the supporting system not only has the ideal deformation characteristics, but also has high supporting resistance. Thus the fully release of plastic energy within surrounding rock and reasonable control of the thickness of the plastic ring were realized. Then the differential deformation between the surrounding rock and support was eliminated by the secondary coupling support of bolt–mesh–cable, and the bolt with high strength was applied in the base angle to control floor. Eventually the collaborative bearing system of surrounding rock–support was formed. Through field tests the validity and rationality of support was also verified. | Yuan Yue Zhu Yongjian Wang Weijun Yu Weijian | 2014 | International Journal of Mining Science and Technology2014，24，6： | 7 |
| 3 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 4 | New method for the preparation of adsorbent with high adsorption capacity显示文摘Polyamidoamine (PAMAM) is a type of macro- molecule having a definite chemical structure and a large number of terminal functional groups. The synthetic ap-proach of the adsorbent with high adsorption capacity in-volved arching of PAMAM onto cellulose beads by reaction with epichlorohydrin. The product thus prepared had a large number of amino groups of 2.94 mmol/g derived from 0.23 mmol/g epoxy groups on cellulose beads. This method pre-sents an effective method for the preparation of high-loading adsorbents. | WANG Yongjian LIU Jianfeng DUO Jia YU Yaoting | 2005 | Chinese Science Bulletin2005，50，21： | 3 |
| 5 | Tumor-targeted delivery of siRNA to silence Sox2 gene expression enhances therapeutic response in hepatocellular carcinoma显示文摘RNA interference(RNAi)is one of the most promising methods for the treatment of malignant tumors.However,developing an efficient biocompatible delivery vector for small interfering RNA(siRNA)remains a challenging issue.This study aimed to prepare a non-viral tumor-targeted carrier,named RGDfC-modified functionalized selenium nanoparticles(RGDfC-SeNPs).RGDfC-SeNPs were used to selectively deliver siSox2 to HepG2 liver cancer cells and tissues for the treatment of hepatocellular carcinoma(HCC).In the current study,RGDfC-SeNPs were successfully synthesized and characterized.It was shown that RGDfC-SeNPs could effectively load siSox2 to prepare an antitumor prodrug RGDfC-Se@siSox2.RGDfC-Se@siSox2 exhibited selective uptake in HepG2 liver cancer cells and LO2 normal liver cells,indicating RGDfC-SeNPs could effectively deliver siSox2 to HepG2 liver cancer cells.RGDfC-Se@siSox2 entered HepG2 cells via clathrin-mediated endocytosis by firstly encircling the cytoplasm and then releasing siSox2 in the lysosomes.RGDfC-Se@siSox2 could effectively silence Sox2 and inhibit the proliferation,migration and invasion of HepG2 cells.RGDfC-Se@siSox2 induced HepG2 cells apoptosis most likely via overproduction of reactive oxygen species and disruption of the mitochondrial membrane potentials.Most importantly,RGDfC-Se@siSox2 significantly inhibited the tumor growth in HepG2 tumor-bearing mice without obvious toxic side effects.These studies indicated that RGDfC-SeNPs may be an ideal gene carrier for delivering siSox2 to HepG2 cells and that RGDfC-Se@siSox2 may be a novel and highly specific gene-targeted prodrug therapy for HCC. | Yu Xia Guoyi Tang Yi Chen Changbing Wang Min Guo Tiantian Xu Mingqi Zhao Yongjian Zhou | 2021 | Bioactive Materials2021，6，5： | 2 |
| 6 | Stress triggering of the Lushan M7. 0 earthquake by the Wenchuan Ms8. 0 earthquake显示文摘The Wenchuan Ms8.0 earthquake and the Lushan M7.0 earthquake occurred in the north and south segments of the Longmenshan nappe tectonic belt,respectively.Based on the focal mechanism and finite fault model of the Wenchuan Ms8.0 earthquake,we calculated the coulomb failure stress change.The inverted coulomb stress changes based on the Nishimura and Chenji models both show that the Lushan M7.0 earthquake occurred in the increased area of coulomb failure stress induced by the Wenchuan Ms8.0 earthquake.The coulomb failure stress increased by approximately 0.135-0.152 bar in the source of the Lushan M7.0earthquake,which is far more than the stress triggering threshold.Therefore,the Lushan M7.0 earthquake was most likely triggered by the coulomb failure stress change. | Wu Jianchao Yu Song Cai Yongjian Lei Dongning Li Heng | 2013 | Geodesy and Geodynamics2013，4，3： | 2 |
| 7 | Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway显示文摘 | Huanlong Liu Xueyan Chen Yu Han Chaoyi Li Pingping Chen Yongjian Zhang Zhenhua Pan | 2013 | Biomedicine & Pharmacotherapy2013，，： | 2 |
| 8 | An ultrasound-triggered cation chelation and reassembly route to one-dimensional Ni-rich cathode material enabling fast charging and stable cycling of Li-ion batteries显示文摘Ni-rich oxides,LiNixMnyCozO2(NMC),are among leading candidates for cathode materials in Li-ion batteries.However,they are mostly fabricated by coprecipitation approach under complex conditions,which usually produces large secondary particles composed of aggregated primary particles.Undesirable cation mixing and crack propagation upon cycling block ion and electron transport,result in fast capacity fading and poor rate capability.Herein,we present an ultrasound-triggered cation chelation and reassembly route for synthesizing one-dimensional precursor with homogeneous element distribution at the atomic level.This process is accomplished by the synergistic combination of ultrasound and surfactant,which can disperse reactants and remove hydration shells surrounding cations so as to accelerate chelating reaction,and then separate and assemble chelates into one dimensional structure.The whole synthesis time is only 20 min(8.9 min of ultrasonic working time)in an open vessel under natural ambient conditions.One-dimensional LiNi0.6Mn0.2Co0.2O2 has a high reversible capacity(184 mAh·g^−1 at 0.1 C)and long cycling stability(95.1%and 82.4%capacity retention for 100 and 1000 cycles,respectively).The short charging time of 76 s is realized at super high current rate of 20 C,which is very important to improve the competitiveness of electric vehicles relative to fuel vehicles.Our synthetic approach can provide a general strategy for the growth of mixed-metal-EDTA chelate precursors by changing the feeding ratio of Ni2+,Mn2+and Co2+cations in reaction for fabricating NMC cathode materials with other compositions. | Yongjian Lai Zhaojie Li Wenxia Zhao Xiaoning Cheng Shuo Xu Xiao Yu Yong Liu | 2020 | Nano Research2020，13，12： | 2 |
| 9 | Dysregulated adaptive immune response contributes to severe COVID-19显示文摘Dear Editor,The outbreak of the new coronavirus 5ARS-CoV-2 has resulted in a global pandemic.Due to the lack of a specific drug against this virus,the current clinical management of this disease mainly depends on supportive care to reduce inflammatory responses and to keep the lung functioning1. | Kuai Yu Jingjing He Yongjian Wu Baosong Xie Xuefei Liu Bo Wei Haibo Zhou Bingliang Lin Zhixiang Zuo Wen Wen Wenxiong Xu Bin Zou Lai Wei Xi Huang Penghui Zhou | 2020 | Cell Research2020，30，9： | 1 |
| 10 | A Method for Improving Doppler Performance of the Side-lobe Redection Filter for Binary Code显示文摘 | Yu Genmiao Luo Yongjian Wu Shunjun | 2001 | Journal of Xidian University2001，，： | 1 |
| 11 | Edge Detection in Ultrasound Imagery Using the Instantaneous Coefficient of Variation显示文摘 | YONGJIAN YU SCOTT T ACTON | 2004 | IEEE Trans Image Processing2004，13，12： | 1 |
| 12 | Speckle reducing anisotropic diffusion显示文摘 | Yu Yongjian Acton ST | 2002 | IEEE Transaction on Image Processing2002，11，11： | 1 |
| 13 | Novel mutations in RSPH4A and TTN genes lead to primary ciliary dyskinesia-hereditary myopathy with early respiratory failure overlap syndrome显示文摘Primary ciliary dyskinesia(PCD)is an autosomal recessive disease caused by defects in motile cilia and clinically characterized by bronchiectasis,situs inversus,nasosinusitis,recurrent respiratory infections,tympanitis,and/or male infertility.In PCD,impaired function or structure of motile cilia leads to abnormality of mucociliary clearance。 | Mengjie Feng Xiu Yu Yongjian Yue Jiacheng Zhong Lingwei Wang | 2023 | Genes & Diseases2023，10，3： | 1 |
| 14 | Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1显示文摘 | Yu Xiyong Song YaoHua Ceng Yongjian | 2008 | Biochem Biophys Res Commun2008，376，3： | 1 |
| 15 | Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells显示文摘The use of two inhibitors of Mek1/2 and Gsk3β(2i)promotes the generation of mouse diploid and haploid embryonic stem cells(ESCs)from the inner cell mass of biparental and uniparental blastocysts,respectively.However,a system enabling long-term maintenance of imprints in ESCs has proven challenging.Here,we report that the use of a two-step a2i(alternative two inhibitors of Src and Gsk3β,TSa2i)derivation/culture protocol results in the establishment of androgenetic haploid ESCs(AG-haESCs)with stable DNA methylation at paternal DMRs(differentially DNA methylated regions)up to passage 60 that can efficiently support generating mice upon oocyte injection.We also show coexistence of H3K9me3 marks and ZFP57 bindings with intact DMR methylations.Furthermore,we demonstrate that TSa2itreated AG-haESCs are a heterogeneous cell population regarding paternal DMR methylation.Strikingly,AGhaESCs with late passages display increased paternal-DMR methylations and improved developmental potential compared to early-passage cells,in part through the enhanced proliferation of H19-DMR hypermethylated cells.Together,we establish AG-haESCs that can longterm maintain paternal imprints. | Hongling Zhang Yuanyuan Li Yongjian Ma Chongping Lai Qian Yu Guangyong Shi Jinsong Li | 2022 | Protein & Cell2022，13，2： | 1 |
| 16 | A Distributed Model of WebGIS Based on Java Servlett显示文摘 | Zheli Liu Shuming Wang Yongjian Yang Xuiqin Yu | 2006 | 通讯和计算机(中英文版)2006，3，7： | 1 |
| 17 | Speckle reducing anisotropic diffusion 显示文摘 | YU Yongjian Acton Scott T | 2002 | IEEE Transactions Image Processing(S1057-7149)2002，11，11： | 1 |
| 18 | Speckle reducing anisotropic diffusion 显示文摘 | Yu Yongjian Acton ST | 2002 | IEEE Transactions on Image Processing2002，11，11： | 1 |
| 19 | Edge detection in ultrasound imagery using the instantaneous coefficient of variation 显示文摘 | Yu Yongjian Acton ST | 2004 | IEEE Transactions on Image Processing2004，13，2： | 1 |
| 20 | Speckle reduction anisotropic diffusion显示文摘 | Yu Yongjian Acton Scott T | 2002 | IEEE Trans Image Processing2002，11，11： | 1 |
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