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| 1 | Pterygium in Aged Population in Doumen County, China显示文摘Purpose:To estimate the prevalence of pterygium and its influence on visual acuity in aged population of Doumen County,southern China.Methods:A population-based survey was conducted in Doumen County,the rural area of southern China,twenty-seven sample units were selected by random sampling.The prevalence and severity of pterygium and it-related low visual acuity were analyzed.Results:Of the total 4762 individuals aged 50 years or over,4214 were examined.The prevalence of pterygium was 33.01% in subjects aged 50 years or above.There was a significantly higher prevalence in female(35.70%)than in male(29.70%,P=0.025).The prevalence of pterygium in age groups of 50s,60s,70s and 80s years old is 33.98%,36.40%,30.73% and 25.40%,respectively.Most of the pterygia were located in the nasal side(93.31%)of cornea,and only 6.69% in the temporal side.0.92% of the eyes had visual acuity less than 0.32,which were directly caused by pterygia.Conclusion:The current survey suggests that the pterygium is one of the most common diseases of external eye in th population ged 50 years and above.It is still leading to the impairment of visual acuity in the rural area. | Kaili Wu, Mingguang He, Jingjing Xu, Shaozhen LiZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2002 | 眼科学报2002，18，3： | 18 |
| 2 | A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings显示文摘In recent years,the developed hemostatic technologies are still difficult to be applied to the hemostasis of massive arterial and visceral hemorrhage,owing to their weak hemostatic function,inferior wet tissue adhesion,and low mechanical properties.Herein,a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust mechanical property(308.47±29.20 kPa)and excellent hemostatic efficiency(96.5%±2.1%)was constructed as a hemostatic sealant.Typically,we combined chitosan(CS)with silk fibroin(SF)by cross-linking them through tannic acid(TA)to maintain the structural stability of the hydrogel,especially for wet tissue adhesion ability(shear adhesive strength=29.66±0.36 kPa).Compared with other materials reported previously,the obtained CS/TA/SF hydrogel yielded a lower amount of blood loss and shorter time to hemostasis in various arterial and visceral bleeding models,which could be ascribed to the synergistic effect of wound closure under wet state as well as intrinsic hemostatic activity of CS.As a superior hemostatic sealant,the unique hydrogel proposed in this work can be exploited to offer significant advantages in the acute wound and massive hemorrhage with the restrictive access of therapeutic moieties. | Ziwen Qiao Xueli Lv Shaohua He Shumeng Bai Xiaochen Liu Linxi Hou Jingjing He Dongmei Tong Renjie Ruan Jin Zhang Jianxun Ding Huanghao Yang | 2021 | Bioactive Materials2021，6，9： | 14 |
| 3 | Genome-wide characterization and analysis of b HLH transcription factors in Panax ginseng显示文摘Ginseng(Panax ginseng C.A. Meyer) is one of the best-selling herbal medicines, with ginsenosides as its main pharmacologically active constituents. Although extensive chemical and pharmaceutical studies of these compounds have been performed, genome-wide studies of the basic helix-loop-helix(b HLH) transcription factors of ginseng are still limited. The b HLH transcription factor family is one of the largest transcription factor families found in eukaryotic organisms, and these proteins are involved in a myriad of regulatory processes. In our study, 169 bHLH transcription factor genes were identified in the genome of P. ginseng, and phylogenetic analysis indicated that these PGb HLHs could be classified into 24 subfamilies. A total of 21 RNA-seq data sets, including two sequencing libraries for jasmonate(JA)-responsive and 19 reported libraries for organ-specific expression analyses were constructed. Through a combination of gene-specific expression patterns and chemical contents,6 PGbHLH genes from 4 subfamilies were revealed to be potentially involved in the regulation of ginsenoside biosynthesis. These 6 PGbHLHs, which had distinct target genes, were further divided into two groups depending on the absence of MYC-N structure. Our results would provide a foundation for understanding the molecular basis and regulatory mechanisms of bHLH transcription factor action in P.ginseng. | Yang Chu Shuiming Xiao He Su Baosheng Liao Jingjing Zhang Jiang Xu Shilin Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 13 |
| 4 | Effect of sintering temperature in argon atmosphere on microstructure and properties of 3D printed alumina ceramic cores显示文摘Alumina ceramics with different sintering temperatures in argon atmosphere were obtained using stereolithography-based 3D printing.The effects of sintering temperature on microstructure and physical and mechanical properties were investigated.The results show that the average particle size,shrinkage,bulk density,crystallite size,flexural strength,Vickers hardness,and nanoindentation hardness increased with the increase in sintering temperature,whereas the open porosity decreased with increasing sintering temperature.No change was observed in phase composition,chemical bond,atomic ratio,and surface roughness.For the sintered samples,the shrinkage in Z direction is much greater than that in X or Y direction.The optimum sintering temperature in argon atmosphere is 1350℃with a shrinkage of 3.0%,3.2%,and 5.5%in X,Y,and Z directions,respectively,flexural strength of 26.7 MPa,Vickers hardness of 198.5 HV,nanoindentation hardness of 33.1 GPa,bulk density of 2.5 g/cm^3,and open porosity of 33.8%.The optimum sintering temperature was 70℃higher than that sintering in air atmosphere when achieved the similar properties. | He LI Yongsheng LIU Yansong LIU Qingfeng ZENG Kehui HU Zhigang LU Jingjing LIANG | 2020 | Journal of Advanced Ceramics2020，9，2： | 13 |
| 5 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 6 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 7 | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care显示文摘Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations. | Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong Rongrong He Chen Cheng Chuan Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 10 |
| 8 | Physicochemical analysis of individual atmospheric fine particles based on effective surface-enhanced Raman spectroscopy显示文摘Fine particles associated with haze pollution threaten the health of more than 400 million people in China. It is therefore of great importance to thoroughly investigate and understand their composition. To determine the physicochemical properties in atmospheric fine particles at the micrometer level, we described a sensitive and feasible surface-enhanced Raman scattering(SERS) method using Ag foil as a substrate. This novel method enhanced the Raman signal intensities up to 10,000 a.u. for ν(NO_3^-) in fine particles.The SERS effect of Ag foil was further studied experimentally and theoretically and found to have an enhancement factor of the order of ~10~4. Size-fractionated real particle samples with aerodynamic diameters of 0.4–2.5 μm were successfully collected on a heavy haze day,allowing ready observation of morphology and identification of chemical components, such as soot, nitrates, and sulfates. These results suggest that the Ag-foil-based SERS technique can be effectively used to determine the microscopic characteristics of individual fine particles, which will help to understand haze formation mechanisms and formulate governance policies. | Zhenli Sun Fengkui Duan Kebin He Jingjing Du Liu Yang Hui Li Tao Ma Shuo Yang | 2019 | Journal of Environmental Sciences2019，31，1： | 9 |
| 9 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 10 | Topographical relief characteristics and its impact on population and economy:A case study of the mountainous area in western Henan,China显示文摘Topographical relief is a key factor that limits population distribution and economic development in mountainous areas.The limitation is especially apparent in the mountain?plain t「ansition zone.Taking the transition zone between the Qinling Mountains and the North China Plain(i.e.the mountainous area in western Henan Province)as an example and based on the 200-m resolution DEM data,we used the mean change-point analysis to determine the optimal statistical unit for topographical relief,and thereafter extracted the relief degree.Taking the 1:100,000 land use data,township population and county-level industrial data,population and economic spatial models were constructed,and 200?m resolution grid population and economic density maps were gen erated.Afterwards,statistical analysis was carried out to quantitatively reveal the impact of topographical relief on population and economy.In addition,the impacts of other topographical factors were discussed.The results showed the following.(1)The relief degree in western Henan is generally low,where 58.6%of the regional topography does not exceed half the height of a reference mountain(relative elevation W250 m).Spatially,the relief degree is high in the west while low in the east,and high in the middle while low in the north and south.There is a positive correlation between relief degree and elevation,and a much stronger correlation between relief degree and slope.(2)The linear fitting degree between the population and economic validation data and the corresponding simulation data are 0.943 and 0.909,respectively,indicating that the spatialized results can reflect the actual population and economic distribution.(3)The impact of topographical relief on population and economy was stronger than that of other topographical factors.The relief degree showed a good logarithmic fit relati on ship with population density(0.911)and economic density(0.874).Specifically,88.65%of the population lives in areas where the topographical relief is W0.5 and 88.03%of the gross regional product was from areas where the relief is W0.3.Compared with the population distribution,the economic development showed an obvious agglomeration trend towards low relief areas. | ZHANG Jingjing ZHU Wenbo ZHU Lianqi CUI Yaoping HE Shasha REN Han | 2019 | Journal of Geographical Sciences2019，29，4： | 8 |
| 11 | Defect and Doping Co‑Engineered Non‑Metal Nanocarbon ORR Electrocatalyst显示文摘Exploring low-cost and earth-abundant oxygen reduction reaction(ORR)electrocatalyst is essential for fuel cells and metal–air batteries.Among them,non-metal nanocarbon with multiple advantages of low cost,abundance,high conductivity,good durability,and competitive activity has attracted intense interest in recent years.The enhanced ORR activities of the nanocarbons are normally thought to originate from heteroatom(e.g.,N,B,P,or S)doping or various induced defects.However,in practice,carbon-based materials usually contain both dopants and defects.In this regard,in terms of the co-engineering of heteroatom doping and defect inducing,we present an overview of recent advances in developing non-metal carbon-based electrocatalysts for the ORR.The characteristics,ORR performance,and the related mechanism of these functionalized nanocarbons by heteroatom doping,defect inducing,and in particular their synergistic promotion effect are emphatically analyzed and discussed.Finally,the current issues and perspectives in developing carbon-based electrocatalysts from both of heteroatom doping and defect engineering are proposed.This review will be beneficial for the rational design and manufacturing of highly efficient carbon-based materials for electrocatalysis. | Jian Zhang Jingjing Zhang Feng He Yijun Chen Jiawei Zhu Deli Wang Shichun Mu Hui Ying Yang | 2021 | Nano-Micro Letters2021，13，4： | 8 |
| 12 | Sorption of uranyl ions on TiO_2:Effects of pH,contact time,ionic strength,temperature and HA显示文摘Sorption of U(VI) onto TiO_2 as functions of pH, ionic strength, contact time, soil humic acid(SHA), solid-to-liquid ratio and temperature was studied under ambient conditions using batch and spectroscopic approaches. The sorption of U(VI) on TiO_2 was significantly dependent on pH and ionic strength. The presence of SHA slightly enhanced the sorption of U(VI) on TiO_2 below pH 4.0, while it inhibited U(VI) sorption in the higher pH range. U(VI)sorption on TiO_2 was favored at high temperatures, and the sorption process was estimated to be endothermic and spontaneous. Reduction of U(VI) to lower valent species was confirmed by X-ray photo-electron spectroscopy analysis. It is very interesting to find that U(VI) sorption on TiO_2 was promoted in solutions with higher back-ground electrolyte concentrations. In the presence of U(VI), higher back-ground electrolyte made more TiO_2 particles aggregate through(001) facets, leading more(101) facets to be exposed. Therefore, the reduction of U(VI) was enhanced by the exposed(101) facets and more U(VI) removal was observed. | Jingjing Wang Bihong He Xiaoyan Wei Ping Li Jianjun Liang Shirong Qiang Qiaohui Fan Wangsuo Wu | 2019 | Journal of Environmental Sciences2019，31，1： | 7 |
| 13 | Cross-cultural adaption and psychometric properties of the Chinese version of the Diabetes Behavior Rating Scale: a pilot study显示文摘Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus(T1 DM). The Diabetes Behavior Rating Scale(DBRS) has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1 DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbach's α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability(r=0.81, P=0.001). Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores(r=.0.32, P=0.003) and hemoglobin A1 c(HbA1 c) levels(r=.0.36, P=0.002). Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T1 DM. | Jing Zhu Jingjing Xu Yang Chen Yong Gu Li Ji Yufeng Zhou Min Zhu Hsiang-Ting Hsu Xiaoping Huang Cuiping Yuan Yun Shi Dan Yan Lili Xie Shuang Chen Tao Yang Wei He | 2018 | Science China(Life Sciences)2018，61，3： | 6 |
| 14 | esveratrol inhibits necroptosis by mediating the TNF-α/RIP1/RIP3/MLKL pathway in myocardial hypoxia/reoxygenation injury显示文摘Resveratrol(RES)protects myocardial cells from hypoxia/reoxygenation(H/R)-caused injury.However,the mechanism of this effect has not been clarified.Thus,in this study,we aimed to determine whether RES attenuates H/R-induced cell necroptosis by inhibiting the tumor necrosis factor-alpha(TNF-α)/receptor-interacting protein kinase 1(RIP1)/RIP3/mixed-lineage kinase domain-like(MLKL)signaling pathway.Rat myocardial ischemia/reperfusion(I/R)models and H/R-injured cell models were constructed.Our study showed that myocardial H/R injury significantly increased the levels of TNF-α,RIP1,RIP3,and p-MLKL/MLKL by western blot analysis.Cell viability assay and 4,6-dianmidino-2-phenylindole(DAPI)-propidium iodide staining showed that the cell viability was decreased,and necroptosis was increased after myocardial H/R injury.The expressions of TNF-α,RIP1,RIP3,and p-MLKL/MLKL in H/R myocardial cells treated with different concentrations of RES were significantly downregulated.In addition,we also found that the cell viability was increased and necroptosis was decreased in dose-dependent manners when H/R-injured cells were treated with RES.In addition,the enhanced effect of TNF-αon necroptosis in myocardial H/R-injured cells was improved by RES,and the effect of RES was confirmed in vivo in I/R rats.This study also showed that RES suppresses necroptosis in H9c2 cells,which may occur through the inhibition of the TNF-α/RIP1/RIP3/MLKL signaling pathway.Our data suggest that necroptosis is a promising therapeutic target and may be a promising therapeutic target for the treatment of myocardial I/R injury. | Yongjun Hu Hongwei Pan Jianqiang Peng Jin He Mingxiang Tang Sulan Yan Jingjing Rong Junshan Li Zhaofen Zheng Haijun Wang Yanfu Liu Xin Zhong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 6 |
| 15 | 60 Years of Development of the Journal of Integrative Plant Biology显示文摘In celebration of JIPB's 60 th anniversary,this paper summarizes and reviews the development process of the journal.To start,we offer our heartfelt thanks to JIPB's pioneer Editors-in-Chief who helped get the journal off the ground and make it successful.Academic achievement is the soul of academic journals,and this paper summarizes JIPB's course of academic development by analyzing it in four stages:the first two stages are mostly qualitative analyses,and the latter two stages are dedicated to quantitative analyses.Most-cited papers were statistically analyzed.Improvements in editing,publication,distribution and online accessibility-which are detailed in this paper-contribute to JIPB's sustainable development.In addition,JIPB's evaluation index and awards are provided with accompanying pictures.At the end of the paper,JIPB's milestones are listed chronologically.We believe that JIPB's development,from a national journal to an international one,parallels the development of the Chinese plant sciences. | Jinzhong Cui Ping He Fenghong Liu Jingjing Tan Lingfeng Chen Joshua Fenn | 2012 | Journal of Integrative Plant Biology2012，54，10： | 5 |
| 16 | CsPrx25,a class III peroxidase in Citrus sinensis,confers resistance to citrus bacterial canker through the maintenance of ROS homeostasis and cell wall lignification显示文摘Citrus bacterial canker(CBC)results from Xanthomonas citri subsp.citri(Xcc)infection and poses a grave threat to citrus production.Class III peroxidases(CIII Prxs)are key proteins to the environmental adaptation of citrus plants to a range of exogenous pathogens,but the role of CIII Prxs during plant resistance to CBC is poorly defined.Herein,we explored the role of CsPrx25 and its contribution to plant defenses in molecular detail.Based on the expression analysis,CsPrx25 was identified as an apoplast-localized protein that is differentially regulated by Xcc infection,salicylic acid,and methyl jasmone acid in the CBC-susceptible variety Wanjincheng(C.sinensis)and the CBC-resistant variety Calamondin(C.madurensis).Transgenic Wanjincheng plants overexpressing CsPrx25 were generated,and these transgenic plants exhibited significantly increased CBC resistance compared with the WT plants.In addition,the CsPrx25-overexpressing plants displayed altered reactive oxygen species(ROS)homeostasis accompanied by enhanced H_(2)O_(2) levels,which led to stronger hypersensitivity responses during Xcc infection.Moreover,the overexpression of CsPrx25 enhanced lignification as an apoplastic barrier for Xcc infection.Taken together,the results highlight how CsPrx25-mediated ROS homeostasis reconstruction and cell wall lignification can enhance the resistance of sweet orange to CBC. | Qiang Li Xiujuan Qin Jingjing Qi Wanfu Dou Christophe Dunand Shanchun Chen Yongrui He | 2020 | Horticulture Research2020，7，1： | 5 |
| 17 | CDP1, a novel component of chloroplast division site positioning system in Arabidopsis显示文摘叶绿体是从 endosymbiotic cyanobacteria 演变的植物特定的细胞器。他们通过二进制分裂划分。叶绿体部门地点的选择为对称的叶绿体部门是枢轴的。在 E。coli,在房间的中点部门地点放被 Min 系统的动态摆动调整,它包括 MinC,头脑和矿。在植物的头脑和矿的相当或相同的事物涉及叶绿体分割。MinC 的相当或相同的事物仍然没在更高的植物被识别。然而,象 FtsZ 一样蛋白质, ARC3,被发现地点放涉及叶绿体分割。这里,我们报导放 1 的那个叶绿体部门地点(AtCDP1 ) 是在 Arabidopsis 涉及叶绿体部门地点放置的新奇叶绿体部门蛋白质。AtCDP1 被与房间部门显型为殖民地在细菌屏蔽一个 Arabidopsis cDNA 表示图书馆发现。AtCDP1 只在 Arabidopsis 在年轻绿纸巾被表示。有多重部门地点的伸长的叶绿体在 loss-of-function cdp1 异种被观察。AtCDP1 的 Overexpression 也引起了一个叶绿体部门显型。蛋白质相互作用试金建议 AtCDP1 可以调停通过和 ARC3 的相互作用放的叶绿体部门地点。总的来说,我们的结果显示 AtCDP1 是放系统,和这个系统的工作机制的叶绿体部门地点的一个新奇部件与在原核生物的房间的传统的 MinCDE 系统的不同。 | Min Zhang Yong Hu Jingjing Jia Dapeng Li Runjie Zhang Hongbo Gao Yikun He | 2009 | Cell Research2009，19，7： | 5 |
| 18 | Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty显示文摘童年肥胖和肥胖相关的新陈代谢的复杂并发症被一本高脂肪的出生后的食谱导致。然而,一个合适的动物模型的缺乏在肥胖研究仍然是可观的挑战。在当前的学习,我们在断奶以后在哺乳期间并且到小狗提供了高脂肪的饮食(HFD ) 给水坝。我们也与导致 HFD 的出生后的肥胖开发了 C57BL/6J 老鼠小狗的一个新奇模型。结果证明用 HFD 喂在小狗导致胖免职和肥胖。而且, HFD 更 potently 比女小狗增加了男性的身体重量(BW ) 。喂 HFD 的女小狗是肥胖的,经历了早熟的发身,并且显示出在视下丘的增加的 kisspeptin 表示。然而,父母肥胖和早熟的发身没在导致 HFD 的出生后的重量获得和小狗的发身发作上施加 synergistic 效果。有趣地,有正常 BW 的一些喂 HFD 的崽也展出了早熟的发身。这发现建议了那篇食谱作文然而并非 BW 扳机发身发作。我们的模型建议肥胖和早熟的发身的好构造有效性。而且,我们的模型能也被用来探索在 dietinduced 之间的相互的相互作用出生后的童年肥胖和发身。 | Rahim Ullah Yan Su Yi Shen Chunlu Li Xiaoqin Xu Jianwei Zhang Ke Huang Naveed Rauf Yang He Jingjing Cheng Huaping Qin Yu-Dong Zhou Junfen Fu | 2017 | Frontiers of Medicine2017，11，2： | 5 |
| 19 | Active digital spoof plasmonics显示文摘Digital coding and digital modulation are the foundation of modern information science.The combination of digital technology with metamaterials provides a powerful scheme for spatial and temporal controls of electromagnetic waves.Such a technique,however,has thus far been limited to the control of free-space light.Its application to plasmonics to shape subwavelength fields still remains elusive.Here,we report the design and experimental realization of a tunable conformal plasmonic metasurface;which is capable of digitally coding and modulating designer surface plasmons at the deep-subwavelength scale.Based on dynamical switching between two discrete dispersion states in a controlled manner;we achieve digital modulations ofboth amplitude and phase of surface waves with nearly 100%modulation depth on a single device.Our study not only introduces a new approach for active dispersion engineering,but also constitutes an important step towards the realization of subwavelength integrated plasmonic circuits. | Hao Chi Zhang Tie Jun Cui Yu Luo Jingjing Zhang Jie Xu Pei Hang He Le Peng Zhang | 2020 | National Science Review2020，7，2： | 5 |
| 20 | BKI1 Regulates Plant Architecture through Coordinated Inhibition of the Brassinosteroid and ERECTA Signaling Pathways in Arabidopsis显示文摘几百次充满白氨酸的重复像受体的 kinases (LRR-RLKs ) 玩在大量植物的不可缺少的角色发展、生理的过程。在基础、不活跃的地位控制 LRR-RLKs 的机制必要却很少学习。BKI1 是唯一的在 Arabidopsis 报导了受体 kinases 的禁止者,它否定地在 brassinosteroid 小径调整 BRI1。在这研究,我们发现 BKI1 能也与另一重要 LRR-RLK 交往, ERECTA (嗯) 。Phenotypic 分析显示出那 BKI1,包括花梗取向并且嗯一起调整植物建筑学,它是最新报导的显型在调停 BR 并且嗯调停发展进程。基因表示分析表明 BKI1 调整嗯应答的基因的一个子集。Kinase 试金证明 BKI1 禁止嗯 kinase 活动。另外, BKI1 抑制在上的版本嗯发信号主要依靠 BRI1 激活。我们的数据提供重要卓见进 RLK 的规定和激活并且建议 BKI1 作为 BRI1 的普通 suppressor 工作并且嗯发信号的小径。 | Dongxu Wang Cangjing Yang Haijiao Wang Zhihua Wu Jianjun Jiang Jingjing Liu Zhuona He Fang Chang Hong Ma Xuelu Wang | 2017 | Molecular Plant2017，10，2： | 5 |
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