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您的检索式：作者名="Yongjiu Chi"
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| 1 | Mapping Near-surface Air Temperature, Pressure, Relative Humidity and Wind Speed over China's Mainland with High Spatiotemporal Resolution显示文摘As part of a joint effort to construct an atmospheric forcing dataset for China's Mainland with high spatiotemporal resolution, a new approach is proposed to construct gridded near-surface temperature, relative humidity, wind speed and surface pressure with a resolution of 1 km×1 km. The approach comprises two steps:(1) fit a partial thin-plate smoothing spline with orography and reanalysis data as explanatory variables to ground-based observations for estimating a trend surface;(2)apply a simple kriging procedure to the residual for trend surface correction.The proposed approach is applied to observations collected at approximately 700 stations over China's Mainland. The generated forcing fields are compared with the corresponding components of the National Centers for Environmental Prediction(NCEP) Climate Forecast System Reanalysis dataset and the Princeton meteorological forcing dataset. The comparison shows that, both within the station network and within the resolutions of the two gridded datasets, the interpolation errors of the proposed approach are markedly smaller than the two gridded datasets. | LI Tao ZHENG Xiaogu DAI Yongjiu YANG Chi CHEN Zhuoqi ZHANG Shupeng WU Guocan WANG Zhonglei HUANG Chengcheng SHEN Yan LIAO Rongwei | 2014 | Advances in Atmospheric Sciences2014，31，5： | 3 |
| 2 | Necroptosis-elicited host immunity:GOx-loaded MoS_(2) nanocatalysts for self-amplified chemodynamic immunotherapy显示文摘Nanoparticles induced potent antitumor immunotherapy plays a significant role for enhancing conventional therapeutic effectiveness.However,revealing the pathway of how nanoagents themselves trigger the host immunity or how to maximize the immunotherapy efficacy still needs further exploration.Herein,rose-like MoS2 nanoflowers modified with 2-deoxy-D-glucose(2-DG)and glucose oxidase(GOx)(MPGGFs)have been successfully fabricated via a one-pot hydrothermal reaction and following one-by-one surface modification as a multifunctional nanocatalyst for photothermal therapy enhanced self-amplified chemodynamic immunotherapy(PTT-co-CDT).By introducing GOx,the obtained MPGGFs exhibited self-amplified chemodynamic therapeutic efficacy under hypoxia tumor microenvironment(TME)because of the raised intracellular H2O2 level via enzyme-catalysis of oxygen.Furthermore,combined with the intrinsic excellent photothermal conversion efficiency of MoS2 nanoflowers,PTT-co-CDT performances by MPGGFs could effectively induce the necroptosis of tumor cells both in vitro and in vivo.Then the induced necroptosis via PTT-co-CDT by MPGGFs could directly trigger host immunity by activating the antigen-specific T-cells(CD4^(+) and CD8^(+)).Finally,the excellent in vivo safety of MPGGFs makes us believe that the successful construction of rose-like multifunctional nanocatalyst not only has great potentials for self-amplified chemodynamic immunotherapy,but also provides a paradigm for exploring necroptosis triggered host immunity for cancer treatment. | Wensheng Xie Jingsong Lu Zhenhu Guo Xiaoxiao Guo Yongjiu Chi Jieling Ye Junxin Zhang Wanling Xu Lingyun Zhao Yen Wei | 2022 | Nano Research2022，15，3： | 0 |
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