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您的检索式：作者名="Yongjun SANG"
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| 1 | Numerical investigation on flow mechanism in a supersonic fluidic oscillator显示文摘A type of supersonic fluidic oscillator is proposed and its ability to generate pulsating supersonic jet is proved in this paper.Unsteady two-dimensional numerical simulations reveal that the fluid transforms from subsonic to supersonic condition in the mixing chamber of oscillator after the supplied flow pressure increases from 1.1×105 Pa to 5.0×105 Pa.When the supersonic flow is formed inside the oscillator,the wall-attached flow represents expansion wave and compression wave alternately.The oscillating frequency will saturate to a certain value with the increase of supplied pressure.Examination of the internal fluid dynamics indicates that the flow direction inside the FeedBack Channel(FBC)is related to the change of the local pressure at the inlet and the outlet of the feedback channel.The vortices produced in the mixing chamber present different distribution characteristics with the change of the fluid’s direction in the FBC.The sweeping jet is divided into two jets with varying flow rate over time by the splitter.In the end of two channels,two jets are accelerated above sound speed by convergent-divergent nozzle.Therefore,pulsating supersonic jets are produced at two outlets for this type of fluidic oscillator. | Yongjun SANG Yong SHAN Jingzhou ZHANG Xiaoming TAN Yuanwei LYU | 2021 | Chinese Journal of Aeronautics2021，34，5： | 1 |
| 2 | Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer显示文摘Chemoimmunotherapy has been approved as standard treatment for triple-negative breast cancer(TNBC),but the clinical outcomes remain unsatisfied.Abnormal epigenetic regulation is associated with acquired drug resistance and T cell exhaustion,which is a critical factor for the poor response to chemoimmunotherapy in TNBC.Herein,macrophage-camouflaged nanoinducers co-loaded with paclitaxel(PTX)and decitabine(DAC)(P/D-mMSNs)were prepared in combination with PD-1 blockade therapy,hoping to improve the efficacy of chemoimmunotherapy through the demethylation of tumor tissue.Camouflage of macrophage vesicle confers P/D-mMSNs with tumor-homing properties.First,DAC can achieve demethylation of tumor tissue and enhance the sensitivity of tumor cells to PTX.Subsequently,PTX induces immunogenic death of tumor cells,promotes phagocytosis of dead cells by dendritic cells,and recruits cytotoxic T cells to infiltrate tumors.Finally,DAC reverses T cell depletion and facilitates immune checkpoint blockade therapy.P/D-mMSNs may be a promising candidate for future drug delivery design and cancer combination therapy in TNBC. | Tong Gao Xiao Sang Xinyan Huang Panpan Gu Jie Liu Yongjun Liu Na Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 3 | On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition显示文摘Cancer immunotherapy has become a promising strategy.However,the effectiveness of immunotherapy is restricted in'cold tumors'characterized with insufficient T cells intratumoral infiltration and failed T cells priming.Herein,an on-demand integrated nano-engager(JOT-Lip)was developed to convert cold tumors to hot via'increased DNA damage and dual immune checkpoint inhibition'strategy.JOT-Lip was engineered by co-loading oxaliplatin(Oxa)and JQ1 into liposomes with T-cell immunoglobulin mucin-3 antibodies(Tim-3 mAb)coupled on the liposomal surface by metalloproteinase-2(MMP-2)-sensitive linker.JQ1 inhibited DNA repair to increase DNA damage and immunogenic cell death(ICD)of Oxa,thus promoting T cells intratumoral infiltration.In addition,JQ1 inhibited PD-1/PD-L1 pathway,achieving dual immune checkpoint inhibition combining with Tim-3 mAb,thus effectively promoting T cells priming.It is demonstrated that JOT-Lip not only increased DNA damage and promoted the release of damage-associated molecular patterns(DAMPs),but also enhanced T cells intratumoral infiltration and promoted T cell priming,which successfully converted cold tumors to hot and showed significant anti-tumor and anti-metastasis effects.Collectively,our study provides a rational design of an effective combination regimen and an ideal co-delivery system to convert cold tumors to hot,which holds great potential in clinical cancer chemoimmunotherapy. | Xiaoqing Liu Shuang Liang Xiao Sang Lili Chang Shunli Fu Han Yang Huizhen Yang Yongjun Liu Na Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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