|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 2 | Feedback control for a class of second order hyperbolic distributed parameter systems显示文摘This paper deals with the problem of state feedback control for a class of the distributed parameter systems with the disturbance term. And the considered distributed parameter systems are composed of the second order hyperbolic partial differential equations. Two different classes of restrictions on the disturbance term are given, one is that the disturbance term satisfies the linear growth constraint condition to the state variables of the system, and the other is that the disturbance term obeys the bound constraint under the significance of L_2. Based on a variable structure method, the state feedback controllers are obtained by means of constructing appropriate Lyapunov functional. The closed-loop systems are globally asymptotically stable on W^(1,2)(0, 1) × L_2(0, 1) space under the effect of the state feedback control laws. Simulation results illustrate the effectiveness of the proposed method. | Qin FU Weiguo GU Panpan GU Jianrong WU | 2016 | Science China(Information Sciences)2016，59，9： | 3 |
| 3 | Techno-economic analysis of MJ class high temperature Superconducting Magnetic Energy Storage(SMES) systems applied to renewable power grids显示文摘High temperature Superconducting Magnetic Energy Storage(SMES) systems can exchange energy with substantial renewable power grids in a small period of time with very high efficiency. Because of this distinctive feature, they store the abundant wind power when the power network is congested and release the energy back to the system when there is no congestion. However, considering the cost and lifespan of SMES systems, there is an urgent demand to conduct a cost-benefit analysis to justify its role in smart grid development. This study explores the application and performs economic analysis of a 5 MJ SMES in a practical renewable power system in China based on the PSCAD/EMTDC software. An optimal location of SMES in Zhangbei wind farm is presented using real power transmission parameters. The stabilities of the renewable power grid with and without SMES are discussed. In addition, a financial feasibility study is conducted by comparing the cost and the savings from wind power curtailment of deploying SMES and battery. The economic analysis tries to find the balance between SMES investment cost and wind farm operation cost by using real data over a calendar year. The technical analysis can help guide the optimal allocation of SMES for compensating power system instability with substantial wind power. Further, the economic analysis provides a useful indication of its practical application feasibility to fight the balance between cost and benefit. | Jiahui Zhu Panpan Chen Chenghong Gu Hongjie Zhang Jianwei Li Huiming Zhang Ming Qiu Jianlin Li Weijia Yuan Ignacio Hernando Gil | 2018 | Global Energy Interconnection2018，1，2： | 3 |
| 4 | Iterative learning control approach for consensus of multi-agent systems with regular linear dynamics显示文摘Dear editor,Iterative learning control(ILC)has a wellestablished research history,as shown in[1,2].By generating a correct control signal from the previous control execution,it can achieve perfect tracking performance on a finite time interval.In the process of ILC design,the D-type[1]and P-type learning schemes[2]are often used to obtain good tracking performance and are applied,respectively,to irregular systems(without direct transmission from inputs to outputs)[1]and regular systems(with direct transmission from inputs to outputs)[2]. | Qin FU Panpan GU Xiangdong LI Jianrong WU | 2017 | Science China(Information Sciences)2017，60，7： | 2 |
| 5 | Iterative learning control for one-dimensional fourth order distributed parameter systems显示文摘This paper addresses the problem of iterative learning control algorithm for high order distributed parameter systems in the presence of initial errors. And the considered distributed parameter systems are composed of the one-dimensional fourth order parabolic equations or the one-dimensional fourth order wave equations. According to the characteristics of the systems, iterative learning control laws are proposed for such fourth order distributed parameter systems based on the P-type learning scheme. When the learning scheme is applied to the systems, the output tracking errors on 2L space are bounded, and furthermore, the tracking errors on 2L space can tend to zero along the iteration axis in the absence of initial errors. Simulation examples illustrate the effectiveness of the proposed method. | Qin FU Panpan GU Jianrong WU | 2017 | Science China(Information Sciences)2017，60，1： | 2 |
| 6 | In situ synthesis and unidirectional insertion of membrane proteins in liposome-immobilized silica stationary phase for rapid preparation of microaffinity chromatography显示文摘Cell membrane affinity chromatography has been widely applied in membrane protein(MP)-targeted drug screening and interaction analysis.However,in current methods,the MP sources are derived from cell lines or recombinant protein expression,which are time-consuming for cell culture or purification,and also difficult to ensure the purity and consistent orientation of MPs in the chromatographic stationary phase.In this study,a novel in situ synthesis membrane protein affinity chromatography(iSMAC)method was developed utilizing cell-free protein expression(CFE)and covalent immobilized affinity chromatography,which achieved efficient in situ synthesis and unidirectional insertion of MPs into liposomes in the stationary phase.The advantages of iSMAC are:1)There is no need to culture cells or prepare recombinant proteins;2)Specific and purified MPs with stable and controllable content can be obtained within 2 h;3)MPs maintain the transmembrane structure and a consistent orientation in the chromatographic stationary phase;4)The flexible and personalized construction of cDNAs makes it possible to analyze drug binding sites.iSMAC was successfully applied to screen PDGFRβinhibitors from Salvia miltiorrhiza and Schisandra chinensis.Micro columns prepared by in-situ synthesis maintain satisfactory analysis activity within 72 h.Two new PDGFRβinhibitors,salvianolic acid B and gomisin D,were screened out with KD values of 13.44 and 7.39μmol/L,respectively.In vitro experiments confirmed that the two compounds decreasedα-SMA and collagen Ⅰ mRNA levels raised by TGF-βin HSC-T6 cells through regulating the phosphorylation of p38,AKT and ERK.In vivo,Sal B could also attenuate CCl_(4)-induced liver fibrosis by downregulating PDGFRβdownstream related protein levels.The iSMAC method can be applied to other general MPs,and provides a practical approach for the rapid preparation of MP-immobilized or other biological solid-phase materials. | Yanqiu Gu Rong Wang Panpan Chen Shengnan Li Xinyi Chai Chun Chen Yue Liu Yan Cao Diya Lv Zhanying Hong Zhenyu Zhu Yifeng Chai Yongfang Yuan Xiaofei Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 7 | Closed-Loop Iterative Learning Control for Discrete Singular Systems with Fixed Initial Shift显示文摘This paper deals with the problem of iterative learning control for a class of discrete singular systems with fixed initial shift. According to the characteristics of the discrete singular systems, a closed-loop learning algorithm is proposed and the corresponding state limiting trajectory is presented.It is shown that the algorithm can guarantee that the system state converges uniformly to the state limiting trajectory on the whole time interval. Then the initial rectifying strategy is introduced to the discrete singular systems for eliminating the effect of the fixed initial shift. Under the action of the initial rectifying strategy, the system state can converge to the desired state trajectory within the pre-specified finite time interval no matter what value the fixed initial shift takes. Finally, a numerical example is given to illustrate the effectiveness of the proposed approach. | GU Panpan TIAN Senping LIU Qian | 2019 | Journal of Systems Science & Complexity2019，32，2： | 1 |
| 8 | Synthesis, Cytotoxic Activity Evaluation of Novel 1,2,3-Triazole Linked Quinazoline Derivatives显示文摘一系列新奇 1,2,3-triazole-quinazoline 衍生物在由常规方法从 anthranilamide 开始的五步被综合。所有标题混合物 10a10r 在 vitro 用 MTT 试金与四根人的癌症房间线(MGC-803, EC-109, MCF-7 和 HGC-27 ) 为细胞毒素的活动被作比较。一些对对测试癌症房间线的有势力活动中等的展出的综合混合物。在他们之中,加重 10 h 和 10q 对 HGC-27 展出了优秀生长抑制,化合物 10 m 也对 MCF-7 拥有了优秀活动,与 IC 50 价值不到 1 慥敳漠 ? 桰瑯 ' 仪G矛棖 P 湥牥瑡潩 ? 桴湡 ?? 湚 ? 潭楤楦摥朠慲桰湥 ? 浳潯桴映汩 ?爠獥数瑣癩汥y ??? 幐吗?? | Panpan Song Fei Cui Na Li Jingchao Xin Qisheng Ma Xiangchuan Meng Chaojie Wang Qinpo Cao Yifei Gu Yu Ke Qiurong Zhang Hongmin Liu | 2017 | Chinese Journal of Chemistry2017，35，10： | 1 |
| 9 | Prehistoric damaging earthquake promoted the decline of'Heluo Ancient State'in Early China显示文摘The emergence of the'Ancient State'is considered an important stage in the discourse on human civilizations.Based on its complex and hierarchical social structure,the Shuanghuaishu site of Henan Province is regarded as an'Ancient state',specifically the'Heluo Ancient State'.The site is situated in the middle reaches of the Yellow River region and played a key role in prehistoric China.However,the reasons behind its decline are unclear.Here,we conducted an integrated investigation of the archaeological excavations and archaeoseismic analyses at the Shuanghuaishu site.We identified paleoseismic remains within paleo-artificial moats,which were formed owing to off-fault structures of soil liquefaction,hillslope landslides,and related ground fractures,along with shake-related wall disruption and building collapse in the residential zone.Charcoal dating was conducted to constrain the age for this earthquake event,which was determined to be approximately 5.0 cal kyr BP.Furthermore,based on the practical curve for earthquake-induced liquefaction,the preliminary estimate of the magnitude of this paleo seismic event is greater than M_(s)5.9-6.0.We propose that the Shuanghuaishu site experienced a recession after the earthquake event,which may have influenced the continuous development of the'Heluo Ancient State'as a regional center settlement. | Xiu HU Peng LU Youli LI Duowen MO Wanfa GU Qingri LIU Ailun GUO Panpan CHEN Hui WANG Yan TIAN Xu WANG Yayi HU Jiqin ZHANG Zhen WANG Quanxing LUO Junjie XU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 10 | Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer显示文摘Chemoimmunotherapy has been approved as standard treatment for triple-negative breast cancer(TNBC),but the clinical outcomes remain unsatisfied.Abnormal epigenetic regulation is associated with acquired drug resistance and T cell exhaustion,which is a critical factor for the poor response to chemoimmunotherapy in TNBC.Herein,macrophage-camouflaged nanoinducers co-loaded with paclitaxel(PTX)and decitabine(DAC)(P/D-mMSNs)were prepared in combination with PD-1 blockade therapy,hoping to improve the efficacy of chemoimmunotherapy through the demethylation of tumor tissue.Camouflage of macrophage vesicle confers P/D-mMSNs with tumor-homing properties.First,DAC can achieve demethylation of tumor tissue and enhance the sensitivity of tumor cells to PTX.Subsequently,PTX induces immunogenic death of tumor cells,promotes phagocytosis of dead cells by dendritic cells,and recruits cytotoxic T cells to infiltrate tumors.Finally,DAC reverses T cell depletion and facilitates immune checkpoint blockade therapy.P/D-mMSNs may be a promising candidate for future drug delivery design and cancer combination therapy in TNBC. | Tong Gao Xiao Sang Xinyan Huang Panpan Gu Jie Liu Yongjun Liu Na Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 11 | Correction: Autophagy receptor CCDC50 modulates STING-mediated interferon response in viral infection and autoimmune disease显示文摘Correction to:Cellular&Molecular Immunology http://gffzzd3cc09b8251d45dfsbkunb5b6nckf6bqc.ffgz.tsg.suse.edu.cn/10.1038/s41423-021-00758-w In the version of this article initially published,one unintended error was made during manuscript editing.The title of the article was not in accordance with that of the original manuscript,and the correct statement is“Autophagy receptor CCDC50 modulates STING-mediated interferon response in viral infection and autoimmune disease”.The results and conclusions are not affected. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，12： | 0 |
| 12 | Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion via integrin/ BRAF/TAK1/ERK/ETV4 signaling显示文摘Objective:PD-L1 and PD-L2 expression levels determine immune evasion and the therapeutic efficacy of immune checkpoint blockade.The factors that drive inducible PD-L1 expression have been extensively studied,but mechanisms that result in constitutive PD-L1 expression in cancer cells are largely unknown.Methods:DNA elements were deleted in cells by CRISPR/Cas9-mediated knockout.Protein function was inhibited by chemical inhibitors.Protein levels were examined by Western blot,mRNA levels were examined by real-time RT-PCR,and surface protein expression was determined by cellular immunofluorescence and flow cytometry.Immune evasion was examined by in vitro T cell-mediated killing.Results:We determined the core regions(chr9:5,496,378–5,499,663)of a previously identified PD-L1L2-super-enhancer(SE).Through systematic analysis,we found that the E26 transformation-specific(ETS)variant transcription factor(ETV4)bound to this core DNA region but not to DNA surrounding PD-L1L2SE.Genetic knockout of ETV4 dramatically reduced the expressions of both PD-L1 and PD-L2.ETV4 transcription was dependent on ERK activation,and BRAF/TAK1-induced ERK activation was dependent on extracellular signaling fromαvβ3 integrin,which profoundly affected ETV4 transcription and PD-L1/L2 expression.Genetic silencing or pharmacological inhibition of components of the PD-L1L2-SE-associated pathway rendered cancer cells susceptible to T cell-mediated killing.Conclusions:We identified a pathway originating from the extracellular matrix that signaled via integrin/BRAF/TAK1/ERK/ETV4 to PD-L1L2-SE to induce PD-L1-mediated immune evasion.These results provided new insights into PD-L1L2-SE activation and pathways associated with immune checkpoint regulation in cancer. | Panpan Ma Xinxin Jin Zhiwei Fan Zhou Wang Suhui Yue Changyue Wu Shiyin Chen Yuanyuan Wu Miaomiao Chen Donghua Gu Siliang Zhang Renfang Mao Yihui Fan | 2022 | Cancer Biology & Medicine2022，19，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员