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| 1 | Is new American Thyroid Association risk classification for hereditary medullary thyroid carcinoma applicable to Chinese patients? A single-center study显示文摘Objective: The American Thyroid Association(ATA) proposed a new risk classification for hereditary medullary thyroid carcinoma(MTC) in 2015. This study aimed to assess whether the new guidelines are suitable for the Chinese population, and reported our experience on prophylactic thyroidectomy.Methods: A total of 73 patients from 22 families were screened as rearranged during transfection(RET) mutation carriers from 2010 to 2016 in Cancer Hospital, Chinese Academy of Medical Science; the medical history for each patient was collected. Based on the initial treatment, we identified the risk factors for poor prognosis by univariate and multivariate logistic regression. Then, 4 RET mutation carriers were enrolled for prophylactic thyroidectomy,and their pathological data and follow-up outcomes were recorded.Results: In univariate and multivariate logistic regression analyses, age at initial surgery and risk classification were significant risk factors for stage Ⅲ/Ⅳ hereditary MTC at initial diagnosis. The likelihood was increased by 11.6% per year of age at initial surgery [95% confidence interval(95% CI), 1.040–1.198; P=0.002). It was 7.888 times more likely to have Ⅲ/Ⅳ stage disease for ATA highest risk patients, compared to ATA moderate risk individuals(95% CI, 1.607–38.717; P=0.003). Postoperative pathological results showed all 4 multiple endocrine neoplasia type 2A(MEN2A) patients had C-cell hyperplasia(CCH); multifocal malignancies were detected in 3 of them. All 4 patients were cured biochemically, and none developed permanent hypoparathyroidism.Conclusions: In Chinese individuals, hereditary MTC aggressiveness is in line with the new ATA risk classification. Germline RET gene mutation carriers should undergo prophylactic thyroidectomy according to basal serum calcitonin levels. | Xiwei Zhang Dangui Yan Junyi Wang Hanfeng Wan Yongxia Zhang Yabing Zhang Yuqin He Wensheng Liu Bin Zhang | 2017 | Chinese Journal of Cancer Research2017，29，3： | 5 |
| 2 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 3 | Synthesis and thermal properties of conjugated poly[(silylene)diaeetylene silazanes]显示文摘 | Yan Mei Tan Yongxia Zhang Zhijie | | 0，，11： | 1 |
| 4 | An outbreak of Mycobacterium marinum infection associated with handling seabass in China显示文摘To the Editor:Mycobacterium marinum is a nontuberculous mycobacterium that can cause opportunistic infections in humans,ranging from a single cutaneous lesion to disseminated disease.[1]It was first isolated from a fish in 1926 and identified as a cause of human infection in 1951.[1]The estimated annual incidence ranges from 0.04 to 0.27 per 100,000 persons in different countries.Outbreaks of M.marinum infections related to handling fish are not common,but have also been reported. | Qing Zhao Fangfang Bao Zihao Mi Zhenzhen Wang Pengcheng Huai Qing Pan Zheng Pang Yaoming Li Nan Cao Xiaotong Xue Buyan Li Xuechao Chen Jinliang Wang Yanxia Cui Wenqian Chang Yuan Zhang Zhenhua Yue Yongxia Liu Zhenhua Wang Weiguo Yan Jinyong Li Hongqing Tian Xianmei Lu Guizhi Zhou Jianjun Liu Hong Liu Furen Zhang | 2022 | Chinese Medical Journal2022，135，21： | 1 |
| 5 | TFCP2蛋白为YAP发挥转录依赖性促肝癌效应所必需显示文摘文章简介虽然促癌蛋白YAP依赖性转录与肝癌发生发展密切相关,但YAP维持其促癌功能的分子机制尚未充分阐明。本研究证明TFCP2是YAP依赖性转录促肝癌效应的必需核因子。 | Xiao Zhang Fenyong Sun Yongxia Qiao Weisheng Zheng Ya Liu Yan Chen Qi Wu Xiangfan Liu Guoqing Zhu Yuxin Chen Yongchun Yu 潘秋辉 王佳谊 | 2018 | 科学新闻2018，0，4： | 0 |
| 6 | Solar Array of Shenzhou Spaceship Localized显示文摘The electricity subsystem of the Shenzhou spaceship passed its review last August,which means that all the solar array products including solar array substrate and yoke had passed all verification tests and entered its flight-type development phase.The solar array substrate and yoke are important composite material prod- | YANG Yan YIN Yongxia | 2016 | Aerospace China2016，17，1： | 0 |
| 7 | A pH Sensitive Fluorescence Probe Based on Tricarbocyanine显示文摘Medical imaging technologies consist of X-ray imagingtechnology, computed tomography(CT), positron emissioncomputed tomography(PET), ultrasound imaging(USG), mag-netic resonance imaging(MRI) and optical imaging(OI)ill. Theyplay an increasingly important role in diagnosis of disease anddrag research. | YAN Luomei ZHOU Hua WU Cunqi WANG Lidan YANG Wei JIN Manyu ZHAO Yongxia XU Jingwei | 2016 | Chemical Research in Chinese Universities2016，32，6： | 0 |
| 8 | Recent advances in the syntheses of pyrroles显示文摘The pyrrole moiety is an important structural motif in functional materials,natural products,and pharmaceuticals.More and more synthetic strategies toward pyrroles have emerged,where various efficient building blocks are developed and these synthons enable the syntheses of pyrroles with different numbers of components.However,no review specifically summarizes the syntheses of pyrroles according to the type and number of employed building blocks.To aid researchers to design appropriate substrates for pyrrole synthesis,herein we summarized the advances in pyrrole syntheses and classified these reactions into four categories according to the number of employed components,which may shed light on developing more efficient synthetic methods toward substituted pyrroles. | Tao Shi Gaofeng Yin Xiaodong Wang Yongxia Xiong Yan Peng Shuang Li Yaofu Zeng Zhen Wang | 2023 | Green Synthesis and Catalysis2023，4，1： | 0 |
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