|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Suppression of murine breast cancer metastasis by selective inhibition of CXCR4 by synthetic polypeptide derived from viral macrophage inflammatory protein Ⅱ显示文摘Stromal cell-derived factor-1 and its receptor CXC chemokine receptor-4(CXCR4)have been implicated in breast cancer metastasis.A significant association between HER2 and CXCR4 expression has been observed in human breast tumor tissues,and overexpression of CXCR4 is essential for HER2-mediated tumor metastasis.Moreover,CXCR4 expression is low in normal breast tissues and high in malignant tumors,suggesting that a blockade of CXCR4 may limit tumor metastasis.The present study investigated the action of a synthetic antagonist 21-mer peptide derived from viral macrophage inflammatory protein Ⅱ against CXCR4(NT21MP)in inhibiting metastasis in vitro and in vivo.The results showed that chemotaxis of SKBR3 cells toward SDF-1αwas reduced by NT21MP in a dose-dependent manner(P<0.05).NT21MP inhibited tumor growth at 500μg/kg and in combination with Herceptin,the anti-HER2 antibody.The in vivo metastatic assay showed that NT21MP significantly inhibited pulmonary metastasis,and the number of metastatic tumor nodes on the surface of the lung was greatly decreased.Compared with the saline-treated control group,PCNA expression was dose-dependently decreased by NT21MP,the percentage of apoptotic cells was increased,and CXCR4 mRNA and protein expression were downregulated.In conclusion,NT21MP inhibits cellular proliferation,promotes apoptosis by downregulating CXCR4 expression,and suppresses the progression of primary and metastatic tumors.CXCR4 may be a useful therapeutic target for breast cancer,and NT21MP may serve as a potential target drug for the treatment of breast cancer metastasis. | YANG QingLin DING YongXing CHEN ChangJie TANG Jie ZHANG Ju YANG ZhiFeng | 2010 | Chinese Science Bulletin2010，55，20： | 6 |
| 2 | A New Route for Sol-gel High Refractive Index ZrO2 Coating显示文摘 | Yongxing Tang Congshan Zhu Weiqing Zhang | 1998 | Proc SPIE1998，3175，： | 1 |
| 3 | NMR,IR and Raman Spectra Study of the Stucture of Boroate Glasses显示文摘 | Tang Yongxing Jiang Zhonghong | 1998 | Journal of Non-crystalline Solids1998，231，： | 1 |
| 4 | NMR,IR and Raman Spectra Study of the Structure of Borate and Borosilicate Glasses显示文摘 | Tang Yongxing Jiang Zhonghong | 1989 | Journal of Non-Crystalline Solids1989，112，3： | 1 |
| 5 | Preparation of ultra-broadband antireflective coatings for amplifier blast shields by a sol–gel method显示文摘A type of λ/4–λ/4 ultra-broadband antireflective coating has been developed using modified low refractive silica and high refractive silica layers by a sol–gel dip coating method for amplifier blast shields of the Shen Guang Ⅱ high power laser facility(SG-Ⅱ facility). Deposition of the first layer(high refractive index silica) involves baking at 200℃ in the post-treatment step. The second layer(low refractive index, n = 1.20) uses low refractive index silica sol modified by acid catalysis. Thermal baking at temperatures no less than 500℃ for 60 min offers chemical stability, ethanol scratch resistance, and resistance to washing with water. The average residual reflection of dual-side-coated fused silica glass was less than 1% in the spectral range from 450 to 950 nm. Transmission gain has been evaluated by taking into account angular light, and the results show that the transmission gain increases with increasing light incidence. Even at 60°, the transmission spectrum of the broadband antireflective coating effectively covered the main absorption peak of Nd:glass. | Huai Xiong Bin Shen Zhiya Chen Xu Zhang Haiyuan Li Yongxing Tang Lili Hu | 2017 | High Power Laser Science and Engineering2017，5，4： | 1 |
| 6 | NMR,IR and Raman spectra study of the structure of borate and borosilicate glasses显示文摘 | TANG Yongxing JIANG Zhonghong SONG Xiuyu | 1989 | J Non-Cryst Solids1989，112，： | 1 |
| 7 | NMR,IR and Raman Spectra Study of the Structure of Borate and Borosilicate Glasses显示文摘 | Tang Yongxing Jiang Zhonghong | 1989 | J Non-cryst Solids1989，112，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员