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| 1 | Applications of gold nanorods in biomedical imaging and related fields显示文摘Gold nanorods (GNRs) have great potential widespread applications in biomedical imaging, drug delivery and photothermal therapy due to unique surface plasmon resonance (SPR) ranging from visible to near infrared (NIR) region, facile synthesis and easy functionalization. In this review, the recent progress of GNRs in bioimaging, drug delivery, photothermal therapy and theranostics is summarized and the recommendations for the future work on GNRs are also covered. | MA ZhiYa XIA HongXing LIU YuPing LIU Bo CHEN Wei ZHAO YuanDi | 2013 | Chinese Science Bulletin2013，58，21： | 6 |
| 2 | MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3显示文摘Central precocious puberty(CPP)refers to a human syndrome of early puberty initiation with characteristic increase in hypothalamic production and release of gonadotropin-releasing hormone(GnRH).Previously,loss-of-function mutations in human MKRN3,encoding a putative E3 ubiquitin ligase,were found to contribute to about 30%of cases of familial CPP.MKRN3 was thereby suggested to serve as a‘brake’of mammalian puberty onset,but the underlying mechanisms remain as yet unknown.Here,we report that genetic ablation of Mkrn3 did accelerate mouse puberty onset with increased production of hypothalamic GnRH1.MKRN3 interacts with and ubiquitinates MBD3,which epigenetically silences GNRH1 through disrupting the MBD3 binding to the GNRH1 promoter and recruitment of DNA demethylase TET2.Our findings have thus delineated a molecular mechanism through which the MKRN3-MBD3 axis controls the epigenetic switch in the onset of mammalian puberty. | Chuanyin Li Wenli Lu Liguang Yang Zhengwei Li Xiaoyi Zhou Rong Guo Junqi Wang Zhebao Wu Zhiya Dong Guang Ning Yujiang Shi Yinmin Gu Peng Chen Zijian Hao Tianting Han Meiqiang Yang Wei Wang Xuehui Huang Yixue Li Shan Gao Ronggui Hu | 2020 | National Science Review2020，7，3： | 2 |
| 3 | Preparation of ultra-broadband antireflective coatings for amplifier blast shields by a sol–gel method显示文摘A type of λ/4–λ/4 ultra-broadband antireflective coating has been developed using modified low refractive silica and high refractive silica layers by a sol–gel dip coating method for amplifier blast shields of the Shen Guang Ⅱ high power laser facility(SG-Ⅱ facility). Deposition of the first layer(high refractive index silica) involves baking at 200℃ in the post-treatment step. The second layer(low refractive index, n = 1.20) uses low refractive index silica sol modified by acid catalysis. Thermal baking at temperatures no less than 500℃ for 60 min offers chemical stability, ethanol scratch resistance, and resistance to washing with water. The average residual reflection of dual-side-coated fused silica glass was less than 1% in the spectral range from 450 to 950 nm. Transmission gain has been evaluated by taking into account angular light, and the results show that the transmission gain increases with increasing light incidence. Even at 60°, the transmission spectrum of the broadband antireflective coating effectively covered the main absorption peak of Nd:glass. | Huai Xiong Bin Shen Zhiya Chen Xu Zhang Haiyuan Li Yongxing Tang Lili Hu | 2017 | High Power Laser Science and Engineering2017，5，4： | 1 |
| 4 | Flexible Optimal Model and Algorithm for Track Utilization in High-speed Railway Stations显示文摘Track utilization is the most important technical operation in high-speed railway stations.It is an effective way to take flexible man-agement based on dispatchers’decision preferences into consideration for making track utilization plans to relieve the influence caused by unmeasurable unstructured factors.Thus,based on the flexible management concept and taking the flexible optimal for track utilization in high-speed railway stations as the object,time and space occupation safety trajectories of arrival routes,departure routes and tracks are all analysed.Then,taking the following constraints into consideration-minimum safety time intervals for var-ious routes and tracks occupation,space-time arc occupation and decision-makers’preferences-a flexible optimal model for track utilization in high-speed railway stations is established to maximize its balance and robustness and to minimize its volatility at the same time.Further,a flexible optimal solution based on a simulated annealing algorithm is designed to make a safety track utilization plan in high-speed railway stations integrating the dispatchers’decision preference.The results from the experiments show that the proposed methodology can effectively make satisfied safety track utilization plans based on decision-makers’preferences,which can improve its balance and robustness level significantly.Meanwhile,its volatility can be reduced as much as possible caused by flexible management based on artificial intervention to ensure the relative stability of the plan. | Quan Gao Yinggui Zhang Zhiya Chen Yuan Chen | 2023 | Transportation Safety and Environment2023，5，3： | 0 |
| 5 | Occurrence and risk assessment of typical PPCPs and biodegradation pathway of ribavirin in wastewater treatment plants显示文摘A large number of pharmaceuticals and personal care products(PPCPs)persist in wastewater,and the consumption of PPCPs for COVID-19 control and prevention has sharply increased during the pandemic.This study investigated the occurrence,removal efficiency,and risk assessment of six typical PPCPs commonly used in China in two wastewater treatment plants(WWTPs).Ribavirin(RBV)is an effective pharmaceutical for severely ill patients with COVID-19,and the possible biodegradation pathway of RBV by activated sludge was discovered.The experimental results showed that PPCPs were detected in two WWTPs with a detection rate of 100%and concentrations ranging between 612 and 2323 ng L^(-1).The detection frequency and concentrations of RBV were substantially higher,with a maximum concentration of 314 ng L^(-1).Relatively high pollution loads were found for the following PPCPs from influent:ibuprofen>ranitidine hydrochloride>RBV>ampicillin sodium>clozapine>sulfamethoxazole.The removal efficiency of PPCPs was closely related to adsorption and biodegradation in activated sludge,and the moving bed biofilm reactor(MBBR)had a higher removal capacity than the anoxic-anaerobic-anoxicoxic(AAAO)process.The removal efficiencies of sulfamethoxazole,ampicillin sodium,ibuprofen,and clozapine ranged from 92.21%to 97.86%in MBBR process and were relatively low,from 61.82%to 97.62%in AAAO process,and the removal of RBV and ranitidine hydrochloride were lower than 42.96%in both MBBR and AAAO processes.The discrepancy in removal efficiency is caused by temperature,hydrophilicity,and hydrophobicity of the compound,and acidity and alkalinity.The transformation products of RBV in activated sludge were detected and identified,and the biodegradation process of RBV could be speculated as follows:first breaks into TCONH_(2) and an oxygen-containing five-membered heterocyclic ring under the nucleosidase reaction,and then TCONH_(2) is finally formed into TCOOH through amide hydrolysis.Aquatic ecological risks based on risk quotient(RQ)assessment showed that PPCPs had high and medium risks in the influent,and the RQ values were all reduced after MBBR and AAAO treatment.Ranitidine hydrochloride and clozapine still showed high and medium risks in the effluent,respectively,and thus presented potential risks to the aquatic ecosystem. | Qixin Liu Xuan Feng Ning Chen Fei Shen Haichuan Zhang Shuo Wang Zhiya Sheng Ji Li | 2022 | Environmental Science and Ecotechnology2022，，3： | 0 |
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