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| 1 | Therapeutic management options for stage Ⅲ non-small cell lung cancer显示文摘Lung cancer is the leading cause of cancer death worldwide.Majority of newly diagnosed lung cancers are non-small cell lung cancer(NSCLC), of which up to half are considered locally advanced at the time of diagnosis.Patients with locally advanced stage Ⅲ NSCLC consists of a heterogeneous population, making management for these patients complex.Surgery has long been the preferred local treatment for patients with resectable disease.For select patients, multimodality therapy involving systemic and radiation therapies in addition to surgery improves treatment outcomes compared to surgery alone.For patients with unresectable disease, concurrent chemoradiation is the preferred treatment.More recently, research into different chemotherapy agents, targeted therapies, radiation fractionation schedules, intensity-modulated radiotherapy, and proton therapy have shown promise to improve treatment outcomes and quality of life.The array of treatment approaches for locally advanced NSCLC is large and constantly evolving.An updated review of past and current literature for the roles of surgery, chemotherapeutic agents, radiation therapy, and targeted therapy for stage Ⅲ NSCLC patients are presented. | Stephanie M Yoon Talha Shaikh Mark Hallman | 2017 | World Journal of Clinical Oncology2017，8，1： | 32 |
| 2 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 3 | Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans显示文摘AIM:To assess the risk of biliary and pancreatic cancers in a large cohort of patients with type 2 diabetes mellitus(DM) .METHODS:Eligibility for this study included patients with type 2 DM(ICD-9 code 250.0) who were discharged from Department of Veteran Affairs hospitals between 1990 and 2000.Non-matched control patients without DM were selected from the same patient treatment files during the same period.Demographic information included age,sex and race.Secondary diagnoses included known risk factors based on their ICD-9 codes.By multivariate logistic regression,the occurrence of biliary and pancreatic cancer was compared between case subjects with DM and controls without DM.RESULTS:A total of 1172496 case and control subjects were analyzed.The mean age for study and control subjects was 65.8 ± 11.3 and 64.8 ± 12.6 years,respectively.The frequency of pancreatic cancer in subjects with DM was increased(0.9%) in comparison to control subjects(0.3%) with an OR of 3.22(95% CI:3.03-3.42) .The incidence of gallbladder andextrahepatic biliary cancers was increased by twofold in diabetic patients when compared to controls.The OR and 95% CI were 2.20(1.56-3.00) and 2.10(1.61-2.53) ,respectively.CONCLUSION:Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer. | M Mazen Jamal Eugene J Yoon Kenneth J Vega Mehrtash Hashemzadeh Kenneth J Chang | 2009 | World Journal of Gastroenterology2009，15，42： | 10 |
| 4 | Role of nanotopography in the development of tissue engineered 3D organs and tissues using mesenchymal stem cells显示文摘Recent regenerative medicine and tissue engineering strategies(using cells, scaffolds, medical devices and gene therapy) have led to fascinating progress of translation of basic research towards clinical applications. In the past decade, great deal of research has focused on developing various three dimensional(3D) organs, such as bone, skin, liver, kidney and ear,using such strategies in order to replace or regenerate damaged organs for the purpose of maintaining or restoring organs' functions that may have been lost due to aging, accident or disease. The surface properties of a material or a device are key aspects in determining the success of the implant in biomedicine, as the majority of biological reactions in human body occur on surfaces or interfaces. Furthermore, it has been established in the literature that cell adhesion and proliferation are, to a great extent, influenced by the micro- and nanosurface characteristics of biomaterials and devices. In addition, it has been shown that the functions of stem cells, mesenchymal stem cells in particular, could be regulated through physical interaction with specific nanotopographical cues. Therefore, guided stem cell proliferation, differentiation and function are of great importance in the regeneration of 3D tissues and organs using tissue engineering strategies. This review will provide an update on the impact of nanotopography on mesenchymal stem cells for the purpose of developing laboratory-based 3D organs and tissues, as well as the most recent research and case studies on this topic. | Shima Salmasi Deepak M Kalaskar Wai-Weng Yoon Gordon W Blunn Alexander M Seifalian | 2015 | World Journal of Stem Cells2015，7，2： | 4 |
| 5 | Evaluation of an erosion-sediment transport model for a hillslope using laboratory flume data显示文摘Climate change can escalate rainfall intensity and cause further increase in sediment transport in arid lands which in turn can adversely affect water quality. Hence, there is a strong need to predict the fate of sediments in order to provide measures for sound erosion control and water quality management. The presence of microtopography on hillslopes influences processes of runoff generation and erosion, which should be taken into account to achieve more accurate modelling results. This study presents a physically based mathematical model for erosion and sediment transport coupled to one-dimensional overland flow equations that simulate rainfall-runoff generation on the rill and interrill areas of a bare hillslope. Modelling effort at such a fine resolution considering the flow connection between interrill areas and rills is rarely verified. The developed model was applied on a set of data gathered from an experimental setup where a 650 cm×136 cm erosion flume was pre-formed with a longitudinal rill and interrill having a plane geometry and was equipped with a rainfall simulator that reproduces natural rainfall characteristics. The flume can be given both longitudinal and lateral slope directions. For calibration and validation, the model was applied on the experimental results obtained from the setup of the flume having 5% lateral and 10% longitudinal slope directions under rainfall intensities of 105 and 45 mm/h, respectively. Calibration showed that the model was able to produce good results based on the R2(0.84) and NSE(0.80) values. The model performance was further tested through validation which also produced good statistics(R2=0.83, NSE=0.72). Results in terms of the sedigraphs, cumulative mass curves and performance statistics suggest that the model can be a useful and an important step towards verifying and improving mathematical models of erosion and sediment transport. | Anya Catherine CARGUELLES MinJae JUNG Kristine Joy BMALLARI GiJung PAK Hafzullah AKSOY Levent M KAVVAS Ebru ERIS JaeYoung YOON YoungJoon LEE SeonHwa HONG | 2014 | Journal of Arid Land2014，6，6： | 3 |
| 6 | Pediatric Nd:YAG laser capsulotomy in the operating room: review of 87 cases显示文摘AIM: To report a large series of children having Nd:YAG laser capsulotomy in the operating room using the lateral decubitus position. METHODS: Medical records of children who underwent Nd:YAG laser capsulotomy in the operating room at Ann & Robert H. Lurie Children's Hospital of Chicago between September 2008 and April 2017 were reviewed. Induction of general anesthesia and intubation was performed in the supine position after which the patient was placed in lateral decubitus position. The Nd:YAG laser capsulotomy was performed using a standard protocol. At the completion of the procedure, the patient was turned back into the supine position and extubated. RESULTS: This study included 87 eyes of 60 patients. Patient's age ranged from 1 to 18 y(mean 6.4±4.1 y). In most cases(84/87, 97%), the procedure was performed under general anesthesia. In all cases, good focus on the membrane was achieved, and the procedure was performed successfully. There were no intraoperative ocular or anesthesia-related complications. CONCLUSION: When performing Nd:YAG laser capsulotomy in the operating room, the lateral decubitus position allowsan easy and safe approach without the risk of potentially devastating complications that have been associated with the previously described sitting and prone positions. | Michael Kinori Narasimhan Jagannathan Anne M Langguth Marjorie A Sasso Marilyn B Mets Bahram Rahmani Hawke Yoon Rebecca Mets-Halgrimson Sudhi P Kurup Janice L Zeid | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 7 | Continuous HMM applied to quantization of on - line Korean character spaces显示文摘 | JUNG K C YOON S M KIM H J | 2000 | Pattern Recognition Letters2000，21，： | 2 |
| 8 | Activation of Toll - like receptor 4 is associated with insulin resistance in adipocytes显示文摘 | Song M J Kim KH Yoon JM | 2006 | Biochem Biophys Res Commun2006，346，3： | 1 |
| 9 | MOS characteristics of ultrathin NO-grown oxynitrides显示文摘 | BHAT M KIM J YOON G W | 1994 | IEEE Trans Elec Dev1994，15，10： | 1 |
| 10 | Dispersion polymerization of acrylamide with quaternary ammonium cationic comonomer in aqueous solution显示文摘 | Song B K Cho M S Yoon K J | 2003 | J Appl Polym Sci2003，87，： | 1 |
| 11 | Anaerobic and aerobic degradation of pyridine by a newly isolated denitrifying bacterium 显示文摘 | Rhee S K Lee G M Yoon J H | 1997 | Appl Environ Microb1997，63，7： | 1 |
| 12 | An engine-,control-unit-in-the-loop simulator of a comnlon-rail diesel engine for cylinder-pressure-based control显示文摘 | Yoon M Chung N H Lee M W | 2009 | Proceedings of the Institution of Mechanical Engineers Part D :Journal of Automobile Engineering2009，223，3： | 1 |
| 13 | Microemulsion templated synthesis of carbon nanotube-supported Pd and Rh nanoparticles for ca- talytic applications显示文摘 | Yoon B Wai C M | 2005 | J Am Chem Soc2005，127，17： | 1 |
| 14 | Effect of water content on transient nonequilibrium NAPL-gas mass transfer during soil vapor extraction显示文摘 | Yoon H K Kim J H Liljestrand H M | 2002 | Journal of ContaminantHydrology2002，54，12： | 1 |
| 15 | 显示文摘 | Kim S J Yoon S G Lee S M | 2003 | Sensors and Actuators B: Chemical2003，96，12： | 1 |
| 16 | Analytical inverse kinematic computation for 7-DOF redundant manipulators with joint limits and its application to redundancy resolution显示文摘 | Shimizu M Kakuya H Yoon W K | 2008 | IEEE Transactions on Robotics2008，24，5： | 1 |
| 17 | Ion distributions near a liquid-liquid interface显示文摘 | Luo G M Malkova S Yoon J | 2006 | Science2006，311，5758： | 1 |
| 18 | Gastric schwannoma 显示文摘 | Yoon HY Kim CB Lee YH et M | 2008 | Yonsei Med J2008，49，6： | 1 |
| 19 | X-band TM01-TEn mode converter with short length for high power显示文摘 | Lee B M Lee W S Yoon Y J | 2004 | Electronics Letters2004，40，18： | 1 |
| 20 | 查看详情显示文摘 | Maeng Y J Yoon B S Suh M H Im W B Lee S H | | 0，，： | 1 |
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