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| 1 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 2 | Reprogramming fibroblasts into induced pluripotent stem cells with Bmil显示文摘 | Jai-Hee Moon June Seok Heo Jun Sung Kim Eun Kyoung Jun Jung Han Lee Aeree Kim Jonggun Kim Kwang Youn Whang Yong-Kook Kang Seungeun Yeo Hee-Joung Lim Dong Wook Han Dong-Wook Kim Sejong Oh Byung Sun Yoon Hans R Scholet Seungkwon You | 2011 | Cell Research2011，21，9： | 6 |
| 3 | Single-nucleotide polymorphisms of the interleukin-18 gene promoter region in rheumatoid arthritis patients: protective effect of AA genotype 显示文摘 | Sivalingam S P Yoon K H Koh D R | 2003 | Tissue Antigens2003，62，6： | 1 |
| 4 | Tribological properties of biomimetic nano- patterned polymeric surfaces on silicon wafer 显示文摘 | Yoon E S Singh R A Kong H | 2006 | Tribology Letter2006，21，： | 1 |
| 5 | The extracellular signal -regulated kinase:multiple substrates regulate diverse cellular functions显示文摘 | Yoon S Seger R | 2006 | Growth Factors2006，24，1： | 1 |
| 6 | N-doping of graphene through electrothermal reactions with Ammonia 显示文摘 | WANG X R LI X L YOON Y K | 2010 | Science2010，324，： | 1 |
| 7 | Association of oligohy-dramnios in women with preterm premature rupture of mem- branes with an inflammatory response in fetal amniotic and maternal compartments 显示文摘 | Yoon BH Kim YA Romero R | 2009 | Am J Obstet Gynecol2009，181，4： | 1 |
| 8 | Sanjoinine A isolated from Semen Zizyphi Spinosi protects against kainic acid-induced convulsions显示文摘 | Yoon S R Jo Y J Yang S | | 0，，11： | 1 |
| 9 | Desmoplastic small round cell tumor: a potentially lethal neoplasm manifesting in the orbit with associated visual symptons 显示文摘 | Yoon M Desai K Fulton R | 2005 | Arch Ophthalmol2005，123，4： | 1 |
| 10 | Polymer matrix degradation and color or formation in melt processed nylon6 /clay nanocomposites显示文摘 | Fornes T D Yoon P J Paul D R | 2003 | Polymer2003，44，24： | 1 |
| 11 | Biomimetics in tribology - recent developments 显示文摘 | Singh R A Yoon E S | 2008 | Journal of Korean Physical Society2008，52，： | 1 |
| 12 | The relationship among inflammatory lesions of the umbilical cord( funisitis), umbilical cord plasma interleukin-6 concentration, amniotic fluid infection , and neonatal sepsis 显示文摘 | Yoon BH Romero R Park JS | 2000 | Am J Obstet Gynecol2000，183，5： | 1 |
| 13 | Amniotic fluid cytokines ( interleukin-6, tumor necrosis factoralpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia显示文摘 | Yoon BH Romero R Jun JK Park KH Park JD Ghezzi F | 1997 | Am J Obstet Gynecol1997，177，4： | 1 |
| 14 | Population- based study of the prevalence of family history of cancer: Implications for cancer screening and prevention显示文摘 | Ramsey SD Yoon P Moonesinghe R | 2006 | Genet Med2006，8，9： | 1 |
| 15 | Monoclonal anti- body analysis of Porcine Reproductive and Respiratory Syn- drome virus epitopes associated with antibody-dependent en- hancement and neutralization of virus infection显示文摘 | Caneel-Tirado S M Evans R 13 Yoon K J | 2004 | Vet Im- munol Immunopathol2004，1023，8： | 1 |
| 16 | The extracellular signal-regulated kinase : multiple substrates regulate diverse cellular fuctions 显示文摘 | Yoon S Seger R | 2006 | Growth Factors2006，24，： | 1 |
| 17 | Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions显示文摘 | Yoon SS Coakley R Lau GW | 2006 | J Clin Invest2006，116，： | 1 |
| 18 | Local damage detection using the two-dimensional gapped smoothing method显示文摘 | Yoon M K Heider D Gillespie J W Ratcliffe C P Crane R M | 2005 | Journal of Sound and Vibration2005，279，12： | 1 |
| 19 | An examination of the role of plasma treatment for lean NOx reduction over sodi um zeolite Y and gamma alumina part 1 : plasma assisted NOx reduction over NaY and Al2O3显示文摘 | Yoon S Panov A G Tonkyn R G | 2002 | Catal Today2002，72，34： | 1 |
| 20 | Ultrasensitive detection of bacteria using core-shell nanoparticles and an NMR-filter system显示文摘 | Lee H Yoon T J Weissleder R | 2009 | Angew Chem Int Ed Engl2009，48，31： | 1 |
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