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您的检索式：作者名="Yossi Weizmann"
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| 1 | Magnetically Amplified DNA Assays (MADA):Sensing of Viral DNA and Single - Base Mismatches by Using Nucleic Acid Modified Magnetic Particles 显示文摘 | Fernando Patolsky Yossi Weizmann Eugenii Katz | 2003 | Angewandte Chemie International Edition2003，42，21： | 1 |
| 2 | Intelligent bio-assembly imaging-guided platform for real-time bacteria sterilizing and infectious therapy显示文摘Bacterial infection is rising as a threatening health issue.Because of the present delay in early diagnosis of bacterial diseases as well as the abuse of antibiotics,it has become a vital issue in the development of in-time detection and therapy of bacterial infections.Herein,we designed a multifunctional nanotheranostics platform based on the unique micro-environment of bacterial infections to achieve specific bioimaging and simultaneous inactivation of the target bacteria.We showed that in bacterial infections,the metal precursors(i.e.,HAuCl_(4),FeCl_(2),and herring sperm DNA)could be readily bio-self-assembled to multifunctional nanoclusters(NCs)that exhibit luminescence,in which AuCl_(4)-was biosynthesized via reductive biomolecules such as NADPH to the fluorescent AuNCs.The DNA may assist as an encapsulation and delivery vector,and Fe^(2+)served as a fluorescence intensifier and reduced reactive oxygen species(ROS)to produce the iron oxides.While the bacteria were being visualized,the microenvironment-responsive NCs were enabled to sterilize bacteria efficiently due to electrostatic effect,cell membrane destruction,inhibition of biofilm formation,and ROS accumulation.Besides,the bio-responsive self-assembled NCs complexes contributed to accelerating bacteria-infected wound healing and showed negligible side effects in long-term toxicity tests in vivo.Also,intracellular molecules involved in microenvironmental response were investigated.The work may become an effective strategy for the detection and real-time sterilization of intractable bacterial infections. | Jiayu Zeng Zengchao Guo Yihan Wang Zhaojian Qin Yi Ma Hui Jiang Yossi Weizmann Xuemei Wang | 2022 | Nano Research2022，15，5： | 0 |
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