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| 1 | Human umbilical cord mesenchymal stem cell-loaded amniotic membrane for the repair of radial nerve injury显示文摘In this study,we loaded human umbilical cord mesenchymal stem cells onto human amniotic membrane with epithelial cells to prepare nerve conduits,i.e.,a relatively closed nerve regeneration chamber.After neurolysis,the injured radial nerve was enwrapped with the prepared nerve conduit,which was fixed to the epineurium by sutures,with the cell on the inner surface of the conduit.Simultaneously,a 1.0 mL aliquot of human umbilical cord mesenchymal stem cell suspension was injected into the distal and proximal ends of the injured radial nerve with 1.0 cm intervals.A total of1.75×107cells were seeded on the amniotic membrane.In the control group,patients received only neurolysis.At 12 weeks after cell transplantation,more than 80%of patients exhibited obvious improvements in muscular strength,and touch and pain sensations.In contrast,these improvements were observed only in 55–65%of control patients.At 8 and 12 weeks,muscular electrophysiological function in the region dominated by the injured radial nerve was significantly better in the transplantation group than the control group.After cell transplantation,no immunological rejections were observed.These findings suggest that human umbilical cord mesenchymal stem cell-loaded amniotic membrane can be used for the repair of radial nerve injury. | Zhi Li Hanjiao Qin Zishan Feng Wei Liu Ye Zhou Lifeng Yang Wei Zhao Youjun Li | 2013 | Neural Regeneration Research2013，8，36： | 13 |
| 2 | Effects of different forms of yeast Saccharomyces cerevisiae on growth performance,intestinal development,and systemic immunity in early-weaned piglets显示文摘The present study was conducted to determine effects of different forms of yeast(Saccharomyces cerevisiae,strain Y200007) on the growth performance,intestinal development,and systemic immunity in early-weaned piglets.A total of 96 piglets(14-d old,initial average body weight of 4.5 kg) were assigned to 4 dietary treatments:(1) basal diet without yeast(Control);(2) basal diet supplemented with 3.00 g/kg live yeast(LY);(3) basal diet supplemented with 2.66 g/kg heat-killed whole yeast(HKY);and(4) basal diet supplemented with 3.00 g/kg superfine yeast powders(SFY).Diets and water were provided ad libitum to the piglets during 3-week experiment.Growth performance of piglets was measured weekly.Samples of blood and small intestine were collected at days 7 and 21 of experiment.Dietary supplementation with LY and SFY improved G:F of piglets at days 1-21 of the experiment(P<0.05) compared to Control group.Serum concentrations of growth hormone(GH),triiodothyronine(T_3),tetraiodothyronine(T_4),and insulin growth factor 1(IGF-1) in piglets at day 21 of the experiment were higher when fed diets supplemented with LY and SFY than those in Control group(P < 0.05).Compared to Control group,contents of serum urea nitrogen of piglets were reduced by the 3 yeast-supplemented diets(P< 0.05).Diets supplemented with LY increased villus height and villus-to-crypt ratio in duodenum and jejunum of piglets(P < 0.05) compared to other two groups at day 7 of the experiment.Feeding diets supplemented with LY and SFY increased(P< 0.05) serum concentrations of IgA,IL-2,and IL-6 levels in piglets compared to Control.The CD4^+/CD8^+ ratio and proliferation of T-lymphocytes in piglets fed diets supplemented with LY were increased compared to that of Control group at day 7 of the experiment(P < 0.05).In conclusion,dietary supplementation with both LY and SFY enhanced feed conversion,small intestinal development,and systemic immunity in early-weaned piglets,with better improvement in feed conversion by dietary supplementation with LY,while dietary supplementation with SFY was more effective in increasing systemic immune functions in early-weaned piglets. | Zongyong Jiang Shaoyong Wei Zhilin Wang Cui Zhu Shenglan Hu Chuntian Zheng Zhuang Chen Youjun Hu Li Wang Xianyong Ma Xuefen Yang | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 13 |
| 3 | Mechanism of lead immobilization by oxalic acid-activated phosphate rocks显示文摘Lead (Pb) chemical fixation is an important environmental aspect for human health. Phosphate rocks (PRs) were utilized as an adsorbent to remove Pb from aqueous solution. Raw PRs and oxalic acid-activated PRs (APRs) were used to investigate the effect of chemical modification on the Pb-binding capacity in the pH range 2.0-5.0. The Pb adsorption rate of all treatments above pH 3.0 reached 90%. The Pb binding on PRs and APRs was pH-independent, except at pH 2.0 in activated treatments. The X-ray diffraction analysis confirmed that the raw PRs formed cerussite after reacting with the Pb solution, whereas the APRs formed pyromorphite. The Fourier Transform Infrared spectroscopy analysis indicated that carbonate (CO32-) in raw PRs and phosphate (PO43-) groups in APRs played an important role in the Pb-binding process. After adsorption, anomalous block-shaped particles were observed by scanning electron microscopy with energy dispersive spectroscopy. The X-ray photoelectron spectroscopy data further indicated that both chemical and physical reactions occurred during the adsorption process according to the binding energy. Because of lower solubility of pyromorphite compared to cerussite, the APRs are more effective in immobilizing Pb than that of PRs. | Guanjie Jiang Yonghong Liu Li Huang Qingling Fu Youjun Deng Hongqing Hu | 2012 | Journal of Environmental Sciences2012，24，5： | 12 |
| 4 | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway显示文摘 | Youjun Li Hao Zhou Fengzhi Li Siew Wee Chan Zhijie Lin Zhiyi Wei Zhou Yang Fusheng Guo Chun Jye Lim Wancai Xing Yuequan Shen Wanjin Hong Jiafu Long Mingjie Zhang | 2015 | Cell Research2015，25，7： | 9 |
| 5 | Evolution and molecular epidemiology of foot-and-mouth disease virus in China显示文摘Foot-and-mouth disease (FMD),caused by foot-and-mouth disease virus (FMDV),is considered one of the most important viral diseases of cloven-hoofed animals,causing severe economic losses in affected regions of the world.Three serotypes (A,O,and Asia 1) of FMDV have been identified in China since 1958.In addition,the occurrence of novel subtypes within these serotypes has made the epidemiology of FMDV more complicated over the last few years.In this review,we summarize the history and the current epidemiological situation in China,genetic diversity (e.g.,quasispecies dynamics,antigenic heterogeneity,and functional constraints),intertypic recombination,and the evidence for positive selection of different FMDV serotypes.We also assess these genetic data to understand the origin,evolution,and transmission of FMDV,the findings of which may be useful in developing control measures for future epidemics. | BAI XingWen LI PingHua BAO HuiFang LIU ZaiXin LI Dong LU ZengJun CAO YiMei SHANG YouJun SHAO JunJun CHANG HuiYun LUO JianXun LIU XiangTao | 2011 | Chinese Science Bulletin2011，56，21： | 7 |
| 6 | A genome-wide analysis of SWEET gene family in cotton and their expressions under different stresses显示文摘Background: The SWEET(Sugars will eventually be exported transporters) gene family plays multiple roles in plant physiological activities and development process. It participates in reproductive development and in the process of sugar transport and absorption, plant senescence and stress responses and plant-pathogen interaction. However,thecomprehensive analysis of SWEET genes has not been reported in cotton.Results: In this study, we identified 22, 31, 55 and 60 SWEET genes from the sequenced genomes of Gossypium arboreum, G. raimondii, G. hirsutum and G. barbadense, respectively. Phylogenetic tree analysis showed that the SWEET genes could be divided into four groups, which were further classified into 14 sub-clades. Further analysis of chromosomal location, synteny analysis and gene duplication suggested that the orthologs showed a good collinearity and segmental duplication events played a crucial role in the expansion of the family in cotton. Specific MtN3_slv domains were highly conserved between Arobidopsis and cotton by exon-intron organization and motif analysis. In addition, the expression pattern in different tissues indicated that the duplicated genes in cotton might have acquired new functions as a result of sub-functionalization or neo-funtionalization. The expression pattern of SWEET genes showed that the different genes were induced by diverse stresses. The identification and functional analysis of SWEET genes in cotton may provide more candidate genes for genetic modification.Conclusion: SWEET genes were classified into four clades in cotton. The expression patterns suggested that the duplicated genes might have experienced a functional divergence. This work provides insights into the evolution of SWEET genes and more candidates for specific genetic modification, which will be useful in future research. | ZHAO Lanjie YAO Jinbo CHEN Wei LI Yan L Youjun GUO Yan WANG Junyi YUAN Li LIU Ziyang ZHANG Yongshan | 2018 | Journal of Cotton Research2018，1，2： | 6 |
| 7 | Cyclone separation in a supercritical water circulating fluidized bed reactor for coallbiomass gasification: Structural design and numerical analysis显示文摘 | Guoxing Li Youjun Lu | 2018 | Particuology2018，16，4： | 6 |
| 8 | Effects of soil nutrients and climate factors on belowground biomass in an alpine meadow in the source region of the Yangtze-Yellow rivers, Tibetan Plateau of China显示文摘Improving our knowledge of the effects of environmental factors(e.g.soil conditions,precipitation and temperature) on belowground biomass in an alpine grassland is essential for understanding the consequences of carbon storage in this biome.The object of this study is to investigate the relative importance of soil nutrients and climate factors on belowground biomass in an alpine meadow in the source region of the Yangtze and Yellow rivers,Tibetan Plateau.Soil organic carbon(SOC),total nitrogen(TN) and total phosphorous(TP) contents and belowground biomass were measured at 22 sampling sites across an alpine meadow on the Tibetan Plateau.We analyzed the data by using the redundancy analysis to determine the main environmental factors affecting the belowground biomass and the contribution of each factor.The results showed that SOC,TN and TP were the main factors that influenced belowground biomass,and the contribution of SOC,TN and TP on biomass was in the range of 47.87%–72.06% at soil depths of 0–30 cm.Moreover,the combined contribution of annual mean temperature(AMT) and mean annual precipitation(MAP) on belowground biomass ranged from 0.92% to 4.10%.A potential mechanism for the differences in belowground biomass was caused by the variations in soil nitrogen and phosphorous,which were coupled with SOC.A significant correlation was observed between MAP and soil nutrients(SOC,TN and TP) at the soil depth of 0–10 cm(P<0.05).We concluded that precipitation is an important driving force in regulating ecosystem functioning as reflected in variations of soil nutrients(SOC,TN and TP) and dynamics of belowground biomass in alpine grassland ecosystems. | WANG Haiming SUN Jian LI Weipeng WU Jianbo CHEN Youjun LIU Wenhui | 2016 | Journal of Arid Land2016，8，6： | 5 |
| 9 | Unexpected complexity of multidrug resistance in the mcr-1-harbouring Escherichia coli显示文摘Dear Editor,The discovery that the mobile colistin resistance gene(mcr-1)is encoded by plasmids and is prevalent in food animals and human beings worldwide(Hasman et al.,2015;Liu et al.,2015)has challenged greatly our traditional idea that polymyxin(consisting of two isoforms:polymyxin B and polymyxin E(colistin))acts as an ultimate line of refuge in the clinical treatment against the severe infections by the multidrug-resistant Gram-negative pathogens(Nation et al.,2015;Paterson and Harris,2015).To make | Rongsui Gao Yue Li Jingxia Lin Chen Tan Youjun Feng | 2016 | Science China(Life Sciences)2016，59，7： | 5 |
| 10 | Field Experiments of Multi-Channel Oceanographic Fluorescence Lidar for Oil Spill and Chlorophyll-a Detection显示文摘A Multi-channel Oceanographic Fluorescence Lidar(MOFL), with a UV excitation at 355 nm and multiple receiving channels at typical wavelengths of fluorescence from oil spills and chlorophyll-a(Chl-a), has been developed using the Laser- induced Fluorescence(LIF) technique. The sketch of the MOFL system equipped with a compact multi-channel photomultiplier tube(MPMT) is introduced in the paper. The methods of differentiating the oil fluorescence from the background water fluorescence and evaluating the Chl-a concentration are described. Two field experiments were carried out to investigate the field performance of the system, i.e., an experiment in coastal areas for oil pollution detection and an experiment over the Yellow Sea for Chl-a monitoring. In the coastal experiment, several oil samples and other fluorescence substances were used to analyze the fluorescence spectral characteristics for oil identification, and to estimate the thickness of oil films at the water surface. The experiment shows that both the spectral shape of fluorescence induced from surface water and the intensity ratio of two channels(I495/I405) are essential to determine oil-spill occurrence. In the airborne experiment, MOFL was applied to measure relative Chl-a concentrations in the upper layer of the ocean. A comparison of relative Chl-a concentration measurements by MOFL and the Moderate Resolution Imaging Spectroradiometer(MODIS) indicates that the two datasets are in good agreement. The results show that the MOFL system is capable of monitoring oil spills and Chl-a in the upper layer of ocean water. | LI Xiaolong ZHAO Chaofang MA Youjun LIU Zhishen | 2014 | Journal of Ocean University of China2014，13，4： | 5 |
| 11 | Global Planted Forest Development: Opportunities,Challenges and Policy Choices显示文摘In recent decades, there has seen a dramatic expansion of global planted forest area and their great impact on human life. It is reported in Forest Resource Assessment 2010 that the current area of global planted forests is about 264 million ha, representing only 7% of the total forest area but able to meet the two thirds of the global demand for logs. Planted forests can not only provide timber, fiber, fuel and non-wood forest products, but also contribute to carbon sequestration, restoration of degraded land, landscape rehabilitation and watershed protection. Besides, planted forests can also provide the recreation and amusement for people. In such sense, in the coming decades, planted forests, driven by various factors such as social- economic conditions, market, consumers' demand and new technologies, will have good opportunities for development, and will also increase their contribution to achieving the series of development objectives worldwide. In the meanwhile, the development of planted forests is also constrained by the factors like policies, laws, regulations, technologies and funds, and therefore faced with the challenges in terms of eco- environment preservation, economic development and protection of community interests. Based on the long- term monitoring and research of planted forest development as well as the field study of planted forests abroad, the paper identified the opportunities and challenges in the development of global planted forests through such methods as the SWOT, policy analysis and the others, and proposed the policy choices for promoting the sustainable development of planted forests: 1) There is a need to further understand the functions of planted forests and the importance of the degraded land restoration; 2) A good institutional guarantee and investment environment should be created for the planted forest development; 3) The advanced concepts and methods in terms of the planted forests management should be actively promoted and applied; 4) There is a need to put more focus on environment management and social responsibility; 5) The intensive management of planted forests needs to rely on science and technology support; 6) The international cooperation should be strengthened to jointly facilitate the sustainable development of planted forests. | HE Youjun CHEN Jie LI Zhiyong Research Institute of Forestry Policy and Information, Chinese Academy of Forestry, Beijing 100091,P.R. China | 2010 | Chinese Forestry Science and Technology2010，9，2： | 4 |
| 12 | Methylation of RAR-β2, RASSF1A, and CDKN2A Genes Induced by Nickel Subsulfide and Nickel-carcinogenesis in Rats显示文摘Objective To investigate the expression variation of RAR‐β2, RASSF1A, and CDKN2A gene in the process of nickel‐induced carcinogenesis. Methods Nickel subsulfide (Ni 3 S 2 ) at dose of 10 mg was given to Wistar rats by intramuscular injection. The mRNA expression of the three genes in induced tumors and their lung metastasis were examined by Real‐time PCR. The methylation status of the 5' region of these genes were detected by Quantitative Real‐time methylation specific PCR. Results The mRNA expressions of the three genes both in muscle and lung tumor were decreased distinctly in comparison with normal tissue. But hypermethylation was found only in muscle tumor. Conclusion These findings suggest that loss of function or decrease of RAR‐β2, RASSF1A, and CDKN2A, as well as the hypermethylation of 5' region of these genes, are related with nickel exposure. | ZHANG Jun ZHANG Jing LI MengJie Wu YouJun FAN YingYing ZHOU Yang TAN LiLi SHAO ZhiHua SHI HongJun | 2011 | Biomedical and Environmental Sciences2011，24，2： | 4 |
| 13 | Image of Landscapes in Ancient Water Towns——Case Study on Zhouzhuang and Tongli of Jiangsu Province显示文摘Researchers in several disciplines and fields agree that the image establishing has both perceptual and affec-tive evaluations.The paper comparatively analyzes the image of landscapes in ancient water towns held by 1619 tourists after the investigations of Zhouzhuang and Tongli of Jiangsu Province.Based on the elements of the image of urban landscapes,the perceptual/cognitive image of tourist landscapes in water towns is developed including path,node,landmark,important courtyard,district and edge.Particularly the important courtyard plays the great role on the per-ceptive image of tourists,however,the perceptual/cognitive images of the district and the edge are obviously weak.Meanwhile,the finding showed that the affective images of tourist landscapes in Zhouzhuang differ with those of Tongli by the method of paired comparison.The main reason is that the affective images are influenced by the impressive scenery spots.Furthermore,the commercialization of streets and pollution of rivers are easy to be functioned negatively. | LI Yabing ZHANG Jie CHEN Youjun | 2006 | Chinese Geographical Science2006，16，4： | 4 |
| 14 | New evidence for the origin of natural gas in Ordos Basin from hydrocarbons of oil water显示文摘The chief aim of the present work is to investigate the controversy origin of natural gas in the Ordos Basin by using the hydrocarbons of oil water. New evidence has been found: There is relatively high content of light hydrocarbons and low content of heavy components in the hydrocarbons fraction of oil water in the middle gas field of the Majiagou Formation, Ordovician reservoir. The hydrocarbons of oil water in Well Shan 12 and Well Shan 78 have relatively high abundance of tricyclic terpane. Tricyclic ter-pane/hopane of the two samples are 1.48 and 0.36, respectively. They also show that pregnane and hompregnane are in relatively high abundance with lower hopane/sterane ratio. Pr/Ph is less than 2.0. These characteristics reflected the source input of marine carbonate sedimentary environment. In contrast, the hydrocarbon of Well Shan 81 is lack of tricyclic terpane series and pregnane. It has a high hopane/sterane ratio and Pr/Ph is 3.27. These parameters are typical character of terrestrial organic | Dujie Hou Xianqing Li Youjun Tang | 2002 | Chinese Science Bulletin2002，47，10： | 4 |
| 15 | Effect of pyrophosphate on the light scatter in KDP crystal显示文摘Pyrophosphate doped potassium dihydrogen phosphate (KDP) crystal was grown from aqueous solution by the temperature lowering method. Light scatter in KDP crystal was detected with the ultramicroscopic method. The light scatter in KDP crystal was aggravated when pyro-phosphate was doped into the growth solution, which was distributed ununiformly in prism and pyramidal sectors of KDP crystal. Different effects of pyrophosphate on prism and pyramidal sectors of KDP crystal can explain this case. The transmission in this crystal was measured, showing that pyrophosphate affects the transmission evidently. | Xun Sun Xinguang Xu Youjun Fu Shenglai Wang Hong Zeng Yiping Li Zhangshou Gao | 2001 | Chinese Science Bulletin2001，46，5： | 3 |
| 16 | Influence of metal ions on sulfonamide antibiotics biochemical behavior in fiber coexisting system显示文摘Metal ions and fiber are common compounds in the livestock and poultry manure,which will affect the fate of organic compounds in aqueous environment. However,limited research has addressed the effect of coexisting metal ions and fiber on the biodegradation of sulfonamide antibiotics. Accordingly, a compositing study was performed to assess the effect of metal ions(Fe3+and Cu2+) on the biodegradation of sulfadimethoxine sodium salt(SDM) in the presence of fiber. The enhanced adsorption of SDM onto fiber in the presence of metal ions can be attributed to the π+–π electron donor acceptor(EDA) interaction. The microbial(Phanerochaete chrysosprium) could easily attach onto fiber forming attached microbial, and the degradation rates of SDM of immobilized bacteria in the presence of Fe3 +were 100%, which were significantly higher than those of free bacteria(45%). This study indicates that Fe3 +and fiber could enhance the biodegradation of SDM. Fiber acts as adsorbent, carrier, and substrate which enhanced the removal of SDM. | Lan Zhang Ruihuan Chen Yun Liu Youjun Deng Zhongpei Li Yuanhua Dong | 2019 | Journal of Environmental Sciences2019，31，6： | 3 |
| 17 | Diversified variants of the mcr-1-carrying plasmid reservoir in the swine lung microbiota显示文摘Dear Editor,Emergence of bacteria with multiple drug resistance is a major problem in global public health.Polymyxin comprising polymyxin E(colistin)and polymyxin B is generally recognized as the last-resort antibiotics with | Zhencui Li Chen Tan Jingxia Lin Youjun Feng | 2016 | Science China(Life Sciences)2016，59，9： | 3 |
| 18 | Discovery of multi-drug resistant,MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China显示文摘An endemic multi-drug resistant ST117 E. coli isolate coproducing MCR-1 and 3 ESBL loci was, for the first time, detected from diseased chicken, Liaoning Province, in Northeast China, from 2011 to 2012. Wholegenome sequencing revealed 5 unique plasmids, namely pHXH-1, pHXH-2, pHXH-3, pHXH-4 and pHXH-5). Among them, pHXH1 and pHXH4 encode ESBL, and pHXH-5 mediates MCR-1 colistin resistance. The results indicate that the potentially-national dissemination of MCR-1-positive pathogens with pan-drug resistance proceeds via food chains. | Sijia Ding Xiaohu Han Jun Li Weifan Gao Zeliang Chen Youjun Feng | 2018 | Science Bulletin2018，63，16： | 2 |
| 19 | Spatiotemporal distributions and environmental drivers of diversity and community structure of nosZ-type denitrifiers and anammox bacteria in sediments of the Bohai Sea and North Yellow Sea, China显示文摘Denitrification and anammox processes are major nitrogen removal processes in coastal ecosystems. However, the spatiotemporal dynamics and driving factors of the diversity and community structure of involved functional bacteria have not been well illustrated in coastal environments, especially in human-dominated ecosystems. In this study, we investigated the distributions of denitrifiers and anammox bacteria in the eutrophic Bohai Sea and the northern Yellow Sea of China in May and November of 2012 by constructing clone libraries employing nosZ and 16S rRNA gene biomarkers. The diversity of nosZ-denitrifier was much higher at the coastal sites compared with the central sites, but not significant among basins or seasons. Alphaproteobacteria were predominant and prevalent in the sediments, whereas Betaproteobacteria primarily occurred at the site near the Huanghe (Yellow) River estuary. Anammox bacteria Candidatus Scalindua was predominant in the sediments, and besides, Candidatus Brocadia and Candidatus Kuenenia were also detected at the site near the Huanghe River estuary that received strong riverine and anthropogenic impacts. Salinity was the most important in structuring communities of nosZ-denitrifier and anammox bacteria. Additionally, anthropogenic perturbations (e.g. nitrogen overloading and consequent high primary productivity, and heavy metal discharges) contributed significantly to shaping community structures of denitrifier and anammox bacteria, suggesting that anthropogenic activities would influence and even change the ecological function of coastal ecosystems. | CAI Youjun ZHANG Xiaoli LI Guihao DONG Jun YANG Anjing WANG Guangyu ZHOU Xiaojian | 2019 | Journal of Oceanology and Limnology2019，37，4： | 2 |
| 20 | The Gravitational-wave physics Ⅱ: Progress显示文摘It has been a half-decade since the first direct detection of gravitational waves, which signifies the coming of the era of the gravitational-wave astronomy and gravitational-wave cosmology. The increasing number of the detected gravitational-wave events has revealed the promising capability of constraining various aspects of cosmology, astronomy, and gravity. Due to the limited space in this review article, we will briefly summarize the recent progress over the past five years, but with a special focus on some of our own work for the Key Project 'Physics associated with the gravitational waves' supported by the National Natural Science Foundation of China. In particular,(1) we have presented the mechanism of the gravitational-wave production during some physical processes of the early Universe, such as inflation, preheating and phase transition, and the cosmological implications of gravitational-wave measurements;(2) we have put constraints on the neutron star maximum mass according to GW170817 observations;(3) we have developed a numerical relativity algorithm based on the finite element method and a waveform model for the binary black hole coalescence along an eccentric orbit. | Ligong Bian Rong-Gen Cai Shuo Cao Zhoujian Cao He Gao Zong-Kuan Guo Kejia Lee Di Li Jing Liu Youjun Lu Shi Pi Jian-Min Wang Shao-Jiang Wang Yan Wang Tao Yang Xing-Yu Yang Shenghua Yu Xin Zhang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 2 |
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