|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 2 | 长白山区野生地椒百里香嫩枝扦插繁殖研究显示文摘以长白山区野生地椒百里香为试材,研究了不同浓度、不同生长调节剂、不同时间处理对地椒百里香嫩枝扦插繁殖的影响。结果表明:植物生长调节剂对平均生根率的影响为ABT>NAA>IBA,分别为94.22%、90.69%、81.33%。但是嫩枝扦插后根部长势最好在NAA1 000mg/L(1s)。因此,长白山区野生地椒百里香嫩枝扦插时,建议选择ABT生根剂。选用ABT生根剂时,处理浓度间差异不大,但浓度500mg/L(2min)时优于其它处理组。当选用NAA溶液时,处理浓度间差异较大,且随着处理浓度的增加效果更佳,最佳处理为1 000mg/L(1s)。当选用IBA溶液时,随着浓度增加,生根率及根部长势越差,50mg/L(12h)为最佳处理。 | 金英花 AHN Younghee 全雪丽 朴哲虎 | 2016 | 北方园艺2016，，3： | 3 |
| 3 | The effects of focused and unfocused written corrective feedback in an English as a foreign language context显示文摘 | Rod Ellis Younghee Sheen Mihoko Murakami Hide Takashima | 2008 | System2008，，3： | 3 |
| 4 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 5 | Identification of common microRNA-mRNA regulatory biomodules in human epithelial cancer显示文摘The complex regulatory network between microRNAs and gene expression remains an unclear domain of active research.We proposed to address in part this complex regulation with a novel approach for the genome-wide identification of biomodules derived from paired microRNA and mRNA profiles,which could reveal correlations associated with a complex network of dys-regulation in human cancer.Two published expression datasets for 68 samples with 11 distinct types of epithelial cancers and 21 samples of normal tissues were used,containing microRNA expression and gene expression profiles,respectively.As results,the microRNA expression used jointly with mRNA expression can provide better classifiers of epithelial cancers against normal epithelial tissue than either dataset alone(P=1×10-10,F-test).We identified a combination of 6 microRNA-mRNA biomodules that optimally classified epithelial cancers from normal epithelial tissue(total accuracy = 93.3%;95% confidence intervals:86%-97%),using penalized logistic regression(PLR) algorithm and three-fold cross-validation.Three of these biomodules are individually sufficient to cluster epithelial cancers from normal tissue using mutual information distance.The biomodules contain 10 distinct microRNAs and 98 distinct genes,including well known tumor markers such as miR-15a,miR-30e,IRAK1,TGFBR2,DUSP16,CDC25B and PDCD2.In addition,there is a significant enrichment(Fisher's exact test P=3×10-10) between putative microRNA-target gene pairs reported in 5 microRNA target databases and the inversely correlated microRNA-mRNA pairs in the biomodules.Further,microRNAs and genes in the biomodules were found in abstracts mentioning epithelial cancers(Fisher's Exact test,unadjusted P<0.05).Taken together,these results strongly suggest that the discovered microRNA-mRNA biomodules correspond to regulatory mechanisms common to human epithelial cancer samples.In conclusion,we developed and evaluated a novel comprehensive method to systematically identify,on a genome scale,microRNA-mRNA expression biomodules common to distinct cancers of the same tissue.These biomodules also comprise novel microRNA and genes as well as an imputed regulatory network,which may accelerate the work of cancer biologists as large regulatory maps of cancers can be drawn efficiently for hypothesis generation. | YANG XiNan LEE Younghee FAN Hong SUN Xiao LUSSIER Yves A | 2010 | Chinese Science Bulletin2010，55，31： | 3 |
| 6 | Antecedents of revisit intention显示文摘 | Seoho Urn Kaye Chon YoungHee Ro | 2006 | Annals of Tourism Research2006，33，4： | 1 |
| 7 | Differential effects of focused and unfocused written correction on the accurate use of grammatical forms by adult ESL learners显示文摘 | Younghee Sheen David Wright Anna Moldawa | 2009 | System2009，，4： | 1 |
| 8 | The effects of focused and unfocused written corrective feedback in an English as a foreign language context显示文摘 | Rod Ellis Younghee Sheen Mihoko Murakami Hide Takashima | 2008 | System2008，，3： | 1 |
| 9 | Application of TRIZ creativity intensification approach to chemical process safety显示文摘 | Junghwan Kim Jinkyung Kim Younghee Lee | 2009 | Journal of Loss Prevention in the Process Industries2009，22，： | 1 |
| 10 | The role of oral and written corrective feedback 显示文摘 | Younghee Sheen | 2010 | Studies in Second Language Acquisition2010，，32： | 1 |
| 11 | A study measuring the performance of electronic resources in academic libraries 显示文摘 | Younghee Noh | 2012 | Aslib Proceeding New Information Perspectives2012，64，2： | 1 |
| 12 | Biopolymer-stabilized emulsions on the basis of interactions betweenβ-lactoglobulin andι-carrageenan显示文摘ι-Carrageenan andβ-lactoglobulin(β-lg)stabilized oil-in-water(O/W)emulsions,which can be used for the oral administration of bioactive but environmentally sensitive ingredients,have been successfully prepared.The effects of protein/polysaccharide ratios,total biopolymer concentration,environmental stress(thermal processing and sonication),and pH on the complex formation betweenι-carrageenan andβ-lactoglobulin have been investigated.We found thatβ-lactoglobulin andι-carrageenan stabilized emulsions can be formed at pH values of 6.0,4.0,and 3.4.However,the microstructures of emulsions stabilized byβ-lactoglobulin andι-carrageenan was identified by optical microscopy,and it indicated that the emulsion prepared at pH 6.0 flocculated more extensively,while its hydrodynamic radius was much bigger than those prepared at pH 4.0 and 3.4.Regarding rheological properties,the emulsion of pH 6.0 showed a more solid-like behavior but with a lower viscosity than those of pH 4.0 and 3.4.The optimum concentration ranges forβ-lg andι-carrageenan to form stable emulsions at pH 4.0 and 3.4 were 0.3 wt-%-0.6 wt-%and 0.4 wt-%-0.7 wt-%,respectively. | Qiaomei RU Younghee CHO Qingrong HUANG | 2009 | Frontiers of Chemical Science and Engineering2009，3，4： | 1 |
| 13 | Development of a risk assessment program for chemical terrorism显示文摘 | Lee Younghee Kim Jinkyung Kim Junghwan | 2010 | Korean Journal of Chemical Engineering2010，27，2： | 1 |
| 14 | The Effect of Focused Written Corrective Feedback and Language Aptitude on ESL Learners' Acquisition of Articles 显示文摘 | Younghee S | 2007 | Tesol Quarterly2007，，2： | 1 |
| 15 | Validity of pressure ulcer risk assessment scales:Cubbin and jackson,Braden and douglas scale显示文摘 | Seongsook J Ihnsook J Younghee L | 2004 | International Journal of Nursing Studies2004，41，： | 1 |
| 16 | A Unified Scheme of Shot Boundary Detection and Anchor Shot Detection in News Video Story Parsing 显示文摘 | HANSUNG LEE JAEHAK YU YOUNGHEE IM | 2011 | Multimedia Tools and Applications2011，51，3： | 1 |
| 17 | Single-image super-resolu- tion using sparse regression and natural image prior 显示文摘 | WANG K YOUNGHEE K | 2010 | IEEE transactions on pattern analysis & machine intelli- gence2010，32，6： | 1 |
| 18 | Application of TRIZ creativity intensification approach to chemical process safety显示文摘 | KIM Junghwan KIM Jinkyung LEE Younghee | 2009 | Journal of Loss Prevention in the Process Industries2009，22，6： | 1 |
| 19 | The tourism area life cycle in kim yujeong literary village显示文摘 | Younghee Lee Weaver D | 2014 | Asia Pacific Journal of Tourism Research2014，19，2： | 1 |
| 20 | Antecedents of revisit intention显示文摘 | Seoho Um Kaye Chon YoungHee Ro | 2006 | Annals of Tourism Research2006，33，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员