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您的检索式：作者名="Youxiang Yan"
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| 1 | Degradation of metronidazole by dielectric barrier discharge in an aqueous solution显示文摘Degradation of metronidazole (MNZ) which is a representative and stable antibiotic by dielectric barrier discharge (DBD) in an aqueous solution has been studied. Effects of initial MNZ concentration, solution pH and coexisting organics on the degradation were investigated. The results illustrated that increasing the input power and the discharge frequency can improve the removal of MNZ. At low initial concentration, the removal of MNZ can reach up to 99.1%. Acidic and neutral conditions are more favorable for MNZ removal than alkaline condition in the early stage of degradation. However, the difference in MNZ removal between those in acidic or neutral media and that in alkaline one could be neglected with prolonging of the treatment time. Therefore, this method can be applied to MNZ degradation with a wide pH range. Coexisting organic matter in water can attenuate the removal to some extent. This study could provide valuable references for the degradation of nitroimidazole antibiotics by DBD. | Zhipeng Yang Anxing Lai Hangyu Chen Youxiang Yan Ye Yang Weiwei Zhang Lei Wang | 2019 | Frontiers of Environmental Science & Engineering2019，13，3： | 1 |
| 2 | Rational design of FLP catalysts for reversible H_2 activation: A DFT study of the geometric and electronic effects显示文摘Frustrated Lewis pairs(FLPs) emerge as a new type of bifunctional metal-free catalysts for reversible H_2 activation, which is important for the storage and liberation of H_2 or further controllable utilizing chemical fuels via hydrogenation/dehydrogenation. Herein, a DFT study was conducted to understand the geometric factors and electronic effects of FLPs on reversible H_2 activation. The Lewis base group mainly contributes to the proton attachment, and influences the kinetics of the H_2 activation. The Lewis acid group mainly relates to the hydride attachment, and affects more significantly on the thermodynamics of H_2 activation. The dimer and quenched structure of FLPs also have a degree of influence on the performance of catalyzed H_2 activation. A series of FLPs with para-substituted phenyl derivatives as LA groups were designed and evaluated. The results indicate that the variation of LA groups has significant impact on thermodynamic energy of dihydrogen adducts but insignificant effect on kinetics. Moreover,we found the thermodynamic energy of products has a good linear relationship with Hammett substituent constants. The solvent effect on H_2 activation was also studied, and polar solvent is beneficial for zwitterionic products. These results should provide deeper insight to understand the relation between FLPs structure and reactivity, which is critical for rational design of more efficient FLPs catalysts for reversible H_2 activation. | Jianyu Zhang Youxiang Shao Yinwu Li Yan Liu Zhuofeng Ke | 2018 | Chinese Chemical Letters2018，29，8： | 0 |
| 3 | Long-term outcomes of brainstem arteriovenous malformations after different management modalities: a single-centre experience显示文摘Objective The aims of this study are to clarify the long-term outcomes of brainstem arteriovenous malformations(AVMs)after different management modalities.Methods The authors retrospectively reviewed 61 brainstem AVMs in their institution between 2011 and 2017.The rupture risk was represented by annualised haemorrhagic rate.Patients were divided into five groups:conservation,microsurgery,embolisation,stereotactic radiosurgery(SRS)and embolisation+SRS.Neurofunctional outcomes were evaluated by the modified Rankin Scale(mRS).Subgroup analysis was conducted between different management modalities to compare the long-term outcomes in rupture or unruptured cohorts.Results All of 61 brainstem AVMs(12 unruptured and 49 ruptured)were followed up for an average of 4.5 years.The natural annualised rupture risk was 7.3%,and the natural annualised reruptured risk in the ruptured cohort was 8.9%.13 cases were conservative managed and 48 cases underwent intervention(including 6 microsurgery,12 embolisation,21 SRS and 9 embolisation+SRS).In the selection of interventional indication,diffuse nidus were often suggested conservative management(p=0.004)and nidus involving the midbrain were more likely to be recommended for intervention(p=0.034).The risk of subsequent haemorrhage was significantly increased in partial occlusion compared with complete occlusion and conservative management(p<0.001,p=0.036,respectively).In the subgroup analysis,the follow-up mRS scores of different management modalities were similar whether in the rupture cohort(p=0.064)or the unruptured cohort(p=0.391),as well as the haemorrhage-free survival(p=0.145).In the adjusted Bonferroni correction analysis of the ruptured cohort,microsurgery and SRS could significantly improve the obliteration rate compared with conservation(p<0.001,p=0.001,respectively)and SRS may have positive effect on avoiding new-onset neurofunctional deficit compared with microsurgery and embolisation(p=0.003,p=0.003,respectively).Conclusions Intervention has similar neurofunctional outcomes as conservation in these brainstem AVM cohorts.If intervention is adopted,partial obliteration should be avoided because of the high subsequent rupture risk. | Yu Chen Ruinan Li Li Ma Xiangyu Meng Debin Yan Hao Wang Xun Ye Hengwei Jin Youxiang Li Dezhi Gao Shibin Sun Ali Liu Shuo Wang Xiaolin Chen Yuanli Zhao | 2021 | Stroke & Vascular Neurology2021，6，1： | 0 |
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