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| 1 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 2 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 3 | Autophagy mediates the secretion of macrophage migration inhibitory factor from cardiomyocytes upon serum-starvation显示文摘Macrophage migration inhibitory factor(MIF) is an inflammatory cytokine. It is elevated early in the blood of acute myocardial infarction patients. However, it is unclear whether and how MIF is released. This study investigated the cellular source and mechanism of MIF release from hearts. An ischemia-mimic treatment induced the secretion of MIF from neonatal rat cardiomyocytes but not from fibroblasts. The treatment did not cause significant leakage of lactate dehydrogenase, suggesting that ischemia induced the MIF secretion without causing severe cell damage. Plasma samples from patients with acute chest pain at the emergency department were collected for the detection of MIF. MIF levels in patients with acute coronary syndrome(ACS)increased early, when cardiac injury markers were not yet elevated, suggesting that ischemia can induce MIF secretion before the occurrence of severe myocardial damage. Serum-starvation caused MIF secretion from rat cardiomyocytes and Langendorffperfused rat hearts. The secretion was suppressed by the inhibition of autophagy by inhibitors or by silencing of Atg5. In conclusion, serum-starvation induces the secretion of MIF from cardiomyocytes via autophagy dependent pathway. Clarifying the mechanism of MIF secretion will be helpful for its application in the early diagnosis and treatment of ACS. | Jimin Wu Xiangning Deng Juan Gao Wei Gao Han Xiao Xinyu Wang Youyi Zhang | 2019 | Science China(Life Sciences)2019，62，8： | 2 |
| 4 | Middleton Transient Stabilization Of Power Systems with an Adaptive Control Law显示文摘 | Wang Youyi David J Hill Long Gao | 1994 | Automatic1994，9，30： | 1 |
| 5 | Robust nonlinear coordinated generator excitation and SVC control for power systems显示文摘 | WANG Youyi TAN Y K GUO Guoxiao | 2000 | International Journal of Electrical Power & Energy Systems2000，22，3： | 1 |
| 6 | Robust control of a class of uncertain nonlinear systems显示文摘 | WANG Youyi XIE Lihua de SOUZA Carlos E | 1992 | Syst Control Lett1992，19，： | 1 |
| 7 | Delay-dependent robust H8 control of uncertain linear state-delayed systems显示文摘 | Wang Youyi Xie Lihua and de Souza Carlos E | 1999 | Automatica 351999，，： | 1 |
| 8 | Robust control of a class of uncertain nonlinear systems显示文摘 | WANG Youyi XIE Lihua Souza C E | 1992 | Sys- tems & Control Letters1992，19，2： | 1 |
| 9 | Amphiphilic ABA copolymers used for surface modification of polysulfone membranes, Part 1: Molecular design, synthesis and characterization 显示文摘 | Wang Jianyu Xu Youyi Zhu Liping | 2008 | Polymer2008，49，15： | 1 |
| 10 | Transient stability enhancement and voltage regulation of power systems显示文摘 | Youyi Wang David J Hill Richard H Middleton | 1993 | IEEE Transactions on Power systems1993，8，2： | 1 |
| 11 | Adaptive Backstepping Speed Controller Design for a Permanent Magnet Synchronous Motor 显示文摘 | Zhou Jianguo Wang Youyi | 2002 | IEE Proceedings on Electric Power Applications2002，149，2： | 1 |
| 12 | Robust control of a class of uncertain nonlinear systems 显示文摘 | WANG Youyi XIE Lihua de SOUZA C E | 1992 | Systems & Control Letters1992，19，2： | 1 |
| 13 | Surface modification by the graft polymerization of acrylic acid显示文摘 | Zhikang Xu Jianli Wang Liqiang Shen Dongfeng Men Youyi Xu Microporous polypropylene hollow fiber membrane Part Ⅰ | 2002 | Journal of Membrane Science2002，196，： | 1 |
| 14 | Robust Control of a Class of Uncertain Nonlinear Systems 显示文摘 | WANG Youyi XIE Lihua DE SOUZA C E | 1992 | System & Control Letters1992，19，12： | 1 |
| 15 | Nonlinear optical properties of silver colloidal solution by in situ synthesis technique 显示文摘 | Deng Yan Sun Youyi Wang Pei | 2007 | Current Ppl Phys2007，8，1： | 1 |
| 16 | Real-time nonlinear adaptive backstepping speed control for a PM synchronous motor显示文摘 | Jianguo Zhou Youyi Wang | 2005 | Control Engineering Practice2005，13，10： | 1 |
| 17 | Augmentation of Transient StabilityUsing a Super-Conducting Coil and Adaptive Nonlinear Control 显示文摘 | Yoke LinTan Youyi Wang | 1998 | IEEE Trans on Power Systems1998，13，2： | 1 |
| 18 | Middleton and Long Gao, Transient stabi lity enhancement and voltage regulation of power system显示文摘 | Wang Youyi David J Hill Richard H | 1993 | IEEE Trans on Power System1993，8，2： | 1 |
| 19 | Robust decentralized control for multimachine power systems显示文摘 | Wang Youyi Hill D J Guo Guoxiao | | 0，，： | 1 |
| 20 | Real-time nonlinear adaptive backstepping speed control for a PM synchronous motor显示文摘 | ZHOU Jianguo WANG Youyi | 2005 | Control Engineering Practice2005，13，： | 1 |
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