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| 1 | Intratumoral dendritic cell vaccin ation elicits potent tumoricidal im munity against malignant glioma in rats显示文摘Dendritic cells(DC)are attractive candidates for innovative cancer immunotherapy by virtu e of their ability to function as powe rful antigen presenting cells and elicit potent antitumor cytotoxic immune r esponses.With the aim of generating antitumor immunity,the authors sought to enhance in vivo tum or antigen presentation by using an i ntratumoral DC vaccination strateg y in the setting of partially irradiated intracranial brain tumo rs.Fisher rats,implanted with 9L gliomas in the right corpus striatum,w ere treated with freshly cultured,unpulsed syngeneic DC inoculated directly into the tumor bed.Intracranially inoculated DCs were found to drain to ipsilateral deep cervical lymph nodes.This was a ssociated with increased local and s ystemic antitumor cytoxicity,as evidenced by robust infiltration of treated tumors with CD4and CD8T ce lls as well as by increased IFN-gamma protein and message levels in in vitr o restimulated splenic lymphocytes.DC therapy resulted in prolonged survival and immunity to s ubsequent intracranial tumor re-ch allenge.These results demonstrate the viability of intratumoral DC vaccination as an effectiv e therapeutic strategy for intracra nial glioma. | Ehtesham M Kabos P Gutierrez MA Samoto K Black KL Yu JS | 2003 | 癌症2003，22，7： | 8 |
| 2 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 3 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 4 | Fluorescence and SEM correlative microscopy for nanomanipulation of subcellular structures显示文摘Nanomanipulation under scanning electron microscopy(SEM)enables direct interactions of a tool with a sample.We recently developed a nanomanipulation technique for the extraction and identification of DNA contained within sub-nuclear locations of a single cell nucleus.In nanomanipulation of sub-cellular structures,a key step is to identify targets of interest through correlating fluorescence and SEM images.The DNA extraction task must be conducted with low accelerating voltages resulting in low imaging resolutions.This is imposed by the necessity of preserving the biochemical integrity of the sample.Such poor imaging conditions make the identification of nanometer-sized fiducial marks difficult.This paper presents an affine scale-invariant feature transform(ASIFT)based method for correlating SEM images and fluorescence microscopy images.The performance of the image correlation approach under different noise levels and imaging magnifications was quantitatively evaluated.The optimal mean absolute error(MAE)of correlation results is 68634 nm under standard conditions.Compared with manual correlation by skilled operators,the automated correlation approach demonstrates a speed that is higher by an order of magnitude.With the SEM-fluorescence image correlation approach,targeted DNA was successfully extracted via nanomanipulation under SEM conditions. | Zheng Gong Brandon K Chen Jun Liu Chao Zhou Dave Anchel Xiao Li Ji Ge David P Bazett-Jones Yu Sun | 2014 | Light(Science & Applications)2014，3，1： | 2 |
| 5 | A study of compact spun yarns显示文摘 | CHONG K P S YU C | 2003 | Textile Research Journal2003，73，4： | 1 |
| 6 | Optical intensity modulators for digital and analog applications 显示文摘 | Li G L Yu P K | 2003 | Journal of Lightwave Technology2003，21，9： | 1 |
| 7 | Effect of Tai Chi on depressive symptoms amongst Chinese older patients with depressive disorders:a randomized clinical trial显示文摘 | CHOU K L LEE P W YU E | 2004 | Int J Geriatr Psych2004，19，11： | 1 |
| 8 | Synthesis of a novel hybrid synergistic flame retardant and its application in PP/IFR 显示文摘 | Qian Y’Wei P Jiang P K Zhao X M Yu H Z | 2011 | Polymer Degradation and Stability2011，96，6： | 1 |
| 9 | Study of 3D micro-ultrasonic machining显示文摘 | Yu Zuyuan Rajurkar K P Tandon A | | 0，，04： | 1 |
| 10 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 11 | Salmonella enterica serotype urbana interference with Brucellosis serology显示文摘 | Nielsen K Smith P Yu W L | 2007 | J Immunoassay Immunochem2007，28，3： | 1 |
| 12 | Purification and characterization of the antimicrobial peptide, ostricacin 显示文摘 | YU P L CHOUDHURY S D AHRENS K | 2001 | Biotechnol Lett2001，23，： | 1 |
| 13 | Conservation of breast cancer mo- lecular subtypes and transcriptional patterns of tumor progression across distinct ethnic populations 显示文摘 | Yu K Lee C H Tan P H | 2004 | Clin Cancer Res2004，10，16： | 1 |
| 14 | The Carboxy - Terminal Portion of the Aflatoxin Pathway Regulatory Protein AFLR of Aspergillus parasiticus Activates GALl : : lacZ C, ene Expres- sion in Saeeharomyces cerevisiae 显示文摘 | Chang P K Yu J Bhantagar D | 1999 | Applied and Eeviron- mental Microbiology1999，65，6： | 1 |
| 15 | Room-temperature Ultraviolet Laser Emission from Selfassembled ZnO Microcrystallite Thin Films 显示文摘 | Tang Z K Wong G K L Yu P | 1998 | Appl Phys Lett1998，72，25： | 1 |
| 16 | Mechanical prop- erty characterization of mouse zona pellucida显示文摘 | SUN YU WAN K T ROBERTS K P | 2003 | IEEE Trans- actions on Micro-bioscience2003，2，4： | 1 |
| 17 | Device-to-device communicationunder-laying cellular communications systems显示文摘 | JANIS P YU C DOPPLER K | 2009 | International JounalCommunications Network and System Sciences2009，2，3： | 1 |
| 18 | Rapid estimation of genetic relatedness among heterogeneous population of alfalfa byrandom amplification of bulked genomic DNA samples 显示文摘 | Yu K F Pauls K P | | Theor Appl Genet i9930，，： | 1 |
| 19 | Room-temperature Ultraviolet Laser Emission Self-assembled ZnO Microcrystallite Thin Films 显示文摘 | Tang Z K Wong G K L Yu P | 1998 | Appl Phys Lett1998，72，25： | 1 |
| 20 | Transmission network fault location observability with minimal PMU placement显示文摘 | LIEN K P LIU C W YU C S | 2006 | IEEE Trans on Power Delivery2006，21，3： | 1 |
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