| 1 | Isolation and polymorphic frequency detection of a novel STR on human chromosome 14q24.3显示文摘A single copy fragment (FD14_ca 1) containing 22 CA repetitive units was isolated with (CA) 15 oligonucleotide probe from a human chromosome 14q24 3 probe pool generated by microdissection, and proved to be a new short tandem repeat (STR) sequence through querying in GenBank of NCBI. The STR has 11 alleles in Chinese, and its polymorphic information content (PIC) is 0 85. Mendelian segregation was shown in 2 Chinese pedigrees with two generations. This STR has been accurately relocalized on chromosome 14q24 3 by fluorescence in situ hybridization (FISH). The accession numbers of this STR in GDB and GenBank database are D14S1435 and G31413 respectively. This STR would be able to be regarded as a novel genetic marker which can increase the genetic map accuracy in this chromosome region and improve the gene diagnosis on some genetic diseases located in chromosome 14q24 3 band. | Zhang Min Yu Longa Zheng Qiping Hu Peirong Sun Xiyuan Zhao Shouyuan | 1998 | Chinese Science Bulletin1998，43，4： | 0 |
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