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| 1 | High-sensitivity self-powered temperature/pressure sensor based on flexible Bi-Te thermoelectric film and porous microconed elastomer显示文摘Electronic skins are artificial skin-type multifunctional sensors,which hold great potentials in intelligent robotics,limb prostheses and human health monitoring.However,it is a great challenge to independently and accurately read various physical signals without power supplies.Here,a self-powered flexible temperature-pressure bimodal sensor based on high-performance thermoelectric films and porous microconed conductive elastic materials is presented.Through introducing flexible heat-sink design and harvesting body heat energy,the thin-film thermoelectric device could not only precisely sense temperature signal but also drive the pressure sensor for detecting external tactile stimulus.The integration of Bi-Te based thermoelectric film with high stability in wide temperature range enables the sensor to sense the ambient temperature with high resolution(<0.1 K)as well as excellent sensitivity(3.77 mV K^(-1)).Meanwhile,the porous microconed elastomer responds to pressure variation with low-pressure detection(16 Pa)and a high sensitivity of 37 kPa^(-1).Furthermore,the bimodal sensor could accurately and simultaneously monitor human wrist pulse and body temperature in real time,which demonstrates promising applications in self-powered electronic skins for human health monitoring systems. | Yaling Wang Wei Zhu Yuan Deng Pengcheng Zhu Yuedong Yu Shaoxiong Hu Ruifeng Zhang | 2022 | Journal of Materials Science & Technology2022，，8： | 4 |
| 2 | Simultaneous Extraction of Carboxylated Celulose Nanocrystals and Nanofibrils via Citric Acid Hydrolysis--A Sustainable Route显示文摘In this study, cellulose nanocrystals(CNC) with surface carboxylic groups were prepared from bleached softwood pulp by hydrolysis with concentrated citric acid at concentrations of 60 wt%~80 wt%. The solid residues from acid hydrolysis were collected for producing cellulose nanofibrils(CNF) via post high-pressure homogenization. Citric acid could be easily recovered after hydrolysis reactions through crystallization due to its low water solubility or through precipitation as a calcium salt followed by acidification. Several important properties of CNC and CNF, such as dimension, crystallinity, surface chemistry, thermal stability, were evaluated. Results showed that the obtained CNC and CNF surfaces contained carboxylic acid groups that facilitated functionalization and dispersion in aqueous processing. The recyclability of citric acid and the carboxylated CNC/CNF give the renewable cellulose nanomaterial huge potential for a wide range of industrial applications. Furthermore, the resultant CNC and CNF were used as reinforcing agents to make sodium carboxymethyl cellulose(CMC) films. Both CNC and CNF showed reinforcing effects in CMC composite films. The tensile strength of CMC films increased by 54.3% and 85.7% with 10 wt% inclusion of CNC and CNF, respectively. This study provides detailed information on carboxylated nanocellulose prepared by critic acid hydrolysis; a sustainable approach for the preparation of CNC/CNF is of significant importance for their various uses. | Chao Liu HaiShun Du Guang Yu YueDong Zhang QingShan Kong Bin Li XinDong Mu | 2017 | Paper And Biomaterials2017，2，4： | 4 |
| 3 | Adenosine monophosphate-activated protein kinase attenuates cardiomyocyte hypertrophy through regulation of FOXO3a/MAFbx signaling pathway显示文摘心肌质量的控制被认为被蛋白质合成和降级的动态平衡决定。最近的研究表明了表明小径戏的那萎缩相关的 forkhead 盒子 O 3a (FOXO3a )/muscle 萎缩 F 盒子(MAFbx ) 在解朊作用的调整的一个中央角色并且在 cardiomyocyte 肥大上施加禁止的效果。在这研究,我们测试了假设激活 monophosphate 的蛋白质 kinase (AMPK ) 激活稀释的那腺苷由调整表明小径和它的下游的蛋白质降级的 FOXO3a/MAFbx 的 cardiomyocyte 肥大。结果证明有 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR ) 的 AMPK 的激活稀释了血管收缩素 II (Ang II ) 导致的 cardiomyocyte 肥大。AICAR 的 antihypertrophic 效果被 AMPK 禁止者混合物 C 弄钝。另外, AMPK 戏剧性地增加了抄写因素 FOXO3a 的活动,起来调整它的下游的 ubiquitin ligase MAFbx 的表示,和提高的 cardiomyocyte 解朊作用。同时,在 MAFbx 是由有 MAFbx-siRNA 的 cardiomyocytes 的 transfection 的 silenced 以后,蛋白质降级和 cardiomyocyte 肥大上的 AMPK 的效果被堵住。这些结果显示 AMPK 由经由表明小径的 FOXO3a/MAFbx 激活蛋白质降级在 cardiomyocyte 肥大的抑制起一个重要作用。 | Baolin Chen Qiang WU Zhaojun Xiong Yuedong Ma Sha Yu Dandan Chen Shengwen Huang Yugang Dong | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 4 |
| 4 | Lactulose mediates suppression of dextran sulfate sodium-induced colon inflammation显示文摘Objective:Assessment of digestion colonic flora lactulose can be induced to produce hydrogen and prove lactulose with a potential anti-inflammatory effects. Methods:We established a mouse model of human ulcerative colitis (UC) by supplying mice with water containing dextran sulfate sodium (DSS). At 7-day, DSS-induced pathogenic outcomes, including loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of TNF-α, IL-1β, malondialdehyde (MDA) and myeloperoxidase (MPO) deficiency in colon lesions, were significantly suppressed by lactulose administration and intraperitoneally injected hydrogen water. Results:After eliminating colon microflora by antibiotics, the anti-inflammatory effects of lactulose were significantly compromised. Histological analysis also revealed that the DSS mediated colonic tissue destruction accompanied by neutrophils infiltration was remarkably suppressed by lactulose and hydrogen water. Conclusion:The present study indicated that lactulose can prevent the development of DSS-induced colitis and alleviate oxidative stress state in colitis. | HAI Yuedong HONG Yu WANG Qi LIU Xudong LI Dexi | 2013 | Journal of Medical Colleges of PLA(China)2013，28，2： | 2 |
| 5 | Nanocatalytic bacteria disintegration reverses immunosuppression of colorectal cancer显示文摘Tumor-associated bacteria(TAB)play a critically important role in regulating the microenvironment of a tumor,which consequently greatly deteriorates the therapeutic effects by chemo-and radiotherapy deactivation and,more considerably,leads to substantial immunosuppression.On the contrary,herein we propose a nanocatalytic tumor-immunotherapeutic modality based on the bacteria disintegration by bacteria-specific oxidative damage under magnetic hyperthermia for highly effective immune response activation-promoted tumor regression.A monodispersed and superparamagnetic nanocatalytic medicine modified by arginyl-glycyl-aspartic acid(RGD)and(3-carboxypropyl)triphenylphosphonium bromide(TPP),named as MNP-RGD-TPP herein,has been synthesized,which features selective accumulation at the TAB by the electrostatic affinity,enabling effective TAB disintegration by the nanocatalytic Fenton reaction producing abundant cytotoxic hydroxyl radicals in situ under alternating magnetic field-induced hyperthermia.More importantly,the lipopolysaccharide has been metabolically secreted from the destructed TAB as pathogen-associated molecular patterns(PAMPs)to M1-polarize tumor-associated macrophages(TAMs)and promote the maturation of dendritic cells(DCs)for innate immuno-response activation of TAMs,followed by cytotoxic T lymphocytes awakening under the PAMPs presentation by the mature DCs against tumor cells.The integrated innate and adaptive immunity activations based on this TAB-promoted nanocatalytic immunomedicine,instead of magnetic heating-induced hyperthermia or the released Fe2+/Fe3+Fenton agent,has been found to achieve excellent therapeutic efficacy in an orthotopic colorectal cancer model,demonstrating the great potential of such an integrated immunity strategy in clinical tumor immunotherapy. | Han Jiang Yuedong Guo Zhiguo Yu Ping Hu Jianlin Shi | 2022 | National Science Review2022，9，11： | 1 |
| 6 | Recent development and application of thin-film thermoelectric cooler显示文摘Recently,the performance and fabrication of thin-ilm thermoeletric materials have been jargely enhanced.Based on this enhancement,the thin-film thermoelectric cooler(TEC)is becoming a research hot topic,due to its high cooling flux and microchip level size.To fulfill a thin-film TEC,interfacial problems are unavoidable,as they may largely reduce the properties of a thin-film TEC.Moreover,the architecture of a thin-film TEC should also be properly designed.In this review,we introduced the enhancement of thermoelectric properties of(Bi,Sb)2(Te,Se)3 solid solution materials by chemical vapor deposition,physical vapor deposition and electro-deposition.Then,the interfacial problems,including contact resistance,interfacial diffusion and thermal contact resistance,were discussed.Furthermore,the design,fabrication,as well as the performance of thin-film TECs were summarized. | Yuedong Yu Wei Zhu Xixia Kong Yaling Wang Pengcheng Zhu Yuan Deng | 2020 | Frontiers of Chemical Science and Engineering2020，14，4： | 1 |
| 7 | Acetone-bu- tanol-ethanol production from corn stover pretreated by alkaline Twin-screw extrusion pretreatment 显示文摘 | Zhang Yuedong Yu Guang and Wang Haisong | 2014 | Bioprocess and Biosystems Engineering2014，37，5： | 1 |
| 8 | Sustainable preparation and characterization of thermally stable and functional cellulose nanocrystals and nanofibrils via formic acid hydrolysis显示文摘In this work,a sustainable method to prepare functional cellulose nanocrystals(CNCs)and cellulose nanofibrils(CNFs)using formic acid(FA)(a recoverable organic acid)was established.After FA hydrolysis,the obtained CNCs could be well dispersed in DMAC.Thus,the CNC products and fibrous cellulosic solid residue(FCSR)in DMAC could be easily separated by a conventional centrifugal process,and the collected FCSR could be further fibrillated to CNFs with relatively low-intensity mechanical fibrillation process.The isolated CNC products showed high crystallinity index(about 75%)and excellent thermal stability(with onset thermal degradation temperature of 325℃).Both the resultant CNCs and CNFs showed better dispersibility in DMSO,DMF and DMAC respectively because of the introduction of ester groups on the surface of the products.The presence of surface ester groups could increase the interface compatibility of nanocelluloses with polymeric matrices and enable their applications in reinforcing polymeric matrix materials(e.g.the composite films like PHVB+CNFs). | Haishun Du Chao Liu Dong Wang Yuedong Zhang Guang Yu Chuanling Si Bin Li Xindong Mu Hui Peng | 2017 | Journal of Bioresources and Bioproducts2017，2，1： | 1 |
| 9 | EST Pipeline System: Detailed and Automated EST Data Processing and Mining显示文摘Expressed sequence tags (ESTs) are widely used in gene survey research these years. The EST Pipeline System, software developed by Hangzhou Genomics Institute (HGI), can automatically analyze different scalar EST sequences by suitable methods. All the analysis reports, including those of vector masking, sequence assembly, gene annotation, Gene Ontology classification, and some other analyses,can be browsed and searched as well as downloaded in the Excel format from the web interface, saving research efforts from routine data processing for biological rules embedded in the data. | Hao Xu, Ling He, Yuanzhong Zhu, Wei Huang, Lijun Fang, Lin Tao, Yuedong Zhu, Lin Cai, Huayong Xu, Liang Zhang, Hong Yu, and Yan ZhouHangzhou Genomics Institute/James D. Watson Institute of Genome Sciences, Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310008, China. | 2003 | Genomics, Proteomics & Bioinformatics2003，1，3： | 1 |
| 10 | Primary Versus Secondary Splenic Pedicle Dissection in Laparoscopic Splenectomy for Splenic Diseases显示文摘 | Qiuliang Yan Jinhui Zhu Xiaoli Zhan Weihong Weng Wanbo Wu Dijian Shen Kai Yu Yuedong Wang | 2013 | Journal of the American College of Surgeons2013，，： | 1 |
| 11 | Recent progress on the pretreatment and fractionation of lignocelluloses for biorefinery at QIBEBT显示文摘Pretreatment and fractionation are amongst the key steps for the conversion of lignocelluloses to sustainable biofuels,biomaterials or biochemicals,as pretreatment/fractionation can break the natural recalcitrance of lignocelluloses,improving the conversion efficiency of downstream processes.This paper reviews the recent progress on the pretreatment and fractionation of lignocelluloses for biorefinery at the Chinese Academy of Sciences-Qingdao Institute of Bioenergy and Bioprocess Technology(QIBEBT).The main technologies developed at the QIBEBT in recent years include alkaline twin-screw extrusion pretreatment,modified alkali pretreatment,hydrogen peroxide-assisted sodium carbonate pretreatment,fractionation with formic acid,as well as the two-step fractionation by hot water treatment coupling ammonium sulfite treatment.With the development of these technologies,a pilot scale platform for the pretreatment and saccharification of biomass has been established in the pilot plant of QIBEBT. | Bin Li Chao Liu Guang Yu Yuedong Zhang Haisong Wang Xindong Mu Hui Peng | 2017 | Journal of Bioresources and Bioproducts2017，2，1： | 0 |
| 12 | Ameliorated enzymatic saccharification of corn stover with a novel modified alkali pretreatment显示文摘Enzymatic saccharification/hydrolysis is one of the key steps for the bioconversion of lignocelluloses into sustainable biofuels.In this work,corn stover was pretreated with a novel modified alkali process(NaOH+anthraquinone(AQ)+sodium lignosulfonate(SLS)),and then enzymatically hydrolyzed with an enzyme cocktail(cellulase(Celluclast 1.5L),β-glucosidase(Novozyme 188)and xylanase(from thermomyceslanuginosus))in the pH range of 4.0-6.5.It was found that the suitable pH for the enzymatic saccharification process to achieve a high glucan yield was between 4.2 and 5.7,while the appropriate pH to obtain a high xylan yield was in the range of 4.0-4.7.The best pH for the enzymatic saccharification process was found to be 4.4 in terms of the final total sugar yield,as xylanase worked most efficiently in the pH range of 4.0-4.7,under the conditions in the study.The addition of xylanase in the enzymatic saccharification process could hydrolyze xylan in the substrates and reduce the nonspecific binding of cellulase,thus improving the total sugar yields. | Guang Yu Huanfei Xu Chao Liu Paul DeRoussel Chunyan Zhang Yuedong Zhang Bin Li Haisong Wang Xindong Mu | 2016 | Journal of Bioresources and Bioproducts2016，1，1： | 0 |
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