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| 1 | Breaches of the Baige Barrier Lake: Emergency response and dam breach flood显示文摘This paper documents the emergency response to the breaches of the Baige Barrier Lake. The lake was successively formed by landslides that occurred on October 10 and November 3, 2018 at the provincial border between Sichuan and Tibet in China. The barrier lake created by the '10.10' landslide breached on October 12 and triggered a flood with a peak discharge around 10000 m^3/s. The residual landslide barrier was enhanced by a second landslide on November 3, resulting in a higher barrier with larger flood potential. An overflow channel was excavated in the crest of the barrier to prompt the breach to be triggered at a lower water level. The second breach happened on November 12 with a measured peak discharge of 31000 m^3/s. Nearly 75000 people were evacuated before the two breaches. In order to prevent the downstream dams from possible over-topping, nearly 3.27×10~8 m^3 of the stored volume was released from the Liyuan reservoir 688 km downstream of Baige Barrier Lake. This paper presents the measured hydrographs and the back-analysis results for the '11.03' barrier lake. It is shown that the modern models of dam breach hydraulics can reasonably reproduce the barrier breach hydrographs;however, further studies are needed to define the key parameters which highly influence the calculated results. Knowledge acquired during the emergency response to the case can be shared with experts working on breaches of embankment dams and can be referenced to promote both the theory study and the engineering practice to mitigate the potential risks caused by this type of catastrophic events. | CAI YaoJun CHENG HaiYun WU ShuaiFeng YANG QiGui WANG Lin LUAN YueSheng CHEN ZuYu | 2020 | Science China(Technological Sciences)2020，63，7： | 19 |
| 2 | WAVELET METHOD FOR CALCULATING THE DEFECT STATES OF TWO-DIMENSIONAL PHONONIC CRYSTALS显示文摘Based on the variational theory,a wavelet-based numerical method is developed to calculate the defect states of acoustic waves in two-dimensional phononic crystals with point and line defects.The supercell technique is applied.By expanding the displacement field and the material constants (mass density and elastic stiffness) in periodic wavelets,the explicit formula- tions of an eigenvalue problem for the plane harmonic bulk waves in such a phononic structure are derived.The point and line defect states in solid-liquid and solid-solid systems are calcu- lated.Comparisons of the present results with those measured experimentally or those from the plane wave expansion method show that the present method can yield accurate results with faster convergence and less computing time. | Zhizhong Yah Yuesheng Wang Chuanzeng Zhang | 2008 | Acta Mechanica Solida Sinica2008，21，2： | 16 |
| 3 | Wave localization in randomly disordered periodic layered piezoelectric structures显示文摘就联合的 mechnoelectrical 而言,在混乱周期的分层的压电的结构的嘘波浪的本地化被学习。在对层正常、正切的方向宣传的波浪被考虑。在二个连续单位房间之间的转移矩阵根据连续性条件被获得。在混乱周期的结构的本地化因素和本地化长度的表情被介绍。为混乱周期的压电的结构,本地化因素和本地化长度的数字结果被介绍并且讨论。它能从结果被看见频率通带和站乐队为订的周期的结构出现,波浪本地化现象发生在混乱的周期的,并且变化的系数越大,波浪本地化的度是越多 greater。当连续压电的材料的性质是类似的,当某个材料参数有大变化时,站乐队的间隔变得更宽广时,在订的周期的结构的站乐队的宽度是很狭窄的。为在方向正常宣传到层的波浪,本地化长度在频率上有更少的依赖,要不是在对层正切的方向宣传本地化长度的波浪强烈依赖于频率。 | Fengming Li Yuesheng Wang Chao Hu Wenhu Huang | 2006 | Acta Mechanica Sinica2006，22，6： | 11 |
| 4 | Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest显示文摘蛋白质说出 NVP (1 ) 从巢 vespae 被孤立。T 他现在的学习的目的是阐明 NVP (1 ) 是否并且怎么调制 HepG2 房间的增长。在 6.6 μg/ml 的集中的 NVP (1 ) 能在阶段 G 1 逮捕房间周期并且禁止 cyclinB, cyclinD1 和 cyclinE 的 mRNA 表示。NVP (1 ) 压制了 cdk2 蛋白质表示,但是增加了 p27 和 p21 蛋白质表示。然而, NVP (1 ) 没改变 p16 蛋白质表示层次。NVP (1 ) 在由原子染色质冷凝作用显示了的 HepG2 房间支持了 apoptosis,并且另外,表明小径的细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 被激活。而且,当 HepG2 房间是有英皇家空军之阶级最低之兵禁止者 PD98059 的 pretreated 时,津贴蛋白质表示水平被稀释。这些结果证明 NVP (1 ) 通过表明小径的英皇家空军之阶级最低之兵禁止 HepG2 的增长。NVP (1 ) 能是为肝癌症的潜在的药。 | Changdong Wang Peng Chen Hongjuan Jin Xu Yan Lu Gan Yi Li Shiyi Zhou Junli Chang Yuesheng Wang Guangxiao Yang Guangyuan He | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 11 |
| 5 | Stable chloroplast transformation of immature scutella and inflorescences in wheat (Triticum aestivum L.)显示文摘在小麦的叶绿体转变被 scutella 的轰炸分别地从不成熟的胚胎和不成熟的开花期完成。小麦叶绿体地点特定的表示向量, pBAGNRK,被放包含新霉素 phosphotransferase II (nptII ) 和绿色的一个表示盒子构造荧光灯蛋白质(gfp ) 作为选择和记者基因,分别地在在小麦的 atpB 和 rbcL 之间的 intergenic 分隔符叶绿体染色体。在 plastome 的 gfp 基因的集成被聚合酶链反应(PCR ) 识别分析并且作为一根探针的用 gfp 基因的南部的弄污。GFP 蛋白质的表示被西方的污点检验。三积极 transformants 被获得, atpB 和 rbcL (指向的地点) 的部分碎片的南部的污点探查证实他们之一是 homoplasmic。GFP 荧光的稳定的表示被共焦的显微镜学从 T1 子孙幼苗在叶纸巾证实。gfp 基因的 PCR 分析也在 T1 子孙证实了 transgene 的继承。这些结果加强小麦叶绿体转变的可行性并且也通过叶绿体转变在小麦为重要农学的特点的介绍给一个新奇方法。 | Cuiju Cui FeiSong Yi Tan Xuan Zhou Wen Zhao Fengyun Ma Yunyi Liu Javeed Hussain Yuesheng Wang Guangxiao Yang Guangyuan He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 10 |
| 6 | WAVE LOCALIZATION IN RANDOMLY DISORDERED PERIODIC PIEZOELECTRIC RODS显示文摘在周期、混乱的周期的压电的杆的波浪繁殖在这篇论文被学习。在二个连续单位房间之间的转移矩阵根据连续性条件被获得。压电的材料的机电的联合被考虑。根据矩阵特征值的理论,在周期的结构的频率乐队被学习。而且,由在两个介绍混乱尺寸更少长度和压电的陶艺的有弹性的常数,在混乱周期的结构的波浪本地化被使用矩阵特征值方法和 Lyapunov 代表方法也学习。调节了周期的结构,这被发现让频率通带和站乐队和本地化现象能发生在错误调子周期的结构。由于压电的效果,而且,为不能通过结构宣传的波浪的频率区域稍微随压电的常数的增加被增加。 | Li Fengming Wang Yuesheng Chen Ali | 2006 | Acta Mechanica Solida Sinica2006，19，1： | 9 |
| 7 | Tuning of band gaps for a two-dimensional piezoelectric phononic crystal with a rectangular lattice显示文摘In this paper,the elastic wave propagation in atwo-dimensional piezoelectric phononic crystal is studiedby considering the mechanic-electric coupling.The gener-alized eigenvalue equation is obtained by the relation of themechanic and electric fields as well as the Bloch-Floquet the-orem.The band structures of both the in-plane and anti-planemodes are calculated for a rectangular lattice by the plane-wave expansion method.The effects of the lattice constantratio and the piezoelectricity with different filling fractionsare analyzed.The results show that the largest gap width isnot always obtained for a square lattice.In some situations,a rectangular lattice may generate larger gaps.The band gapcharacteristics are influenced obviously by the piezoelectric-ity with the larger lattice constant ratios and the filling frac-tions. | Yize Wang Fengming Li Yuesheng Wang Kikuo Kishimoto Wenhu Huang | 2009 | Acta Mechanica Sinica2009，25，1： | 8 |
| 8 | ELASTIC WAVE LOCALIZATION IN TWO-DIMENSIONAL PHONONIC CRYSTALS WITH ONE-DIMENSIONAL QUASI-PERIODICITY AND RANDOM DISORDER显示文摘在里面飞机并且反飞机橡皮波浪宣传在的乐队结构二维订并且混乱(在一个方向) phononic 晶体在这份报纸被学习。波浪繁殖的本地化被介绍由 plane-wave-based 转移矩阵方法是计算的本地化因素的概念由于随机的混乱讨论。由以一个特殊方法从频率把伪频率当作偏差,在另外的方向在一个方向和翻译对称有伪频率(Fibonacci 顺序) 的二种伪 phononic 水晶被考虑,乐队结构被使用本地化因素描绘。结果证明本地化因素是在描绘二维的完美、随机混乱、伪周期的 phononic 晶体的乐队差距的一个有效参数。phononic 晶体的乐队结构能被不同随机的混乱调节或改变伪周期的参数。伪 phononic 晶体比的与更狭窄的宽度展出更多的乐队差距订并且随机混乱的系统。 | Ali Chen Yuesheng Wang Guilan Yu Yafang Guo Zhengdao Wang | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 8 |
| 9 | Real-time PCR diagnosis of Schistosoma japonicum in low transmission areas of China显示文摘Background:Schistosomiasis in the People’s Republic of China(PRC)can be traced back to antiquity.In the past 60 years,the Chinese government has made great efforts to control this persistent disease with elimination slated by 2020 through the implementation of a comprehensive control strategy.This strategy aims to reduce the role of bovines and humans as sources of infection as a pre-requisite for elimination through transmission interruption.The goal of elimination will be achievable only by the implementation of a sustainable surveillance and control system,with sensitive diagnosis a key feature so that the true disease burden is not underestimated.Currently used diagnostics lack the necessary sensitivity to accurately determine the prevalence of Schistosoma japonicum infection in areas with low infection intensities.It is of critical importance to find and treat people and to identify animals with low-level infections if the National Control Programme for China is to achieve schistosomiasis elimination.Methods:We evaluated a real-time polymerase chain reaction(qPCR)assay using 633 human stool samples collected from five villages in Hunan,Anhui,Hubei,and Jiangxi provinces,and 182 bovine(70 cattle and 112 buffalo)stool samples obtained from four villages in Hunan,Anhui,and Jiangxi provinces in the PRC.All stool samples were subjected to the miracidium hatching test(MHT,a diagnostic procedure used in the National Schistosomiasis Control Programme)and the qPCR assay.Samples positive by MHT were subjected to either the Kato-Katz technique for humans,or the formalin-ethyl acetate sedimentation-digestion(FEA-SD)procedure for bovines,to determine infection intensities.Results:The qPCR assay exhibited a high level of sensitivity in the detection of S.japonicum infections.With both the human and bovine samples,a significantly higher prevalence was determined using the qPCR assay(11.06%humans,24.73%bovines)than with the MHT(0.93%humans,7.69%bovines).The animal contamination index(calculated using data obtained with the qPCR technique)for all positive bovines was 27618000 eggs per day,indicating a considerable amount of environmental egg contamination that would be underestimated using less sensitive diagnostic procedures.Conclusions:The qPCR assay we have evaluated will be applicable as a future field diagnostic and surveillance tool in low-transmission zones where schistosomiasis elimination is targeted and for monitoring post-intervention areas to verify that elimination has been maintained. | Pei He Catherine A.Gordon Gail M.Williams Yuesheng Li Yuanyuan Wang Junjian Hu Darren J.Gray Allen G.Ross Donald Harn Donald P.McManus | 2018 | Infectious Diseases of Poverty2018，7，1： | 7 |
| 10 | WAVE PROPAGATION IN PIEZOELECTRIC/PIEZOMAGNETIC LAYERED PERIODIC COMPOSITES显示文摘这份报纸在分层的周期的 composites 由组成涉及波浪繁殖的动态行为压电并且 piezomagnetic 阶段。兰姆波浪的分散关系被导出。分散曲线和排水量地与不同压电的体积部分被计算。分散弄弯的 BaTiO3/CoFe2O4 composites 表演的数字结果在一个盘子中类似于对称的兰姆波浪。交换在之间纵(即厚度) 模式和联合模式发生在在开始的二个分支的分散曲线之间的转线路点。随 BaTiO3 体积部分的增加,转线路点在一个更低的波浪数字出现,波浪速度更高。这些调查结果为磁电的变换器应用程序是有用的。 | Yu Pang Jinxi Liu Yuesheng Wang Daining Fang | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 7 |
| 11 | Evolution of misfit dislocation network and tensile properties in Ni-based superalloys:a molecular dynamics simulation显示文摘The structural evolution of dislocation network is closely related to ' rafting and tensile properties.In this work,the effects of strain rate and temperature on the structural evolution of interface dislocation network in Ni-based superalloys are studied by molecular dynamics simulations.The correlation between the evolution of dislocation network and tensile properties is also explored.The results indicate that the dislocation network shows different degrees of deformation and damage at various strain rates and temperatures.The ' rafting depends on the damage structure of dislocation network at various strain rates and temperatures.Moreover,the tensile properties of interface in Ni-based superalloys are closely related to the evolution of dislocation network and dislocation motion mechanisms. | WU WenPing GUO YaFang WANG YueSheng | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，3： | 5 |
| 12 | WAVE LOCALIZATION IN RANDOMLY DISORDERED PERIODIC PIEZOELECTRIC RODS WITH INITIAL STRESS显示文摘在有起始的应力的混乱的周期的压电的杆的有弹性的波浪本地化用转移矩阵和 Lyapunov 代表方法被学习。电场作为伪静电干扰被接近。乐队差距特征上的起始的压力的效果被调查。本地化因素和本地化长度的数字计算被执行。它能从结果被观察乐队结构能被施加合适的起始的压力调节。为压电的杆长度和有弹性的常数的不同价值,乐队结构和本地化现象是很不同的。更大的混乱度能导致更多的明显的本地化现象。 | Yize Wang Fengming Li Kikuo Kishimoto Yuesheng Wang Wenhu Huang | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 5 |
| 13 | ZIF-derived Co-N-C ORR catalyst with high performance in proton exchange membrane fuel cells显示文摘Metal and nitrogen-doped carbon(M-N-C)materials have been considered as the most promising non-precious metal oxygen reduction(ORR)catalysts to replace expensive Pt catalysts.Due to high Fenton catalytic activity of Fe element and the resulting instability,Co-based N-C(Co-N-C)catalysts without Fenton catalytic activity should be a worthier ORR catalyst being explored.Although the high ORR activity of Co-N-C catalyst has been demonstrated in aqueous half-cell tests,their performance under PEMFC working condition is still far away from that of state-of-the-art Fe-N-C catalysts.In this study,a high-performance Co-N-C catalyst was synthesized by one-step pyrolyzing Co-doped ZIF-8(zeolitic imidazolate framework-8)particles in-situ grown on the highsurface-area KJ600 carbon black with high electronic conductivity.The resulting Co-N-C catalyst exhibited high intrinsic ORR activity,fast mass transfer rate and high electronic conductivity,and thus yielded a remarkable peak power density of 0.92 W cm^(-2) in H_(2)-O_(2) PEMFC,which is comparable to state-of-the-art Fe-N-C catalyst.This strategy is helpful to synthesize highly active M-N-C ORR catalysts with improved mass transfer and electric conductivity. | Ruixiang Wang Pengyang Zhang Yucheng Wang Yuesheng Wang Karim Zaghib Zhiyou Zhou | 2020 | Progress in Natural Science:Materials International2020，30，6： | 4 |
| 14 | WAVE PROPAGATION IN TWO-DIMENSIONAL DISORDERED PIEZOELECTRIC PHONONIC CRYSTALS显示文摘波浪繁殖用有限差别的时间域(FDTD ) 在二维的混乱压电的 phononic 晶体被学习方法。为混乱的不同的格,传播系数是计算的。乐队差距上的混乱的影响被调查。结果证明在压电的 phononic 晶体的混乱比在高频率在低频率区域在乐队差距上有更重要的影响。在乐队差距和位置混乱的方向的宽度之间的关系也被讨论。当位置混乱沿着对波浪传播垂直的方向时,压电的 phononic 晶体比沿着波浪传播方向的位置混乱的案例在低频率区域有更宽的乐队差距。乐队差距上的尺寸混乱的效果类似于地点混乱的,这能也被发现。当不安系数大时,它更多比在压电的 phononic 晶体与尺寸和地点混乱在压电的 phononic 晶体在通行证乐队上读了效果与单个混乱。在更高的频率区域,压电的效果减少传播系数。要不是更大的混乱度,压电的效果将被减少。 | Jinqiang Li Fengming Li Yuesheng Wang Kikuo Kishimoto | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 4 |
| 15 | The toxic effect of solubilizing excipients on Tetrahymena thermophila BF_5 growth investigated by microcalorimetry显示文摘The toxic effect of different solubilizing excipients on the growth and metabolism of Tetrahymena thermophila BF5(T.t.BF5) at various concentrations was investigated by microcalorimetry.The thermogenic curves of T.t.BF5 growth were determined at 28°C,and were evaluated by dynamic parameters.The results indicated that the values of growth rate constant(k),maximum power(P1,P2),peak time(T1,T2) and total quantity of heat(Q) varied for different excipients.There was a good linear relationship between k and concentrations(r>0.95,P<0.01).5% inhibition concentration(IC5) of poloxamer 188,Tween 80,PEG 600,PEG 400 and Tween 20 was 2.18,1.07,1.35,0.58,and 0.045 mg/mL,respectively.After the principal component analysis(PCA),Q,k and P1 could characterize the effect of these excipients on T.t.BF5 growth.Comprehensive evaluation indicated that compared with the control group,poloxamer 188 had the weakest toxicity and Tween 20 had the strongest toxicity. | ZHANG ShaoFeng YAN Dan TANG HuiYing YANG Ming WANG YueSheng XIAO XiaoHe | 2010 | Chinese Science Bulletin2010，55，18： | 4 |
| 16 | 3D Seed-Germination-Like MXene with In Situ Growing CNTs/Ni Heterojunction for Enhanced Microwave Absorption via Polarization and Magnetization显示文摘Ti_(3)C_(2)Tx MXene is widely regarded as a potential micro-wave absorber due to its dielectric multi-layered structure.However,missing magnetic loss capability of pure MXene leads to the unmatched electromagnetic parameters and unsatisfied impedance matching condi-tion.Herein,with the inspiration from dielectric-magnetic synergy,this obstruction is solved by fabricating magnetic CNTs/Ni hetero-structure decorated MXene substrate via a facile in situ induced growth method.Ni2+ions are successfully attached on the surface and interlamination of each MXene unit by intensive electrostatic adsorption.Benefiting from the possible“seed-germination”effect,the“seeds”Ni^(2+)grow into“buds”Ni nanoparticles and“stem”carbon nanotubes(CNTs)from the enlarged“soil”of MXene skeleton.Due to the improved impedance matching con-dition,the MXene-CNTs/Ni hybrid holds a superior microwave absorp-tion performance of−56.4 dB at only 2.4 mm thickness.Such a distinctive 3D architecture endows the hybrids:(i)a large-scale 3D magnetic coupling network in each dielectric unit that leading to the enhanced magnetic loss capability,(ii)a massive multi-heterojunction interface structure that resulting in the reinforced polarization loss capability,confirmed by the off-axis electron holography.These outstanding results provide novel ideas for developing magnetic MXene-based absorbers. | Xiao Li Wenbin You Chunyang Xu Lei Wang Liting Yang Yuesheng Li Renchao Che | 2021 | Nano-Micro Letters2021，13，10： | 4 |
| 17 | Evaluation of the acoustic nonlinearity parameter of materials with Rayleigh waves excited directly显示文摘An experimental technique for the determination of the relative acoustic nonlinearity parameter of materials with Rayleigh waves excited directly is presented.Rayleigh surface waves were directly generated in materials by the specific piezoelectric transducer fixed at the specimen's edge,and were measured with a laser interferometer system.After the Rayleigh wave signals were processed with FFT method,the relative acoustic nonlinearity parameter of materials was then determined from the absolute magnitudes of the fundamental and second harmonics of Rayleigh surface waves.This procedure was used to determine the acoustic nonlinearity parameters of aluminum alloys 2024 and 6061.It is shown that the results comply well with those available in the literature;this method can thus be used to evaluate the acoustic nonlinearity parameter of materials effectively.This technique can provide a practical way in the nondestructive characterization of degradation of materials and structures in the early fatigue life. | SHUI Guoshuang WANG Yuesheng Jianmin Qu Jin-Yeon Kim Laurence J. Jacobs | 2010 | Chinese Journal of Acoustics2010，29，2： | 3 |
| 18 | Studies on the Effects of the Immunosuppressant FK-506 on the High-risk Corneal Graft Rejection显示文摘Purpose: To evaluate the clinical efficacy of FK-506 on suppressing high-risk cornea transplantation rejection.Methods: In a randomized controlled clinical trial, 56 eyes of 56 patients with high-risk keratoplasty (including total corneal transplantation TCT, total corneal transplantation with circular lamellar sclera CST, vascularization corneal transplantation and corneal retransplantation) were divided into the experimental group and the control group(each with 28 eyes).The experimental group was treated by FK-506 eyedrops (0.5 mg/ml) and TobraDex eyedrops, compared with the control group that was treated by 1% CsA eyedrops and TobraDex eyedrops. In the average 8.1-month follow-up period, the visual acuity, graft transparent duration and Rejection Index (RI) of grafts were observed. Results: In the follow-up period, the graft rejection rate of the experimental and the control group was 63.6% and 95.2% respectively (χ2=4. 72, P < 0. 05) with significant difference.Conclusions: The local application of FK-506 suppressed effectively the graft rejection of corneal transplantation of the patients at high risk. | Minhua Wang, Yuesheng Lin, Jiaqi Chen, Yongming Liu, Hanping Xie, Chengtian YeZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2002 | 眼科学报2002，18，3： | 3 |
| 19 | Multifunction switching by a flat structurally tunable acoustic metasurface for transmitted waves显示文摘In this paper a flat structurally tunable acoustic metasurface is constructed based on the helical unit cell. The length of the acoustic channel can be tuned by the screw-in depth of the helix. Accordingly, the wave phase for the transmitted acoustic wave can be tuned and the wavefront can be manipulated. Then multifunctions such as anomalous refraction, point focusing, beam focusing and self-bending can be realized and switched just by screwing in or out the helixes. At the same time, the broadband operating frequency is also realized. The experiments for anomalous refraction and point focusing are also performed, and the results show that the designed metasurface is effective. The present studies have important applications in dynamic manipulation of acoustic waves by metasurfaces. | ALi Chen QuanYu Tang HaoYu Wang ShengDong Zhao YueSheng Wang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 20 | SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer显示文摘Alternative splicing is a critical process to generate protein diversity.However,whether and how alternative splicing regulates autophagy remains largely elusive.Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor.Specifically,SRSF1 inhibits autophagosome formation by reducing the accumulation of LC3-ⅡI and numbers of autophagosomes in different cell lines.Mechanistically,SRSF1 promotes the splicing of the long isoform of Bcl-x that interacts with Beclinl,thereby dissociating the Beclin1-PIK3C3 complex.In addition,SRSF1 also directly interacts with PIK3C3 to disrupt the interaction between Beclinl and PIK3C3.Consequently,the decrease of SRSF1 stabilizes the Beclinl and PIK3C3 complex and activates autophagy.Interestingly,SRSF1 can be degraded by starvation-and oxidative stresses-induced autophagy through interacting with LC3-Ⅱ,whereas reduced SRSF1 further promotes autophagy.This positive feedback is critical to inhibiting Gefitinib-resistant cancer cell progression both in vitro and in vivo.Consistently,the expression level of SRSF1 is inversely correlated to LC3 level in clinical cancer samples.Our study not only provides mechanistic insights of alternative splicing in autophagy regulation but also discovers a new regulatory role of SRSF1 in tumorigenesis,thereby offering a novel avenue for potential cancer therapeutics. | Yuesheng Lv Wenjing Zhang Jinyao Zhao Bing Sun Yangfan Qi Haoyu Ji Chaoqun Chen Jinrui Zhang Junxiu Sheng Taishu Wang Daniel Dominguez Han Liu Quentin Liu Songshu Meng Xiaoling Li Yang Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
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