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| 1 | Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation显示文摘The clinical application of doxorubicin(DOX) in cancer chemotherapy is limited by its lifethreatening cardiotoxic effects. Chrysophanol(CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role in a variety of biological processes.However, the effects of CHR’s cardioprotection in DOX-induced cardiomyopathy is poorly understood. In this study, we found that the cardiac apoptosis, mitochondrial injury and cellular PARylation levels were significantly increased in H9 C2 cells treated by Dox, while these effects were suppressed by CHR. Similar results were observed when PARP1 activity was suppressed by its inhibitors 3-aminobenzamide(3 AB)and ABT888. Ectopic expression of PARP1 effectively blocked this CHR’s cardioprotection against DOX-induced cardiomyocyte injury in H9 C2 cells. Furthermore, pre-administration with both CHR and 3 AB relieved DOX-induced cardiac apoptosis, mitochondrial impairment and heart dysfunction in Sprague–Dawley rat model. These results revealed that CHR protects against DOX-induced cardiotoxicity by suppressing cellular PARylation and provided critical evidence that PARylation may be a novel target for DOX-induced cardiomyopathy. | Jing Lu Jingyan Li Yuehuai Hu Zhen Guo Duanping Sun Panxia Wang Kaiteng Guo Dayue Darrel Duan Si Gao Jianmin Jiang Junjian Wang Peiqing Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 8 |
| 2 | Real-time PCR diagnosis of Schistosoma japonicum in low transmission areas of China显示文摘Background:Schistosomiasis in the People’s Republic of China(PRC)can be traced back to antiquity.In the past 60 years,the Chinese government has made great efforts to control this persistent disease with elimination slated by 2020 through the implementation of a comprehensive control strategy.This strategy aims to reduce the role of bovines and humans as sources of infection as a pre-requisite for elimination through transmission interruption.The goal of elimination will be achievable only by the implementation of a sustainable surveillance and control system,with sensitive diagnosis a key feature so that the true disease burden is not underestimated.Currently used diagnostics lack the necessary sensitivity to accurately determine the prevalence of Schistosoma japonicum infection in areas with low infection intensities.It is of critical importance to find and treat people and to identify animals with low-level infections if the National Control Programme for China is to achieve schistosomiasis elimination.Methods:We evaluated a real-time polymerase chain reaction(qPCR)assay using 633 human stool samples collected from five villages in Hunan,Anhui,Hubei,and Jiangxi provinces,and 182 bovine(70 cattle and 112 buffalo)stool samples obtained from four villages in Hunan,Anhui,and Jiangxi provinces in the PRC.All stool samples were subjected to the miracidium hatching test(MHT,a diagnostic procedure used in the National Schistosomiasis Control Programme)and the qPCR assay.Samples positive by MHT were subjected to either the Kato-Katz technique for humans,or the formalin-ethyl acetate sedimentation-digestion(FEA-SD)procedure for bovines,to determine infection intensities.Results:The qPCR assay exhibited a high level of sensitivity in the detection of S.japonicum infections.With both the human and bovine samples,a significantly higher prevalence was determined using the qPCR assay(11.06%humans,24.73%bovines)than with the MHT(0.93%humans,7.69%bovines).The animal contamination index(calculated using data obtained with the qPCR technique)for all positive bovines was 27618000 eggs per day,indicating a considerable amount of environmental egg contamination that would be underestimated using less sensitive diagnostic procedures.Conclusions:The qPCR assay we have evaluated will be applicable as a future field diagnostic and surveillance tool in low-transmission zones where schistosomiasis elimination is targeted and for monitoring post-intervention areas to verify that elimination has been maintained. | Pei He Catherine A.Gordon Gail M.Williams Yuesheng Li Yuanyuan Wang Junjian Hu Darren J.Gray Allen G.Ross Donald Harn Donald P.McManus | 2018 | Infectious Diseases of Poverty2018，7，1： | 7 |
| 3 | 长链非编码RNA在肿瘤中的研究(英文)显示文摘Long non-coding RNAs(lncRNAs), gradually being paid attention to, have been found playing a critical role in regulation of cellular processes such as cell growth and apoptosis, what is more, accumulating evidence indicates that lncRNAs also play a critical role in regulation of carcinogenesis and cancer progression. Here, we will summarize the recent researches about some lncRNAs in the development of cancers, hoping to give a new view about the study in the mechanisms involved in carcinogenesis and tumor progression. | Tingting Yu Ximing Xu Yi Hu Junjian Deng Biao Chen Nana Han Meixia Zhang | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，1： | 1 |
| 4 | The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication显示文摘The coronavirus disease 2019(COVID-19)is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)that poses a major threat to global public health.Although COVID-19 primarily affects the respiratory system,causing severe pneumonia and acute respiratory distress syndrome in severe cases,it can also result in multiple extrapulmonary complications. | Qin Ning Di Wu Xiaojing Wang Dong Xi Tao Chen Guang Chen Hongwu Wang Huiling Lu Ming Wang Lin Zhu Junjian Hu Tingting Liu Ke Ma Meifang Han Xiaoping Luo | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 5 | Dosimetric consequences of tumor volume changes after kilovoltage cone-beam computed tomography for non-operative lung cancer during adaptive intensity-modulated radiotherapy or fractionated stereotactic radiotherapy显示文摘Objective The aim of this study was to investigate tumor volume changes with kilovoltage cone-beam computed tomography(k V-CBCT) and their dosimetric consequences for non-operative lung cancer during intensity-modulated radiotherapy(IMRT) or fractionated stereotactic radiotherapy.Methods Eighteen patients with non-operative lung cancer who received IMRT consisting of 1.8–2.2 Gy/fraction and five fractions per week or stereotactic radiotherapy with 5–8 Gy/fraction and three fractions a week were studied. k V-CBCT was performed once per week during IMRT and at every fraction during stereotactic radiotherapy. The gross tumor volume(GTV) was contoured on the k V-CBCT images,and adaptive treatment plans were created using merged k V-CBCT and primary planning computed tomography image sets. Tumor volume changes and dosimetric parameters,including the minimum dose to 95%(D95) or 1%(D1) of the planning target volume(PTV),mean lung dose(MLD),and volume of lung tissue that received more than 5(V5),10(V10),20(V20),and 30(V30) Gy were retrospectively analyzed.Results The average maximum change in GTV observed during IMRT or fractionated stereotactic radiotherapy was –25.85%(range,–13.09% ––56.76%). The D95 and D1 of PTV for the adaptive treatment plans in all patients were not significantly different from those for the initial or former adaptive treatment plans. In patients with tumor volume changes of >20% in the third or fourth week of treatment during IMRT,adaptive treatment plans offered clinically meaningful decreases in MLD and V5,V10,V20,and V30; however,in patients with tumor volume changes of < 20% in the third or fourth week of treatment as well as in patients with stereotactic radiotherapy,there were no significant or clinically meaningful decreases in the dosimetric parameters.Conclusion Adaptive treatment planning for decreasing tumor volume during IMRT may be beneficial for patients who experience tumor volume changes of >20% in the third or fourth week of treatment. | Jian Hu Ximing Xu Guangjin Yuan Wei Ge Liming Xu Aihua Zhang Junjian Deng | 2015 | Oncology and Translational Medicine2015，1，5： | 0 |
| 6 | Expression and Analysis of Microtus fortis Against Schistosoma japonicum CD72显示文摘 | Yang Xiang Junjian Hu | 2014 | Journal of Life Sciences2014，8，9： | 0 |
| 7 | Experimental Investigation on Macro Spray Characteristics of Octanol-Biodiesel-Diesel Ternary Fuel Blend显示文摘This study investigates the spray characteristics of ternary blends composed of octanol, biodiesel, and diesel fuel.Experiments are conducted using six materials to examine the variation in spray characteristic and to verify and compare a previously established spray tip penetration model with a modified model. The results show that the addition of OB100(30%of octanol, 70% of biodiesel) improves the spray characteristics of the fuel. Specifically, the addition of 10% or 20% of OB100 leads to a slight increase in the spray tip penetration, average spray cone angle, maximum spray width, and the spray area of the fuel blend;however, further addition of OB100 causes a corresponding decrease in these parameters. Based on previous research, this study uses kinematic viscosity instead of dynamic viscosity and density to modify the prediction model of spray tip penetration. The modified model exhibits a better fit quality and agreement with the experimental data,making it more suitable for predicting the spray tip penetration of fuel blends compared to the Hiroyasu-Arai model. | Tian Junjian Qiu Zhicong Zhao Lifei Li Fengyu Hu Peng Lin Qizhao | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，4： | 0 |
| 8 | Amorphous calcium magnesium phosphate nanocomposites with superior osteogenic activity for bone regeneration显示文摘The seek of bioactive materials for promoting bone regeneration is a challenging and longterm task.Functionalization with inorganic metal ions or drug molecules is considered effective strategies to improve the bioactivity of various existing biomaterials.Herein,amorphous calcium magnesium phosphate(ACMP)nanoparticles and simvastatin(SIM)-loaded ACMP(ACMP/SIM)nanocomposites were developed via a simple co-precipitation strategy.The physiochemical property of ACMP/SIM was explored using transmission electron microscope(TEM),Fourier transform infrared spectroscopy(FTIR),powder X-ray diffraction(XRD)and highperformance liquid chromatograph(HPLC),and the role of Mg^(2+) in the formation of ACMP/SIM was revealed using X-ray absorption near-edge structure(XANES).After that,the transformation process of ACMP/SIM in simulated body fluid(SBF)was also tracked to simulate and explore the in vivo mineralization performance of materials.We find that ACMP/SIM releases ions of Ca^(2+),Mg^(2+)and PO_(4)^(3),when it is immersed in SBF at 37℃,and a phase transformation occurred during which the initially amorphous ACMP turns into self-assembled hydroxyapatite(HAP).Furthermore,ACMP/SIM displays high cytocompatibility and promotes the proliferation and osteogenic differentiation of MC3T3-E1 cells.For the in vivo studies,lamellar ACMP/SIM/Collagen scaffolds with aligned pore structures were prepared and used to repair a rat defect model in calvaria.ACMP/SIM/Collagen scaffolds show a positive effect in promoting the regeneration of calvaria defect after 12weeks.The bioactive ACMP/SIM nanocomposites are promising as bone repair materials.Considering the facile preparation process and superior in vitro/vivo bioactivity,the as-prepared ACMP/SIM would be a potential candidate for bone related biomedical applications. | Yingying Jiang Shuo Tan Jianping Hu Xin Chen Feng Chen Qianting Yao Zhi Zhou Xiansong Wang Zifei Zhou Yunshan Fan Junjian Liu Yize Lin Lijia Liu Shisheng He | 2021 | Regenerative Biomaterials2021，8，6： | 0 |
| 9 | Removal of the rate table:MEMS gyrocompass with virtual maytagging显示文摘High-performance micro-electro-mechanical system(MEMS)gyrocompasses for north-finding systems have been very popular for decades.In this paper,a MEMS north-finding system(NFS)based on virtual maytagging(VM)is presented for the first time.In stark contrast to previous schemes of MEMS-based NFSs(e.g.,carouseling,maytagging)and the abandoning rate table,we developed a honeycomb disk resonator gyroscope(HDRG)and two commercial accelerometers for azimuth detection.Instead of the physical rotation of the integrated turntable in traditional NFSs,the vibratory working modes of the HDRG are rotated periodically with electronic control to reduce the uncertainty in the azimuth.After systematically analyzing the principle of NFSs with VM,we designed tests to verify the practicability at the sensor level.A bias instability of 0.0078°/h can be obtained during one day with VM in an HDRG.We also implemented comparative north-finding experiments to further check our strategy at the system level.The accuracy in the azimuth can reach 0.204°for 5 min at 28.2°latitude with VM and 0.172°with maytagging.The results show that without any mechanical turning parts,VM technology makes it possible to develop high-precision handheld MEMS NFSs. | Tongqiao Miao Qingsong Li Liangqian Chen Junjian Li Xiaoping Hu Xuezhong Wu Wenqi Wu Dingbang Xiao | 2023 | Microsystems & Nanoengineering2023，9，6： | 0 |
| 10 | On the Solutions to Reform Red Cross Spirit Education During COVID-19 Pandemic显示文摘COVID-19 pandemic causes various challenges to education,especially in Red Cross Spirit education,which may affect students’growth.This study gives detailed analysis of the challenges that Red Cross Spirit education encounters.Then,this study attempts to seek out suitable solutions from three perspectives:schools,teachers,and parents,hoping to provide reference for teaching or education in other disciplines and make a contribution to students’growth. | HONG Mei WU Le HU Junjian | 2023 | US-China Foreign Language2023，21，1： | 0 |
| 11 | A novel and effective hyperthermia method for Schistosomiasis japonica prevention and treatment显示文摘The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 %(37 °C, 5 min) to 0(49 °C, 10 min) with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy(P \ 0.05). Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45–49 °C for5 min within 8 h of infection, worm reduction rate(WRR)reached 74 %–83 %(P \ 0.01). The sensitivity of adultschistosoma to heat was also investigated using microwave intraperitoneal hyperthermia(thermal dosages 42–43 °C,20 min). The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel(PZQ)-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus,hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage. | Huixia Yang Tao Tang Pei He Youren Zhang Le Xie Guangqi Liu Li Li Weichao Kong Jingdingsha Li Ruiting Liu Yukun Li Junjian Hu Xiaowen Wang Liya Li Guanghong Xiang Geoffrey Gobert Yuesheng Li Jintian Tang | 2015 | Science Bulletin2015，60，16： | 0 |
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