| 1 | Roles of Te and Mn in the two phases of manganite with nominal composition La_(0.6)Sr_(0.1)Te_xMnO_3显示文摘Powder samples with nominal composition La0.6Sr0.1TexMnO3 (x = 0.00, 0.05, 0.10, 0.15, 0.20) were prepared using the sol-gel method with thermal treatment up to 1473 K. On the basis of powder X-ray diffraction (XRD), thermogravimetric and magnetic measurements, it was found that almost all of the Te and a few of the Mn ions were lost from the samples when they were calcined at 1473 K. The reason for the Te loss and a quantitative phase analysis for the samples calcined at 1473 K are discussed in detail. | LI Yanfeng JI Denghui ZHAO Zhiwei TANG Guide LIU Shaopeng ZHANG Yuge LI Zhuangzhi HOU Denglu ZHU Minggang | 2011 | Rare Metals2011，30，3： | 2 |
| 2 | Single-Exosome Profiling Identifies ITGB3+and ITGAM+Exosome Subpopulations as Promising Early Diagnostic Biomarkers and Therapeutic Targets for Colorectal Cancer显示文摘Tumor metastasis is a hallmark of colorectal cancer(CRC),in which exosome plays a crucial role with its function in intercellular communication.Plasma exosomes were collected from healthy control(HC)donors,localized primary CRC and liver-metastatic CRC patients.We performed proximity barcoding assay(PBA)for single-exosome analysis,which enabled us to identify the alteration in exosome subpopulations associated with CRC progression.By in vitro and in vivo experiments,the biological impact of these subpopulations on cancer proliferation,migration,invasion,and metastasis was investigated.The potential application of exosomes as diagnostic biomarkers was evaluated in 2 independent validation cohorts by PBA.Twelve distinct exosome subpopulations were determined.We found 2 distinctly abundant subpopulations:one ITGB3-positive and the other ITGAM-positive.The ITGB3-positive cluster is rich in liver-metastatic CRC,compared to both HC group and primary CRC group.On the contrary,ITGAM-positive exosomes show a large-scale increase in plasma of HC group,compared to both primary CRC and metastatic CRC groups.Notably,both discovery cohort and validation cohort verified ITGB3+exosomes as potential diagnostic biomarker.ITGB3+exosomes promote proliferation,migration,and invasion capability of CRC.In contrast,ITGAM+exosomes suppress CRC development.Moreover,we also provide evidence that one of the sources of ITGAM+exosomes is macrophage.ITGB3+exosomes and ITGAM+exosomes are proven 2 potential diagnostic,prognostic,and therapeutic biomarkers for management of CRC. | Wei Guo Yanling Cai Xianming Liu Yuge Ji Cuiyu Zhang Liyan Wang Wenting Liao Yuefei Liu Nan Cui Jinsheng Xiang Zesong Li Di Wu Jingxin Li | 2023 | Research2023，，3： | 0 |
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