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| 1 | Transforming the Loess Plateau of China显示文摘This paper aims to show the importance of land consolidation in transforming the Loess Plateau of China. The paper comprehensively analyzes how over recent decades the Grain for Green Project and Gully Land Consolidation Project jointly transformed the ecology and landscape of the Loess Plateau and the livelihood of its residents. The findings show that these two projects have achieved a balance between green protection, new land creation, and improved food security and livelihood of local people in the hilly areas of China. The paper points out that the successful transformation of the Plateau lies in a holistic approach incorporating various components of the human and natural systems. Finally, the paper highlights the necessity of retaining these two land consolidation projects as part of an ongoing policy in the mountain and hilly areas of China, changing agricultural management to suit the new relationship between humans and the land. | Yuheng LI Guoming DU Yansui LIU | 2016 | Frontiers of Agricultural Science and Engineering2016，3，3： | 3 |
| 2 | The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention显示文摘Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs(lnc RNAs) play key roles in diverse biological, physiological and pathological contexts. However, the roles of lnc RNAs in mechanotransduction and their relationships with bone formation remain unknown. In this study, we screened mechanosensing lnc RNAs in osteoblasts and identified Neat1, the most clearly decreased lnc RNA under simulated microgravity. Of note, not only Neat1 expression but also the specific paraspeckle structure formed by Neat1 was sensitive to different mechanical stimulations, which were closely associated with osteoblast function. Paraspeckles exhibited small punctate aggregates under simulated microgravity and elongated prolate or larger irregular structures under mechanical loading. Neat1 knockout mice displayed disrupted bone formation, impaired bone structure and strength, and reduced bone mass. Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation. In vivo, Neat1 knockout in mice weakened the bone phenotypes in response to mechanical loading and hindlimb unloading stimulation. Mechanistically, paraspeckles promoted nuclear retention of E3 ubiquitin ligase Smurf1 m RNA and downregulation of their translation, thus inhibiting ubiquitination-mediated degradation of the osteoblast master transcription factor Runx2, a Smurf1 target. Our study revealed that Neat1 plays an essential role in osteoblast function under mechanical stimulation, which provides a paradigm for the function of the lnc RNA-assembled structure in response to mechanical stimulation and offers a therapeutic strategy for long-term spaceflight-or bedrest-induced bone loss and age-related osteoporosis. | Caizhi Liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li | 2022 | Bone Research2022，10，2： | 3 |
| 3 | Impacts of ti currents and Kuroshio intrusion on the generation nonlinear internal waves in Luzon Strait 显示文摘 | Du Tao Tseng Yuheng Yan Xiaohai | 2008 | Journal Geophysical Research-Oceans2008，113，8： | 1 |
| 4 | Evaluation of Cell Type Annotation R Packages on Single-cell RNA-seq显示文摘Annotating cell types is a critical step in single-cell RNA sequencing(scRNA-seq)data analysis.Some supervised or semi-supervised classification methods have recently emerged to enable automated cell type identification.However,comprehensive evaluations of these methods are lacking.Moreover,it is not clear whether some classification methods originally designed for analyzing other bulk omics data are adaptable to scRNA-seq analysis.In this study,we evaluated ten cell type annotation methods publicly available as R packages.Eight of them are popular methods developed specifically for single-cell research,including Seurat,scmap,SingleR,CHETAH,SingleCellNet,scID,Garnett,and SCINA.The other two methods were repurposed from deconvoluting DNA methylation data,i.e.,linear constrained projection(CP)and robust partial correlations(RPC).We conducted systematic comparisons on a wide variety of public scRNA-seq datasets as well as simulation data.We assessed the accuracy through intra-dataset and inter-dataset predictions;the robustness over practical challenges such as gene filtering,high similarity among cell types,and increased cell type classes;as well as the detection of rare and unknown cell types.Overall,methods such as Seurat,SingleR,CP,RPC,and SingleCellNet performed well,with Seurat being the best at annotating major cell types.Additionally,Seurat,SingleR,CP,and RPC were more robust against downsampling.However,Seurat did have a major drawback at predicting rare cell populations,and it was suboptimal at differentiating cell types highly similar to each other,compared to SingleR and RPC.All the code and data are available from http://gffzz188fe103f8f1460asukv0vpfqvqnw6ob0.ffgz.tsg.suse.edu.cn/qianhuiSenn/scRNA_cell_deconv_benchmark. | Qianhui Huang Yu Liu Yuheng Du Lana X.Garmire | 2021 | Genomics, Proteomics & Bioinformatics2021，19，2： | 1 |
| 5 | HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation显示文摘Bone marrow mesenchymal stem cell(BMSC)osteogenic differentiation and osteoblast function play critical roles in bone formation,which is a highly regulated process.Long noncoding RNAs(lncRNAs)perform diverse functions in a variety of biological processes,including BMSC osteogenic differentiation.Although several studies have reported that HOX transcript antisense RNA(HOTAIR)is involved in BMSC osteogenic differentiation,its effect on bone formation in vivo remains unclear.Here,by constructing transgenic mice with BMSC(Prx1-HOTAIR)-and osteoblast(Bglap-HOTAIR)-specific overexpression of HOTAIR,we found that Prx1-HOTAIR and Bglap-HOTAIR transgenic mice show different bone phenotypes in vivo.Specifically,Prx1-HOTAIR mice showed delayed bone formation,while Bglap-HOTAIR mice showed increased bone formation.HOTAIR inhibits BMSC osteogenic differentiation but promotes osteoblast function in vitro.Furthermore,we identified that HOTAIR is mainly located in the nucleus of BMSCs and in the cytoplasm of osteoblasts.HOTAIR displays a nucleocytoplasmic translocation pattern during BMSC osteogenic differentiation.We first identified that the RNA-binding protein human antigen R(HuR)is responsible for HOTAIR nucleocytoplasmic translocation.HOTAIR is essential for osteoblast function,and cytoplasmic HOTAIR binds to miR-214 and acts as a ceRNA to increase Atf4 protein levels and osteoblast function.BglapHOTAIR mice,but not Prx1-HOTAIR mice,showed alleviation of bone loss induced by unloading.This study reveals the importance of temporal and spatial regulation of HOTAIR in BMSC osteogenic differentiation and bone formation,which provides new insights into precise regulation as a target for bone loss. | Yuheng Li Weijia Sun Jianwei Li Ruikai Du Wenjuan Xing Xinxin Yuan Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Junjie Pan Youyou Li Qi Li Guanghan Kan Xuan Han Shukuan Ling Xiqing Sun Yingxian Li | 2023 | Bone Research2023，11，4： | 0 |
| 6 | Boosting the high-rate performance and cycling life of NaTi_(2)(PO_(4))_(3) anode by forming N-doped carbon coating derived from polyacrylonitrile显示文摘Poor electron conductivity is the key issue influencing the rate capability of NaTi_(2)(PO_(4))_(3)(NTP).Hence,herein,polyacrylonitrile(PAN)was utilized as a NTP modifier by simply mixing NTP in a liquid PAN suspension,followed by sintering at 850℃ for 5 h.The product with a PAN/NTP mass ratio of 0.3 delivered splendid rate capabilities(achieving lithiation capacities of 282.9,243.0,207.1,173.1,133.5,and 257.5 mAh g^(−1) at 0.1,0.2,0.4,0.8,1.6,and 0.1 A^(−1),respectively)and excellent long cycling life(capacity retention of 165.5 mAh g^(−1) after 1200 cycles at 0.5 A g−1).Based on detailed structural and compositional characterizations,as well as cyclic voltammetry(CV)and electrochemical impedance spectroscopy(EIS),the uniform N-doped carbon coating stemming from PAN carbonization around the NTP particles promoted electron transfer,while the oxygen vacancies induced by N-doping in NTP facilitated Li+diffusion.The boosted and well matched electronic and ionic conductivities give rise to the optimized electrochemical performance. | Huan Yang Zhongnian Yang Yujun Bai Wenjing Du Yuheng Wang Jiru Xian | 2023 | ChemPhysMater2023，2，4： | 0 |
| 7 | Field-induced anisotropic magnetic phase transitions and tricritical phenomena in GdCr_(6)Ge_(6)显示文摘The interaction between complex magnetic structures and non-trivial band structures in ternary rare-earth GdCr_(6)Ge_(6) induces exotic and abundant electro-magnetic phenomena.In this work,we perform a systematical investigation on critical behaviors and magnetic properties of the single-crystal GdCr_(6)Ge_(6).The temperature,field,and angle dependence of magnetization unveils strong magnetic anisotropy along the c-axis and isotropic characteristic in the ab-plane.Critical exponentsβ=0.252(1),γ=0.905(9),δ=4.606(3)for H//ab,andβ=0.281(3),γ=0.991(8),δ=4.541(5)for H//c are obtained by the modified Arrott plot method(MAP)and critical isotherm(CI)analysis.The determined exponents for both directions are consistent with the theoretical prediction of a tricritical mean-field model.Based on detailed magnetization measurements and universality scaling,comprehensive magnetic phase diagrams of GdCr6Ge6for H//ab and H//c are constructed,which reveal that the external field induces a ferromagnetic(FM)transition for H//ab while a ferrimagnetic(FIM)one for H//c.Two tricritical points are determined for H//ab(11.2 K,266.3 Oe)and H//c(11.3 K,3.3 kOe)on the phase diagrams,respectively.The field-induced anisotropic magnetic configurations and multiple phases are clarified,where the moments of Gd and Cr form FM coupling for H//ab while FIM one for H//c via the interaction between Gd and Cr sublattices. | Zan Du Azizur Rahman Jiangpeng Song Jun Zhao Wei Liu Jiyu Fan Chunlan Ma Min Ge Yimin Xiong Li Pi Lei Zhang Yuheng Zhang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 0 |
| 8 | Visualization of Ferroelectric Domains in Thin Films of Molecular Materials Using Confocal Micro-Raman Spectroscopy显示文摘Ferroelectrics are an important class of functional materials.Among all their unique properties,the study of their ferroelectric domains and domain walls is of great interest due to their importance in ferroelectric applications.There are many methods to characterize ferroelectric domains,namely,scanning probe microscopy,optical microscopy,electron microscopy,etc.Currently,newly emerged molecular ferroelectrics are attracting much attention from chemists,physicists and researchers in material sciences due to their structural flexibility,light mass,simple fabrication,etc.However,for the characterization of molecular ferroelectric domains,most conventional methods require either a complicated preparation process or direct contact between physical probes and material surfaces,limiting the development of molecular ferroelectric materials.In this report,we have demonstrated that confocal micro-Raman spectroscopy,as a nondestructive and noncontact in-situ method,is very suitable for studying the ferroelectric polarization and structures of domains in molecular ferroelectrics.Taking recently reported molecular ferroelectric trimethylchloromethyl ammonium trichlorocadmium(II)(TMCM-CdCl_(3))as an example,the non-180°domains have been characterized and visualized at different temperatures.Such a simple and extendable method requires minimum sample preparation,which would further benefit the research of molecular ferroelectric domain engineering and promote the miniaturization and integration of molecular ferroelectric films. | ZHOU Wenqin FENG Zijie XIONG Yuan DU Guowei LIN Xiumei SU Qidong LOU Yuheng AN Shili YOU Yumeng | 2022 | Chemical Research in Chinese Universities2022，38，6： | 0 |
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