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| 1 | Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity显示文摘Six new indole alkaloid sulfonic acids(1–6), together with two analogues(7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95(H3N2), respectively. | Lingjie Meng Qinglan Guo Yufeng Liu Minghua Chen Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 14 |
| 2 | Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots显示文摘A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A(1), was isolated from an aqueous extract of the Isatis indigotica roots 'ban lan gen'. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J-and NOESY correlation-based configurational analysis, circular dichroism(CD) data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated. | Lingjie Meng Qinglan Guo Minghua Chen JiANDong Jiang Yuhuan Li Jiangong Shi | 2018 | Chinese Chemical Letters2018，29，8： | 7 |
| 3 | Comparative study on virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients显示文摘Dear Editor,An acute viral pneumonia(COVID-19),caused by the novel coronavirus known as SARS-CoV-2,was first identified during December 2019 in China(Zhu et al.,2020).SARSCoV-2 was found to be highly transmissible in humans(Wang et al.,2020)and is now a pandemic spreading to over 140 countries and causing over 150,000 infections and 6,000 deaths as of March 15,2020.Diagnosis is critical for confirmation and treatment of COVID-19.Currently the primary criterion for diagnosis of COVID-19 is viral RNA detection for respiratory samples.Recently,two studies on virus loads in clinical samples reported that viral loads in nasal and throat swabs and sputum specimens peaked at 3–7 days after illness onset(d.a.o.)and virtually disappeared before 15 d.a.o.(Pan et al.,2020;Zou et al.,2020).Another study showed that the median duration of virus shedding in throat swabs was 20 d.a.o.in survivors and was detectable until death in non-survivors(Zhou et al.,2020).Additionally,live viruses have been isolated in the feces and urine samples of COVID-19 patients.However,the viral dynamics in these types of specimens has not yet been clearly elucidated,as well as comparative studies on virus shedding in the upper respiratory,intestinal,and urinary tracts. | Ning Zhang Yuhuan Gong Fanping Meng Yi Shi Jun Wang Panyong Mao Xia Chuai Yuhai Bi Penghui Yang Fusheng Wang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 4 | Iodine Promoted Ultralow Zn Nucleation Overpotential and Zn-Rich Cathode for Low-Cost, Fast-Production and High-Energy Density Anode-Free Zn-Iodine Batteries显示文摘The anode-free design is a promising strategy to increase the energy density of aqueous Zn metal batteries(AZMBs).However,the scarcity of Zn-rich cathodes and the rapid loss of limited Zn greatly hinder their commercial applications.To address these issues,a novel anode-free Zniodine battery(AFZIB)was designed via a simple,low-cost and scalable approach.Iodine plays bifunctional roles in improving the AFZIB overall performance:enabling high-performance Zn-rich cathode and modulating Zn deposition behavior.On the cathode side,the ZnI_(2) serves as Zn-rich cathode material.The graphene/polyvinyl pyrrolidone heterostructure was employed as an efficient host for ZnI_(2) to enhance electron conductivity and suppress the shuttle effect of iodine species.On the anode side,trace I_(3)^(−) additive in the electrolyte creates surface reconstruction on the commercial Cu foil.The in situ formed zincophilic Cu nanocluster allows ultralow-overpotential and uniform Zn deposition and superior reversibility(average coulombic efficiency>99.91% over 7,000 cycles).Based on such a configuration,AFZIB exhibits significantly increased energy density(162 Wh kg^(−1)) and durable cycle stability(63.8% capacity retention after 200 cycles)under practical application conditions.Considering the low cost and simple preparation methods of the electrode materials,this work paves the way for the practical application of AZMBs. | Yixiang Zhang Lequan Wang Qingyun Li Bo Hu Junming Kang Yuhuan Meng Zedong Zhao Hongbin Lu | 2022 | Nano-Micro Letters2022，14，12： | 1 |
| 5 | Accurate detection method of pig's temperature based on non-point source thermal infrared image显示文摘Body temperature measurement is a very important task in the sow breeding process.The authors used an infrared camera to detect the temperature of the body surface of the sows,relying on calculating the average of the infrared image temperature in the ear root region.Based on the grayscale value of the target image of the infrared image and the corresponding temperature value of 180 infrared images,a G-T(Gray-Temperature)model was established by linear least squares method,which achieved temperature inversion of each pixel of the target pig.For the different growth stages and different breeds of sows,the R-square of the all established models is greater than 0.95.The average relative error of the model inversion of the body temperature was only 0.076977%.This means that the body temperature of the sows could be detected without relying on the software.Based on the G-T model,the authors design a kind of sow's ear root recognition and body surface temperature detection algorithm for different sow population scenarios. | Zaiqin Zhang Hao Wang Tonghai Liu Yueqiang Wang Hang Zhang Feiyan Yuan Xue Yang Shunlai Xu Yuhuan Meng | 2021 | CAAI Transactions on Intelligence Technology2021，6，3： | 1 |
| 6 | Synthesis and antiviral activities of a novel class of thioflavone and flavonoid analogues显示文摘A novel class of thioflavone and flavonoid derivatives has been prepared and their antiviral activities against enterovirus 71(EV71)and the coxsackievirus B3(CVB3)and B6(CVB6)were evaluated.Compounds 7d and 9b showed potent antiviral activities against EV71 with ICso values of 8.27 and 5.48μM,respectively.Compound 7f,which has been synthesized for the first time in this work,showed the highest level of inhibitory activity against both CVB3 and CVB6 with an ICso value of 0.62 and 0.87μM.Compounds 4b,7a,9c and 9e also showed strong inhibitory activities against both the CVB3 and CV B6 at low concentrations(IC_(50)=1.42-7.15μM),whereas compounds 4d,7c,7e and 7g showed strong activity against CVB6(IC_(50)=2.91-3.77μM)together with low levels of activity against CVB3.Compound 7d exhibited stronger inhibitory activity against CVB3(IC_(50)=6.44μM)thaln CVB6(IC_(50)>8.29μM).The thioflavone derivatives 7a,7c,7d,7e,7f and 7g,represent a new class of lead compounds for the development of novel antiviral agents. | Dajun Zhang Xingyue Ji Rongmei Gao Huiqiang Wang Shuai Meng Zhaojin Zhong Yuhuan Lin Jiandong Jiang Zhuorong Li | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 0 |
| 7 | Sorption mechanisms of diphenylarsinic acid on natural magnetite and siderite:Evidence from sorption kinetics,sequential extraction and extended X-ray absorption fine-structure spectroscopy analysis显示文摘Diphenylarsinic acid(DPAA)is both the prime starting material and major metabolite of chemical weapons(CWs).Because of its toxicity and the widespread distribution of abandoned CWs in burial site,DPAA sorption by natural Fe minerals is of considerable interest.Here we report the first study on DPAA sorption by natural magnetite and siderite using macroscopic sorption kinetics,sequential extraction procedure(SEP)and microscopic extended X-ray absorption fine-structure spectroscopy(EXAFS).Our results show that the sorption pseudo-equilibrated in 60 minutes and that close to 50%and 20%–30%removal can be achieved for magnetite and siderite,respectively,at the initial DPAA concentrations of 4–100 mg/L.DPAA sorption followed pseudo-secondary and intra-particle diffusion kinetics models,and the whole process was mainly governed by intra-particle diffusion and chemical bonding.SEP and EXAFS results revealed that DPAA mainly formed inner-sphere complexes on magnetite(>80%),while on siderite it simultaneously resulted in outer-sphere and inner-sphere complexes.EXAFS analysis further confirmed the formation of inner-sphere bidentate binuclear corner-sharing complexes(^(2)C)for DPAA.Comparison of these results with previous studies suggests that phenyl groups are likely to impact the sorption capacity and structure of DPAA by increasing steric hindrance or affecting the way the central arsenic(As)atom maintains charge balance.These results improve our knowledge of DPAA interactions with Fe minerals,which will help to develop remediation technology and predict the fate of DPAA in soil-water environments. | Meng Zhu Yuhuan He Xiaobao Wei Haoran Qi Yunpeng Zhang Yijun Zhang Ruyi Yang Yongming Luo | 2022 | Frontiers of Environmental Science & Engineering2022，16，9： | 0 |
| 8 | m^6A RNA甲基化由microRNA调控并且促进细胞向多能性状态的重编程转变显示文摘细胞出版社《细胞-干细胞》杂志创刊于2007年,聚焦于干细胞领域,出版该领域的研究论文和综述。通过与作者、评论员、科学编委会的密切合作,杂志的编辑人员以保持细胞出版社期刊一贯的高标准为使命,对该领域的研究结果予以及时报道。该杂志2015年公布的影响因子为22.268。 | Tong Chen Ya-Juan Han Ying Zhang Miao-Miao Li Meng Wang Weifang Han Yongsheng Wu Ying Lv Jie Hao Libin Wang Ang Li Ying Yang Kang-Xuan Jin Xu Zhao Yuhuan Li Xiao-Li Ping Wei-Yi Lai Li-Gang Wu Guibin Jiang Hai-Lin Wang Lisi Sang 王秀杰 杨运桂 周琪 | 2016 | 科学新闻2016，0，1： | 0 |
| 9 | The effects of miR-375 expression in NSCLC via the 14-3-3ζ/ERK/MYC pathway显示文摘Objective There are several reports that suggest a significant role played by microRNAs(miRNAs) in cell invasion, metastasis, differentiation, and apoptosis in lung cancers. miR-375 is one such miRNA that has been detected in a variety of tumors, but its specific activity in non-small cell lung cancer(NSCLC) remains unclear. Methods In this study, we regulated the expression of miR-375, to evaluate its influence on the 14-3-3ζ/ERK/MYC pathway in NSCLC. Results The results of our experiments suggest that miR-375 and 14-3-3ζ are highly expressed in NSCLC, and the over-expression of miR-375 increases the invasive, metastatic, and proliferative ability and decreases the apoptotic ability of NSCLC cells. In addition, protein expression levels of 14-3-3ζ, p-ERK, and MYC increased following the overexpression of miR-375. Conclusion Overall, our findings indicate that miR-375 increases the malignant potential of NSCLC via the 14-3-3ζ/ERK/MYC pathway. | Haining Meng Junyu Wu Qiao Huang Jiwen Ren Jiawei Huang Weijun Yuan Xuekun He Yuhuan Wang Congxian Cui Shengwei Xu Ruowu Shen | 2018 | Oncology and Translational Medicine2018，4，5： | 0 |
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