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| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17显示文摘雌激素涉及支持肺癌症房间分割和转移。云母和 MICB 为 NKG2D 作为 ligands 工作,在生来的杀手(NK ) 上表示的重要 immunoreceptor 房间。然而,雌激素是否调整 MICA/B 表示并且影响肿瘤免疫者逃跑,仍然保持未知。在这研究,我们测量了非小的房间肺癌症(NSCLC ) 房间线与雌激素对待的云母, MICB 和 ADAM17in 的 mRNA 层次。LTEP-a2 和 A549 上的 MICA/B 的表面表示用流动 cytometry 被检测。我们证明 mRNA 和在肺腺癌房间线的 MICA/B 的能分泌的蛋白质层次是由 estradiol 的 upregulated。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。MICA/B downregulated 的这分泌物 NK92 房间的表面上的 NKG2D 受体并且损害了 NK 房间的细胞毒素的活动。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。而且,在 estradiol 和云母的表示的集中之间的重要关联在 NSCLC 病人的肿瘤纸巾被发现。因此,我们断定雌激素能通过 ADAM17 调整 MICA/B 的表示和分泌物,它帮助肺癌症房间逃离调停 NKG2D 的有免疫力的监视。 | Jing Ren Yunzhong Nie Mingming Lv Sunan Shen Ruijing Tang Yujun Xu Yayi Hou Shuli Zhao Tingting Wang | 2015 | Cellular & Molecular Immunology2015，12，6： | 6 |
| 3 | Preparation and ion exchange properties of egg-shell glass beads with different surface morphologies显示文摘A subcritical water treatment method was developed for preparing porous-surfaced glass beads with an egg-shell structure in a batch reactor. Based on the 'corrosion-ion-migration-recondensation' strategy, ordinary soda-lime glass beads with a diameter of about 100 m were made first to react with subcritical water to effect controlled quantity of silicate dissolution of glass by adjusting treatment time and temperature. The dissolved silicate was then made to recondense on the glass core to form different porous shell morphologies: pores, flakes and fibers. Among these, glass beads coated with fibers with surface area of 154.5 m2/g, pore volume of 0.27 cm3/g and pore size of 7.1 nm were obtained at 573 K after 2 h of treatment. The prepared porous-surfaced glass beads were then used as adsorbent for heavy metal ions, showing various ion exchange properties. Glass beads covered with fibers displayed fast kinetics and high sorption capacity because of their egg-shell structure and high surface area. More than 90% of copper ions were adsorbed within 100 min from a solution with an initial concentration of 110 mg/L at 313 K. Ion sorption capacities were 149.33, 81.33 and 42.96 mg/g respectively for Ag+, Cu2+ and Ni2+ at 313 K. A green and low-cost method was thus developed to produce egg-shell-structured porous glass with high sorption capacity. | Chun Shen Yujun Wang Jianhong Xu Yangcheng Lu Guangsheng Luo | 2012 | Particuology2012，10，3： | 6 |
| 4 | Effects of different biochars on antibiotic resistance genes during swine manure thermophilic composting显示文摘Elimination of antibiotic resistance genes(ARGs)in animal manure from concentrated animal feeding operations by thermophilic composting has drawn increasing attention.This study investigated the effects of sawdust biochar,corn stover biochar and peanut hull biochar with three spiked levels on ARGs in swine manure during thermophilic composting.Thirteen ARGs corresponding to four classes of antibiotics(tetracyclines,sulfonamides,macrolides and quinolones)were determined in the composting piles.Results indicated that the ten tested composting groups became fully mature after 30-day thermophilic composting process.tetM,tetO and ermB were reduced in all tested groups;tetC and tetG,tetX,sul1,sul2,ermF,qnrD and aac(6’)-Ib were mostly reduced under low level biochar addition but increased under higher level biochar addition;gyrA increased under medium biochar addition and reduced in other groups;oqxB remained comparatively stable throughout the composting process.The addition levels of spiked biochar are more important than types of spiked biochar on the removal of ARGs in the composting pile.The average removal rates of ARGs in the control group,low,medium and high level biochar addition groups were 0.24 logs,0.52-0.72 logs,-0.52-0.18 logs and-0.19-0.21 logs,respectively.In summary,low level biochar addition could enhance the elimination of studied ARGs in swine manure during the composting process,while medium level biochar addition to the composting piles would increase the risk of ARGs’propagation. | Jian Wang Bin Sui Yujun Shen Haibo Meng Lixin Zhao Haibin Zhou Ran Li Jingtao Ding Hongsheng Cheng Xi Zhang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 5 |
| 5 | Neddylation is required for herpes simplex virus type I (HSV- 1)-induced early phase interferon-beta production显示文摘 | Xueying Zhang Zhenjie Ye Yujun Pei Guihua Qiu Qingyang Wang Yunlu Xu Beifen Shen Jiyan Zhang | 2016 | Cellular & Molecular Immunology2016，13，5： | 5 |
| 6 | Association of the Late Cornified Envelope-3 Genes with Psoriasis and Psoriatic Arthritis:A Systematic Review显示文摘Psoriasis(Ps)and psoriatic arthritis(Ps A)are genetically complex diseases with strong genetic evidence.Recently,susceptibility genes for Ps and Ps A have been identified within the late cornified envelop(LCE)gene cluster,especially the cluster 3(LCE3)genes.It is noteworthy that the deletion of LCE3B and LCE3C(LCE3C_LCE3B-del)is significantly associated with these two diseases.Gene-gene interactions between LCE3 genes and other genes are associated with Ps and Ps A.LCE3 genes also have pleiotropic effect on some autoimmune diseases,such as rheumatoid arthritis,atopic dermatitis and systemic lupus erythematosus.Further studies need to focus on the potential function of LCE3 genes in the pathogenesis of Ps and Ps A in the future. | Changbing Shen Jing Gao Xianyong Yin Yujun Sheng Liangdan Sun Yong Cui Xuejun Zhang | 2015 | Journal of Genetics and Genomics2015，42，2： | 4 |
| 7 | Metagenome analysis reveals potential microbial functions in topsoil of wheat-maize rotation system with five-year application of fertilizers显示文摘Fertilization mode affects soil quality and ecological health.The effects of four fertilization regimens on lignocellulose content,readily degradable carbohydrate decomposition,and potential microbial functions in the topsoil of a wheat-maize rotation system between 2012 and 2017 were investigated.The fertilization regimens of control(control NFNB),high chemical fertilizer(HCF),high biochar plus low chemical fertilizer(HBLCF),and biochar-based fertilizer(BBF)were compared on soil fundamental properties,microbial structure,and potential function in soil carbohydrate degradation based on metagenome analysis.The diversity of carbohydrate-active enzyme genes in the topsoil microbial consortia in the four trials was primarily distributed within the ten ecologically most dominant phyla.Application of BBF was associated with the lowest decline in total nitrogen and P2O5(2012-2017:6.5%and 28.1%,respectively)and the most effective carbohydrate decomposition(2015-2017:67.0%for cellulose and 59.9%for readily degradable carbohydrate).Carbohydrate transport and metabolism accounted for 6.0%of reads assigned functional classification under the BBF regimen.These findings reveal the ecologically functional diversity of topsoil microorganisms and suggest BBF application as a promising strategy for sustainable agriculture and beneficial to soil health. | Yujun Shen Lixin Zhao Haibo Meng Hongsheng Cheng Jingtao Ding Jiarui Wang Shanshan Dong Xi Zhang Liqiu Song Shengwei Zheng | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 3 |
| 8 | Forest succession in post-agricultural Larix olgensis plantations in northeast China显示文摘In order to understand the management of regional vegetation,numerical classification and ordination are widely used to investigate community distribution and vegetation features.In particular,two-way indicator-species analysis programs(TWINSPAN)classifies plots and species into different groups.De-trended correspondence analysis(DCA)and canonical correspondence analysis(CCA)reflects the relationship between community and site conditions.Afforestation with Larix olgensis Herry.Plantations is a suitable restoration strategy on post-agricultural fields in the Lesser Khingan Mountains.The results of this study show how these plantations develop over time to establish a reliable pathway model by measuring and clarifying the succession process.Twenty-eight L.olgensis plantations along a 48-year chronosequence of afforestation were investigated with a quadrat sampling method.Species composition,community structure attributes of diversity,and site conditions were analyzed.Communities were classified by TWINSPAN into five successional stages:immature,juvenile,mid-aged,nearmature and mature.Classifications were validated by DCA and CCA analysis.Site conditions such as soil and litter thickness,soil organic matter,soil density,and pH were measured.Successional stages varied in community composition and species population,accompanied by time from afforestation and a gradient of site conditions.This gradient showed changes in vegetation occurrence and diversity coinciding with changes in soil conditions.The study showed that L.olgensis plantations had marked predominance in growth and were associated with improved soil fertility and the formation of a stable plant community. | Wei Ma Shen Lei Yujun Sun Jason Grabosky | 2020 | Journal of Forestry Research2020，31，6： | 3 |
| 9 | Endoplasmic reticulum stress is involved in okadaic acid-induced tau phosphorylation and neurotoxic effects of okadaic acid显示文摘The role of the endoplasmic reticulum in Alzheimer's disease pathogenesis remains poorly understood. The present study investigated the correlation of okadaic acid-induced tau hyperphosphorylation and neurotoxicity with endoplasmic reticulum stress. Following co-culture of various concentrations of okadaic acid (25, 50, 100, and 200 nmol/L) and human neuroblastoma SH-SY5Y cells, okadaic acid, a selective protein phosphatase (PP-1, PP-2A) inhibitor, reduced cell viability in a concentration-dependent manner, which was closely associated with okadaic acid-induced tau phosphorylation. In addition, expressions of the unfolded protein response activation marker glucose-regulated protein 78 (BiP/Grp78) and the CCAAT/enhancer binding protein homologous protein (CHOP)/Gadd153 increased following okadaic acid treatment. Furthermore, the unfolded protein response was activated in human embryonic kidney 293 (HEK 293) cells overexpressing tau following okadaic acid treatment, but untransfected HEK 293 cells did not exhibit activation of the unfolded protein response. These data indicate that endoplasmic reticulum stress is involved in mechanisms underlying tau phosphorylation and the cytotoxic effects of okadaic acid. | Lijie Feng Yuxian Shen Aimin Sun Yujun Shen Shengyun Fang Jun Li | 2010 | Neural Regeneration Research2010，5，20： | 3 |
| 10 | Investigation and analysis of the linkage mechanism and whole process cost of livestock manure organic fertilizer显示文摘In recent years,the utilization of manure resources for livestock and poultry farming has attracted a widespread attention,and manure resources utilization models suitable for different regional characteristics have formed gradually.Among them,the production of organic fertilizer from animal manure is a vital utilization method.However,there are still some problems such as high production costs,difficult sales,and the unwillingness of farmers to use organic fertilizers which have affected the breeding cycle and the sustainability of manure treatment in livestock and poultry breeding.This article selected 371 organic fertilizer plants,related farms and farmers in China,focusing on the main links of the entire process of livestock manure-organic fertilizer-farm application,and studied the mode of animal manure collection by organic fertilizer plants.The costs of organic fertilizer production and farmland application were discussed.Moreover,suggestions were made for the promotion and implementation of large-scale organic fertilizers to make good utilization of manure resources in livestock and poultry farming. | Shanshan Dong Bin Sui Yujun Shen Haibo Meng Lixin Zhao Jingtao Ding Haibin Zhou Xi Zhang Hongsheng Cheng Jian Wang Ran Li Liqiu Song Pengxiang Xu Ji Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 2 |
| 11 | Tunable Dynamic Black Phosphorus/Insulator/Si Heterojunction Direct-Current Generator Based on the Hot Electron Transport显示文摘Static heterojunction-based electronic devices have been widely applied because carrier dynamic processes between semiconductors can be designed through band gap engineering.Herein,we demonstrate a tunable direct-current generator based on the dynamic heterojunction,whose mechanism is based on breaking the symmetry of drift and diffusion currents and rebounding hot carrier transport in dynamic heterojunctions.Furthermore,the output voltage can be delicately adjusted and enhanced with the interface energy level engineering of inserting dielectric layers.Under the ultrahigh interface electric field,hot electrons will still transfer across the interface through the tunneling and hopping effect.In particular,the intrinsic anisotropy of black phosphorus arising from the lattice structure produces extraordinary electronic,transport,and mechanical properties exploited in our dynamic heterojunction generator.Herein,the voltage of 6.1 V,current density of 124.0 A/m^(2),power density of 201.0 W/m^(2),and energy-conversion efficiency of 31.4%have been achieved based on the dynamic black phosphorus/AlN/Si heterojunction,which can be used to directly and synchronously light up light-emitting diodes.This direct-current generator has the potential to convert ubiquitous mechanical energy into electric energy and is a promising candidate for novel portable and miniaturized power sources in the in situ energy acquisition field. | Yanghua Lu Sirui Feng Runjiang Shen Yujun Xu Zhenzhen Hao Yanfei Yan Haonan Zheng Xutao Yu Qiuyue Gao Panpan Zhang Shisheng Lin | 2019 | Research2019，，1： | 2 |
| 12 | Enhanced CO2 adsorption capacity and stability using CaO‐based adsorbents treated by hydration显示文摘 | Shengping Wang Hui Shen Shasha Fan Yujun Zhao Xinbin Ma Jinlong Gong | 2013 | AIChE J2013，，10： | 1 |
| 13 | Preparation of cu-coated diamond particles and Its Influence on the performances of diamond/cu composites 显示文摘 | Yujun Zhang Huachun Cai Zhuoshen shen | 2013 | Advanced Materials Research2013，，602603： | 1 |
| 14 | Effect of aeration rate, C/N ratio and moisture content on the stability and maturity of compost显示文摘 | Rui Guo Guoxue Li Tao Jiang Frank Schuchardt Tongbin Chen Yuanqiu Zhao Yujun Shen | 2012 | Bioresource Technology2012，，： | 1 |
| 15 | Dissection the endocytic routes of viral capsid proteins-coated upconversion nanoparticles by single-particle tracking显示文摘Real-time exploring the cellular endocytic pathway of viral capsid proteins(VCPs)functionalized nanocargos at the single-particle level can provide deep insight into the kinetic information involved in virus infection.In this work,porcine circovirus type 2(PCV2)VCPs with different functions are modified onto the surface of upconversion nanoparticles(VCPs-UCNPs)to investigate the cellular internalization process in real-time.Clathrin-mediated endocytosis is found to be the essential uptake mechanism for these VCPs-UCNPs.Besides,it is verified that P_(1)-UCNPs(PCV2 VCPs with nuclear localization signal,namely P1)can be easily assembled close to the perinuclear area,which is different from that of P_(2)-UCNPs(PCV2 VCPs without nuclear localization signal,namely P_(2)).Interestingly,multistep entry processes are observed.Particularly,confined diffusion is observed during the transmembrane process.The intracellular transport of VCPs-UCNPs is dependent on microtubules toward the cell interior.During this process,P_(1)-UCNPs display increased velocities with active transport,while diffusion much faster around the perinuclear area.But for P_(2)-UCNPs,there are only two phases involved in their endocytosis process.This study presents distinct dynamic mechanisms for the nanocargos with different functions,which would make a useful contribution to the development of robust drug delivery systems. | Yujun Ning Lin Wei Shen Lin Yifan Jiang Naidong Wang Lehui Xiao | 2022 | Chinese Chemical Letters2022，33，10： | 1 |
| 16 | Impact of struvite crystallization on nitrogen losses during composting of pig manure and cornstalk显示文摘 | Limei Ren Frank Schuchardt Yujun Shen Guoxue Li Chunping Li | 2009 | Waste Management2009，，5： | 1 |
| 17 | Apoptotic Caspases Regulate Induction of iPSCs from Human Fibroblasts显示文摘 | Fang Li Zhimin He Jingping Shen Qian Huang Wenrong Li Xinjian Liu Yujun He Frank Wolf Chuan-Yuan Li | 2010 | Cell Stem Cell2010，，4： | 1 |
| 18 | Heavy metals and community structure of microorganism changes during livestock manure composting with inoculation of effective microorganisms显示文摘Effective microorganisms(EM)is usually used in composting to improve the composting process.However,the effect of EM on heavy metals evolution was still unclear.This study was performed to illustrate the microbial community changes that occur during composting with the addition of EM and to determine the evolution of heavy metal speciation during this process.The requirement of harmlessness for pig manure was met after the addition of EM at a dosage of 0.5%,with a germination index of 96.42%.The bacterial and fungal diversity were both found to decrease during the composting process.Additionally,the bioavailability of Cu and Pb decreased significantly during composting.Significant correlations were observed between the microbial composition and the percentage of different heavy metals fractions;however,the mechanism responsible for this correlation requires further investigation.This study has the potential to contribute to control of heavy metal contamination during the process of recycling pig manure through the controlled addition of EM. | Haibin Zhou Yujun Shen Ran Li Haibo Meng Xi Zhang Jian Wang Hongsheng Cheng Shanshan Dong Liqiu Song Jingtao Ding Qiongyi Cheng | 2020 | International Journal of Agricultural and Biological Engineering2020，13，6： | 1 |
| 19 | Online monitoring of volatile organic compound production and emission during sewage sludge composting显示文摘 | Yujun Shen Tong-Bin Chen Ding Gao Guodi Zheng Hongtao Liu Qiwei Yang | 2012 | Bioresource Technology2012，，： | 1 |
| 20 | Microstructure and mechanical property of directionally solidified NiAl–Cr(Mo)–(Hf, Dy) alloy at different withdrawal rates显示文摘 | Lei Wang Jun Shen Zhao Shang Jianfei Zhang Yujun Du Hengzhi Fu | 2014 | Materials Science & Engineering A2014，，： | 1 |
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